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7. Bilateral Superficial Cervical Plexus Block Combined with General Anesthesia Administered in Thyroid Operations

Author

Shih, Ming-Lang, Duh, Quan-Yang, Hsieh, Chung-Bao, Liu, Yao-Chi, Lu, Chueng-He, Wong, Chih-Shung, Yu, Jyh-Cherng, and Yeh, Chun-Chang

Subjects
Medicine & Public Health, Vascular Surgery, Thoracic Surgery, General Surgery, Cardiac Surgery, Abdominal Surgery, Surgery
Abstract

We investigated the analgesic efficacy of bilateral superficial cervical plexus block in patients undergoing thyroidectomy and to determine whether it reduces the adverse effects of general anesthesia.We prospectively recruited 162 patients who underwent elective thyroid operations from March 2006 to October 2007. They were randomly assigned to receive a bilateral superficial cervical block (12 ml per side) with isotonic saline (group A; n = 56), bupivacaine 0.5% (group B; n = 52), or levobupivacaine 0.5% (group C; n = 54) after induction of general anesthesia. The analgesic efficacy of the block was assessed with: intraoperative anesthetics (desflurane), numbers of patients needing postoperative analgesics, the time to the first analgesics required, and pain intensity by visual analog scale (VAS). Postoperative nausea and vomiting (PONV) for 24 h were also assessed by the “PONV grade.” We also compared hospital stay, operative time, and discomfort in swallowing.There were no significant differences in patient characteristics. Each average end-tidal desflurane concentration was 5.8, 3.9, and 3.8% in groups A, B, and C, respectively (p

Published
2010

13. Teneligliptin Co-Infusion Alleviates Morphine Tolerance by Inhibition of Spinal Microglial Cell Activation in Streptozotocin-Induced Diabetic Rats.

Author

Kuthati, Yaswanth, Rao, Vaikar Navakanth, Huang, Wei-Hsiu, Busa, Prabhakar, and Wong, Chih-Shung

Subjects
STREPTOZOTOCIN, MICROGLIA, CD26 antigen, NUCLEAR proteins, MORPHINE, OPIOID receptors
Abstract

Morphine (MOR) is a commonly prescribed drug for the treatment of moderate to severe diabetic neuropathic pain (DNP). However, long-term MOR treatment is limited by morphine analgesic tolerance (MAT). The activation of microglial cells and the release of glia-derived proinflammatory cytokines are known to play an important role in the development of MAT. In this study, we aimed to investigate the effects of the dipeptidyl peptidase-4 inhibitor (DPP-4i) teneligliptin (TEN) on MOR-induced microglial cell activation and MAT in DNP rats. DNP was induced in four groups of male Wistar rats through a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg, freshly dissolved in 5 mmol/L citrate buffer, pH 4.5). Sham rats were administered with the vehicle. Seven days after STZ injection, all rats were implanted with an intrathecal (i.t) catheter connected to a mini-osmotic pump, divided into five groups, and infused with the following combinations: sham + saline (1 µL/h, i.t), DNP + saline (1 µL/h, i.t), DNP + MOR (15 µg/h, i.t), DNP + TEN (2 µg/h, i.t), and DNP + MOR (15 µg/h, i.t) + TEN (2 µg/h, i.t) for 7 days at a rate of 1 μL/h. The MAT was confirmed through the measurement of mechanical paw withdrawal threshold and tail-flick tests. The mRNA expression of neuroprotective proteins nuclear factor erythroid 2-related factor (Nrf2) and heme oxygenase-1 (HO-1) in the dorsal horn was evaluated by quantitative PCR (qPCR). Microglial cell activation and mononucleate cell infiltration in the spinal cord dorsal horn were assessed by immunofluorescence assay (IFA) and Western blotting (WB). The results showed that co-infusion of TEN with MOR significantly attenuated MAT in DNP rats through the restoration of neuroprotective proteins Nrf2 and HO-1 and suppression of microglial cell activation in the dorsal horn. Though TEN at a dose of 2 μg has mild antinociceptive effects, it is highly effective in limiting MAT. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan : national prospective cohort study

Author

Taiwan Allopurinol-SCAR Consortium, Ko, Tai-Ming, Tsai, Chang-Youh, Chen, Shih-Yang, Chen, Kuo-Shu, Yu, Kuang-Hui, Chu, Chih-Sheng, Huang, Chung-Ming, Wang, Chrong-Reen, Weng, Chia-Tse, Yu, Chia-Li, Hsieh, Song-Chou, Tsai, Jer-Chia, Lai, Wen-Ter, Tsai, Wen-Chan, Yin, Guang-Dar, Ou, Tsan-Teng, Cheng, Kai-Hung, Yen, Jeng-Hsien, Liou, Teh-Ling, Lin, Tsung-Hsien, Chen, Der-Yuan, Hsiao, Pi-Jung, Weng, Meng-Yu, Chen, Yi-Ming, Chen, Chen-Hung, Liu, Ming-Fei, Yen, Hsueh-Wei, Lee, Jia-Jung, Kuo, Mei-Chuan, Wu, Chen-Ching, Hung, Shih-Yuan, Luo, Shue-Fen, Yang, Ya-Hui, Chuang, Hui-Ping, Chou, Yi-Chun, Liao, Hung-Ting, Wang, Chia-Wen, Huang, Chun-Lin, Chang, Chia-Shuo, Lee, Ming-Ta Michael, Chen, Pei, Wong, Chih-Shung, Chen, Chien-Hsiun, Wu, Jer-Yuarn, Chen, Yuan-Tsong, and Shen, Chen-Yang

Published
2015

20. What information and the extent of information research participants need in informed consent forms: a multi-country survey

Author

Karbwang, Juntra, Koonrungsesomboon, Nut, Torres, Cristina E., Jimenez, Edlyn B., Kaur, Gurpreet, Mathur, Roli, Sholikhah, Eti N., Wanigatunge, Chandanie, Wong, Chih-Shung, Yimtae, Kwanchanok, Abdul Malek, Murnilina, Ahamad Fouzi, Liyana, Ali, Aisyah, Chan, Beng Z., Chandratilake, Madawa, Chiew, Shoen C., Chin, Melvyn Y. C., Gamage, Manori, Gitek, Irene, Hakimi, Mohammad, Hussin, Narwani, Jamil, Mohd F. A., Janarsan, Pavithra, Julia, Madarina, Kanungo, Suman, Karunanayake, Panduka, Kollanthavelu, Sattian, Kong, Kian K., Kueh, Bing-Ling, Kulkarni, Ragini, Kumaran, Paul P., Kumarasiri, Ranjith, Lim, Wei H., Lim, Xin J., Mahmud, Fatihah, Mantaring, III, Jacinto B. V., Md Ali, Siti M., Mohd Noor, Nurain, Muhunthan, Kopalasuntharam, Nagandran, Elanngovan, Noor, Maisarah, Ooi, Kim H., Pradeepan, Jebananthy A., Sadewa, Ahmad H., Samaranayake, Nilakshi, Sri Ranganathan, Shalini, Subasingha, Wasanthi, Subramaniam, Sivasangari, Sulaiman, Nadirah, Tay, Ju F., Teng, Leh H., Tew, Mei M., Tharavanij, Thipaporn, Tok, Peter S. K., Weeratna, Jayanie, Wibawa, Tri, Wickremasinghe, Renu, Wongwai, Phanthipha, Yadav, Subhash, and FERCAP Multi-Country Research Team

Published
2018
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36. Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study

Author

Ko, Tai-Ming, Tsai, Chang-Youh, Chen, Shih-Yang, Chen, Kuo-Shu, Yu, Kuang-Hui, Chu, Chih-Sheng, Huang, Chung-Ming, Wang, Chrong-Reen, Weng, Chia-Tse, Yu, Chia-Li, Hsieh, Song-Chou, Tsai, Jer-Chia, Lai, Wen-Ter, Tsai, Wen-Chan, Yin, Guang-Dar, Ou, Tsan-Teng, Cheng, Kai-Hung, Yen, Jeng-Hsien, Liou, Teh-Ling, Lin, Tsung-Hsien, Chen, Der-Yuan, Hsiao, Pi-Jung, Weng, Meng-Yu, Chen, Yi-Ming, Chen, Chen-Hung, Liu, Ming-Fei, Yen, Hsueh-Wei, Lee, Jia-Jung, Kuo, Mei-Chuan, Wu, Chen-Ching, Hung, Shih-Yuan, Luo, Shue-Fen, Yang, Ya-Hui, Chuang, Hui-Ping, Chou, Yi-Chun, Liao, Hung-Ting, Wang, Chia-Wen, Huang, Chun-Lin, Chang, Chia-Shuo, Lee, Ming-Ta Michael, Chen, Pei, Wong, Chih-Shung, Chen, Chien-Hsiun, Wu, Jer-Yuarn, Chen, Yuan-Tsong, and Shen, Chen-Yang

Published
2015
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43. Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain

Author

Kuthati,Yaswanth, Busa,Prabhakar, Goutham Davuluri,Venkata Naga, and Wong,Chih Shung

Subjects
International Journal of Nanomedicine
Abstract

Yaswanth Kuthati,1 Prabhakar Busa,2 Venkata Naga Goutham Davuluri,3 Chih Shung Wong1 1Department of Anesthesiology, Cathy General Hospital, Taipei, Taiwan; 2Department of Life Sciences, National Dong Hwa University, Hualien, Taiwan; 3Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, TaiwanCorrespondence: Chih Shung WongDepartment of Anesthesiology, Cathay General Hospital, #280, Renai Road, Section 4, Taipei, TaiwanTel +886 2 27082121 Ext 3510Email w82556@gmail.comBackground: Reactive oxygen species (ROS) induced oxidative stress is linked to numerous neurological diseases, including neuropathic pain. Natural ROS scavenging enzymes like superoxide dismutase (SOD) and catalase have been found to be efficient in alleviating neuropathic pain. However, their sensitivity towards extreme pH and a short half-life limit their efficacy in vivo. Manganese oxide nanoparticles (MONPs) are recently known to possess ROS scavenging properties. In this study, MONPs were examined for their therapeutic effect on neuropathic pain.Methods: The MONPs were synthesized by a hydrothermal method. The synthesized MONPs were characterized by UV/Vis, TEM, SEM, FTIR, NTA and XRD. The biocompatibility of the nanoparticles is evaluated in neural cells using LDH assay. MONPs were evaluated for their antioxidant activity by DPPH assay. In addition, in vitro ROS scavenging properties were examined in bone marrow-derived macrophage (BMDM) cells using 2ʹ,7ʹ-dichlorofluorescin diacetate (DCFDA) assay. To evaluate the in vivo efficacy of nanoparticles, neuropathic pain was induced in Wistar rats by partial sciatic nerve transection (PSNT). On post-transection days 14 to 18, rats were intrathecally injected with MONPs and paw withdrawal threshold was measured. The spinal cords were collected and processed for Western blotting and histological analysis.Results: The synthesized MONPs were biocompatible and showed effective antioxidant activity against DPPH free radical scavenging. Further, the nanoparticles scavenged ROS efficiently in vitro in BMDM and their intrathecal administration significantly reduced mechanical allodynia as well as the expression of cyclooxygenase-2 (COX-2), an important mediator of chronic and inflammatory pain in the spinal dorsal horns of PSNT rats.Conclusion: As ROS play a significant role in neuropathic pain, we expect that MONPs could be a promising tool for the treatment of various inflammatory diseases and might also serve as a potential nanocarrier for the delivery of analgesics.Keywords: allodynia, MONPs, reactive oxygen species and neuropathic pain

Published
2019

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