3,821 results on '"Wong, Tien Yin"'
Search Results
2. HRDC challenge: a public benchmark for hypertension and hypertensive retinopathy classification from fundus images
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Qian, Bo, Wang, Xiangning, Guan, Zhouyu, Yang, Dawei, Ran, Anran, Li, Tingyao, Wang, Zheyuan, Wen, Yang, Shu, Xinming, Xie, Jinyang, Liu, Shichang, Xing, Guanyu, Silva-Rodríguez, Julio, Kobbi, Riadh, Li, Ping, Chen, Tingli, Bi, Lei, Kim, Jinman, Jia, Weiping, Li, Huating, Qin, Jing, Zhang, Ping, Cheng, Ching-Yu, Heng, Pheng-Ann, Wong, Tien Yin, Cheung, Carol Y., Tham, Yih-Chung, Thalmann, Nadia Magnenat, and Sheng, Bin
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- 2024
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3. The ophthalmologist’s guide to evaluating the certainty of evidence using the GRADE approach
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Zeraatkar, Dena, Pitre, Tyler, Phillips, Mark, Steel, David H., Wykoff, Charles C., Wong, Tien Yin, Bhandari, Mohit, and Chaudhary, Varun
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- 2024
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4. VisionFM: a Multi-Modal Multi-Task Vision Foundation Model for Generalist Ophthalmic Artificial Intelligence
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Qiu, Jianing, Wu, Jian, Wei, Hao, Shi, Peilun, Zhang, Minqing, Sun, Yunyun, Li, Lin, Liu, Hanruo, Liu, Hongyi, Hou, Simeng, Zhao, Yuyang, Shi, Xuehui, Xian, Junfang, Qu, Xiaoxia, Zhu, Sirui, Pan, Lijie, Chen, Xiaoniao, Zhang, Xiaojia, Jiang, Shuai, Wang, Kebing, Yang, Chenlong, Chen, Mingqiang, Fan, Sujie, Hu, Jianhua, Lv, Aiguo, Miao, Hui, Guo, Li, Zhang, Shujun, Pei, Cheng, Fan, Xiaojuan, Lei, Jianqin, Wei, Ting, Duan, Junguo, Liu, Chun, Xia, Xiaobo, Xiong, Siqi, Li, Junhong, Lo, Benny, Tham, Yih Chung, Wong, Tien Yin, Wang, Ningli, and Yuan, Wu
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
We present VisionFM, a foundation model pre-trained with 3.4 million ophthalmic images from 560,457 individuals, covering a broad range of ophthalmic diseases, modalities, imaging devices, and demography. After pre-training, VisionFM provides a foundation to foster multiple ophthalmic artificial intelligence (AI) applications, such as disease screening and diagnosis, disease prognosis, subclassification of disease phenotype, and systemic biomarker and disease prediction, with each application enhanced with expert-level intelligence and accuracy. The generalist intelligence of VisionFM outperformed ophthalmologists with basic and intermediate levels in jointly diagnosing 12 common ophthalmic diseases. Evaluated on a new large-scale ophthalmic disease diagnosis benchmark database, as well as a new large-scale segmentation and detection benchmark database, VisionFM outperformed strong baseline deep neural networks. The ophthalmic image representations learned by VisionFM exhibited noteworthy explainability, and demonstrated strong generalizability to new ophthalmic modalities, disease spectrum, and imaging devices. As a foundation model, VisionFM has a large capacity to learn from diverse ophthalmic imaging data and disparate datasets. To be commensurate with this capacity, in addition to the real data used for pre-training, we also generated and leveraged synthetic ophthalmic imaging data. Experimental results revealed that synthetic data that passed visual Turing tests, can also enhance the representation learning capability of VisionFM, leading to substantial performance gains on downstream ophthalmic AI tasks. Beyond the ophthalmic AI applications developed, validated, and demonstrated in this work, substantial further applications can be achieved in an efficient and cost-effective manner using VisionFM as the foundation.
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- 2023
5. Blood biomarkers improve the prediction of prevalent and incident severe chronic kidney disease
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Nusinovici, Simon, Li, Hengtong, Chong, Crystal, Yu, Marco, Sørensen, Ida Maria Hjelm, Bisgaard, Line Stattau, Christoffersen, Christina, Bro, Susanne, Liu, Sylvia, Liu, Jian-Jun, Chi, Lim Su, Wong, Tien-Yin, Tan, Gavin S. W., Cheng, Ching-Yu, and Sabanayagam, Charumathi
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- 2024
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6. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
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Suzuki, Ken, Hatzikotoulas, Konstantinos, Southam, Lorraine, Taylor, Henry J., Yin, Xianyong, Lorenz, Kim M., Mandla, Ravi, Huerta-Chagoya, Alicia, Melloni, Giorgio E. M., Kanoni, Stavroula, Rayner, Nigel W., Bocher, Ozvan, Arruda, Ana Luiza, Sonehara, Kyuto, Namba, Shinichi, Lee, Simon S. K., Preuss, Michael H., Petty, Lauren E., Schroeder, Philip, Vanderwerff, Brett, Kals, Mart, Bragg, Fiona, Lin, Kuang, Guo, Xiuqing, Zhang, Weihua, Yao, Jie, Kim, Young Jin, Graff, Mariaelisa, Takeuchi, Fumihiko, Nano, Jana, Lamri, Amel, Nakatochi, Masahiro, Moon, Sanghoon, Scott, Robert A., Cook, James P., Lee, Jung-Jin, Pan, Ian, Taliun, Daniel, Parra, Esteban J., Chai, Jin-Fang, Bielak, Lawrence F., Tabara, Yasuharu, Hai, Yang, Thorleifsson, Gudmar, Grarup, Niels, Sofer, Tamar, Wuttke, Matthias, Sarnowski, Chloé, Gieger, Christian, Nousome, Darryl, Trompet, Stella, Kwak, Soo-Heon, Long, Jirong, Sun, Meng, Tong, Lin, Chen, Wei-Min, Nongmaithem, Suraj S., Noordam, Raymond, Lim, Victor J. Y., Tam, Claudia H. T., Joo, Yoonjung Yoonie, Chen, Chien-Hsiun, Raffield, Laura M., Prins, Bram Peter, Nicolas, Aude, Yanek, Lisa R., Chen, Guanjie, Brody, Jennifer A., Kabagambe, Edmond, An, Ping, Xiang, Anny H., Choi, Hyeok Sun, Cade, Brian E., Tan, Jingyi, Broadaway, K. Alaine, Williamson, Alice, Kamali, Zoha, Cui, Jinrui, Thangam, Manonanthini, Adair, Linda S., Adeyemo, Adebowale, Aguilar-Salinas, Carlos A., Ahluwalia, Tarunveer S., Anand, Sonia S., Bertoni, Alain, Bork-Jensen, Jette, Brandslund, Ivan, Buchanan, Thomas A., Burant, Charles F., Butterworth, Adam S., Canouil, Mickaël, Chan, Juliana C. N., Chang, Li-Ching, Chee, Miao-Li, Chen, Ji, Chen, Shyh-Huei, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, Cushman, Mary, Danesh, John, Das, Swapan K., de Silva, H. Janaka, Dedoussis, George, Dimitrov, Latchezar, Doumatey, Ayo P., Du, Shufa, Duan, Qing, Eckardt, Kai-Uwe, Emery, Leslie S., Evans, Daniel S., Evans, Michele K., Fischer, Krista, Floyd, James S., Ford, Ian, Franco, Oscar H., Frayling, Timothy M., Freedman, Barry I., Genter, Pauline, Gerstein, Hertzel C., Giedraitis, Vilmantas, González-Villalpando, Clicerio, González-Villalpando, Maria Elena, Gordon-Larsen, Penny, Gross, Myron, Guare, Lindsay A., Hackinger, Sophie, Hakaste, Liisa, Han, Sohee, Hattersley, Andrew T., Herder, Christian, Horikoshi, Momoko, Howard, Annie-Green, Hsueh, Willa, Huang, Mengna, Huang, Wei, Hung, Yi-Jen, Hwang, Mi Yeong, Hwu, Chii-Min, Ichihara, Sahoko, Ikram, Mohammad Arfan, Ingelsson, Martin, Islam, Md. Tariqul, Isono, Masato, Jang, Hye-Mi, Jasmine, Farzana, Jiang, Guozhi, Jonas, Jost B., Jørgensen, Torben, Kamanu, Frederick K., Kandeel, Fouad R., Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kaur, Varinderpal, Kawaguchi, Takahisa, Keaton, Jacob M., Kho, Abel N., Khor, Chiea-Chuen, Kibriya, Muhammad G., Kim, Duk-Hwan, Kronenberg, Florian, Kuusisto, Johanna, Läll, Kristi, Lange, Leslie A., Lee, Kyung Min, Lee, Myung-Shik, Lee, Nanette R., Leong, Aaron, Li, Liming, Li, Yun, Li-Gao, Ruifang, Ligthart, Symen, Lindgren, Cecilia M., Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Locke, Adam E., Louie, Tin, Luan, Jian’an, Luk, Andrea O., Luo, Xi, Lv, Jun, Lynch, Julie A., Lyssenko, Valeriya, Maeda, Shiro, Mamakou, Vasiliki, Mansuri, Sohail Rafik, Matsuda, Koichi, Meitinger, Thomas, Melander, Olle, Metspalu, Andres, Mo, Huan, Morris, Andrew D., Moura, Filipe A., Nadler, Jerry L., Nalls, Michael A., Nayak, Uma, Ntalla, Ioanna, Okada, Yukinori, Orozco, Lorena, Patel, Sanjay R., Patil, Snehal, Pei, Pei, Pereira, Mark A., Peters, Annette, Pirie, Fraser J., Polikowsky, Hannah G., Porneala, Bianca, Prasad, Gauri, Rasmussen-Torvik, Laura J., Reiner, Alexander P., Roden, Michael, Rohde, Rebecca, Roll, Katheryn, Sabanayagam, Charumathi, Sandow, Kevin, Sankareswaran, Alagu, Sattar, Naveed, Schönherr, Sebastian, Shahriar, Mohammad, Shen, Botong, Shi, Jinxiu, Shin, Dong Mun, Shojima, Nobuhiro, Smith, Jennifer A., So, Wing Yee, Stančáková, Alena, Steinthorsdottir, Valgerdur, Stilp, Adrienne M., Strauch, Konstantin, Taylor, Kent D., Thorand, Barbara, Thorsteinsdottir, Unnur, Tomlinson, Brian, Tran, Tam C., Tsai, Fuu-Jen, Tuomilehto, Jaakko, Tusie-Luna, Teresa, Udler, Miriam S., Valladares-Salgado, Adan, van Dam, Rob M., van Klinken, Jan B., Varma, Rohit, Wacher-Rodarte, Niels, Wheeler, Eleanor, Wickremasinghe, Ananda R., van Dijk, Ko Willems, Witte, Daniel R., Yajnik, Chittaranjan S., Yamamoto, Ken, Yamamoto, Kenichi, Yoon, Kyungheon, Yu, Canqing, Yuan, Jian-Min, Yusuf, Salim, Zawistowski, Matthew, Zhang, Liang, Zheng, Wei, Raffel, Leslie J., Igase, Michiya, Ipp, Eli, Redline, Susan, Cho, Yoon Shin, Lind, Lars, Province, Michael A., Fornage, Myriam, Hanis, Craig L., Ingelsson, Erik, Zonderman, Alan B., Psaty, Bruce M., Wang, Ya-Xing, Rotimi, Charles N., Becker, Diane M., Matsuda, Fumihiko, Liu, Yongmei, Yokota, Mitsuhiro, Kardia, Sharon L. R., Peyser, Patricia A., Pankow, James S., Engert, James C., Bonnefond, Amélie, Froguel, Philippe, Wilson, James G., Sheu, Wayne H. H., Wu, Jer-Yuarn, Hayes, M. Geoffrey, Ma, Ronald C. W., Wong, Tien-Yin, Mook-Kanamori, Dennis O., Tuomi, Tiinamaija, Chandak, Giriraj R., Collins, Francis S., Bharadwaj, Dwaipayan, Paré, Guillaume, Sale, Michèle M., Ahsan, Habibul, Motala, Ayesha A., Shu, Xiao-Ou, Park, Kyong-Soo, Jukema, J. Wouter, Cruz, Miguel, Chen, Yii-Der Ida, Rich, Stephen S., McKean-Cowdin, Roberta, Grallert, Harald, Cheng, Ching-Yu, Ghanbari, Mohsen, Tai, E-Shyong, Dupuis, Josee, Kato, Norihiro, Laakso, Markku, Köttgen, Anna, Koh, Woon-Puay, Bowden, Donald W., Palmer, Colin N. A., Kooner, Jaspal S., Kooperberg, Charles, Liu, Simin, North, Kari E., Saleheen, Danish, Hansen, Torben, Pedersen, Oluf, Wareham, Nicholas J., Lee, Juyoung, Kim, Bong-Jo, Millwood, Iona Y., Walters, Robin G., Stefansson, Kari, Ahlqvist, Emma, Goodarzi, Mark O., Mohlke, Karen L., Langenberg, Claudia, Haiman, Christopher A., Loos, Ruth J. F., Florez, Jose C., Rader, Daniel J., Ritchie, Marylyn D., Zöllner, Sebastian, Mägi, Reedik, Marston, Nicholas A., Ruff, Christian T., van Heel, David A., Finer, Sarah, Denny, Joshua C., Yamauchi, Toshimasa, Kadowaki, Takashi, Chambers, John C., Ng, Maggie C. Y., Sim, Xueling, Below, Jennifer E., Tsao, Philip S., Chang, Kyong-Mi, McCarthy, Mark I., Meigs, James B., Mahajan, Anubha, Spracklen, Cassandra N., Mercader, Josep M., Boehnke, Michael, Rotter, Jerome I., Vujkovic, Marijana, Voight, Benjamin F., Morris, Andrew P., and Zeggini, Eleftheria
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- 2024
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7. A deep learning system for predicting time to progression of diabetic retinopathy
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Dai, Ling, Sheng, Bin, Chen, Tingli, Wu, Qiang, Liu, Ruhan, Cai, Chun, Wu, Liang, Yang, Dawei, Hamzah, Haslina, Liu, Yuexing, Wang, Xiangning, Guan, Zhouyu, Yu, Shujie, Li, Tingyao, Tang, Ziqi, Ran, Anran, Che, Haoxuan, Chen, Hao, Zheng, Yingfeng, Shu, Jia, Huang, Shan, Wu, Chan, Lin, Shiqun, Liu, Dan, Li, Jiajia, Wang, Zheyuan, Meng, Ziyao, Shen, Jie, Hou, Xuhong, Deng, Chenxin, Ruan, Lei, Lu, Feng, Chee, Miaoli, Quek, Ten Cheer, Srinivasan, Ramyaa, Raman, Rajiv, Sun, Xiaodong, Wang, Ya Xing, Wu, Jiarui, Jin, Hai, Dai, Rongping, Shen, Dinggang, Yang, Xiaokang, Guo, Minyi, Zhang, Cuntai, Cheung, Carol Y., Tan, Gavin Siew Wei, Tham, Yih-Chung, Cheng, Ching-Yu, Li, Huating, Wong, Tien Yin, and Jia, Weiping
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- 2024
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8. AI-integrated ocular imaging for predicting cardiovascular disease: advancements and future outlook
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Huang, Yu, Cheung, Carol Y, Li, Dawei, Tham, Yih Chung, Sheng, Bin, Cheng, Ching Yu, Wang, Ya Xing, and Wong, Tien Yin
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- 2024
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9. Artificial intelligence in ophthalmology II: glaucoma
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Raghavan, Lavanya, primary, Cheng, Ching-Yu, additional, and Wong, Tien Yin, additional
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- 2024
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10. Contributors
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Avogaro, Angelo, primary, BouGhanem, Ghazi, additional, Bril, Fernando, additional, Chakravarthy, Usha, additional, Chocarro-Calvo, Ana, additional, Ciudin, Andreea, additional, Donato, Maristella, additional, Escolà-Gil, Joan Carles, additional, Fawzi, Amani, additional, García-Fontana, Beatriz, additional, García-Jiménez, Custodia, additional, García-Martínez, José Manuel, additional, Granado-Casas, Minerva, additional, Groop, Per-Henrik, additional, Hayón-Ponce, María, additional, Hernández, Cristina, additional, Jude, Edward B., additional, Julve, Josep, additional, Lecube, Albert, additional, Mauricio, Didac, additional, Mohan, Viswanathan, additional, Mung, Sai Man, additional, Muñoz-Torres, Manuel, additional, Pardina, Eva, additional, Pedrol, Nuria Alonso, additional, Perez Montes de Oca, Alejandra, additional, Pongrac Barlovic, Drazenka, additional, Pradeepa, Rajendra, additional, Rattazzi, Marcello, additional, Rossell-Rusiñol, Joana, additional, Rossell, Joana, additional, Sacchetta, Luca, additional, Sadda, Srinivas R., additional, Santiago-Vacas, Evelyn, additional, Simó, Rafael, additional, Solini, Anna, additional, Spallone, Vincenza, additional, Sun, Jennifer K., additional, Tan, Tien-En, additional, Tan, Gavin S.W., additional, Tondo, Mireia, additional, Tricò, Domenico, additional, Vlacho, Bogdan, additional, Vujosevic, Stela, additional, and Wong, Tien Yin, additional
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- 2024
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11. Artificial intelligence in ophthalmology III: systemic disease prediction
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Ran, An Ran, primary, Hui, Herbert Y.H., additional, Cheung, Carol Y., additional, and Wong, Tien Yin, additional
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- 2024
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12. Artificial intelligence in ophthalmology I: retinal diseases
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Li, Dawei, primary, Zheng, Yingfeng, additional, and Wong, Tien Yin, additional
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- 2024
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13. Diabetic retinopathy: New insights
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Tan, Tien-En, primary, Tan, Gavin S.W., additional, Sadda, Srinivas R., additional, Chakravarthy, Usha, additional, Sun, Jennifer K., additional, and Wong, Tien Yin, additional
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- 2024
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14. List of contributors
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Ahn, Joseph C., primary, Anand, Shankara, additional, Arnaout, O., additional, Bandyopadhyay, Anuja, additional, Bartholomew, Erin, additional, Bates, David W., additional, Bender, Sarah M.L., additional, Bhullar, Puneet K., additional, Bhutani, Tina, additional, Boaro, A., additional, Boyer, Edward W., additional, Brown, Ethan D.L., additional, Carreiro, Stephanie, additional, Chahla, Jorge, additional, Chandran, Viji Pulikkel, additional, Cheng, Ching-Yu, additional, Cheung, Carol Y., additional, Choudhary, Anirudh, additional, Choudhury, Avishek, additional, Chung, Mimi, additional, Ciurtin, Coziana, additional, Comfere, Nneka I., additional, Corriveau-Lecavalier, Nick, additional, Côté, Mélina, additional, del Alamo, Diego, additional, Dias, Roger D., additional, Dönnes, Pierre, additional, Duong, Dat, additional, Ebnali, Mahdi, additional, El Sherbini, Adham, additional, ElZarrad, M. Khair, additional, Fakhouri, Tala H., additional, Fakhoury, Marc, additional, Fein, Joshua A., additional, Fischer, Uwe M., additional, Glicksberg, Benjamin S., additional, Goldstein, Cathy, additional, Gonem, Sherif, additional, Green, Darren V.S., additional, Gupta, Raghav, additional, Hakimi, Marwa, additional, Halamka, John D., additional, Han, Christina S., additional, Hannah-Shmouni, Fady, additional, Harrer, Stefan, additional, Hazime, Ali Amer, additional, Howard, Michael A., additional, Hui, Herbert Y.H., additional, Ildardashty, Alexander, additional, J.F. Shaikh, Hashim, additional, Jeliazkov, Jeliazko R., additional, Jones, David T., additional, Juhn, Young J., additional, Jury, Elizabeth C., additional, Kandaswamy, Swaminathan, additional, Kang, Yanna, additional, Kann, Benjamin H., additional, Kaplin, Scott, additional, Karpiak, Joel, additional, Kassir, Elias, additional, Kaur, Harsimran, additional, Khan, Sohil, additional, Khatib, Reem, additional, Kherabi, Yousra, additional, Knake, Lindsey A., additional, Krittanawong, Chayakrit, additional, Kuhn, Veronica C., additional, Kunze, Kyle, additional, Lamarche, Benoît, additional, Laplante, Simon, additional, Lehmann, Lisa Soleymani, additional, Li, Dawei, additional, Liao, Wilson, additional, Likitlersuang, Jirapat, additional, Liu, Qi, additional, Madani, Amin, additional, Malik, Momin M., additional, Mann, Matthias, additional, Masood, Sameer, additional, Mathur, Piyush, additional, McManus, Sean, additional, Menard, Jeffrey, additional, Mivalt, Filip, additional, Murphree, Dennis, additional, Myers, Thomas G., additional, Narayan, Sanjiv M., additional, Natarajan, Vivek, additional, Pandav, Krunal, additional, Parwani, Anil V., additional, Pedraza Bermeo, Adriana Marcela, additional, Peiffer-Smadja, Nathan, additional, Peng, Junjie, additional, Peng, Lily, additional, Peters, Margot S., additional, Petrick, Nicholas, additional, Polce, Evan, additional, Poojari, Pooja Gopal, additional, Price, W. Nicholson, additional, Raghavan, Lavanya, additional, Rajan, Asha K., additional, Ran, An Ran, additional, Rangu, Sowmith, additional, Rashid, Muhammed, additional, Reddy, Charitha D., additional, Rider, Nicholas L., additional, Rigatti, Marc, additional, Rivers, Michael, additional, Robinson, George, additional, Rogers, Albert J., additional, Rogerson, Colin M., additional, Ryu, Euijung, additional, Sahiner, Berkman, additional, Sarnaik, Kunaal, additional, Shafi, Saba, additional, Shah, Vijay H., additional, Shapovalov, Maxim V., additional, Sharma, Samin K, additional, Shekhar, Skand, additional, Shin, Harold, additional, Shouval, Roni, additional, Smith, Kenneth, additional, Sokumbi, Olayemi, additional, Solomon, Benjamin D., additional, Somani, Sulaiman S., additional, Sternke, Matt C., additional, Strauss, Maximillian T., additional, Syrowatka, Ania, additional, Tang, W. H. Wilson, additional, Teven, Chad M., additional, Tewari, Ashutosh Kumar, additional, Thunga, Girish, additional, Urena, Estefania, additional, Verma, Ashish, additional, Vietas, Jay, additional, Waikel, Rebekah L., additional, Wi, Chung-Il, additional, Winter, Meredith C., additional, Wong, Melissa S., additional, Wong, Tien Yin, additional, Wu, Chao-Ping, additional, Yeroushalmi, Samuel, additional, Zenati, Marco A., additional, Zeng, Wen-Feng, additional, and Zheng, Yingfeng, additional
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- 2024
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15. Genetic insights into resting heart rate and its role in cardiovascular disease
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van de Vegte, Yordi J., Eppinga, Ruben N., van der Ende, M. Yldau, Hagemeijer, Yanick P., Mahendran, Yuvaraj, Salfati, Elias, Smith, Albert V., Tan, Vanessa Y., Arking, Dan E., Ntalla, Ioanna, Appel, Emil V., Schurmann, Claudia, Brody, Jennifer A., Rueedi, Rico, Polasek, Ozren, Sveinbjornsson, Gardar, Lecoeur, Cecile, Ladenvall, Claes, Zhao, Jing Hua, Isaacs, Aaron, Wang, Lihua, Luan, Jian’an, Hwang, Shih-Jen, Mononen, Nina, Auro, Kirsi, Jackson, Anne U., Bielak, Lawrence F., Zeng, Linyao, Shah, Nabi, Nethander, Maria, Campbell, Archie, Rankinen, Tuomo, Pechlivanis, Sonali, Qi, Lu, Zhao, Wei, Rizzi, Federica, Tanaka, Toshiko, Robino, Antonietta, Cocca, Massimiliano, Lange, Leslie, Müller-Nurasyid, Martina, Roselli, Carolina, Zhang, Weihua, Kleber, Marcus E., Guo, Xiuqing, Lin, Henry J., Pavani, Francesca, Galesloot, Tessel E., Noordam, Raymond, Milaneschi, Yuri, Schraut, Katharina E., den Hoed, Marcel, Degenhardt, Frauke, Trompet, Stella, van den Berg, Marten E., Pistis, Giorgio, Tham, Yih-Chung, Weiss, Stefan, Sim, Xueling S., Li, Hengtong L., van der Most, Peter J., Nolte, Ilja M., Lyytikäinen, Leo-Pekka, Said, M. Abdullah, Witte, Daniel R., Iribarren, Carlos, Launer, Lenore, Ring, Susan M., de Vries, Paul S., Sever, Peter, Linneberg, Allan, Bottinger, Erwin P., Padmanabhan, Sandosh, Psaty, Bruce M., Sotoodehnia, Nona, Kolcic, Ivana, Arnar, David O., Gudbjartsson, Daniel F., Holm, Hilma, Balkau, Beverley, Silva, Claudia T., Newton-Cheh, Christopher H., Nikus, Kjell, Salo, Perttu, Mohlke, Karen L., Peyser, Patricia A., Schunkert, Heribert, Lorentzon, Mattias, Lahti, Jari, Rao, Dabeeru C., Cornelis, Marilyn C., Faul, Jessica D., Smith, Jennifer A., Stolarz-Skrzypek, Katarzyna, Bandinelli, Stefania, Concas, Maria Pina, Sinagra, Gianfranco, Meitinger, Thomas, Waldenberger, Melanie, Sinner, Moritz F., Strauch, Konstantin, Delgado, Graciela E., Taylor, Kent D., Yao, Jie, Foco, Luisa, Melander, Olle, de Graaf, Jacqueline, de Mutsert, Renée, de Geus, Eco J. C., Johansson, Åsa, Joshi, Peter K., Lind, Lars, Franke, Andre, Macfarlane, Peter W., Tarasov, Kirill V., Tan, Nicholas, Felix, Stephan B., Tai, E-Shyong, Quek, Debra Q., Snieder, Harold, Ormel, Johan, Ingelsson, Martin, Lindgren, Cecilia, Morris, Andrew P., Raitakari, Olli T., Hansen, Torben, Assimes, Themistocles, Gudnason, Vilmundur, Timpson, Nicholas J., Morrison, Alanna C., Munroe, Patricia B., Strachan, David P., Grarup, Niels, Loos, Ruth J. F., Heckbert, Susan R., Vollenweider, Peter, Hayward, Caroline, Stefansson, Kari, Froguel, Philippe, Groop, Leif, Wareham, Nicholas J., van Duijn, Cornelia M., Feitosa, Mary F., O’Donnell, Christopher J., Kähönen, Mika, Perola, Markus, Boehnke, Michael, Kardia, Sharon L. R., Erdmann, Jeanette, Palmer, Colin N. A., Ohlsson, Claes, Porteous, David J., Eriksson, Johan G., Bouchard, Claude, Moebus, Susanne, Kraft, Peter, Weir, David R., Cusi, Daniele, Ferrucci, Luigi, Ulivi, Sheila, Girotto, Giorgia, Correa, Adolfo, Kääb, Stefan, Peters, Annette, Chambers, John C., Kooner, Jaspal S., März, Winfried, Rotter, Jerome I., Hicks, Andrew A., Smith, J. Gustav, Kiemeney, Lambertus A. L. M., Mook-Kanamori, Dennis O., Penninx, Brenda W. J. H., Gyllensten, Ulf, Wilson, James F., Burgess, Stephen, Sundström, Johan, Lieb, Wolfgang, Jukema, J. Wouter, Eijgelsheim, Mark, Lakatta, Edward L. M., Cheng, Ching-Yu, Dörr, Marcus, Wong, Tien-Yin, Sabanayagam, Charumathi, Oldehinkel, Albertine J., Riese, Harriette, Lehtimäki, Terho, Verweij, Niek, and van der Harst, Pim
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- 2023
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16. Validation of a deep-learning-based retinal biomarker (Reti-CVD) in the prediction of cardiovascular disease: data from UK Biobank
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Tseng, Rachel Marjorie Wei Wen, Rim, Tyler Hyungtaek, Shantsila, Eduard, Yi, Joseph K., Park, Sungha, Kim, Sung Soo, Lee, Chan Joo, Thakur, Sahil, Nusinovici, Simon, Peng, Qingsheng, Kim, Hyeonmin, Lee, Geunyoung, Yu, Marco, Tham, Yih-Chung, Bakhai, Ameet, Leeson, Paul, Lip, Gregory Y.H., Wong, Tien Yin, and Cheng, Ching-Yu
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- 2023
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17. Deep learning system to predict the 5-year risk of high myopia using fundus imaging in children
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Foo, Li Lian, Lim, Gilbert Yong San, Lanca, Carla, Wong, Chee Wai, Hoang, Quan V., Zhang, Xiu Juan, Yam, Jason C., Schmetterer, Leopold, Chia, Audrey, Wong, Tien Yin, Ting, Daniel S. W., Saw, Seang-Mei, and Ang, Marcus
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- 2023
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18. Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes
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Fan, Qiao, Li, Hengtong, Wang, Xiaomeng, Tham, Yih-Chung, Teo, Kelvin Yi Chong, Yasuda, Masayuki, Lim, Weng Khong, Kwan, Yuet Ping, Teo, Jing Xian, Chen, Ching-Jou, Chen, Li Jia, Ahn, Jeeyun, Davila, Sonia, Miyake, Masahiro, Tan, Patrick, Park, Kyu Hyung, Pang, Chi Pui, Khor, Chiea Chuan, Wong, Tien Yin, Yanagi, Yasuo, Cheung, Chui Ming Gemmy, and Cheng, Ching-Yu
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- 2023
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19. Contributions of Lipid-Related Metabolites and Complement Proteins to Early and Intermediate Age-Related Macular Degeneration
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Nusinovici, Simon, Zhou, Lei, Wang, Xinyue, Tham, Yih Chung, Wang, Xiaomeng, Wong, Tien Yin, Chakravarthy, Usha, and Cheng, Ching-Yu
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- 2024
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20. Transition probabilities of diabetic retinopathy and death in an Asian population with diabetes
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Seshasai, Sudarshan, He, Feng, Lam, Betty, Hamzah, Haslina, Cheng, Ching-Yu, Li, Jialiang, Wong, Tien Yin, Tan, Gavin Siew Wei, and Sabanayagam, Charumathi
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- 2024
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21. International incidence and temporal trends for rhegmatogenous retinal detachment: A systematic review and meta-analysis
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Ge, Jasmine Yaowei, Teo, Zhen Ling, Chee, Miao Li, Tham, Yih-Chung, Rim, Tyler Hyungtaek, Cheng, Ching-Yu, Wong, Tien Yin, Wong, Edmund Yick Mun, Lee, Shu Yen, and Cheung, Ning
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- 2024
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22. Imaging Modalities for Assessing the Vascular Component of Diabetic Retinal Disease: Review and Consensus for an Updated Staging System
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Tan, Tien-En, Jampol, Lee M., Ferris, Frederick L., Tadayoni, Ramin, Sadda, Srinivas R., Chong, Victor, Domalpally, Amitha, Blodi, Barbara L., Duh, Elia J., Curcio, Christine A., Antonetti, David A., Dutta, Sanjoy, Levine, S. Robert, Sun, Jennifer K., Gardner, Thomas W., and Wong, Tien Yin
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- 2024
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23. Application of a Deep Learning System to Detect Papilledema on Nonmydriatic Ocular Fundus Photographs in an Emergency Department
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Fraser, Clare L., Micieli, Jonathan A., Costello, Fiona, Bénard-Séguin, Étienne, Yang, Hui, Chan, Carmen Kar Mun, Cheung, Carol Y, Chan, Noel CY, Hamann, Steffen, Gohier, Philippe, Vautier, Anaïs, Rougier, Marie-Bénédicte, Chiquet, Christophe, Vignal-Clermont, Catherine, Hage, Rabih, Khanna, Raoul Kanav, Tran, Thi Ha Chau, Lagrèze, Wolf Alexander, Jonas, Jost B, Ambika, Selvakumar, Fard, Masoud Aghsaei, La Morgia, Chiara, Carbonelli, Michele, Barboni, Piero, Carelli, Valerio, Romagnoli, Martina, Amore, Giulia, Nakamura, Makoto, Fumio, Takano, Petzold, Axel, Wenniger lj, Maillette de Buy, Kho, Richard, Fonseca, Pedro L., Bikbov, Mukharram M., Milea, Dan, Najjar, Raymond P, Ting, Daniel, Tang, Zhiqun, Loo, Jing Liang, Tow, Sharon, Singhal, Shweta, Vasseneix, Caroline, Wong, Tien Yin, Lamoureux, Ecosse, Yu Chen, Ching, Aung, Tin, Schmetterer, Leopold, Sanda, Nicolae, Thuman, Gabriele, Hwang, Jeong-Min, Vanikieti, Kavin, Suwan, Yanin, Padungkiatsagul, Tanyatuth, Yu-Wai-Man, Patrick, Jurkute, Neringa, Hong, Eun Hee, Biousse, Valerie, Newman, Nancy J., Peragallo, Jason H., Datillo, Michael, Kedar, Sachin, Lin, Mung Yan, Patil, Ajay, Aung, Andre, Boyko, Matthew, Alsakran, Wael Abdulraman, Zayani, Amani, Bouthour, Walid, Banc, Ana, Mosley, Rasha, Labella, Fernando, Miller, Neil R., Chen, John J., Mejico, Luis J., Kilangalanga, Janvier Ngoy, Biousse, Valérie, Najjar, Raymond P., Wright, David W., Keadey, Matthew T., Wong, Tien Y., and Bruce, Beau B.
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- 2024
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24. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
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Phelps, Nowell H, Singleton, Rosie K, Zhou, Bin, Heap, Rachel A, Mishra, Anu, Bennett, James E, Paciorek, Christopher J, Lhoste, Victor PF, Carrillo-Larco, Rodrigo M, Stevens, Gretchen A, Rodriguez-Martinez, Andrea, Bixby, Honor, Bentham, James, Di Cesare, Mariachiara, Danaei, Goodarz, Rayner, Archie W, Barradas-Pires, Ana, Cowan, Melanie J, Savin, Stefan, Riley, Leanne M, Aguilar-Salinas, Carlos A, Baker, Jennifer L, Barkat, Amina, Bhutta, Zulfiqar A, Branca, Francesco, Caixeta, Roberta B, Cuschieri, Sarah, Farzadfar, Farshad, Ganapathy, Shubash, Ikeda, Nayu, Iotova, Violeta, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Lin, Hsien-Ho, Ma, Jun, Mbanya, Jean Claude N, Miranda, J Jaime, Pradeepa, Rajendra, Rodríguez-Artalejo, Fernando, Sorić, Maroje, Turley, Maria, Wang, Limin, Webster-Kerr, Karen, Aarestrup, Julie, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdeen, Ziad A, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Abubakar Garba, Jamila, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J, Adu-Afarwuah, Seth, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Ågren, Åsa, Aguenaou, Hassan, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lahou, Badreya, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Al Qaoud, Nawal M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Aldwairji, Maryam A, Alexius, Sylvia, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkerwi, Ala'a, Alkhatib, Buthaina M, Allin, Kristine, Alomary, Shaker A, Alomirah, Husam F, Alshangiti, Arwa M, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Ängquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assefa, Nega, Aspelund, Thor, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Aung, May Soe, Aurélio de Valois, Correia Júnior Marco, Auvinen, Juha, Avdičová, Mária, Avi, Shina, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Babu, Bontha V, Bacopoulou, Flora, Bæksgaard Jørgensen, Maja, Baharudin, Azli, Bahijri, Suhad, Bajramovic, Izet, Bakacs, Marta, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Banegas, José R, Baran, Joanna, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, Joao Luiz, Bata, Iqbal, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berhane, Yemane, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Berrios Carrasola, Ximena, Bettiol, Heloísa, Beutel, Manfred E, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Biasch, Katia, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Anne A, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Blychfeld Magnazu, Moran, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boer, Jolanda MA, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Botomba, Steve, Bourne, Rupert RA, Bovet, Pascal, Boymatova, Khadichamo, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Braithwaite, Tasanee, Brajkovich, Imperia, Breckenkamp, Juergen, Breda, João, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brophy, Sinead, Brug, Johannes, Bruno, Graziella, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de León, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, José, Can, Günay, Cândido, Ana Paula c, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajús, José A, Casanueva, Felipe F, Casas, Maribel, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Angelique, Chan, Queenie, Charchar, Fadi J, Charles, Marie-Aline, Chaturvedi, Himanshu K, Chaturvedi, Nish, Che Abdul Rahim, Norsyamlina, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Cojocaru, Cosmin R, Colorado-Yohar, Sandra, Compañ-Gabucio, Laura-María, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, 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Alexander D, DeGennaro, Vincent Jr, Delisle, Hélène, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Dereń, Katarzyna, Deschamps, Valérie, Devrishov, Ruslan D, Dhimal, Meghnath, Di Castelnuovo, Augusto, Dias-da-Costa, Juvenal Soares, Díaz-Sánchez, María Elena, Diaz, Alejandro, Díaz Fernández, Pedro, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Dong, Yanhui, Donoso, Silvana P, Döring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Dörr, Marcus, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duleva, Vesselka L, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dwyer, Terence, Dyussupova, Azhar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ammari, Laila, El Ati, Jalila, Eldemire-Shearer, Denise, Elliott, Paul, Enang, Ofem, Endevelt, Ronit, Engle-Stone, Reina, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Evans, Roger G, Faeh, David, Fagherazzi, Guy, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farrugia Sant'Angelo, Victoria, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Fawzi, Wafaie W, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Gerson, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferreira, Haroldo S, Ferrer, Eldridge, Ferrieres, Jean, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, 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- 2024
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25. Large language models for diabetes care: Potentials and prospects
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Sheng, Bin, Guan, Zhouyu, Lim, Lee-Ling, Jiang, Zehua, Mathioudakis, Nestoras, Li, Jiajia, Liu, Ruhan, Bao, Yuqian, Bee, Yong Mong, Wang, Ya-Xing, Zheng, Yingfeng, Tan, Gavin Siew Wei, Ji, Hongwei, Car, Josip, Wang, Haibo, Klonoff, David C., Li, Huating, Tham, Yih-Chung, Wong, Tien Yin, and Jia, Weiping
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- 2024
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26. DRAC 2022: A public benchmark for diabetic retinopathy analysis on ultra-wide optical coherence tomography angiography images
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Qian, Bo, Chen, Hao, Wang, Xiangning, Guan, Zhouyu, Li, Tingyao, Jin, Yixiao, Wu, Yilan, Wen, Yang, Che, Haoxuan, Kwon, Gitaek, Kim, Jaeyoung, Choi, Sungjin, Shin, Seoyoung, Krause, Felix, Unterdechler, Markus, Hou, Junlin, Feng, Rui, Li, Yihao, El Habib Daho, Mostafa, Yang, Dawei, Wu, Qiang, Zhang, Ping, Yang, Xiaokang, Cai, Yiyu, Tan, Gavin Siew Wei, Cheung, Carol Y., Jia, Weiping, Li, Huating, Tham, Yih Chung, Wong, Tien Yin, and Sheng, Bin
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- 2024
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27. Retinal Thickness Prediction from Multi-modal Fundus Photography
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Sun, Yihua, Li, Dawei, Kim, Seongho, Wang, Ya Xing, Wang, Jinyuan, Wong, Tien Yin, Liao, Hongen, Song, Su Jeong, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Greenspan, Hayit, editor, Madabhushi, Anant, editor, Mousavi, Parvin, editor, Salcudean, Septimiu, editor, Duncan, James, editor, Syeda-Mahmood, Tanveer, editor, and Taylor, Russell, editor
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- 2023
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28. Artificial Intelligence in Predicting Systemic Disease from Ocular Imaging : Teleophthalmology and Digital Health: A Practical Guide to Applications
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Betzler, Bjorn Kaijun, Rim, Tyler Hyungtaek, Cheung, Carol Y., Wong, Tien Yin, Cheng, Ching-Yu, Yogesan, Kanagasingam, editor, Goldschmidt, Leonard, editor, Cuadros, Jorge, editor, and Ricur, Giselle, editor
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- 2023
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29. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
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Duperron, Marie-Gabrielle, Knol, Maria J., Le Grand, Quentin, Evans, Tavia E., Mishra, Aniket, Tsuchida, Ami, Roshchupkin, Gennady, Konuma, Takahiro, Trégouët, David-Alexandre, Romero, Jose Rafael, Frenzel, Stefan, Luciano, Michelle, Hofer, Edith, Bourgey, Mathieu, Dueker, Nicole D., Delgado, Pilar, Hilal, Saima, Tankard, Rick M., Dubost, Florian, Shin, Jean, Saba, Yasaman, Armstrong, Nicola J., Bordes, Constance, Bastin, Mark E., Beiser, Alexa, Brodaty, Henry, Bülow, Robin, Carrera, Caty, Chen, Christopher, Cheng, Ching-Yu, Deary, Ian J., Gampawar, Piyush G., Himali, Jayandra J., Jiang, Jiyang, Kawaguchi, Takahisa, Li, Shuo, Macalli, Melissa, Marquis, Pascale, Morris, Zoe, Muñoz Maniega, Susana, Miyamoto, Susumu, Okawa, Masakazu, Paradise, Matthew, Parva, Pedram, Rundek, Tatjana, Sargurupremraj, Muralidharan, Schilling, Sabrina, Setoh, Kazuya, Soukarieh, Omar, Tabara, Yasuharu, Teumer, Alexander, Thalamuthu, Anbupalam, Trollor, Julian N., Valdés Hernández, Maria C., Vernooij, Meike W., Völker, Uwe, Wittfeld, Katharina, Wong, Tien Yin, Wright, Margaret J., Zhang, Junyi, Zhao, Wanting, Zhu, Yi-Cheng, Schmidt, Helena, Sachdev, Perminder S., Wen, Wei, Yoshida, Kazumichi, Joutel, Anne, Satizabal, Claudia L., Sacco, Ralph L., Bourque, Guillaume, Lathrop, Mark, Paus, Tomas, Fernandez-Cadenas, Israel, Yang, Qiong, Mazoyer, Bernard, Boutinaud, Philippe, Okada, Yukinori, Grabe, Hans J., Mather, Karen A., Schmidt, Reinhold, Joliot, Marc, Ikram, M. Arfan, Matsuda, Fumihiko, Tzourio, Christophe, Wardlaw, Joanna M., Seshadri, Sudha, Adams, Hieab H. H., and Debette, Stéphanie
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- 2023
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30. The BONSAI (Brain and Optic Nerve Study with Artificial Intelligence) deep learning system can accurately identify pediatric papilledema on standard ocular fundus photographs
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Fraser, Clare L., Micieli, Jonathan A., Costello, Fiona, Étienne Bénard-Séguin, Yang, Hui, Mun Chan, Carmen Kar, Cheung, Carol Y., Chan, Noel CY., Hamann, Steffen, Gohier, Philippe, Vautier, Anaïs, Rougier, Marie-Bénédicte, Chiquet, Christophe, Vignal-Clermont, Catherine, Hage, Rabih, Khanna, Raoul Kanav, Chau Tran, Thi Ha, Lagrèze, Wolf Alexander, Jonas, Jost B., Ambika, Selvakumar, Fard, Masoud Aghsaei, La Morgia, Chiara, Carbonelli, Michele, Barboni, Piero, Carelli, Valerio, Romagnoli, Martina, Amore, Giulia, Nakamura, Makoto, Fumio, Takano, Petzold, Axel, de Buy Wenniger L.J., Maillette, Kho, Richard, Fonseca, Pedro L., Bikbov, Mukharram M., Milea, Dan, Najjar, Raymond P., Ting, Daniel, Tang, Zhiqun, Loo, Jing Liang, Tow, Sharon, Singhal, Shweta, Vasseneix, Caroline, Wong, Tien Yin, Lamoureux, Ecosse, Chen, Ching Yu, Aung, Tin, Schmetterer, Leopold, Sanda, Nicolae, Thuman, Gabriele, Hwang, Jeong-Min, Vanikieti, Kavin, Suwan, Yanin, Padungkiatsagul, Tanyatuth, Yu-Wai-Man, Patrick, Jurkute, Neringa, Hong, Eun Hee, Biousse, Valerie, Newman, Nancy J., Peragallo, Jason H., Datillo, Michael, Kedar, Sachin, Lin, Mung Yan, Patil, Ajay, Aung, Andre, Boyko, Matthew, Alsakran, Wael Abdulraman, Zayani, Amani, Bouthour, Walid, Banc, Ana, Mosley, Rasha, Labella, Fernando, Miller, Neil R., Chen, John J., Mejico, Luis J., Kilangalanga, Janvier Ngoy, Cioplean, Daniela, Dragomir, Mihaela, Chia, Audrey, and Biousse, Valérie
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- 2024
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31. Latest developments of generative artificial intelligence and applications in ophthalmology
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Feng, Xiaoru, Xu, Kezheng, Luo, Ming-Jie, Chen, Haichao, Yang, Yangfan, He, Qi, Song, Chenxin, Li, Ruiyao, Wu, You, Wang, Haibo, Tham, Yih Chung, Ting, Daniel Shu Wei, Lin, Haotian, Wong, Tien Yin, and Lam, Dennis Shun-chiu
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- 2024
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32. Deep Learning‐Enabled Vasculometry Depicts Phased Lesion Patterns in High Myopia Progression
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He, Hai-Long, Liu, Yi-Xin, Liu, Hanruo, Zhang, Xiaomei, Song, Hao, Xu, Tian-Ze, Fang, Yuxin, Ma, Ya, Ren, Hao-Ying, Ling, Sai-Guang, Dong, Zhou, Xu, Jie, Qin, Lei, Wong, Tien Yin, Ang, Marcus, and Jin, Zi-Bing
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- 2024
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33. Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy
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Li, Ling-Jun, Nahar, Mosammat Nazmun, Du, Ruochen, Chan, Jerry Kok Yen, Tan, June Vic Khi, Eriksson, Johan G., Wong, Tien Yin, Chan, Shiao-Yng, Su, Lin Lin, Chong, Yap Seng, and Zhang, Cuilin
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- 2023
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34. Relationship Between Retinal Layer Thickness and Genetic Susceptibility to Age-Related Macular Degeneration in Asian Populations
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Cheong, Kai Xiong, Li, Hengtong, Tham, Yih Chung, Teo, Kelvin Yi Chong, Tan, Anna Cheng Sim, Schmetterer, Leopold, Wong, Tien Yin, Cheung, Chui Ming Gemmy, Cheng, Ching-Yu, and Fan, Qiao
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- 2023
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35. Six-Year Incidence of Visual Impairment in a Multiethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study
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Lim, Zhi Wei, Chee, Miao-Li, Soh, Zhi Da, Majithia, Shivani, Sahil, Thakur, Tan, See Teng, Sabanayagam, Charumathi, Wong, Tien Yin, Cheng, Ching-Yu, and Tham, Yih-Chung
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- 2023
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36. ChatGPT: promise and challenges for deployment in low- and middle-income countries
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Wang, Xiaofei, Sanders, Hayley M., Liu, Yuchen, Seang, Kennarey, Tran, Bach Xuan, Atanasov, Atanas G., Qiu, Yue, Tang, Shenglan, Car, Josip, Wang, Ya Xing, Wong, Tien Yin, Tham, Yih-Chung, and Chung, Kevin C.
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- 2023
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37. The Singapore National Precision Medicine Strategy
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Wong, Eleanor, Bertin, Nicolas, Hebrard, Maxime, Tirado-Magallanes, Roberto, Bellis, Claire, Lim, Weng Khong, Chua, Chee Yong, Tong, Philomena Mei Lin, Chua, Raymond, Mak, Kenneth, Lim, Tit Meng, Cheong, Wei Yang, Thien, Kwee Eng, Goh, Khean Teik, Chai, Jin-Fang, Lee, Jimmy, Sung, Joseph Jao-Yiu, Wong, Tien Yin, Chin, Calvin Woon Loong, Gluckman, Peter D., Goh, Liuh Ling, Ban, Kenneth Hon Kim, Tan, Tin Wee, Sim, Xueling, Cheng, Ching-Yu, Davila, Sonia, Karnani, Neerja, Leong, Khai Pang, Liu, Jianjun, Prabhakar, Shyam, Maurer-Stroh, Sebastian, Verma, Chandra Shekhar, Krishnaswamy, Pavitra, Goh, Rick Siow Mong, Chia, Irenaeus, Ho, Clarissa, Low, Doreen, Virabhak, Suchin, Yong, Jacklyn, Zheng, Weiling, Seow, Shih Wee, Seck, Yee Kwang, Koh, Mingshi, Chambers, John C., Tai, E. Shyong, and Tan, Patrick
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- 2023
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38. Defining the structure–function relationship of specific lesions in early and advanced age-related macular degeneration
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Tan, Ting Fang, Yap, Chun Lin, Peterson, Claire L., Wong, Damon, Wong, Tien Yin, Cheung, Chui Ming Gemmy, Schmetterer, Leopold, and Tan, Anna Cheng Sim
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- 2024
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39. Extending the diabetic retinopathy screening intervals in Singapore: methodology and preliminary findings of a cohort study
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Aravindhan, Amudha, Fenwick, Eva K., Chan, Aurora Wing Dan, Man, Ryan Eyn Kidd, Tan, Ngiap Chuan, Wong, Wei Teen, Soo, Wern Fern, Lim, Shin Wei, Wee, Sabrina Yi-Mei, Sabanayagam, Charumathi, Finkelstein, Eric, Tan, Gavin, Hamzah, Haslina, Chakraborty, Bibhas, Acharyya, Sanchalika, Shyong, Tai E., Scanlon, Peter, Wong, Tien Yin, and Lamoureux, Ecosse L.
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- 2024
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40. X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
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Scholz, Markus, Horn, Katrin, Pott, Janne, Wuttke, Matthias, Kühnapfel, Andreas, Nasr, M. Kamal, Kirsten, Holger, Li, Yong, Hoppmann, Anselm, Gorski, Mathias, Ghasemi, Sahar, Li, Man, Tin, Adrienne, Chai, Jin-Fang, Cocca, Massimiliano, Wang, Judy, Nutile, Teresa, Akiyama, Masato, Åsvold, Bjørn Olav, Bansal, Nisha, Biggs, Mary L., Boutin, Thibaud, Brenner, Hermann, Brumpton, Ben, Burkhardt, Ralph, Cai, Jianwen, Campbell, Archie, Campbell, Harry, Chalmers, John, Chasman, Daniel I., Chee, Miao Ling, Chee, Miao Li, Chen, Xu, Cheng, Ching-Yu, Cifkova, Renata, Daviglus, Martha, Delgado, Graciela, Dittrich, Katalin, Edwards, Todd L., Endlich, Karlhans, Michael Gaziano, J., Giri, Ayush, Giulianini, Franco, Gordon, Scott D., Gudbjartsson, Daniel F., Hallan, Stein, Hamet, Pavel, Hartman, Catharina A., Hayward, Caroline, Heid, Iris M., Hellwege, Jacklyn N., Holleczek, Bernd, Holm, Hilma, Hutri-Kähönen, Nina, Hveem, Kristian, Isermann, Berend, Jonas, Jost B., Joshi, Peter K., Kamatani, Yoichiro, Kanai, Masahiro, Kastarinen, Mika, Khor, Chiea Chuen, Kiess, Wieland, Kleber, Marcus E., Körner, Antje, Kovacs, Peter, Krajcoviechova, Alena, Kramer, Holly, Krämer, Bernhard K., Kuokkanen, Mikko, Kähönen, Mika, Lange, Leslie A., Lash, James P., Lehtimäki, Terho, Li, Hengtong, Lin, Bridget M., Liu, Jianjun, Loeffler, Markus, Lyytikäinen, Leo-Pekka, Magnusson, Patrik K. E., Martin, Nicholas G., Matsuda, Koichi, Milaneschi, Yuri, Mishra, Pashupati P., Mononen, Nina, Montgomery, Grant W., Mook-Kanamori, Dennis O., Mychaleckyj, Josyf C., März, Winfried, Nauck, Matthias, Nikus, Kjell, Nolte, Ilja M., Noordam, Raymond, Okada, Yukinori, Olafsson, Isleifur, Oldehinkel, Albertine J., Penninx, Brenda W. J. H., Perola, Markus, Pirastu, Nicola, Polasek, Ozren, Porteous, David J., Poulain, Tanja, Psaty, Bruce M., Rabelink, Ton J., Raffield, Laura M., Raitakari, Olli T., Rasheed, Humaira, Reilly, Dermot F., Rice, Kenneth M., Richmond, Anne, Ridker, Paul M., Rotter, Jerome I., Rudan, Igor, Sabanayagam, Charumathi, Salomaa, Veikko, Schneiderman, Neil, Schöttker, Ben, Sims, Mario, Snieder, Harold, Stark, Klaus J., Stefansson, Kari, Stocker, Hannah, Stumvoll, Michael, Sulem, Patrick, Sveinbjornsson, Gardar, Svensson, Per O., Tai, E-Shyong, Taylor, Kent D., Tayo, Bamidele O., Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H. L., Thomas, Laurent F., Tremblay, Johanne, Tönjes, Anke, van der Most, Peter J., Vitart, Veronique, Völker, Uwe, Wang, Ya Xing, Wang, Chaolong, Wei, Wen Bin, Whitfield, John B., Wild, Sarah H., Wilson, James F., Winkler, Thomas W., Wong, Tien-Yin, Woodward, Mark, Sim, Xueling, Chu, Audrey Y., Feitosa, Mary F., Thorsteinsdottir, Unnur, Hung, Adriana M., Teumer, Alexander, Franceschini, Nora, Parsa, Afshin, Köttgen, Anna, Schlosser, Pascal, and Pattaro, Cristian
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- 2024
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41. Artificial intelligence education: An evidence-based medicine approach for consumers, translators, and developers
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Ng, Faye Yu Ci, Thirunavukarasu, Arun James, Cheng, Haoran, Tan, Ting Fang, Gutierrez, Laura, Lan, Yanyan, Ong, Jasmine Chiat Ling, Chong, Yap Seng, Ngiam, Kee Yuan, Ho, Dean, Wong, Tien Yin, Kwek, Kenneth, Doshi-Velez, Finale, Lucey, Catherine, Coffman, Thomas, and Ting, Daniel Shu Wei
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- 2023
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42. Artificial intelligence and digital health in global eye health: opportunities and challenges
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Tan, Ting Fang, Thirunavukarasu, Arun J, Jin, Liyuan, Lim, Joshua, Poh, Stanley, Teo, Zhen Ling, Ang, Marcus, Chan, R V Paul, Ong, Jasmine, Turner, Angus, Karlström, Jonas, Wong, Tien Yin, Stern, Jude, and Ting, Daniel Shu-Wei
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- 2023
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43. Risk prediction models for type 2 diabetes using either fasting plasma glucose or HbA1c in Chinese, Malay, and Indians: Results from three multi-ethnic Singapore cohorts
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Seah, Jowy Yi Hong, Yao, Jiali, Hong, Yueheng, Lim, Charlie Guan Yi, Sabanayagam, Charumathi, Nusinovici, Simon, Gardner, Daphne Su-Lyn, Loh, Marie, Müller-Riemenschneider, Falk, Tan, Chuen Seng, Yeo, Khung Keong, Wong, Tien Yin, Cheng, Ching-Yu, Ma, Stefan, Tai, E Shyong, Chambers, John C, van Dam, Rob M, and Sim, Xueling
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- 2023
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44. Association of common genetic variants with brain microbleeds: A Genome-wide Association Study
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Knol, Maria J, Lu, Dongwei, Traylor, Matthew, Adams, Hieab HH, Romero, José Rafael J, Smith, Albert V, Fornage, Myriam, Hofer, Edith, Liu, Junfeng, Hostettler, Isabel C, Luciano, Michelle, Trompet, Stella, Giese, Anne-Katrin, Hilal, Saima, van den Akker, Erik B, Vojinovic, Dina, Li, Shuo, Sigurdsson, Sigurdur, van der Lee, Sven J, Jack, Clifford R, Wilson, Duncan, Yilmaz, Pinar, Satizabal, Claudia L, Liewald, David CM, van der Grond, Jeroen, Chen, Christopher, Saba, Yasaman, van der Lugt, Aad, Bastin, Mark E, Windham, B Gwen, Cheng, Ching Yu, Pirpamer, Lukas, Kantarci, Kejal, Himali, Jayandra J, Yang, Qiong, Morris, Zoe, Beiser, Alexa S, Tozer, Daniel J, Vernooij, Meike W, Amin, Najaf, Beekman, Marian, Koh, Jia Yu, Stott, David J, Houlden, Henry, Schmidt, Reinhold, Gottesman, Rebecca F, MacKinnon, Andrew D, DeCarli, Charles, Gudnason, Vilmundur, Deary, Ian J, van Duijn, Cornelia M, Slagboom, P Eline, Wong, Tien Yin, Rost, Natalia S, Jukema, J Wouter, Mosley, Thomas H, Werring, David J, Schmidt, Helena, Wardlaw, Joanna M, Ikram, M Arfan, Seshadri, Sudha, Launer, Lenore J, Markus, Hugh S, and Initiative, for the Alzheimer’s Disease Neuroimaging
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Stroke ,Human Genome ,Neurosciences ,Brain Disorders ,Genetics ,Prevention ,Aetiology ,2.1 Biological and endogenous factors ,Aged ,Aged ,80 and over ,Alleles ,Apolipoprotein E2 ,Apolipoprotein E4 ,Apolipoproteins E ,Case-Control Studies ,Cerebral Hemorrhage ,Cerebral Small Vessel Diseases ,Cohort Studies ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Polymorphism ,Single Nucleotide ,Risk ,White Matter ,Alzheimer's Disease Neuroimaging Initiative ,Clinical Sciences ,Cognitive Sciences ,Neurology & Neurosurgery - Abstract
ObjectiveTo identify common genetic variants associated with the presence of brain microbleeds (BMBs).MethodsWe performed genome-wide association studies in 11 population-based cohort studies and 3 case-control or case-only stroke cohorts. Genotypes were imputed to the Haplotype Reference Consortium or 1000 Genomes reference panel. BMBs were rated on susceptibility-weighted or T2*-weighted gradient echo MRI sequences, and further classified as lobar or mixed (including strictly deep and infratentorial, possibly with lobar BMB). In a subset, we assessed the effects of APOE ε2 and ε4 alleles on BMB counts. We also related previously identified cerebral small vessel disease variants to BMBs.ResultsBMBs were detected in 3,556 of the 25,862 participants, of which 2,179 were strictly lobar and 1,293 mixed. One locus in the APOE region reached genome-wide significance for its association with BMB (lead single nucleotide polymorphism rs769449; odds ratio [OR]any BMB [95% confidence interval (CI)] 1.33 [1.21-1.45]; p = 2.5 × 10-10). APOE ε4 alleles were associated with strictly lobar (OR [95% CI] 1.34 [1.19-1.50]; p = 1.0 × 10-6) but not with mixed BMB counts (OR [95% CI] 1.04 [0.86-1.25]; p = 0.68). APOE ε2 alleles did not show associations with BMB counts. Variants previously related to deep intracerebral hemorrhage and lacunar stroke, and a risk score of cerebral white matter hyperintensity variants, were associated with BMB.ConclusionsGenetic variants in the APOE region are associated with the presence of BMB, most likely due to the APOE ε4 allele count related to a higher number of strictly lobar BMBs. Genetic predisposition to small vessel disease confers risk of BMB, indicating genetic overlap with other cerebral small vessel disease markers.
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- 2020
45. A saturated map of common genetic variants associated with human height
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Yengo, Loïc, Vedantam, Sailaja, Marouli, Eirini, Sidorenko, Julia, Bartell, Eric, Sakaue, Saori, Graff, Marielisa, Eliasen, Anders U., Jiang, Yunxuan, Raghavan, Sridharan, Miao, Jenkai, Arias, Joshua D., Graham, Sarah E., Mukamel, Ronen E., Spracklen, Cassandra N., Yin, Xianyong, Chen, Shyh-Huei, Ferreira, Teresa, Highland, Heather H., Ji, Yingjie, Karaderi, Tugce, Lin, Kuang, Lüll, Kreete, Malden, Deborah E., Medina-Gomez, Carolina, Machado, Moara, Moore, Amy, Rüeger, Sina, Sim, Xueling, Vrieze, Scott, Ahluwalia, Tarunveer S., Akiyama, Masato, Allison, Matthew A., Alvarez, Marcus, Andersen, Mette K., Ani, Alireza, Appadurai, Vivek, Arbeeva, Liubov, Bhaskar, Seema, Bielak, Lawrence F., Bollepalli, Sailalitha, Bonnycastle, Lori L., Bork-Jensen, Jette, Bradfield, Jonathan P., Bradford, Yuki, Braund, Peter S., Brody, Jennifer A., Burgdorf, Kristoffer S., Cade, Brian E., Cai, Hui, Cai, Qiuyin, Campbell, Archie, Cañadas-Garre, Marisa, Catamo, Eulalia, Chai, Jin-Fang, Chai, Xiaoran, Chang, Li-Ching, Chang, Yi-Cheng, Chen, Chien-Hsiun, Chesi, Alessandra, Choi, Seung Hoan, Chung, Ren-Hua, Cocca, Massimiliano, Concas, Maria Pina, Couture, Christian, Cuellar-Partida, Gabriel, Danning, Rebecca, Daw, E. Warwick, Degenhard, Frauke, Delgado, Graciela E., Delitala, Alessandro, Demirkan, Ayse, Deng, Xuan, Devineni, Poornima, Dietl, Alexander, Dimitriou, Maria, Dimitrov, Latchezar, Dorajoo, Rajkumar, Ekici, Arif B., Engmann, Jorgen E., Fairhurst-Hunter, Zammy, Farmaki, Aliki-Eleni, Faul, Jessica D., Fernandez-Lopez, Juan-Carlos, Forer, Lukas, Francescatto, Margherita, Freitag-Wolf, Sandra, Fuchsberger, Christian, Galesloot, Tessel E., Gao, Yan, Gao, Zishan, Geller, Frank, Giannakopoulou, Olga, Giulianini, Franco, Gjesing, Anette P., Goel, Anuj, Gordon, Scott D., Gorski, Mathias, Grove, Jakob, Guo, Xiuqing, Gustafsson, Stefan, Haessler, Jeffrey, Hansen, Thomas F., Havulinna, Aki S., Haworth, Simon J., He, Jing, Heard-Costa, Nancy, Hebbar, Prashantha, Hindy, George, Ho, Yuk-Lam A., Hofer, Edith, Holliday, Elizabeth, Horn, Katrin, Hornsby, Whitney E., Hottenga, Jouke-Jan, Huang, Hongyan, Huang, Jie, Huerta-Chagoya, Alicia, Huffman, Jennifer E., Hung, Yi-Jen, Huo, Shaofeng, Hwang, Mi Yeong, Iha, Hiroyuki, Ikeda, Daisuke D., Isono, Masato, Jackson, Anne U., Jäger, Susanne, Jansen, Iris E., Johansson, Ingegerd, Jonas, Jost B., Jonsson, Anna, Jørgensen, Torben, Kalafati, Ioanna-Panagiota, Kanai, Masahiro, Kanoni, Stavroula, Kårhus, Line L., Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kawaguchi, Takahisa, Kember, Rachel L., Kentistou, Katherine A., Kim, Han-Na, Kim, Young Jin, Kleber, Marcus E., Knol, Maria J., Kurbasic, Azra, Lauzon, Marie, Le, Phuong, Lea, Rodney, Lee, Jong-Young, Leonard, Hampton L., Li, Shengchao A., Li, Xiaohui, Li, Xiaoyin, Liang, Jingjing, Lin, Honghuang, Lin, Shih-Yi, Liu, Jun, Liu, Xueping, Lo, Ken Sin, Long, Jirong, Lores-Motta, Laura, Luan, Jian’an, Lyssenko, Valeriya, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamakou, Vasiliki, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Mattheisen, Manuel, Mavarani, Laven, McDaid, Aaron F., Meidtner, Karina, Melendez, Tori L., Mercader, Josep M., Milaneschi, Yuri, Miller, Jason E., Millwood, Iona Y., Mishra, Pashupati P., Mitchell, Ruth E., Møllehave, Line T., Morgan, Anna, Mucha, Soeren, Munz, Matthias, Nakatochi, Masahiro, Nelson, Christopher P., Nethander, Maria, Nho, Chu Won, Nielsen, Aneta A., Nolte, Ilja M., Nongmaithem, Suraj S., Noordam, Raymond, Ntalla, Ioanna, Nutile, Teresa, Pandit, Anita, Christofidou, Paraskevi, Pärna, Katri, Pauper, Marc, Petersen, Eva R. B., Petersen, Liselotte V., Pitkänen, Niina, Polašek, Ozren, Poveda, Alaitz, Preuss, Michael H., Pyarajan, Saiju, Raffield, Laura M., Rakugi, Hiromi, Ramirez, Julia, Rasheed, Asif, Raven, Dennis, Rayner, Nigel W., Riveros, Carlos, Rohde, Rebecca, Ruggiero, Daniela, Ruotsalainen, Sanni E., Ryan, Kathleen A., Sabater-Lleal, Maria, Saxena, Richa, Scholz, Markus, Sendamarai, Anoop, Shen, Botong, Shi, Jingchunzi, Shin, Jae Hun, Sidore, Carlo, Sitlani, Colleen M., Slieker, Roderick C., Smit, Roelof A. J., Smith, Albert V., Smith, Jennifer A., Smyth, Laura J., Southam, Lorraine, Steinthorsdottir, Valgerdur, Sun, Liang, Takeuchi, Fumihiko, Tallapragada, Divya Sri Priyanka, Taylor, Kent D., Tayo, Bamidele O., Tcheandjieu, Catherine, Terzikhan, Natalie, Tesolin, Paola, Teumer, Alexander, Theusch, Elizabeth, Thompson, Deborah J., Thorleifsson, Gudmar, Timmers, Paul R. H. J., Trompet, Stella, Turman, Constance, Vaccargiu, Simona, van der Laan, Sander W., van der Most, Peter J., van Klinken, Jan B., van Setten, Jessica, Verma, Shefali S., Verweij, Niek, Veturi, Yogasudha, Wang, Carol A., Wang, Chaolong, Wang, Lihua, Wang, Zhe, Warren, Helen R., Bin Wei, Wen, Wickremasinghe, Ananda R., Wielscher, Matthias, Wiggins, Kerri L., Winsvold, Bendik S., Wong, Andrew, Wu, Yang, Wuttke, Matthias, Xia, Rui, Xie, Tian, Yamamoto, Ken, Yang, Jingyun, Yao, Jie, Young, Hannah, Yousri, Noha A., Yu, Lei, Zeng, Lingyao, Zhang, Weihua, Zhang, Xinyuan, Zhao, Jing-Hua, Zhao, Wei, Zhou, Wei, Zimmermann, Martina E., Zoledziewska, Magdalena, Adair, Linda S., Adams, Hieab H. H., Aguilar-Salinas, Carlos A., Al-Mulla, Fahd, Arnett, Donna K., Asselbergs, Folkert W., Åsvold, Bjørn Olav, Attia, John, Banas, Bernhard, Bandinelli, Stefania, Bennett, David A., Bergler, Tobias, Bharadwaj, Dwaipayan, Biino, Ginevra, Bisgaard, Hans, Boerwinkle, Eric, Böger, Carsten A., Bønnelykke, Klaus, Boomsma, Dorret I., Børglum, Anders D., Borja, Judith B., Bouchard, Claude, Bowden, Donald W., Brandslund, Ivan, Brumpton, Ben, Buring, Julie E., Caulfield, Mark J., Chambers, John C., Chandak, Giriraj R., Chanock, Stephen J., Chaturvedi, Nish, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Ching-Yu, Christophersen, Ingrid E., Ciullo, Marina, Cole, John W., Collins, Francis S., Cooper, Richard S., Cruz, Miguel, Cucca, Francesco, Cupples, L. Adrienne, Cutler, Michael J., Damrauer, Scott M., Dantoft, Thomas M., de Borst, Gert J., de Groot, Lisette C. P. G. M., De Jager, Philip L., de Kleijn, Dominique P. V., Janaka de Silva, H., Dedoussis, George V., den Hollander, Anneke I., Du, Shufa, Easton, Douglas F., Elders, Petra J. M., Eliassen, A. Heather, Ellinor, Patrick T., Elmståhl, Sölve, Erdmann, Jeanette, Evans, Michele K., Fatkin, Diane, Feenstra, Bjarke, Feitosa, Mary F., Ferrucci, Luigi, Ford, Ian, Fornage, Myriam, Franke, Andre, Franks, Paul W., Freedman, Barry I., Gasparini, Paolo, Gieger, Christian, Girotto, Giorgia, Goddard, Michael E., Golightly, Yvonne M., Gonzalez-Villalpando, Clicerio, Gordon-Larsen, Penny, Grallert, Harald, Grant, Struan F. A., Grarup, Niels, Griffiths, Lyn, Gudnason, Vilmundur, Haiman, Christopher, Hakonarson, Hakon, Hansen, Torben, Hartman, Catharina A., Hattersley, Andrew T., Hayward, Caroline, Heckbert, Susan R., Heng, Chew-Kiat, Hengstenberg, Christian, Hewitt, Alex W., Hishigaki, Haretsugu, Hoyng, Carel B., Huang, Paul L., Huang, Wei, Hunt, Steven C., Hveem, Kristian, Hyppönen, Elina, Iacono, William G., Ichihara, Sahoko, Ikram, M. Arfan, Isasi, Carmen R., Jackson, Rebecca D., Jarvelin, Marjo-Riitta, Jin, Zi-Bing, Jöckel, Karl-Heinz, Joshi, Peter K., Jousilahti, Pekka, Jukema, J. Wouter, Kähönen, Mika, Kamatani, Yoichiro, Kang, Kui Dong, Kaprio, Jaakko, Kardia, Sharon L. R., Karpe, Fredrik, Kato, Norihiro, Kee, Frank, Kessler, Thorsten, Khera, Amit V., Khor, Chiea Chuen, Kiemeney, Lambertus A. L. M., Kim, Bong-Jo, Kim, Eung Kweon, Kim, Hyung-Lae, Kirchhof, Paulus, Kivimaki, Mika, Koh, Woon-Puay, Koistinen, Heikki A., Kolovou, Genovefa D., Kooner, Jaspal S., Kooperberg, Charles, Köttgen, Anna, Kovacs, Peter, Kraaijeveld, Adriaan, Kraft, Peter, Krauss, Ronald M., Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lange, Leslie A., Langenberg, Claudia, Launer, Lenore J., Le Marchand, Loic, Lee, Hyejin, Lee, Nanette R., Lehtimäki, Terho, Li, Huaixing, Li, Liming, Lieb, Wolfgang, Lin, Xu, Lind, Lars, Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Loeffler, Markus, London, Barry, Lubitz, Steven A., Lye, Stephen J., Mackey, David A., Mägi, Reedik, Magnusson, Patrik K. E., Marcus, Gregory M., Vidal, Pedro Marques, Martin, Nicholas G., März, Winfried, Matsuda, Fumihiko, McGarrah, Robert W., McGue, Matt, McKnight, Amy Jayne, Medland, Sarah E., Mellström, Dan, Metspalu, Andres, Mitchell, Braxton D., Mitchell, Paul, Mook-Kanamori, Dennis O., Morris, Andrew D., Mucci, Lorelei A., Munroe, Patricia B., Nalls, Mike A., Nazarian, Saman, Nelson, Amanda E., Neville, Matt J., Newton-Cheh, Christopher, Nielsen, Christopher S., Nöthen, Markus M., Ohlsson, Claes, Oldehinkel, Albertine J., Orozco, Lorena, Pahkala, Katja, Pajukanta, Päivi, Palmer, Colin N. A., Parra, Esteban J., Pattaro, Cristian, Pedersen, Oluf, Pennell, Craig E., Penninx, Brenda W. J. H., Perusse, Louis, Peters, Annette, Peyser, Patricia A., Porteous, David J., Posthuma, Danielle, Power, Chris, Pramstaller, Peter P., Province, Michael A., Qi, Qibin, Qu, Jia, Rader, Daniel J., Raitakari, Olli T., Ralhan, Sarju, Rallidis, Loukianos S., Rao, Dabeeru C., Redline, Susan, Reilly, Dermot F., Reiner, Alexander P., Rhee, Sang Youl, Ridker, Paul M., Rienstra, Michiel, Ripatti, Samuli, Ritchie, Marylyn D., Roden, Dan M., Rosendaal, Frits R., Rotter, Jerome I., Rudan, Igor, Rutters, Femke, Sabanayagam, Charumathi, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sanghera, Dharambir K., Sattar, Naveed, Schmidt, Börge, Schmidt, Helena, Schmidt, Reinhold, Schulze, Matthias B., Schunkert, Heribert, Scott, Laura J., Scott, Rodney J., Sever, Peter, Shiroma, Eric J., Shoemaker, M. Benjamin, Shu, Xiao-Ou, Simonsick, Eleanor M., Sims, Mario, Singh, Jai Rup, Singleton, Andrew B., Sinner, Moritz F., Smith, J. Gustav, Snieder, Harold, Spector, Tim D., Stampfer, Meir J., Stark, Klaus J., Strachan, David P., ‘t Hart, Leen M., Tabara, Yasuharu, Tang, Hua, Tardif, Jean-Claude, Thanaraj, Thangavel A., Timpson, Nicholas J., Tönjes, Anke, Tremblay, Angelo, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Tusié-Luna, Maria-Teresa, Uitterlinden, Andre G., van Dam, Rob M., van der Harst, Pim, Van der Velde, Nathalie, van Duijn, Cornelia M., van Schoor, Natasja M., Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Völzke, Henry, Wacher-Rodarte, Niels H., Walker, Mark, Wang, Ya Xing, Wareham, Nicholas J., Watanabe, Richard M., Watkins, Hugh, Weir, David R., Werge, Thomas M., Widen, Elisabeth, Wilkens, Lynne R., Willemsen, Gonneke, Willett, Walter C., Wilson, James F., Wong, Tien-Yin, Woo, Jeong-Taek, Wright, Alan F., Wu, Jer-Yuarn, Xu, Huichun, Yajnik, Chittaranjan S., Yokota, Mitsuhiro, Yuan, Jian-Min, Zeggini, Eleftheria, Zemel, Babette S., Zheng, Wei, Zhu, Xiaofeng, Zmuda, Joseph M., Zonderman, Alan B., Zwart, John-Anker, Chasman, Daniel I., Cho, Yoon Shin, Heid, Iris M., McCarthy, Mark I., Ng, Maggie C. Y., O’Donnell, Christopher J., Rivadeneira, Fernando, Thorsteinsdottir, Unnur, Sun, Yan V., Tai, E. Shyong, Boehnke, Michael, Deloukas, Panos, Justice, Anne E., Lindgren, Cecilia M., Loos, Ruth J. F., Mohlke, Karen L., North, Kari E., Stefansson, Kari, Walters, Robin G., Winkler, Thomas W., Young, Kristin L., Loh, Po-Ru, Yang, Jian, Esko, Tõnu, Assimes, Themistocles L., Auton, Adam, Abecasis, Goncalo R., Willer, Cristen J., Locke, Adam E., Berndt, Sonja I., Lettre, Guillaume, Frayling, Timothy M., Okada, Yukinori, Wood, Andrew R., Visscher, Peter M., and Hirschhorn, Joel N.
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- 2022
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46. Clinical operational considerations and responses to lockdown and reopening in the Covid-19 pandemic: experience of a tertiary ophthalmology centre in Singapore
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Lim, Hou Boon, Tan, Tien-En, Fenner, Beau J., Heah, Jenny, Arundhati, Anshu, Khor, Wei Boon, Boey, Pui Yi, Lee, Shu Yen, Wong, Edmund Y. M., and Wong, Tien Yin
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- 2022
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47. A five-safes approach to a secure and scalable genomics data repository
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Shih, Chih Chuan, Chen, Jieqi, Lee, Ai Shan, Bertin, Nicolas, Hebrard, Maxime, Khor, Chiea Chuen, Li, Zheng, Juan Tan, Joanna Hui, Meah, Wee Yang, Peh, Su Qin, Mok, Shi Qi, Sim, Kar Seng, Liu, Jianjun, Wang, Ling, Wong, Eleanor, Li, Jingmei, Tin, Aung, Cheng, Ching-Yu, Heng, Chew-Kiat, Yuan, Jian-Min, Koh, Woon-Puay, Saw, Seang Mei, Friedlander, Yechiel, Sim, Xueling, Chai, Jin Fang, Chong, Yap Seng, Davila, Sonia, Goh, Liuh Ling, Lee, Eng Sing, Wong, Tien Yin, Karnani, Neerja, Leong, Khai Pang, Yeo, Khung Keong, Chambers, John C., Lim, Su Chi, Goh, Rick Siow Mong, Tan, Patrick, and Dorajoo, Rajkumar
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- 2023
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48. Identification of type 2 diabetes loci in 433,540 East Asian individuals
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Spracklen, Cassandra N, Horikoshi, Momoko, Kim, Young Jin, Lin, Kuang, Bragg, Fiona, Moon, Sanghoon, Suzuki, Ken, Tam, Claudia HT, Tabara, Yasuharu, Kwak, Soo-Heon, Takeuchi, Fumihiko, Long, Jirong, Lim, Victor JY, Chai, Jin-Fang, Chen, Chien-Hsiun, Nakatochi, Masahiro, Yao, Jie, Choi, Hyeok Sun, Iyengar, Apoorva K, Perrin, Hannah J, Brotman, Sarah M, van de Bunt, Martijn, Gloyn, Anna L, Below, Jennifer E, Boehnke, Michael, Bowden, Donald W, Chambers, John C, Mahajan, Anubha, McCarthy, Mark I, Ng, Maggie CY, Petty, Lauren E, Zhang, Weihua, Morris, Andrew P, Adair, Linda S, Akiyama, Masato, Bian, Zheng, Chan, Juliana CN, Chang, Li-Ching, Chee, Miao-Li, Chen, Yii-Der Ida, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, Du, Shufa, Gordon-Larsen, Penny, Gross, Myron, Guo, Xiuqing, Guo, Yu, Han, Sohee, Howard, Annie-Green, Huang, Wei, Hung, Yi-Jen, Hwang, Mi Yeong, Hwu, Chii-Min, Ichihara, Sahoko, Isono, Masato, Jang, Hye-Mi, Jiang, Guozhi, Jonas, Jost B, Kamatani, Yoichiro, Katsuya, Tomohiro, Kawaguchi, Takahisa, Khor, Chiea-Chuen, Kohara, Katsuhiko, Lee, Myung-Shik, Lee, Nanette R, Li, Liming, Liu, Jianjun, Luk, Andrea O, Lv, Jun, Okada, Yukinori, Pereira, Mark A, Sabanayagam, Charumathi, Shi, Jinxiu, Shin, Dong Mun, So, Wing Yee, Takahashi, Atsushi, Tomlinson, Brian, Tsai, Fuu-Jen, van Dam, Rob M, Xiang, Yong-Bing, Yamamoto, Ken, Yamauchi, Toshimasa, Yoon, Kyungheon, Yu, Canqing, Yuan, Jian-Min, Zhang, Liang, Zheng, Wei, Igase, Michiya, Cho, Yoon Shin, Rotter, Jerome I, Wang, Ya-Xing, Sheu, Wayne HH, Yokota, Mitsuhiro, Wu, Jer-Yuarn, Cheng, Ching-Yu, Wong, Tien-Yin, Shu, Xiao-Ou, Kato, Norihiro, and Park, Kyong-Soo
- Subjects
Human Genome ,Diabetes ,Biotechnology ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Metabolic and endocrine ,Aldehyde Dehydrogenase ,Mitochondrial ,Alleles ,Ankyrins ,Asian People ,Body Mass Index ,Case-Control Studies ,Diabetes Mellitus ,Type 2 ,Europe ,Eye Proteins ,Asia ,Eastern ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Homeodomain Proteins ,Humans ,Male ,Nerve Tissue Proteins ,RNA ,Messenger ,Transcription Factors ,Transcription ,Genetic ,General Science & Technology - Abstract
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes-NKX6-3 and ANK1-in different tissues4-6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways.
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- 2020
49. Artificial Intelligence and Deep Learning in Ophthalmology
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Wang, Zhaoran, Keane, Pearse A., Chiang, Michael, Cheung, Carol Y., Wong, Tien Yin, Ting, Daniel Shu Wei, Lidströmer, Niklas, editor, and Ashrafian, Hutan, editor
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- 2022
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50. Development and Validation of a Deep Learning System to Detect Glaucomatous Optic Neuropathy Using Fundus Photographs
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Liu, Hanruo, Li, Liu, Wormstone, I Michael, Qiao, Chunyan, Zhang, Chun, Liu, Ping, Li, Shuning, Wang, Huaizhou, Mou, Dapeng, Pang, Ruiqi, Yang, Diya, Zangwill, Linda M, Moghimi, Sasan, Hou, Huiyuan, Bowd, Christopher, Jiang, Lai, Chen, Yihan, Hu, Man, Xu, Yongli, Kang, Hong, Ji, Xin, Chang, Robert, Tham, Clement, Cheung, Carol, Ting, Daniel Shu Wei, Wong, Tien Yin, Wang, Zulin, Weinreb, Robert N, Xu, Mai, and Wang, Ningli
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Neurosciences ,Eye Disease and Disorders of Vision ,Clinical Research ,Neurodegenerative ,Prevention ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Eye ,Area Under Curve ,Cross-Sectional Studies ,Databases ,Factual ,Deep Learning ,Diagnostic Techniques ,Ophthalmological ,False Positive Reactions ,Female ,Fundus Oculi ,Glaucoma ,Open-Angle ,Humans ,Male ,Optic Nerve Diseases ,Photography ,Predictive Value of Tests ,ROC Curve ,Sensitivity and Specificity ,Opthalmology and Optometry ,Ophthalmology & Optometry - Abstract
ImportanceA deep learning system (DLS) that could automatically detect glaucomatous optic neuropathy (GON) with high sensitivity and specificity could expedite screening for GON.ObjectiveTo establish a DLS for detection of GON using retinal fundus images and glaucoma diagnosis with convoluted neural networks (GD-CNN) that has the ability to be generalized across populations.Design, setting, and participantsIn this cross-sectional study, a DLS for the classification of GON was developed for automated classification of GON using retinal fundus images obtained from the Chinese Glaucoma Study Alliance, the Handan Eye Study, and online databases. The researchers selected 241 032 images were selected as the training data set. The images were entered into the databases on June 9, 2009, obtained on July 11, 2018, and analyses were performed on December 15, 2018. The generalization of the DLS was tested in several validation data sets, which allowed assessment of the DLS in a clinical setting without exclusions, testing against variable image quality based on fundus photographs obtained from websites, evaluation in a population-based study that reflects a natural distribution of patients with glaucoma within the cohort and an additive data set that has a diverse ethnic distribution. An online learning system was established to transfer the trained and validated DLS to generalize the results with fundus images from new sources. To better understand the DLS decision-making process, a prediction visualization test was performed that identified regions of the fundus images utilized by the DLS for diagnosis.ExposuresUse of a deep learning system.Main outcomes and measuresArea under the receiver operating characteristics curve (AUC), sensitivity and specificity for DLS with reference to professional graders.ResultsFrom a total of 274 413 fundus images initially obtained from CGSA, 269 601 images passed initial image quality review and were graded for GON. A total of 241 032 images (definite GON 29 865 [12.4%], probable GON 11 046 [4.6%], unlikely GON 200 121 [83%]) from 68 013 patients were selected using random sampling to train the GD-CNN model. Validation and evaluation of the GD-CNN model was assessed using the remaining 28 569 images from CGSA. The AUC of the GD-CNN model in primary local validation data sets was 0.996 (95% CI, 0.995-0.998), with sensitivity of 96.2% and specificity of 97.7%. The most common reason for both false-negative and false-positive grading by GD-CNN (51 of 119 [46.3%] and 191 of 588 [32.3%]) and manual grading (50 of 113 [44.2%] and 183 of 538 [34.0%]) was pathologic or high myopia.Conclusions and relevanceApplication of GD-CNN to fundus images from different settings and varying image quality demonstrated a high sensitivity, specificity, and generalizability for detecting GON. These findings suggest that automated DLS could enhance current screening programs in a cost-effective and time-efficient manner.
- Published
- 2019
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