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2. The kinetic space of multistationarity in dual phosphorylation

Author

Feliu, E., Kaihnsa, N., de Wolff, T., and Yürük, O.

Subjects
Quantitative Biology - Molecular Networks, Mathematics - Algebraic Geometry, Mathematics - Dynamical Systems
Abstract

Multistationarity in molecular systems underlies switch-like responses in cellular decision making. Determining whether and when a system displays multistationarity is in general a difficult problem. In this work we completely determine the set of kinetic parameters that enable multistationarity in a ubiquitous motif involved in cell signaling, namely a dual phosphorylation cycle. In addition we show that the regions of multistationarity and monostationarity are both path connected. We model the dynamics of the concentrations of the proteins over time by means of a parametrized polynomial ordinary differential equation (ODE) system arising from the mass-action assumption. Since this system has three linear first integrals defined by the total amounts of the substrate and the two enzymes, we study for what parameter values the ODE system has at least two positive steady states after suitably choosing the total amounts. We employ a suite of techniques from (real) algebraic geometry, which in particular concern the study of the signs of a multivariate polynomial over the positive orthant and sums of nonnegative circuit polynomials.

Published
2020

6. Home parenteral nutrition (HPN) using individually compounded PN via A 7/8/9-Multi-chamber system versus PN via 2/3-chamber bags in subjects with metastatic or localized solid tumors requiring HPN - The IKF-010 Pekannuss trial

Author

Al-Batran, S.-E., primary, Roetzer, I., additional, Wohn, L., additional, Blau, W., additional, Zander, T., additional, Luley, K.B., additional, Ivanyi, P., additional, Hofheinz, R.-D., additional, Groschek, M., additional, Kreiss-Sender, J., additional, Baur, C., additional, Wolff, T., additional, Wenning, B., additional, Decker-Baumann, C., additional, Bouymayan, S., additional, Sookthai, D., additional, Schaaf, M., additional, Riedel, J., additional, Goetze, T.O., additional, and Haag, G.M., additional

Published
2023
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12. A local smoothing estimate in higher dimensions

Author

Laba, I. and Wolff, T.

Subjects
Mathematics - Classical Analysis and ODEs
Abstract

We prove the higher-dimensional analogue of Wolff's local smoothing estimate (Geom. Funct. Anal. 2001) for large p. As in the 2+1-dimensional case, the estimate is sharp for any given value of p, but it is likely that the range of p can be improved., Comment: 25 pages

Published
2002

14. Choices of Stent and Cerebral Protection in the Ongoing ACST-2 Trial: A Descriptive Study

Author

Fraedrich, G., Rantner, B., Gizewski, E., Gruber, I., Hendriks, J., Cras, P., Lauwers, P., van Scheil, P., Vermassen, F., Van Herzeele, I., Geenens, M., Hemelsoet, D., Lerut, P., Lambrecht, B., Saad, G., Peeters, A., Bosiers, M., da Silva, E., de Luccia, N., Sitrangulo, J.C., Jr., Estenssoro, A.E.V., Presti, C., Casella, I., Monteiro, J.A.T., Campos, W., Jr., Puech-Leao, P., Petrov, V., Bachvarov, C., Hill, M., Mitha, A., Wong, J., Liu, C.-W., Bao, L., Yu, C., Cvjetko, I., Vidjak, V., Fiedler, J., Ostry, S., Sterba, L., Kostal, P., Staffa, R., Vlachovsky, R., Privara, M., Kriz, Z., Vojtisek, B., Krupa, P., Reif, M., Benes, V., Buchvald, P., Endrych, L., Prochazka, V., Kuliha, M., Otahal, D., Hrbac, T., Netuka, D., Mohapl, M., Kramier, F., Eldessoki, M., Heshmat, H., Abd-Allah, F., Palmiste, V., Margus, S., Toomsoo, T., Becquemin, J.-P., Bergeron, P., Abdulamit, T., Cardon, J.-M., Debus, S., Thomalla, G., Fiehler, J., Gerloss, C., Grzyska, U., Storck, M., LaMacchia, E., Eckstein, H.H., Söllner, H., Berger, H., Kallmayer, M., Popert, H., Zimmermann, A., Guenther, A., Klingner, C., Mayer, T., Schubert, J., Zanow, J., Scheinert, D., Banning-Eichenseer, U., Bausback, Y., Branzan, D., Braünilch, S., Lenzer, J., Schidt, A., Staab, H., Ulirch, M., Barlinn, J., Haase, K., Abramyuk, A., Bodechtel, U., Gerber, J., Reeps, C., Pfeiffer, T., Torello, G., Cöster, A., Giannoukas, A., Spanos, K., Matsagkas, M., Koutias, S., Vasdekis, S., Kakisis, J., Moulakakis, K., Lazaris, A., Liapas, C., Brountzos, E., Lazarides, M., Ioannou, N., Polydorou, A., Fulop, B., Fako, E., Voros, E., Bodosi, M., Nemeth, T., Barzo, P., Pazdernyik, S., Entz, L., Szeberin, Z., Dosa, E., Nemes, B., Jaranyi, Z., Pazdernyia, S., Madhaban, P., Hoffman, A., Nikolsky, E., Beyar, R., Casana, R., Tolva, V., Silingardi, R., Lauricella, A., Coppi, G., Nicoloci, E., Tusini, N., Strozzi, F., Vecchiati, E., Ferri, M., Ferrero, E., Psacharopulo, D., Gaggiano, A., Viazzo, A., Farchioni, L., Parlani, G., Caso, V., De Rangoy, P., Verzini, F., Castelli, P., DeLodovici, M.L., Carrafiello, G., Ierardi, A.M., Piffaretti, G., Nano, G., Occhiuto, M.T., Malacrida, G., Tealdi, D., Steghter, S., Stella, A., Pini, R., Faggioli, G., Sacca, S., Negri, M.D., Palombo, M., Perfumo, M.C., Fadda, G.F., Kasemi, H., Cernetti, C., Tonello, D., Visonà, A., Mangialardi, N., Ronchey, S., Altavista, M.C., Michelagnoli, S., Chisci, E., Speziale, F., Capoccia, L., Veroux, P., Giaquinta, A., Patti, F., Pulli, R., Boggia, P., Angiletta, D., Amatucci, G., Spinetti, F., Mascoli, F., Tsolaki, E., Civilini, E., Reimers, B., Setacci, C., Pogany, G., Odero, A., Accrocca, F., Bajardi, G., Takashi, I., Masayuki, E., Hidenori, E., Aidashova, B., Kospanov, N., Bakke, S., Skjelland, M., Czlonkowska, A., Kobayashi, A., Proczka, R., Dowzenko, A., Czepel, W., Polanski, J., Bialek, P., Ozkinis, G., Snoch-Ziólkiewicz, M., Gabriel, M., Stanisic, M., Iwanowski, W., Andziak, P., Gonçalves, F.B., Starodubtsev, V., Ignatenko, P., Karpenko, A., Radak, D., Aleksic, N., Sagic, D., Davidovic, L., Koncar, I., Tomic, I., Colic, M., Bartkoy, D., Rusnak, F., Gaspirini, M., Praczek, P., Milosevic, Z., Flis, V., Bergauer, A., Kobilica, N., Miksic, K., Matela, J., Blanco, E., Guerra, M., Riambau, V., Gillgren, P., Skioldebrand, C., Nymen, N., Berg, B., Delle, M., Formgren, J., Kally, T.B., Qvarfordt, P., Plate, G., Pärson, H., Lindgren, H., Bjorses, K., Gottsäter, A., Warvsten, M., Kristmundsson, T., Forssell, C., Malina, M., Holst, J., Kuhme, T., Sonesson, B., Lindblad, B., Kolbel, T., Acosta, S., Bonati, L., Traenka, C., Mueller, M., Lattman, T., Wasner, M., Mujagic, E., Von Hessling, A., Isaak, A., Stierli, P., Eugster, T., Mariani, L., Stippich, C., Wolff, T., Kahles, T., de Borst, G.J., Toorop, R., Moll, F., Lo, R., Meershoek, A., Jahrome, A.K., Vos, A.W.F., Schuiling, W., Keunen, R., Reijnen, M., Macsweeney, S., McConachie, N., Southam, A., Stansby, G., Lees, T., Lambert, D., Clarke, M., Wyatt, M., Kappadath, S., Wales, L., Jackson, R., Raudonaitis, A., MacDonald, S., Dunlop, P., Brown, A., Vetrivel, S., Bajoriene, M., Gopi, R., McCollum, C., Wolowczyk, L., Ghosh, J., Seriki, D., Ashleigh, R., Butterfield, J., Welch, M., Smyth, J.V., Briley, D., Schulz, U., Perkins, J., Hands, L., Kuker, W., Darby, C., Handa, A., Sekaran, L., Poskitt, K., Bulbulia, R., Morrison, J., Guyler, P., Grunwald, I., Brown, J., Jakeways, M., Tysoe, S., Hargroves, D., Gunathilagan, G., Insall, R., Senaratne, J., Beard, J., Cleveland, T., Nawaz, S., Lonsdale, R., Turner, D., Gaines, P., Nair, R., Chetter, I., Robinson, G., Akomolafe, B., Hatfield, J., Saastamoinen, K., Crinnion, J., Egun, A.A., Thomas, J., Drinkwater, S., D'Souza, S., Thomson, G., Gregory, B., Babu, S., Ashley, S., Joseph, T., Gibbs, R., Tebit, G., Mehrzad, A., Enevoldson, P., Mendalow, D., Parry, A., Tervitt, G., Clifton, A., Nazzel, M., Halliday, A., Peto, R., Pan, H., Potter, J., Bullbulia, R., Mihaylova, B., Flather, M., Mansfield, A., Simpson, D., Thomas, D., Gray, W., Farrell, B., Davies, C., Rahimi, K., Gough, M., Cao, P., Rothwell, P., Belli, A., Mafham, M., Herrington, W., Sandercock, P., Gray, R., Shearman, C., Molyneux, A., Gray, A., Clarke, A., Sneade, M., Tully, L., Brudlo, W., Lay, M., Munday, A., Berry, C., Tochlin, S., Cox, J., Kurien, R., Chester, J., de Waard, D.D., Huibers, A., and Bonati, L.H.

Published
2017
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15. Selective Methanol Oxidation to Green Oxygenates—Catalyst Screening, Reaction Kinetics and Performance in Fixed-Bed and Membrane Reactors

Author

Walter, J., Wolff, T., and Hamel, C.

Subjects
selective methanol oxidation, green oxygenates, solid acid/base catalysts, reaction kinetics, membrane reactors, Physical and Theoretical Chemistry, Catalysis, General Environmental Science
Abstract

Experimental and simulation-based investigations are carried out for the selective oxidation of green methanol to the oxygenates dimethoxymethane (DMM) and methyl formate (MF), including an initial catalyst screening, the derivation of a reaction kinetic model, and a feasibility study of a fixed-bed and a membrane reactor with oxygen distribution. The catalyst screening of different supports and loading of vanadium revealed a 6.6 wt.-% VOx/TiO2 catalyst offering the highest potential to the formation for the target products. Kinetic experiments performed in a broad range of operation conditions, e.g., residence time, temperature, and oxygen concentration, are used for the postulation of a reaction network, providing the basis for mathematical modeling of the individual five reaction rates with a reduced mechanistic approach. A simulation study based on the derived reaction kinetics and parameters revealed the high potential of a distributed oxygen dosing at high residence times, outperforming the conventional fixed-bed reactor by up to 6% in the yield of DMM and up to 19% in the yield of MF. The formation of DMM is favored at low temperatures, whereas the formation of MF is supported by high temperatures.

Published
2023
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17. A searchable image resource of Drosophila GAL4-driver expression patterns with single neuron resolution

Author

Meissner, G.W., Nern, A., Dorman, Z., DePasquale, G.M., Forster, K., Gibney, T., Hausenfluck, J.H., He, Y., Iyer, N.A., Jeter, J., Johnson, L., Johnston, R.M., Lee, K., Melton, B., Yarbrough, B., Zugates, C.T., Clements, Jody, Goina, C., Otsuna, H., Rokicki, K., Svirskas, R.R., Aso, Y., Card, G.M., Dickson, B.J., Ehrhardt, E., Goldammer, J., Ito, M., Kainmueller, D., Korff, W., Mais, L., Minegishi, R., Namiki, S., Rubin, G.M., Sterne, G.R., Wolff, T., and Malkesman, O.

Subjects
Function and Dysfunction of the Nervous System
Abstract

Precise, repeatable genetic access to specific neurons via GAL4/UAS and related methods is a key advantage of Drosophila neuroscience. Neuronal targeting is typically documented using light microscopy of full GAL4 expression patterns, which generally lack the single-cell resolution required for reliable cell type identification. Here we use stochastic GAL4 labeling with the MultiColor FlpOut approach to generate cellular resolution confocal images at large scale. We are releasing aligned images of 74,000 such adult central nervous systems. An anticipated use of this resource is to bridge the gap between neurons identified by electron or light microscopy. Identifying individual neurons that make up each GAL4 expression pattern improves the prediction of split-GAL4 combinations targeting particular neurons. To this end we have made the images searchable on the NeuronBridge website. We demonstrate the potential of NeuronBridge to rapidly and effectively identify neuron matches based on morphology across imaging modalities and datasets.

Published
2023

19. Effects of anacetrapib on plasma lipids in specific patient subgroups in the DEFINE (Determining the Efficacy and Tolerability of CETP INhibition with AnacEtrapib) trial

Author

Gerstman, M., Howes, L., Kostner, K., Nestel, P., Sullivan, D., Brath, H., Patsch, J., Paulweber, B., Toplak, H., Constance, C.M., Howlett, E., Mymin, D., Pliamm, L., Saunders, K.K., Tardif, J.-C., Tytus, R., Aschner, P., Keinänen-Klukaanniemi, S., Strandberg, T., Taskinen, M.-R., Luc, G., Richter, D., Schlienger, J.L., Zaïr, Y., Appel, K.-F., Baar, M., Luley, C., Overhoff, U., Pomykaj, T., Schaefer, T., Lau, S.T., Lee, K.L.F., Tan, K., Tomlinson, B., Tsang, M.W., Badacsonyi, K., Kalina, Á., Kanakaridisz, N., Márk, L., Péterfai, É., Regos, L., Reiber, I., Takács, J., Vértes, A., Elis, A., Gavish, D., Harats, D., Hussein, O., Hayek, T., Leitersdorf, E., Bin Abdul Ghapar, A.K., Chee, K.H., Ismail, S.B., Ling, K.H., Ramanathan, G.R.L., Sim, K.H., Alvarado, R., Benavides, M., Cardona, G.E., Gonzalez, G., Verdejo, J., Basart, D.C.G., Imholz, B.P.M., Jonker, J.J.C., Nierop, P.R., Posma, J.L., Twickler, Th.B., Barrington-Ward, E., Cutfield, R., Friedlander, D.H., Scott, R.S., Istad, H., Langslet, G., Skjelvan, G.K., Campodónico Hoyos, S.J., Coloma Araniya, R., Gallegos C., A., Pino Morales, C.A., Watanabe, L., Arutyunov, G.P., Blokhin, A.B., Bubnova, M.G., Marcevich, S.Y., Álvarez Sánchez, C., Álvarez-Sala Walther, L.A., Gil Extremera, B., Perez Jimenez, F., de Teresa Parreño, L., Anderberg, C.-P., Hedin, U., Hellberg, A., Höök, P., Kjellström, T., Nilsson, P., Olsson, A.G., Rosenqvist, U., Tolagen, K., Wolff, T., Baskin, A., Bays, H.E., Bernstein, R.I., Bittar, N., Brinton, E.A., Chee, L.H.K., Cottiero, R.A., D'Agostino, R.D., Davidson, M.H., Denker, P.S., Garcia, R.K., Hippert, R.K., Isakov, T., Kaster, S.R., Kerzner, B., Klein, E.J., Koren, M.J., Kutner, M.E., Liljenquist, D., Lorch, D.G., Jr., Lorraine, R., Lubin, B.C., Lunde, N.M., Majchrzak, T.J., McKenney, J.M., Mukherjee, S., Muse, D.D., Otruba, M.S., Pappas, J.E., Patrick, K., Powell, S.J., Riffer, E., Rink, L.D., Rohlf, J.L., Rosen, J.B., Rosenbilt, P.D., Roth, E.M., Rubenstein, C.J., Rubino, J., Rudolph, L.A., Schneider, A., Short, W.G., Silverfield, J.C., Suresh, D.P., Tarshis, G.A., Toth, P.D., Townsend, R.W., Wahl, T.O., Brinton, Eliot A., Kher, Uma, Shah, Sukrut, Cannon, Christopher P., Davidson, Michael, Gotto, Antonio M., Ashraf, Tanya B., McCrary Sisk, Christine, Dansky, Hayes, Mitchel, Yale, and Barter, Philip

Published
2015
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20. Renal failure: a non-cardiac source of high sensitivity cardiac troponin T

Author

Papachristou, A, primary, Puelacher, C, additional, Glarner, N, additional, Strebel, I, additional, Steiger, J, additional, Diebold, M, additional, Lurati Buse, G, additional, Bolliger, D, additional, Steiner, L A, additional, Gurke, L, additional, Wolff, T, additional, Mujagic, E, additional, Gualandro, D M, additional, Mueller, C, additional, and Breidthardt, T, additional

Published
2022
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40. Studies on the Formation of Hepatic DNA Adducts by the Antiandrogenic and Gestagenic Drug, Cyproterone Acetate : 1. Adduct Levels in Various Species Including Man and 2. Persistence and Accumulation in the Rat

Author

Werner, S., Topinka, J., Kunz, S., Beckurts, T., Heidecke, C.-D., Schwarz, L. R., Wolff, T., Snyder, Robert, editor, Sipes, I. Glenn, editor, Jollow, David J., editor, Monks, Terrence J., editor, Kocsis, James J., editor, Kalf, George F., editor, Greim, Helmut, editor, and Witmer, Charlotte M., editor

Published
1996
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