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11 results on '"Wong, J W H"'

5. A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients

Author

Beck, D, primary, Thoms, J A I, additional, Palu, C, additional, Herold, T, additional, Shah, A, additional, Olivier, J, additional, Boelen, L, additional, Huang, Y, additional, Chacon, D, additional, Brown, A, additional, Babic, M, additional, Hahn, C, additional, Perugini, M, additional, Zhou, X, additional, Huntly, B J, additional, Schwarzer, A, additional, Klusmann, J-H, additional, Berdel, W E, additional, Wörmann, B, additional, Büchner, T, additional, Hiddemann, W, additional, Bohlander, S K, additional, To, L B, additional, Scott, H S, additional, Lewis, I D, additional, D'Andrea, R J, additional, Wong, J W H, additional, and Pimanda, J E, additional

Published
2017
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6. Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias

Author

Tursky, M L, primary, Beck, D, additional, Thoms, J A I, additional, Huang, Y, additional, Kumari, A, additional, Unnikrishnan, A, additional, Knezevic, K, additional, Evans, K, additional, Richards, L A, additional, Lee, E, additional, Morris, J, additional, Goldberg, L, additional, Izraeli, S, additional, Wong, J W H, additional, Olivier, J, additional, Lock, R B, additional, MacKenzie, K L, additional, and Pimanda, J E, additional

Published
2014
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7. A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients

Author

Beck, D, Thoms, J A I, Palu, C, Herold, T, Shah, A, Olivier, J, Boelen, L, Huang, Y, Chacon, D, Brown, A, Babic, M, Hahn, C, Perugini, M, Zhou, X, Huntly, B J, Schwarzer, A, Klusmann, J-H, Berdel, W E, Wörmann, B, Büchner, T, Hiddemann, W, Bohlander, S K, To, L B, Scott, H S, Lewis, I D, D'Andrea, R J, Wong, J W H, and Pimanda, J E

Abstract

Prognostic gene expression signatures have been proposed as clinical tools to clarify therapeutic options in acute myeloid leukemia (AML). However, these signatures rely on measuring large numbers of genes and often perform poorly when applied to independent cohorts or those with older patients. Long intergenic non-coding RNAs (lincRNAs) are emerging as important regulators of cell identity and oncogenesis, but knowledge of their utility as prognostic markers in AML is limited. Here we analyze transcriptomic data from multiple cohorts of clinically annotated AML patients and report that (i) microarrays designed for coding gene expression can be repurposed to yield robust lincRNA expression data, (ii) some lincRNA genes are located in close proximity to hematopoietic coding genes and show strong expression correlations in AML, (iii) lincRNA gene expression patterns distinguish cytogenetic and molecular subtypes of AML, (iv) lincRNA signatures composed of three or four genes are independent predictors of clinical outcome and further dichotomize survival in European Leukemia Net (ELN) risk groups and (v) an analytical tool based on logistic regression analysis of quantitative PCR measurement of four lincRNA genes (LINC4) can be used to determine risk in AML.

Published
2018
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10. Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk.

Author

Krilis M, Qi M, Ioannou Y, Zhang JY, Ahmadi Z, Wong JWH, Vlachoyiannopoulos PG, Moutsopoulos HM, Koike T, Sturgess AD, Chong BH, Krilis SA, and Giannakopoulos B

Subjects
Antiphospholipid Syndrome blood, Antiphospholipid Syndrome immunology, Case-Control Studies, Healthy Volunteers, Humans, Lipid Peroxidation, Nitrates metabolism, Platelet Aggregation immunology, Protein Processing, Post-Translational immunology, Risk Factors, Thrombosis blood, beta 2-Glycoprotein I blood, beta 2-Glycoprotein I metabolism, Antiphospholipid Syndrome complications, Thrombosis immunology, beta 2-Glycoprotein I immunology
Abstract

Β 2 -Glycoprotein I (β 2 GPI) is an important anti-thrombotic protein and is the major auto-antigen in the antiphospholipid syndrome (APS). The clinical relevance of nitrosative stress in post translational modification of β 2 GPI was examined.The effects of nitrated (n)β 2 GPI on its anti-thrombotic properties and its plasma levels in primary and secondary APS were determined with appropriate clinical control groups. β2-glycoprotein I was nitrated at tyrosines 218, 275 and 309. β 2 -glycoprotein I binds to lipid peroxidation modified products through Domains IV and V. Nitrated β 2 GPI loses this binding (p < 0.05) and had diminished activity in inhibiting platelet adhesion to vWF under high shear flow (p < 0.01). Levels of nβ 2 GPI were increased in patients with primary APS compared to patients with either secondary APS (p < 0.05), autoimmune disease without APS (p < 0.05) or non-autoimmune patients with arterial thrombosis (p < 0.01) and healthy individuals (p < 0.05).In conclusion tyrosine nitration of plasma β 2 GPI is demonstrated and has important implications with regards to the pathophysiology of platelet mediated thrombosis in APS. Elevated plasma levels of nβ 2 GPI in primary APS may be a risk factor for thrombosis warranting further investigation., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2021
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