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An efficient mathematical strategy in the field of solution processed electrochromic (EC) films is outlined as a combination of an experimental work, modeling, and information extraction from massive computational data via statistical software. Design of Experiment (DOE) was used for statistical multivariate analysis and prediction of mixtures through a multiple regression model, as well as the optimization of a five-component sol--gel precursor subjected to complex constraints. This approach significantly reduces the number of experiments to be realized, from 162 in the full factorial (L = 3) and 72 in the extreme vertices (D = 2) approach down to only 30 runs, while still maintaining a high accuracy of the analysis. By carrying out a finite number of experiments, the empirical modeling in this study shows reasonably good prediction ability in terms of the overall EC performance. An optimized ink formulation was employed in a prototype of a passive EC matrix fabricated in order to test and trial this optically active material system together with a solid-state electrolyte for the prospective application in EC displays. Coupling of DOE with chromogenic material formulation shows the potential to maximize the capabilities of these systems and ensures increased productivity in many potential solution-processed electrochemical applications. [ABSTRACT FROM AUTHOR]

Abstract: A dye sensitized TiO2 photodetector has been integrated with a DNA detection method based on non-cross-linking hybridization of DNA-functionalized gold nanoparticles, resulting in a disposable colorimetric biosensor. We present a new approach for the fabrication of dye sensitized TiO2 photodetectors by an inkjet printing technique—a non-contact digital, additive, no mask and no vacuum patterning method, ideal for cost efficient mass production. The developed biosensor was compared against a dye sensitized photodetector fabricated by the traditional “doctor blade” method. Detection of gold nanoparticle aggregation was possible for concentrations as low as 1.0nM for the “doctor blade” system, and 1.5nM for the inkjet printed photodetector. The demonstrated sensitivity limits of developed biosensors are comparable to those of spectrophotometric techniques (1.0nM). Our results show that a difference higher than 17% by traditional photodetector and 6% by inkjet printed in the photoresponses for the complementary and non-complementary gold nanoprobe assays could be attained for a specific DNA sequence from Mycobacterium tuberculosis, the etiologic agent of human tuberculosis. The decrease of costs associated with molecular diagnostic provided by a platform such as the one presented here may prove of paramount importance in developing countries. [Copyright &y& Elsevier]

An efficient mathematical strategy in the field of solution processed electrochromic (EC) films is outlined as a combination of an experimental work, modeling, and information extraction from massive computational data via statistical software. Design of Experiment (DOE) was used for statistical multivariate analysis and prediction of mixtures through a multiple regression model, as well as the optimization of a five-component sol-gel precursor subjected to complex constraints. This approach significantly reduces the number of experiments to be realized, from 162 in the full factorial (L=3) and 72 in the extreme vertices (D=2) approach down to only 30 runs, while still maintaining a high accuracy of the analysis. By carrying out a finite number of experiments, the empirical modeling in this study shows reasonably good prediction ability in terms of the overall EC performance. An optimized ink formulation was employed in a prototype of a passive EC matrix fabricated in order to test and trial this optically active material system together with a solid-state electrolyte for the prospective application in EC displays. Coupling of DOE with chromogenic material formulation shows the potential to maximize the capabilities of these systems and ensures increased productivity in many potential solution-processed electrochemical applications.