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1. Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes

Author

Hyun-Yong Kim, Jung-Ran Noh, Sung-Je Moon, Dong-Hee Choi, Yong-Hoon Kim, Kyoung-Shim Kim, Hong-Sun Yook, Jin-Pyo An, Won-Keon Oh, Jung Hwan Hwang, and Chul-Ho Lee

Subjects
Antioxidants, apoptosis, reactive oxygen species, liver, oxidative stress, injury, enzyme, extracts, Pathology, RB1-214, Biology (General), QH301-705.5
Abstract

Objective: We aimed to investigate the effect of Sicyos angulatus (SA) ethanolic extracts as antioxidants and potential treatments for liver disease. Methods: To establish a mouse model of liver injury, C57BL/6 male mice were injected via the caudal vein with a single dose of concanavalin A (Con A, 15 mg kg−1). SA extracts were administered once by oral gavage 30 min before Con A injection. Results: In vitro studies showed that SA decreased tert-butyl hydroperoxide (t-BHP)-induced reactive oxygen species (ROS) production. SA administration reduced plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, as well as hepatic ROS levels, in a dose-dependent manner. Moreover, SA increased the activities of the hepatic antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase in a dose-dependent manner. Furthermore, SA treatment reduced pro-apoptotic protein levels. Con A-mediated cytosolic release of Smac/DIABLO and apoptosis-inducing factor (AIF), which are markers of necrosis, were dramatically decreased in HepG2 cells treated with SA. Conclusion: SA ameliorated liver injury and might be a good strategy for the treatment of liver injury.

Published
2018
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2. Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes

Author

Hong-Sun Yook, Yong-Hoon Kim, Jung-Ran Noh, Chul-Ho Lee, Dong-Hee Choi, Won-Keon Oh, Hyun-Yong Kim, Jung Hwan Hwang, Kyoung-Shim Kim, Jin-Pyo An, and Sung-Je Moon

Subjects
0301 basic medicine, Male, extracts, Physiology, injury, Clinical Biochemistry, Sicyos angulatus, Pharmacology, medicine.disease_cause, liver, Biochemistry, Loranthaceae, Antioxidants, 03 medical and health sciences, Mice, Downregulation and upregulation, tert-Butylhydroperoxide, medicine, lcsh:Pathology, Animals, oxidative stress, Aspartate Aminotransferases, lcsh:QH301-705.5, Acute liver injury, chemistry.chemical_classification, reactive oxygen species, Reactive oxygen species, Glutathione Peroxidase, biology, Plant Extracts, Superoxide Dismutase, Biochemistry (medical), apoptosis, Alanine Transaminase, Cell Biology, Anti oxidant, biology.organism_classification, Glutathione, Mice, Inbred C57BL, enzyme, 030104 developmental biology, Enzyme, chemistry, lcsh:Biology (General), Apoptosis, Lipid Peroxidation, Oxidative stress, Research Article, lcsh:RB1-214
Abstract

Objective: We aimed to investigate the effect of Sicyos angulatus (SA) ethanolic extracts as antioxidants and potential treatments for liver disease. Methods: To establish a mouse model of liver injury, C57BL/6 male mice were injected via the caudal vein with a single dose of concanavalin A (Con A, 15 mg kg−1). SA extracts were administered once by oral gavage 30 min before Con A injection. Results:In vitro studies showed that SA decreased tert-butyl hydroperoxide (t-BHP)-induced reactive oxygen species (ROS) production. SA administration reduced plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, as well as hepatic ROS levels, in a dose-dependent manner. Moreover, SA increased the activities of the hepatic antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase in a dose-dependent manner. Furthermore, SA treatment reduced pro-apoptotic protein levels. Con A-mediated cytosolic release of Smac/DIABLO and apoptosis-inducing factor (AIF), which are markers of necrosis, were dramatically decreased in HepG2 cells treated with SA. Conclusion: SA ameliorated liver injury and might be a good strategy for the treatment of liver injury.

Published
2018

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