6,419 results on '"Wong G"'
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2. Multidisciplinary Perspectives of Current Approaches and Clinical Gaps in the Management of Hyperphosphatemia
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Vallée M, Weinstein J, Battistella M, Papineau R, Moseley D, and Wong G
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chronic kidney disease ,nutrition ,phosphate ,phosphate binders ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Michel Vallée,1 Jordan Weinstein,2 Marisa Battistella,3 Roxanne Papineau,4 Dianne Moseley,5 Gordon Wong6 1Université de Montréal - Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada; 2Division of Nephrology, St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada; 3University Health Network- Toronto General Hospital, Toronto, Ontario, Canada; 4Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, Québec, Canada; 5Trillium Health Partners, Mississauga, Ontario, Canada; 6Trillium Health Partners, Credit Valley Nephrology, Mississauga, Ontario, CanadaCorrespondence: Gordon WongTrillium Health Partners, Credit Valley Nephrology, 2300 Eglinton Ave. West Suite #501, Mississauga, Ontario, L5M 2V8, CanadaEmail gwong1030@gmail.comAbstract: Population-based studies have shown that most patients with advanced chronic kidney disease (CKD) do not have optimal phosphate levels. Meta-analyses suggest that there is a morbidity and mortality benefit associated with the lowering of serum phosphate levels. However, to date there is no conclusive evidence from randomized controlled trials (RCTs) that lowering serum phosphate levels reduces the risk of morbidity and mortality. However, hyperphosphatemia may pose a risk to patients and treatment should be considered. We therefore sought to conduct a multidisciplinary review to help guide clinical decision-making pending results of ongoing RCTs. Restricting dietary phosphate intake is frequently the first step in the management of hyperphosphatemia. Important considerations when proposing dietary restriction include the patient’s socioeconomic status, lifestyle, dietary preferences, comorbidities, and nutritional status. While dietary phosphate restriction may be a valid strategy in certain patients, serum phosphate reductions achieved solely by limiting dietary intake are modest and should be considered in conjunction with other interventions. Conventional dialysis is also typically insufficient; however phosphate removal may be augmented by increased frequency or duration of dialysis, or through enhanced methods such as hemodiafiltration. Phosphate binders have been shown to reduce absorption of dietary phosphate and lower serum phosphate levels. There are several phosphate binders available, and while they all lower phosphate levels to variable degrees, they differ with respect to their pill burden, potential to induce or exacerbate vascular calcification or ectopic calcification, tissue accumulation, safety, and tolerability. The widespread treatment of hyperphosphatemia requires convincing data from RCTs to ascertain whether lowering serum phosphate levels improves patient-important outcomes, as well as the optimal method and degree of phosphate control. In the interim, the decision and approach used to treat hyperphosphatemia should be based on the best available data, as well as patient needs and clinical judgment.Keywords: chronic kidney disease, nutrition, phosphate, phosphate binders
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- 2021
3. Ordered magnetic fields around the 3C 84 central black hole
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Paraschos, G. F., Kim, J. -Y., Wielgus, M., Röder, J., Krichbaum, T. P., Ros, E., Agudo, I., Myserlis, I., Moscibrodzka, M., Traianou, E., Zensus, J. A., Blackburn, L., Chan, C. -K., Issaoun, S., Janssen, M., Johnson, M. D., Fish, V. L., Akiyama, K., Alberdi, A., Alef, W., Algaba, J. C., Anantua, R., Asada, K., Azulay, R., Bach, U., Baczko, A. -K., Ball, D., Baloković, M., Barrett, J., Bauböck, M., Benson, B. A., Bintley, D., Blundell, R., Bouman, K. L., Bower, G. C., Boyce, H., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Bustamante, S., Byun, D. -Y., Carlstrom, J. E., Ceccobello, C., Chael, A., Chang, D. O., Chatterjee, K., Chatterjee, S., Chen, M. T., Chen, Y., Cheng, X., Cho, I., Christian, P., Conroy, N. S., Conway, J. E., Cordes, J. M., Crawford, T. M., Crew, G. B., Cruz-Osorio, A., Cui, Y., Dahale, R., Davelaar, J., De Laurentis, M., Deane, R., Dempsey, J., Desvignes, G., Dexter, J., Dhruv, V., Doeleman, S. S., Dougal, S., Dzib, S. A., Eatough, R. P., Emami, R., Falcke, H., Farah, J., Fomalont, E., Ford, H. A., Foschi, M., Fraga-Encinas, R., Freeman, W. T., Friberg, P., Fromm, C. M., Fuentes, A., Galison, P., Gammie, C. F., García, R., Gentaz, O., Georgiev, B., Goddi, C., Gold, R., Gómez-Ruiz, A. I., Gómez, J. L., Gu, M., Gurwell, M., Hada, K., Haggard, D., Haworth, K., Hecht, M. H., Hesper, R., Heumann, D., Ho, L. C., Ho, P., Honma, M., Huang, C. L., Huang, L., Hughes, D. H., Ikeda, S., Impellizzeri, C. M. V., Inoue, M., James, D. J., Jannuzi, B. T., Jeter, B., Jaing, W., Jiménez-Rosales, A., Jorstad, S., Joshi, A. V., Jung, T., Karami, M., Karuppusamy, R., Kawashima, T., Keating, G. K., Kettenis, M., Kim, D. -J., Kim, J., Kino, M., Koay, J. Y., Kocherlakota, P., Kofuji, Y., Koch, P. M., Koyama, S., Kramer, C., Kramer, J. A., Kramer, M., Kuo, C. -Y., La Bella, N., Lauer, T. R., Lee, D., Lee, S. -S., Leung, P. K., Levis, A., Li, Z., Lico, R., Lindahl, G., Lindqvist, M., Lisakov, M., Liu, J., Liu, K., Liuzzo, E., Lo, W. -P., Lobanov, A. P., Loinard, L., Lonsdale, C. J., Lowitz, A. E., Lu, R. -S., MacDonald, N. R., Mao, J., Marchili, N., Markoff, S., Marrone, D. P., Marscher, A. P., Martí-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Michalik, D., Mizuno, I., Mizuno, Y., Moran, J. M., Moriyama, K., Mulaudzi, W., Müller, C., Müller, H., Mus, A., Musoke, G., Nadolski, A., Nagai, H., Nagar, N. M., Nakamura, M., Narayanan, G., Natarajan, I., Nathanail, A., Fuentes, S. Navarro, Neilsen, J., Neri, R., Ni, C., Noutsos, A., Nowak, M. A., Oh, J., Okino, H., Olivares, H., Ortiz-León, G. N., Oyama, T., Özel, F., Palumbo, D. C. M., Park, J., Parsons, H., Patel, N., Pen, U. -L., Piétu, V., Plambeck, R., PopStefanija, A., Porth, O., Pötzl, F. M., Prather, B., Preciado-López, J. A., Psaltis, D., Pu, H. -Y., Ramakrishnan, V., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ricarte, A., Ripperda, B., Roelofs, F., Rogers, A., Romero-Cañizales, C., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruiz, I., Ruszczyk, C., Rygl, K. L. J., Sánchez, S., Sánchez-Argüelles, D., Sánchez-Portal, M., Sasada, M., Satapathy, K., Savolainen, T., Schloerb, F. P., Schonfeld, J., Schuster, K., Shao, L., Shen, Z., Small, D., Sohn, B. W., SooHoo, J., Salas, L. D. Sosapanta, Souccar, K., Sun, H., Tazaki, F., Tetarenko, A. J., Tiede, P., Tilanus, R. P. J., Titus, M., Torne, P., Toscano, T., Trent, T., Trippe, S., Turk, M., van Bemmel, I., van Langevelde, H. J., van Rossum, D. R., Vos, J., Wagner, J., Ward-Thompson, D., Wardle, J., Washington, J. E., Weintroub, J., Wharton, R., Wiik, K., Witzel, G., Wondrak, M. F., Wong, G. N., Wu, Q., Yadlapalli, N., Yamaguchi, P., Yfantis, A., Yoon, D., Young, A., Young, K., Younsi, Z., Yu, W., Yuan, F., Yuan, Y. -F., Zhang, S., Zhao, G. Y., and Zhao, S. -S.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
3C84 is a nearby radio source with a complex total intensity structure, showing linear polarisation and spectral patterns. A detailed investigation of the central engine region necessitates the use of VLBI above the hitherto available maximum frequency of 86GHz. Using ultrahigh resolution VLBI observations at the highest available frequency of 228GHz, we aim to directly detect compact structures and understand the physical conditions in the compact region of 3C84. We used EHT 228GHz observations and, given the limited (u,v)-coverage, applied geometric model fitting to the data. We also employed quasi-simultaneously observed, multi-frequency VLBI data for the source in order to carry out a comprehensive analysis of the core structure. We report the detection of a highly ordered, strong magnetic field around the central, SMBH of 3C84. The brightness temperature analysis suggests that the system is in equipartition. We determined a turnover frequency of $\nu_m=(113\pm4)$GHz, a corresponding synchrotron self-absorbed magnetic field of $B_{SSA}=(2.9\pm1.6)$G, and an equipartition magnetic field of $B_{eq}=(5.2\pm0.6)$G. Three components are resolved with the highest fractional polarisation detected for this object ($m_\textrm{net}=(17.0\pm3.9)$%). The positions of the components are compatible with those seen in low-frequency VLBI observations since 2017-2018. We report a steeply negative slope of the spectrum at 228GHz. We used these findings to test models of jet formation, propagation, and Faraday rotation in 3C84. The findings of our investigation into different flow geometries and black hole spins support an advection-dominated accretion flow in a magnetically arrested state around a rapidly rotating supermassive black hole as a model of the jet-launching system in the core of 3C84. However, systematic uncertainties due to the limited (u,v)-coverage, however, cannot be ignored., Comment: 15 pages, 6 figures, published in A&A
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- 2024
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4. CTRP13 ablation improves systemic glucose and lipid metabolism.
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Chen, Fangluo, Sarver, Dylan, Saqib, Muzna, Zhou, Mingqi, Aja, Susan, Seldin, Marcus, and Wong, G
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Diabetes ,Dyslipidemia ,Insulin sensitivity ,Metabolic syndrome ,Obesity ,Secreted hormone ,Animals ,Female ,Humans ,Male ,Mice ,Adipokines ,Body Weight ,Glucose ,Insulin Resistance ,Lipid Metabolism ,Lipids ,Metabolic Syndrome - Abstract
OBJECTIVE: Tissue crosstalk mediated by secreted hormones underlies the integrative control of metabolism. We previously showed that CTRP13/C1QL3, a secreted protein of the C1q family, can improve glucose metabolism and insulin action in vitro and reduce food intake and body weight in mice when centrally delivered. A role for CTRP13 in regulating insulin secretion in isolated islets has also been demonstrated. It remains unclear, however, whether the effects of CTRP13 on cultured cells and in mice reflect the physiological function of the protein. Here, we use a loss-of-function mouse model to address whether CTRP13 is required for metabolic homeostasis. METHODS: WT and Ctrp13 knockout (KO) mice fed a standard chow or a high-fat diet were subjected to comprehensive metabolic phenotyping. Transcriptomic analyses were carried out on visceral and subcutaneous fat, liver, and skeletal muscle to identify pathways altered by CTRP13 deficiency. RNA-seq data was further integrated with the Metabolic Syndrome in Man (METSIM) cohort data. Adjusted regression analysis was used to demonstrate that genetic variation of CTRP13 expression accounts for a significant proportion of variance between differentially expressed genes (DEGs) in adipose tissue and metabolic traits in humans. RESULTS: Contrary to expectation, chow-fed Ctrp13-KO male mice had elevated physical activity, lower body weight, and improved lipid handling. On a high-fat diet (HFD), Ctrp13-KO mice of either sex were consistently more active and leaner. Loss of CTRP13 reduced hepatic glucose output and improved glucose tolerance, insulin sensitivity, and triglyceride clearance, though with notable sex differences. Consistent with the lean phenotype, transcriptomic analyses revealed a lower inflammatory profile in visceral fat and liver. Reduced hepatic steatosis was correlated with the suppression of lipid synthesis and enhanced lipid catabolism gene expression. Visceral fat had the largest number of DEGs and mediation analyses on the human orthologs of the DEGs suggested the potential causal contribution of CTRP13 to human metabolic syndrome. CONCLUSIONS: Our results suggest that CTRP13 is a negative metabolic regulator, and its deficiency improves systemic metabolic profiles. Our data also suggest the reduction in circulating human CTRP13 levels seen in obesity and diabetes may reflect a compensatory physiologic response to counteract insulin resistance.
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- 2023
5. Women’s engagement with community perinatal mental health services: a realist evaluation
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Fisher, L., Davey, A., Wong, G., Morgan-Trimmer, S., Howard, L. M., Sharp, H., Atmore, K. H., Brook, J., Collins, G., Domoney, J., Makinde, E., McCree, C., and O’Mahen, Heather A
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- 2024
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6. Protecting quantum modes in optical fibres
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Butt, M. A. T., Roth, P., Wong, G. K. L., Frosz, M. H., Sanchez-Soto, L. L., Anashkina, E. A., Andrianov, A. V., Banzer, P., Russell, P. S. J., and Leuchs, G.
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Quantum Physics - Abstract
Polarization-preserving fibers maintain the two polarization states of an orthogonal basis. Quantum communication, however, requires sending at least two nonorthogonal states and these cannot both be preserved. We present a new scheme that allows for using polarization encoding in a fiber not only in the discrete, but also in the continuous-variable regime. For the example of a helically twisted photonic-crystal fibre, we experimentally demonstrate that using appropriate nonorthogonal modes, the polarization-preserving fiber does not fully scramble these modes over the full Poincar\'e sphere, but that the output polarization will stay on a great circle; that is, within a one-dimensional protected subspace, which can be parametrized by a single variable. This will allow for more efficient measurements of quantum excitations in nonorthogonal modes., Comment: 7 pages, 4 figures, accepted in Phys. Rev. Applied
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- 2023
7. GBT20, a 20.48 Gbps PAM4 Optical Transmitter Module for Particle Physics Experiments
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Deng, B., Zhang, L., Chao, C. -P., Chen, S. -W., Cruda, E., Gong, D., Hou, S., Huang, G., Huang, X., Li, C. -Y., Liu, C., Liu, T., Liu, E. R., Sun, Q., Sun, X., Wong, G., and Ye, J.
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Physics - Instrumentation and Detectors - Abstract
We present a pluggable radiation-tolerant 4-level Pulse-Amplitude-Modulation (PAM4) optical transmitter module called GBT20 (Giga-Bit Transmitter at 20 Gbps) for particle-physics experiments. GBT20 has an OSFP or firefly connector to input 16-bit data each at 1.28 Gbps. The GBT20 drives a VCSEL die with an LC lens or a VCSEL TOSA and interfaces an optical fiber with a standard LC connector. The minimum module, including the host connector, occupies 41 mm x 13 mm x 6 mm. At 20.48 Gbps, the minimum Transmitter Dispersion Eye Closure Quaternary (TDECQ) is around 0.7 dB. The power consumption is around 164 mW in the low-power mode. The SEE cross-section is below 7.5x10^(-14) cm^2. No significant performance degrades after a TID of 5.4 kGy., Comment: 7 pages, 7 figures
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- 2023
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8. Metastatic renal cell carcinoma: update on epidemiology, genetics, and therapeutic modalities
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Graves A, Hessamodini H, and Wong G,Lim WH
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renal cell carcinoma ,treatment ,review ,metastasis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Angela Graves,1 Hannah Hessamodini,1 Germaine Wong,2 Wai H Lim1,3 1Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia; 2Centre for Kidney Research, University of Sydney, Sydney, NSW, Australia; 3School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia Abstract: The treatment of advanced renal cell carcinoma (RCC) remains a major therapeutic challenge for clinicians. Despite advances in the understanding of the immunobiology of RCC and the availability of several novel targeted agents, there has been little improvement in the survival of patients with metastatic RCC. This review will focus on the recent understanding of risk factors and treatment options and outcomes of metastatic RCC, in particular, targeted therapeutic agents that inhibit vascular endothelial growth factor and mammalian target of rapamycin pathways. Prospective studies are required to determine whether sequential targeted therapy will further improve progression-free survival in RCC. Ongoing research to develop novel agents with better tolerability and enhanced efficacy in the treatment of metastatic RCC is required. Keywords: metastatic renal cell carcinoma, targeted treatment, immunotherapy, cytokines
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- 2013
9. A deep spectromorphological study of the $\gamma$-ray emission surrounding the young massive stellar cluster Westerlund 1
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Aharonian, F., Ashkar, H., Backes, M., Martins, V. Barbosa, Becherini, Y., Berge, D., Bi, B., Böttcher, M., de Lavergne, M. de Bony, Bradascio, F., Brose, R., Brun, F., Bulik, T., Burger-Scheidlin, C., Cangemi, F., Caroff, S., Casanova, S., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, O., Cristofari, P., Mbarubucyeye, J. Damascene, Djannati-Ataï, A., Ernenwein, J. -P., Feijen, K., de Clairfontaine, G. Fichet, Fontaine, G., Funk, S., Gabici, S., Gallant, Y. A., Ghafourizadeh, S., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Goswami, P., Grondin, M. -H., Härer, L. K., Haupt, M., Hinton, J. A., Hörbe, M., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Jamrozy, M., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Katz, U., Khélifi, B., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Mezek, G. Kukec, Lang, R. G., Stum, S. Le, Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Martí-Devesa, G., Marx, R., Maurin, G., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Muller, J., Murach, T., Nakashima, K., de Naurois, M., Nayerhoda, A., Niemiec, J., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Prokhorov, D. A., Pühlhofer, G., Punch, M., Quirrenbach, A., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Renaud, M., Reville, B., Rieger, F., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schüssler, F., Schutte, H. M., Schwanke, U., Shapopi, J. N. S., Specovius, A., Spencer, S., Stawarz, Ł., Steenkamp, R., Steinmassl, S., Steppa, C., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Terrier, R., Thorpe-Morgan, C., Tsirou, M., Tsuji, N., Tuffs, R., Unbehaun, T., van Eldik, C., van Soelen, B., Vecchi, M., Veh, J., Venter, C., Vink, J., Wagner, S. J., White, R., Wierzcholska, A., Wong, Yu Wun, Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zhu, S. J., Zouari, S., Żywucka, N., Blackwell, R., Braiding, C., Burton, M., Cubuk, K., Filipović, M., Tothill, N., and Wong, G.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Young massive stellar clusters are extreme environments and potentially provide the means for efficient particle acceleration. Indeed, they are increasingly considered as being responsible for a significant fraction of cosmic rays (CRs) accelerated within the Milky Way. Westerlund 1, the most massive known young stellar cluster in our Galaxy is a prime candidate for studying this hypothesis. While the very-high-energy $\gamma$-ray source HESS J1646-458 has been detected in the vicinity of Westerlund 1 in the past, its association could not be firmly identified. We aim to identify the physical processes responsible for the $\gamma$-ray emission around Westerlund 1 and thus to better understand the role of massive stellar clusters in the acceleration of Galactic CRs. Using 164 hours of data recorded with the High Energy Stereoscopic System (H.E.S.S.), we carried out a deep spectromorphological study of the $\gamma$-ray emission of HESS J1646-458. We furthermore employed H I and CO observations of the region to infer the presence of gas that could serve as target material for interactions of accelerated CRs. We detected large-scale ($\sim 2^\circ$ diameter) $\gamma$-ray emission with a complex morphology, exhibiting a shell-like structure and showing no significant variation with $\gamma$-ray energy. The combined energy spectrum of the emission extends to several tens of TeV, and is uniform across the entire source region. We did not find a clear correlation of the $\gamma$-ray emission with gas clouds as identified through H I and CO observations. We conclude that, of the known objects within the region, only Westerlund 1 can explain the bulk of the $\gamma$-ray emission. Several CR acceleration sites and mechanisms are conceivable, and discussed in detail. (abridged), Comment: 15 pages, 9 figures. Corresponding authors: L. Mohrmann, S. Ohm, R. Rauth, A. Specovius. v2: corrected affiliation of M. Vecchi (still incorrect in journal version)
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- 2022
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10. Dysregulated systemic metabolism in a Down syndrome mouse model
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Sarver, Dylan C, Xu, Cheng, Velez, Leandro M, Aja, Susan, Jaffe, Andrew E, Seldin, Marcus M, Reeves, Roger H, and Wong, G William
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Biochemistry and Cell Biology ,Biological Sciences ,Intellectual and Developmental Disabilities (IDD) ,Obesity ,Down Syndrome ,Nutrition ,Genetics ,Digestive Diseases ,Brain Disorders ,Diabetes ,Liver Disease ,2.1 Biological and endogenous factors ,Underpinning research ,1.1 Normal biological development and functioning ,Aetiology ,Metabolic and endocrine ,Oral and gastrointestinal ,Female ,Male ,Mice ,Animals ,Humans ,Aneuploidy ,Glucose Intolerance ,Lipid Metabolism ,Trisomy ,Down syndrome ,Insulin resistance ,Physiology ,Biochemistry and cell biology - Abstract
ObjectiveTrisomy 21 is one of the most complex genetic perturbations compatible with postnatal survival. Dosage imbalance arising from the triplication of genes on human chromosome 21 (Hsa21) affects multiple organ systems. Much of Down syndrome (DS) research, however, has focused on addressing how aneuploidy dysregulates CNS function leading to cognitive deficit. Although obesity, diabetes, and associated sequelae such as fatty liver and dyslipidemia are well documented in the DS population, only limited studies have been conducted to determine how gene dosage imbalance affects whole-body metabolism. Here, we conduct a comprehensive and systematic analysis of key metabolic parameters across different physiological states in the Ts65Dn trisomic mouse model of DS.MethodsTs65Dn mice and euploid littermates were subjected to comprehensive metabolic phenotyping under basal (chow-fed) state and the pathophysiological state of obesity induced by a high-fat diet (HFD). RNA sequencing of liver, skeletal muscle, and two major fat depots were conducted to determine the impact of aneuploidy on tissue transcriptome. Pathway enrichments, gene-centrality, and key driver estimates were performed to provide insights into tissue autonomous and non-autonomous mechanisms contributing to the dysregulation of systemic metabolism.ResultsUnder the basal state, chow-fed Ts65Dn mice of both sexes had elevated locomotor activity and energy expenditure, reduced fasting serum cholesterol levels, and mild glucose intolerance. Sexually dimorphic deterioration in metabolic homeostasis became apparent when mice were challenged with a high-fat diet. While obese Ts65Dn mice of both sexes exhibited dyslipidemia, male mice also showed impaired systemic insulin sensitivity, reduced mitochondrial activity, and elevated fibrotic and inflammatory gene signatures in the liver and adipose tissue. Systems-level analysis highlighted conserved pathways and potential endocrine drivers of adipose-liver crosstalk that contribute to dysregulated glucose and lipid metabolism.ConclusionsA combined alteration in the expression of trisomic and disomic genes in peripheral tissues contribute to metabolic dysregulations in Ts65Dn mice. These data lay the groundwork for understanding the impact of aneuploidy on in vivo metabolism.
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- 2023
11. A 20 Gbps PAM4 Data Transmitter ASIC for Particle Physics Experiments
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Zhang, L., Cruda, E. M., Chao, C-P., Chen, S-W., Deng, B., Francisco, R., Gong, D., Guo, D., Hou, S., Huang, G., Huang, X., Kulis, S., Li, C-Y., Liu, C., Liu, E. R., Liu, T., Moreira, P., Prinzie, J., Sun, H., Sun, Q., Sun, X., Wong, G., Yang, D., Ye, J., and Zhang, W.
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Physics - Instrumentation and Detectors - Abstract
We present the design and test results of a novel data transmitter ASIC operating up to 20.48 Gbps with 4-level Pulse-Amplitude-Modulation (PAM4) for particle physics experiments. This ASIC, named GBS20, is fabricated in a 65 nm CMOS technology. Two serializers share a 5.12 GHz Phase Locked Loop (PLL) clock. The outputs from the serializers are combined into a PAM4 signal that directly drives a Vertical-Cavity-Surface-Emitting-Laser (VCSEL). The input data channels, each at 1.28 Gbps, are scrambled with an internal 27-1 Pseudo-Random Binary Sequence (PRBS), which also serves as a frame aligner. GBS20 is tested to work at 10.24 and 20.48 Gbps with a VCSEL-based Transmitter-Optical-Subassembly (TOSA). The power consumption of GBS20 is below 238 mW and reduced to 164 mW in the low-power mode., Comment: 7 pages, 7 figures
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- 2022
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12. Modelling the Gamma-Ray Morphology of HESS J1804-216 from Two Supernova Remnants in a Hadronic Scenario
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Feijen, K., Einecke, S., Rowell, G., Braiding, C., Burton, M. G., and Wong, G. F.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
HESS J1804-216 is one of the brightest yet most mysterious TeV gamma-ray sources discovered to date. Previous arc-minute scale studies of the interstellar medium (ISM) surrounding this TeV gamma-ray source revealed HESS J1804-216 is likely powered by a mature supernova remnant (SNR) or pulsar, hence its origin remains uncertain. In this paper, we focus on the diffusive escape of cosmic-ray protons from potential SNR accelerators. These cosmic rays interact with the ISM to produce TeV gamma-rays. We utilise the isotropic diffusion equation solution for particles escaping from a shell, to model the energy-dependent escape and propagation of protons into the ISM. This work is the first attempt at modelling the spatial morphology of gamma-rays towards HESS J1804-216, using arc-minute ISM observations from both Mopra and the Southern Galactic Plane Survey. The spectral and spatial distributions of gamma-rays for the two nearby potential SNR counterparts, SNR G8.7-0.1 and the progenitor SNR of PSR J1803-2137, are presented here. We vary the diffusion parameters and particle spectrum and use a grid search approach to find the best combination of model parameters. We conclude that moderately slow diffusion is required for both candidates. The most promising candidate to be powering the TeV gamma-rays from HESS J1804-216 in a hadronic scenario is the progenitor SNR of PSR J1803-213., Comment: 13 pages, 13 figures, 4 tables
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- 2022
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13. A novel HIV vaccine targets the 12 protease cleavage sites
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Luo M, Tang D, Capina R, Yuan X, Prego C, Pinto JC, Alonso M, Barry C, Pilon R, Daniuk C, Tuff J, Pillet S, La D, Bielawny T, Czarnecki C, Lacap P, Peters H, Wong G, Kimani M, Wachihi C, Kimani J, Ball TB, Sandstrom P, Kobinger G, and Plummer FA
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Immunologic diseases. Allergy ,RC581-607 - Published
- 2012
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14. Assessment of an AI-based tool for population-wide collection of placental morphological data
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Camm, E.J., Wong, G., Pan, Y., Wang, J.Z., Goldstein, J.A., Arcot, A., Murphy, C.N., Hansji, H., Mangwiro, Y.T., Saffery, R., Wlodek, M.E., Wyrwoll, C.S., Gernand, A.D., and Kaitu’u-Lino, T.J.
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- 2024
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15. The Role of Adaptive Ray Tracing in Analyzing Black Hole Structure
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Gelles, Z., Prather, B. S., Palumbo, D. C. M., Johnson, M. D., Wong, G. N., and Georgiev, B.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The recent advent of the Event Horizon Telescope (EHT) has made direct imaging of supermassive black holes a reality. Simulated images of black holes produced via general relativistic ray tracing and radiative transfer provide a key counterpart to these observational efforts. Black hole images have a wide range of physically interesting image structures, ranging from extremely fine scales in their lensed "photon rings" to the very large scales in their relativistic jets. The multi-scale nature of the black hole system is therefore suitable for a multi-scale approach to generating simulated images that capture all key elements of the system. Here, we present a prescription for adaptive ray tracing, which enables efficient computation of extremely high resolution images of black holes. Using the polarized ray-tracing code ipole, we image a combination of semi-analytic and GRMHD models, and we show that images can be reproduced with mean squared error of less than 0.1% even after tracing 12x fewer rays. We then use adaptive ray tracing to explore properties of the photon ring. We illustrate the behavior of individual subrings in GRMHD simulations, and we explore their signatures in interferometric visibilities., Comment: 17 pages, 12 figures. Published in ApJ on May 3, 2021
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- 2021
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16. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice
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Mishra, Sumita, Sadagopan, Nandhini, Dunkerly-Eyring, Brittany, Rodriguez, Susana, Sarver, Dylan C, Ceddia, Ryan P, Murphy, Sean A, Knutsdottir, Hildur, Jani, Vivek P, Ashok, Deepthi, Oeing, Christian U, O'Rourke, Brian, Gangoiti, Jon A, Sears, Dorothy D, Wong, G William, Collins, Sheila, and Kass, David
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Estrogen ,Obesity ,Cardiovascular ,Heart Disease ,Nutrition ,2.1 Biological and endogenous factors ,Aetiology ,Oral and gastrointestinal ,Stroke ,Cancer ,Metabolic and endocrine ,3' ,5'-Cyclic-AMP Phosphodiesterases ,Adipose Tissue ,Animals ,Female ,Male ,Metabolic Syndrome ,Mice ,Mice ,Transgenic ,Mitochondria ,PPAR alpha ,Fatty acid oxidation ,Metabolism ,Phosphodiesterases ,Medical and Health Sciences ,Immunology - Abstract
Central obesity with cardiometabolic syndrome (CMS) is a major global contributor to human disease, and effective therapies are needed. Here, we show that cyclic GMP-selective phosphodiesterase 9A inhibition (PDE9-I) in both male and ovariectomized female mice suppresses preestablished severe diet-induced obesity/CMS with or without superimposed mild cardiac pressure load. PDE9-I reduces total body, inguinal, hepatic, and myocardial fat; stimulates mitochondrial activity in brown and white fat; and improves CMS, without significantly altering activity or food intake. PDE9 localized at mitochondria, and its inhibition in vitro stimulated lipolysis in a PPARα-dependent manner and increased mitochondrial respiration in both adipocytes and myocytes. PPARα upregulation was required to achieve the lipolytic, antiobesity, and metabolic effects of PDE9-I. All these PDE9-I-induced changes were not observed in obese/CMS nonovariectomized females, indicating a strong sexual dimorphism. We found that PPARα chromatin binding was reoriented away from fat metabolism-regulating genes when stimulated in the presence of coactivated estrogen receptor-α, and this may underlie the dimorphism. These findings have translational relevance given that PDE9-I is already being studied in humans for indications including heart failure, and efficacy against obesity/CMS would enhance its therapeutic utility.
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- 2021
17. Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories
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Razavi-Shearer, D., Child, H., Razavi-Shearer, K., Voeller, A., Razavi, H., Buti, M., Tacke, F., Terrault, N., Zeuzem, S., Abbas, Z., Aghemo, A., Akarca, U.S., Al Masri, N., Alalwan, A., Blomé, M. Alanko, Jerkeman, A., Aleman, S., Kamal, H., Alghamdi, A., Alghamdi, M., Alghamdi, S., Al-Hamoudi, W., Ali, E., Aljumah, A., Altraif, I., Amarsanaa, J., Asselah, T., Baatarkhuu, O., Babameto, A., Ben-Ari, Z., Berg, T., Biondi, M., Braga, W., Brandão-Mello, C., Brown, R., Brunetto, M., Cabezas, J., Cardoso, M., Martins, A., Chan, H.L.Y., Cheinquer, H., Chen, C.-J., Yang, H.-I., Chen, P.-J., Chien, C.-H., Chuang, W.-L., Garza, L. Cisneros, Coco, B., Coffin, C., Coppola, N., Cornberg, M., Craxi, A., Crespo, J., Cuko, L., De Ledinghen, V., Duberg, A.-S., Etzion, O., Ferraz, M.L., Ferreira, P., Forns, X., Foster, G., Fung, J., Gaeta, G., García-Samaniego, J., Genov, J., Gheorghe, L., Gholam, P., Gish, R., Glenn, J., Hamid, S., Hercun, J., Hsu, Y.-C., Hu, C.-C., Huang, J.-F., Idilman, R., Jafri, W., Janjua, N., Jelev, D., Jia, J., Kåberg, M., Kaita, K., Kao, J.-H., Khan, A., Kim, D.Y., Kondili, L., Lagging, M., Lampertico, P., Lázaro, P., Lazarus, J.V., Lee, M.-H., Lim, Y.-S., Lobato, C., Macedo, G., Marinho, R., Marotta, P., Mendes-Correa, M.C., Méndez-Sánchez, N., Navas, M.-C., Ning, Q., Örmeci, N., Orrego, M., Osiowy, C., Pan, C., Pessoa, M., Piracha, Z., Pop, C., Qureshi, H., Raimondo, G., Ramji, A., Ribeiro, S., Ríos-Hincapié, C., Rodríguez, M., Rosenberg, W., Roulot, D., Ryder, S., Saeed, U., Safadi, R., Shouval, D., Sanai, F., Sanchez-Avila, J.F., Santantonio, T., Sarrazin, C., Seto, W.-K., Simonova, M., Tanaka, J., Tergast, T., Tsendsuren, O., Valente, C., Villalobos-Salcedo, J.M., Waheed, Y., Wong, G., Wong, V., Yip, T., Wu, J.-C., Yu, M.-L., Yuen, M.-F., Yurdaydin, C., and Zuckerman, E.
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- 2024
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18. CTRP6 promotes the macrophage inflammatory response, and its deficiency attenuates LPS-induced inflammation
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Xu, Cheng, Sarver, Dylan C., Lei, Xia, Sahagun, Ageline, Zhong, Jun, Na, Chan Hyun, Rudich, Assaf, and Wong, G. William
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- 2024
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19. Arc-minute-scale studies of the interstellar gas towards HESS$\,$J1804$-$216: Still an unidentified TeV $\gamma$-ray source
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Feijen, K., Rowell, G., Einecke, S., Braiding, C., Burton, M. G., Maxted, N., Voisin, F., and Wong, G. F.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Galactic TeV $\gamma$-ray source HESS$\,$J1804$-$216 is currently an unidentified source. In an attempt to unveil its origin, we present here the most detailed study of interstellar gas using data from the Mopra Southern Galactic Plane CO Survey, 7 and 12$\,$mm wavelength Mopra surveys and Southern Galactic Plane Survey of HI. Several components of atomic and molecular gas are found to overlap HESS$\,$J1804$-$216 at various velocities along the line of sight. The CS(1-0) emission clumps confirm the presence of dense gas. Both correlation and anti-correlation between the gas and TeV $\gamma$-ray emission have been identified in various gas tracers, enabling several origin scenarios for the TeV $\gamma$-ray emission from HESS$\,$J1804$-$216. For a hadronic scenario, SNR$\,$G8.7$-$0.1 and the progenitor SNR of PSR$\,$J1803$-$2137 require cosmic ray (CR) enhancement factors of $\mathord{\sim} 50$ times the solar neighbour CR flux value to produce the TeV $\gamma$-ray emission. Assuming an isotropic diffusion model, CRs from both these SNRs require a slow diffusion coefficient, as found for other TeV SNRs associated with adjacent ISM gas. The morphology of gas located at 3.8$\,$kpc (the dispersion measure distance to PSR$\,$J1803$-$2137) tends to anti-correlate with features of the TeV emission from HESS$\,$J1804$-$216, making the leptonic scenario possible. Both pure hadronic and pure leptonic scenarios thus remain plausible., Comment: 29 pages, 23 figures, 5 tables, accepted for publication in PASA
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- 2020
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20. Bremsstrahlung in GRMHD models of accreting black holes
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Yarza, R., Wong, G. N., Ryan, B. R., and Gammie, C. F.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The role of bremsstrahlung in the emission from hot accretion flows around slowly accreting supermassive black holes is not thoroughly understood. In order to appraise the importance of bremsstrahlung relative to other radiative processes, we compute spectral energy distributions (SEDs) of accretion disks around slowly accreting supermassive black holes including synchrotron radiation, inverse Compton scattering, and bremsstrahlung. We compute SEDs for (i) four axisymmetric radiative general relativistic magnetohydrodynamics (RadGRMHD) simulations of $10^{8}M_{\odot}$ black holes with accretion rates between $10^{-8}\dot{M}_{\text{Edd}}$ and $10^{-5}\dot{M}_{\text{Edd}}$, (ii) four axisymmetric RadGRMHD simulations of M87$^\ast$ with varying dimensionless spin $a_\ast$ and black hole mass, and (iii) a 3D GRMHD simulation scaled for Sgr A$^\ast$. At $10^{-8}\dot{M}_{\text{Edd}}$, most of the luminosity is synchrotron radiation, while at $10^{-5}\dot{M}_{\text{Edd}}$ the three radiative processes have similar luminosities. In most models, bremsstrahlung dominates the SED near $512\text{ keV}$. In the M87$^\ast$ models, bremsstrahlung dominates this part of the SED if $a_{\ast} = 0.5$, but inverse Compton scattering dominates if $a_{\ast}= 0.9375$. Since scattering is more variable than bremsstrahlung, this result suggests that $512\text{ keV}$ variability could be a diagnostic of black hole spin. In the appendix, we compare some bremsstrahlung formulae found in the literature., Comment: 10 pages, 5 figures, accepted for publication in ApJ
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- 2020
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21. SYMBA: An end-to-end VLBI synthetic data generation pipeline
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Roelofs, F., Janssen, M., Natarajan, I., Deane, R., Davelaar, J., Olivares, H., Porth, O., Paine, S. N., Bouman, K. L., Tilanus, R. P. J., van Bemmel, I. M., Falcke, H., Akiyama, K., Alberdi, A., Alef, W., Asada, K., Azulay, R., Baczko, A., Ball, D., Baloković, M., Barrett, J., Bintley, D., Blackburn, L., Boland, W., Bower, G. C., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Byun, D., Carlstrom, J. E., Chael, A., Chan, C., Chatterjee, S., Chatterjee, K., Chen, M., Chen, Y., Cho, I., Christian, P., Conway, J. E., Cordes, J. M., Crew, G. B., Cui, Y., De Laurentis, M., Dempsey, J., Desvignes, G., Dexter, J., Doeleman, S. S., Eatough, R. P., Fish, V. L., Fomalont, E., Fraga-Encinas, R., Friberg, P., Fromm, C. M., Gómez, J. L., Galison, P., Gammie, C. F., García, R., Gentaz, O., Georgiev, B., Goddi, C., Gold, R., Gu, M., Gurwell, M., Hada, K., Hecht, M. H., Hesper, R., Ho, L. C., Ho, P., Honma, M., Huang, C. L., Huang, L., Hughes, D. H., Ikeda, S., Inoue, M., Issaoun, S., James, D. J., Jannuzi, B. T., Jeter, B., Jiang, W., Johnson, M. D., Jorstad, S., Jung, T., Karami, M., Karuppusamy, R., Kawashima, T., Keating, G. K., Kettenis, M., Kim, J., Kino, M., Koay, J. Yi, Koch, P. M., Koyama, S., Kramer, M., Kramer, C., Krichbaum, T. P., Kuo, C., Lauer, T. R., Lee, S., Li, Y., Li, Z., Lindqvist, M., Lico, R., Liu, K., Liuzzo, E., Lo, W., Lobanov, A. P., Loinard, L., Lonsdale, C., Lu, R., MacDonald, N. R., Mao, J., Markoff, S., Marrone, D. P., Marscher, A. P., Martí-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Mizuno, Y., Mizuno, I., Moran, J. M., Moriyama, K., Moscibrodzka, M., Müller, C., Nagai, H., Nagar, N. M., Nakamura, M., Narayan, R., Narayanan, G., Neri, R., Ni, C., Noutsos, A., Okino, H., Ortiz-León, G. N., Oyama, T., Özel, F., Palumbo, D. C. M., Patel, N., Pen, U., Pesce, D. W., Piétu, V., Plambeck, R., PopStefanija, A., Prather, B., Preciado-López, J. A., Psaltis, D., Pu, H., Ramakrishnan, V., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ripperda, B., Rogers, A., Ros, E., Rose, M., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruszczyk, C., Ryan, B. R., Rygl, K. L. J., Sánchez, S., Sánchez-Arguelles, D., Sasada, M., Savolainen, T., Schloerb, F. Peter, Schuster, K., Shao, L., Shen, Z., Small, D., Sohn, B. Won, SooHoo, J., Tazaki, F., Tiede, P., Titus, M., Toma, K., Torne, P., Trent, T., Trippe, S., Tsuda, S., van Langevelde, H. J., van Rossum, D. R., Wagner, J., Wardle, J., Ward-Thompson, D., Weintroub, J., Wex, N., Wharton, R., Wielgus, M., Wong, G. N., Wu, Q., Young, A., Young, K., Younsi, Z., Yuan, F., Yuan, Y., Zensus, J. A., Zhao, G., Zhao, S., and Zhu, Z.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Realistic synthetic observations of theoretical source models are essential for our understanding of real observational data. In using synthetic data, one can verify the extent to which source parameters can be recovered and evaluate how various data corruption effects can be calibrated. These studies are important when proposing observations of new sources, in the characterization of the capabilities of new or upgraded instruments, and when verifying model-based theoretical predictions in a comparison with observational data. We present the SYnthetic Measurement creator for long Baseline Arrays (SYMBA), a novel synthetic data generation pipeline for Very Long Baseline Interferometry (VLBI) observations. SYMBA takes into account several realistic atmospheric, instrumental, and calibration effects. We used SYMBA to create synthetic observations for the Event Horizon Telescope (EHT), a mm VLBI array, which has recently captured the first image of a black hole shadow. After testing SYMBA with simple source and corruption models, we study the importance of including all corruption and calibration effects. Based on two example general relativistic magnetohydrodynamics (GRMHD) model images of M87, we performed case studies to assess the attainable image quality with the current and future EHT array for different weather conditions. The results show that the effects of atmospheric and instrumental corruptions on the measured visibilities are significant. Despite these effects, we demonstrate how the overall structure of the input models can be recovered robustly after performing calibration steps. With the planned addition of new stations to the EHT array, images could be reconstructed with higher angular resolution and dynamic range. In our case study, these improvements allowed for a distinction between a thermal and a non-thermal GRMHD model based on salient features in reconstructed images., Comment: 20 pages, 15 figures, accepted for publication in A&A
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- 2020
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22. Classification of premalignant pancreatic cancer mass-spectrometry data using decision tree ensembles
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Wong G William and Ge Guangtao
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Pancreatic cancer is the fourth leading cause of cancer death in the United States. Consequently, identification of clinically relevant biomarkers for the early detection of this cancer type is urgently needed. In recent years, proteomics profiling techniques combined with various data analysis methods have been successfully used to gain critical insights into processes and mechanisms underlying pathologic conditions, particularly as they relate to cancer. However, the high dimensionality of proteomics data combined with their relatively small sample sizes poses a significant challenge to current data mining methodology where many of the standard methods cannot be applied directly. Here, we propose a novel methodological framework using machine learning method, in which decision tree based classifier ensembles coupled with feature selection methods, is applied to proteomics data generated from premalignant pancreatic cancer. Results This study explores the utility of three different feature selection schemas (Student t test, Wilcoxon rank sum test and genetic algorithm) to reduce the high dimensionality of a pancreatic cancer proteomic dataset. Using the top features selected from each method, we compared the prediction performances of a single decision tree algorithm C4.5 with six different decision-tree based classifier ensembles (Random forest, Stacked generalization, Bagging, Adaboost, Logitboost and Multiboost). We show that ensemble classifiers always outperform single decision tree classifier in having greater accuracies and smaller prediction errors when applied to a pancreatic cancer proteomics dataset. Conclusion In our cross validation framework, classifier ensembles generally have better classification accuracies compared to that of a single decision tree when applied to a pancreatic cancer proteomic dataset, thus suggesting its utility in future proteomics data analysis. Additionally, the use of feature selection method allows us to select biomarkers with potentially important roles in cancer development, therefore highlighting the validity of this method.
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- 2008
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23. Radio Emission from Interstellar Shocks: Young Type Ia Supernova Remnants and the Case of N 103B in the Large Magellanic Cloud
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Alsaberi, R. Z. E., Barnes, L. A., Filipovic, M. D., Maxted, N. I., Sano, H., Rowell, G., Bozzetto, L. M., Gurovich, S., Urovsevic, D., Onic, D., For, B. Q., Manojlovic, P., Wong, G., Galvin, T., Kavanagh, P., Ralph, N., Crawford, E. J., Sasaki, M., Haberl, F., Maggi, P., Tothil, N. F. H., and Fukui, Y.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Here we present a radio continuum study based on new and archival data from the Australia Telescope Compact Array towards N 103B, a young (<=1000 yrs) spectroscopically confirmed type Ia SNR in the Large Magellanic Cloud (LMC) and proposed to have originated from a single degenerate progenitor. The radio morphology of this SNR is asymmetrical with two bright regions towards the north-west and south-west of the central location as defined by radio emission. N 103B identified features include: a radio spectral index of -0.75+-0.01 (consistent with other young type Ia SNRs in the Galaxy); a bulk SNR expansion rate as in X-rays; morphology and polarised electrical field vector measurements where we note radial polarisation peak towards the north-west of the remnant at both 5500 and 9000 MHz. The spectrum is concave-up and the most likely reason is the non-linear diffusive shock acceleration effects or presence of two different populations of ultra-relativistic electrons. We also note unpolarized clumps near the south-west region which is in agreement with this above scenario. We derive a typical magnetic field strength for N 103B, of 16.4 microG for an average rotation measurement of 200 rad m^-2. However, we estimate the equipartition field to be of the order of ~235 microG with an estimated minimum energy of Emin=6.3*10^48 erg. The close (~0.5 degree) proximity of N 103B to the LMC mid-plane indicates that an early encounter with dense interstellar medium may have set an important constrain on SNR evolution. Finally, we compare features of N 103B, to six other young type Ia SNRs in the LMC and Galaxy, with a range of proposed degeneracy scenarios to highlight potential differences due to a different models. We suggest that the single degenerate scenario might point to morphologically asymmetric type Ia supernova explosions.
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- 2019
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24. The ASKAP-EMU Early Science Project:Radio Continuum Survey of the Small Magellanic Cloud
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Joseph, T. D., Filipović, M. D., Crawford, E. J., Bojičić, I., Alexander, E. L., Wong, G. F., Andernach, H., Leverenz, H., Norris, R. P., Alsaberi, R. Z. E., Anderson, C., Barnes, L. A., Bozzetto, L. M., Bufano, F., Bunton, J. D., Cavallaro, F., Collier, J. D., Dénes, H., Fukui, Y., Galvin, T., Haberl, F., Ingallinera, A., Kapinska, A. D., Koribalski, B. S., Kothes, R., Li, D., Maggi, P., Maitra, C., Manojlović, P., Marvil, J., Maxted, N. I., Brien, A. N. O, Oliveira, J. M., Pennock, C. M., Riggi, S., Rowell, G., Rudnick, L., Sano, H., Sasaki, M., Seymour, N., Soria, R., Stupar, M., Tothill, N. F. H., Trigilio, C., Tsuge, K., Umana, G., Urošević, D., van Loon, J. Th., Vardoulaki, E., Velović, V., Yew, M., Leahy, D., Chu, Y. -H., Micha\{l}owski, M. J., Kavanagh, P. J., and Grieve, K. R.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present two new radio continuum images from the Australian Square Kilometre Array Pathfinder (ASKAP) survey in the direction of the Small Magellanic Cloud (SMC). These images are part of the Evolutionary Map of the Universe (EMU) Early Science Project (ESP) survey of the Small and Large Magellanic Clouds. The two new source lists produced from these images contain radio continuum sources observed at 960 MHz (4489 sources) and 1320 MHz (5954 sources) with a bandwidth of 192 MHz and beam sizes of 30.0"x30.0" and 16.3"x15.1", respectively. The median Root Mean Squared (RMS) noise values are 186$\mu$Jy beam$^{-1}$ (960 MHz) and 165$\mu$Jy beam$^{-1}$ (1320 MHz). To create point source catalogues, we use these two source lists, together with the previously published Molonglo Observatory Synthesis Telescope (MOST) and the Australia Telescope Compact Array (ATCA) point source catalogues to estimate spectral indices for the whole population of radio point sources found in the survey region. Combining our ASKAP catalogues with these radio continuum surveys, we found 7736 point-like sources in common over an area of 30 deg$^2$. In addition, we report the detection of two new, low surface brightness supernova remnant candidates in the SMC. The high sensitivity of the new ASKAP ESP survey also enabled us to detect the bright end of the SMC planetary nebula sample, with 22 out of 102 optically known planetary nebulae showing point-like radio continuum emission. Lastly, we present several morphologically interesting background radio galaxies., Comment: 18 pages, 23 figues, 9 tables, Accepted for publication in the Monthly Notices of the Royal Astronomical Society
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- 2019
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25. A Supernova Remnant Counterpart for HESS J1832-085
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Maxted, Nigel I., Filipovic, M. D., Hurley-Walker, N., Bojicic, I., Rowell, G. P., Haberl, F., Ruiter, A. J., Seitenzahl, I. R., Panther, F., Wong, G. F., Braiding, C., Burton, M., Puhlhofer, G., Sano, H., Fukui, Y., Sasaki, M., Tian, W., Su, H., Cui, X., Leahy, D., and Hancock, P. J.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We examine the new Galactic supernova remnant (SNR) candidate, G23.11+0.18, as seen by the Murchison Widefield Array (MWA) radio telescope. We describe the morphology of the candidate and find a spectral index of -0.63+/-0.05 in the 70-170MHz domain. A coincident TeV gamma-ray detection in High-Energy Stereoscopic System (HESS) data supports the SNR nature of G23.11+0.18 and suggests that G23.11+0.18 is accelerating particles beyond TeV energies, thus making this object a promising new cosmic ray hadron source candidate. The remnant cannot be seen in current optical, infrared and X-ray data-sets. We do find, however, a dip in CO-traced molecular gas at a line-of-sight velocity of ~85 km/s, suggesting the existence of a G23.11+0.18 progenitor wind-blown bubble. Furthermore, the discovery of molecular gas clumps at a neighbouring velocity towards HESS J1832-085 adheres to the notion that a hadronic gamma-ray production mechanism is plausible towards the north of the remnant. Based on these morphological arguments, we propose an interstellar medium association for G23.11+0.18 at a kinematic distance of 4.6+/-0.8 kpc., Comment: 22 pages, 12 figures, Accepted for publication in The Astrophysical Journal
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- 2019
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26. Murchison Widefield Array and XMM-Newton observations of the Galactic supernova remnant G5.9+3.1
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Onić, D., Filipović, M. D., Bojičić, I., Hurley-Walker, N., Arbutina, B., Pannuti, T. G., Maitra, C., Urošević, D., Haberl, F., Maxted, N., Wong, G. F., Rowell, G., Bell, M. E., Callingham, J. R., Dwarakanath, K. S., For, B. -Q., Hancock, P. J., Hindson, L., Johnston-Hollitt, M., Kapińska, A. D., Lenc, E., McKinley, B., Morgan, J., Offringa, A. R., Porter, L. E., Procopio, P., Staveley-Smith, L., Wayth, R. B., Wu, C., and Zheng, Q.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
In this paper we discuss the radio continuum and X-ray properties of the so-far poorly studied Galactic supernova remnant (SNR) G5.9+3.1. We present the radio spectral energy distribution (SED) of the Galactic SNR G5.9+3.1 obtained with the Murchison Widefield Array (MWA). Combining these new observations with the surveys at other radio continuum frequencies, we discuss the integrated radio continuum spectrum of this particular remnant. We have also analyzed an archival XMM-Newton observation, which represents the first detection of X-ray emission from this remnant. The SNR SED is very well explained by a simple power-law relation. The synchrotron radio spectral index of G5.9+3.1, is estimated to be 0.42$\pm$0.03 and the integrated flux density at 1GHz to be around 2.7Jy. Furthermore, we propose that the identified point radio source, located centrally inside the SNR shell, is most probably a compact remnant of the supernova explosion. The shell-like X-ray morphology of G5.9+3.1 as revealed by XMM-Newton broadly matches the spatial distribution of the radio emission, where the radio-bright eastern and western rims are also readily detected in the X-ray while the radio-weak northern and southern rims are weak or absent in the X-ray. Extracted MOS1+MOS2+PN spectra from the whole SNR as well as the north, east, and west rims of the SNR are fit successfully with an optically thin thermal plasma model in collisional ionization equilibrium with a column density N_H~0.80x$10^{22}$ cm$^{-2}$ and fitted temperatures spanning the range kT~0.14-0.23keV for all of the regions. The derived electron number densities n_e for the whole SNR and the rims are also roughly comparable (ranging from ~$0.20f^{-1/2}$ cm$^{-3}$ to ~$0.40f^{-1/2}$ cm$^{-3}$, where f is the volume filling factor). We also estimate the swept-up mass of the X-ray emitting plasma associated with G5.9+3.1 to be ~$46f^{-1/2}M_{\odot}$., Comment: Accepted for publication in A&A
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- 2019
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27. Discovery of a Pulsar-powered Bow Shock Nebula in the Small Magellanic Cloud Supernova Remnant DEMS5
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Alsaberi, Rami Z. E., Maitra, C., Filipovi'c, M. D., Bozzetto, L. M., Haberl, F., Maggi, P., Sasaki, M., Manjolovi'c, P., Velovi'c, V., Kavanagh, P., Maxted, N. I., Urovsevi'c, D., Rowell, G. P., Wong, G. F., For, B. -Q., O'Brien, A. N., Galvin, T. J., Staveley-Smith, L., Norris, R. P., Jarrett, T., Kothes, R., Luken, K. J., Hurley-Walker, N., Sano, H., Oni'c, D., Dai, S., Pannuti, T. G., Tothill, N. F. H., Crawford, E. J., Yew, M., Bojivci'c, I., D'enes, H., McClure-Griffiths, N., Gurovich, S., and Fukui, Y.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report the discovery of a new Small Magellanic Cloud Pulsar Wind Nebula (PWN) at the edge of the Supernova Remnant (SNR)-DEM S5. The pulsar powered object has a cometary morphology similar to the Galactic PWN analogs PSR B1951+32 and 'the mouse'. It is travelling supersonically through the interstellar medium. We estimate the Pulsar kick velocity to be in the range of 700-2000 km/s for an age between 28-10 kyr. The radio spectral index for this SNR PWN pulsar system is flat (-0.29 $\pm$ 0.01) consistent with other similar objects. We infer that the putative pulsar has a radio spectral index of -1.8, which is typical for Galactic pulsars. We searched for dispersion measures (DMs) up to 1000 cm/pc^3 but found no convincing candidates with a S/N greater than 8. We produce a polarisation map for this PWN at 5500 MHz and find a mean fractional polarisation of P $\sim 23$ percent. The X-ray power-law spectrum (Gamma $\sim 2$) is indicative of non-thermal synchrotron emission as is expected from PWN-pulsar system. Finally, we detect DEM S5 in Infrared (IR) bands. Our IR photometric measurements strongly indicate the presence of shocked gas which is expected for SNRs. However, it is unusual to detect such IR emission in a SNR with a supersonic bow-shock PWN. We also find a low-velocity HI cloud of $\sim 107$ km/s which is possibly interacting with DEM S5. SNR DEM S5 is the first confirmed detection of a pulsar-powered bow shock nebula found outside the Galaxy., Comment: 20 pages, 15 figures, accepted for publication in MNRAS
- Published
- 2019
- Full Text
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28. The Mopra Southern Galactic Plane CO Survey - Data Release 3
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Braiding, Catherine, Wong, G. F., Maxted, N. I., Romano, D., Burton, M. G., Blackwell, R., Filipović, M. D., Freeman, M. S. R., Indermuehle, B., Lau, J., Rebolledo, D., Rowell, G., Snoswell, C., Tothill, N. F. H., Voisin, F., and de Wilt, P.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We present observations of fifty square degrees of the Mopra carbon monoxide (CO) survey of the Southern Galactic Plane, covering Galactic longitudes $l = 300$-$350^\circ$ and latitudes $|b| \le 0.5^\circ$. These data have been taken at 0.6 arcminute spatial resolution and 0.1 km/s spectral resolution, providing an unprecedented view of the molecular clouds and gas of the Southern Galactic Plane in the 109-115 GHz $J = 1$-0 transitions of $^{12}$CO, $^{13}$CO, C$^{18}$O and C$^{17}$O. We present a series of velocity-integrated maps, spectra and position-velocity plots that illustrate Galactic arm structures and trace masses on the order of $\sim$10$^{6}$ M$_{\odot}$ per square degree; and include a preliminary catalogue of C$^{18}$O clumps located between $l=330$-$340^\circ$. Together with information about the noise statistics of the survey these data can be retrieved from the Mopra CO website, the PASA data store and the Harvard Dataverse (doi:10.7910/DVN/LH3BDN )., Comment: 53 pages, 40 figures; full data set available via http://newt.phys.unsw.edu.au/mopraco/ ; https://data-portal.hpc.swin.edu.au/dataset/the-mopra-southern-galactic-plane-co-survey-data-release-3 ; or https://doi.org/10.7910/DVN/LH3BDN
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- 2019
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29. Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment
- Author
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Krishnan, Sai Nivedita, Thanasupawat, Thatchawan, Arreza, Leanne, Wong, G. William, Sfanos, Karen, Trock, Bruce, Arock, Michel, Shah, G. Girish, Glogowska, Aleksandra, Ghavami, Saeid, Hombach-Klonisch, Sabine, and Klonisch, Thomas
- Published
- 2023
- Full Text
- View/download PDF
30. Dysregulated systemic metabolism in a Down syndrome mouse model
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Sarver, Dylan C., Xu, Cheng, Velez, Leandro M., Aja, Susan, Jaffe, Andrew E., Seldin, Marcus M., Reeves, Roger H., and Wong, G. William
- Published
- 2023
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31. Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling
- Author
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Yu, Huimin, Zhang, Zixin, Li, Gangping, Feng, Yan, Xian, Lingling, Bakhsh, Fatemeh, Xu, Dongqing, Xu, Cheng, Vong, Tyrus, Wu, Bin, Selaru, Florin M., Wan, Fengyi, Donowitz, Mark, and Wong, G. William
- Published
- 2023
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32. A bacterial sense of touch: T4P retraction motor as a means of surface sensing by Pseudomonas aeruginosa PA14
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Geiger, C. J., primary, Wong, G. C. L., additional, and O'Toole, G. A., additional
- Published
- 2024
- Full Text
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33. A Morphological Study of the Supernova Remnant RX J0852.0-4622 (Vela Jr.)
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Maxted, Nigel I., Filipovic, M. D., Sano, H., Allen, G. E., Pannuti, T. G., Rowell, G. P., Grech, A., Roper, Q., Wong, G. F., Galvin, T. J., Fukui, Y., Collier, J. D., Crawford, E. J., Grieve, K., Horta, A. D., Manojlovic, P., and O'Brien, A.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
We conduct a multi-wavelength morphological study of the Galactic supernova remnant RXJ0852.0-4622 (also known as Vela Jr., Vela Z and G266.2-1.2). RX J0852.0-4622 is coincident with the edge of the larger Vela supernova remnant causing confusion in the attribution of some filamentary structures to either RX J0852.0-4622 or its larger sibling. We find that the RX J0852.0-4622 radio continuum emission can be characterised by a 2-dimensional shell with a radius of 0.90+/-0.01deg (or 11.8+/-0.6pc at an assumed distance of 750pc) centred at (l,b)=(133.08+/-0.01 deg,-46.34+/-0.01deg) (or RA=8h52m19.2s, Dec=-46deg20'24.0'', J2000), consistent with X-ray and gamma-ray emission. Although [OIII] emission features are generally associated with the Vela SNR, one particular [OIII] emission feature, which we denote as "the Vela Claw", morphologically matches a molecular clump that is thought to have been stripped by the stellar progenitor of the RX J0852.0-4622 SNR. We argue that the Vela Claw feature is possibly associated with RX J0852.0-4622. Towards the north-western edge of RX J0852.0-4622, we find a flattening of the radio spectral index towards another molecular clump also thought to be associated with RX J0852.0-4622. It is currently unclear whether this feature and the Vela Claw result from interactions between the RX J0852.0-4622 shock and the ISM., Comment: 15 pages, 7 figures, Accepted for Publication in the Astrophysical Journal (ApJ)
- Published
- 2018
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34. Strong circular dichroism in twisted single-ring hollow-core photonic crystal fiber
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Roth, P., Chen, Y., Günendi, M. C., Beravat, R., Edavalath, N. N., Frosz, M. H., Ahmed, G., Wong, G. K. L., and Russell, P. St. J.
- Subjects
Physics - Optics - Abstract
We report a series of experimental, analytical and numerical studies demonstrating strong circular dichroism in helically twisted hollow-core single-ring photonic crystal fiber (SR-PCF), formed by spinning the preform during fiber drawing. In the SR-PCFs studied, the hollow core is surrounded by a single ring of non-touching capillaries. Coupling between these capillaries results in the formation of helical Bloch modes carrying orbital angular momentum. In the twisted fiber, strong circular birefringence appears in the ring, so that when a core mode with a certain circular polarization state (say LC) phase-matches to the ring, the other (RC) is strongly dephased. If in addition the orbital angular momentum is the same in core and ring, and the polarization states are non-orthogonal (e.g., slightly elliptical), the LC core mode will experience high loss while the RC mode is efficiently transmitted. The result is a single-circular-polarization SR-PCF that acts as a circular polarizer over a certain wavelength range. Such fibers have many potential applications, for example, for generating circularly polarized light in gas-filled SR-PCF and realizing polarizing elements in the deep and vacuum ultraviolet.
- Published
- 2018
35. Searching for an interstellar medium association for HESS J1534-571
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Maxted, Nigel I., Braiding, C., Wong, G. F., Rowell, G. P., Burton, M. G., Filipovic, M. D., Voisin, F., Urosevic, D., Vukotic, B., Pavlovic, M. Z., Sano, H., and Fukui, Y.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Galactic supernova remnant HESS J1534-571 (also known as G323.7-1.0) has a shell-like morphology in TeV gamma-ray emission and is a key object in the study of cosmic ray origin. Little is known about its distance and local environment. We examine Mopra $^{12}$CO/$^{13}$CO(1-0) data, Australian Telescope Compact Array HI, and Parkes HI data towards HESS J1534-571. We trace molecular clouds in at least five velocity ranges, including clumpy interstellar medium structures near a dip in HI emission at a kinematic velocity consistent with the Scutum-Crux arm at ~3.5 kpc. This feature may be a cavity blown-out by the progenitor star, a scenario that suggests HESS J1534-571 resulted from a core-collapse event. By employing parametrisations fitted to a sample of supernova remnants of known distance, we find that the radio continuum brightness of HESS J1534-571 is consistent with the ~3.5 kpc kinematic distance of the Scutum-Crux arm HI dip. Modelling of the supernova evolution suggests an ~8-24 kyr age for HESS J1534-571 at this distance., Comment: 16 pages, 10 Figures, Accepted for publication in MNRAS
- Published
- 2018
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36. Is Online Video-Based Education an Effective Method to Teach Basic Surgical Skills to Students and Surgical Trainees? A Systematic Review and Meta-analysis
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Mao, B.P., Teichroeb, M.L., Lee, T., Wong, G., Pang, T., and Pleass, H.
- Published
- 2022
- Full Text
- View/download PDF
37. Twist-tuned suppression of higher-order modes in single-ring hollow-core photonic crystal fibers
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Edavalath, N. N., Günendi, M. C., Beravat, R., Wong, G. K. L., Frosz, M. H., Ménard, J. -M., and Russell, P. ST. J.
- Subjects
Physics - Optics - Abstract
Optimum suppression of higher order modes in single-ring hollow-core photonic crystal fibers (SR-PCFs) occurs when the capillary-to-core diameter ratio d/D = 0.68. Here we report that, in SR-PCFs with sub-optimal values of d/D, higher-order mode suppression can be recovered by spinning the preform during fiber drawing, thus introducing a continuous helical twist. This geometrically increases the effective axial propagation constant (initially too low) of the LP01-like modes of the capillaries surrounding the core, enabling robust single-mode operation. The effect is explored by means of extensive numerical modeling, an analytical model and a series of experiments. Prism-assisted side-coupling is used to investigate the losses and near-field patterns of individual fiber modes in both the straight and twisted cases. More than 12 dB/m improvement in higher order mode suppression is achieved experimentally in a twisted PCF. The measurements also show that the higher order mode profiles change with twist rate, as predicted by numerical simulations. Helical twisting offers an additional tool for achieving effectively endlessly single-mode operation in hollow-core SR-PCFs.
- Published
- 2017
38. Organic molecules revealed in Mars’s Bagnold Dunes by Curiosity’s derivatization experiment
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Millan, M., Teinturier, S., Malespin, C. A., Bonnet, J. Y., Buch, A., Dworkin, J. P., Eigenbrode, J. L., Freissinet, C., Glavin, D. P., Navarro-González, R., Srivastava, A., Stern, J. C., Sutter, B., Szopa, C., Williams, A. J., Williams, R. H., Wong, G. M., Johnson, S. S., and Mahaffy, P. R.
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- 2022
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39. Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment (GRACE)
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Wong, T., primary, Tosteson, T., additional, Zhao, W., additional, Wong, G., additional, and Feller-Kopman, D.J., additional
- Published
- 2024
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40. Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age
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Sarver, Dylan C, primary, Saqib, Muzna, additional, Chen, Fangluo, additional, and Wong, G. William, additional
- Published
- 2024
- Full Text
- View/download PDF
41. Wireless Sensor Network for Temperature and Humidity Monitoring Systems Based on NodeMCU ESP8266
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Shun, Wong G., Muda, W. Mariam W., Hassan, W. Hafiza W., Annuar, A. Z., Barbosa, Simone Diniz Junqueira, Editorial Board Member, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Kotenko, Igor, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Anbar, Mohammed, editor, Abdullah, Nibras, editor, and Manickam, Selvakumar, editor
- Published
- 2020
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42. Prescription patterns of direct oral anticoagulants and concomitant use of interacting medications in the Netherlands
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Harskamp, R. E., Himmelreich, J. C. L., Wong, G. W. M., and Teichert, M.
- Published
- 2021
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43. A survey of the cold molecular gas in gravitationally lensed star-forming galaxies at z>2
- Author
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Aravena, M., Spilker, J. S., Bethermin, M., Bothwell, M., Chapman, S. C., de Breuck, C., Furstenau, R. M., Gónzalez-López, J., Greve, T. R., Litke, K., Ma, J., Malkan, M., Marrone, D. P., Murphy, E. J., Stark, A., Strandet, M., Vieira, J. D., Weiss, A., Welikala, N., Wong, G. F., and Collier, J. D.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Using the Australia Telescope Compact Array (ATCA), we conducted a survey of CO J=1-0 and J=2-1 line emission towards strongly lensed high-redshift dusty star forming galaxies (DSFGs) previously discovered with the South Pole Telescope (SPT). Our sample comprises 17 sources that had CO-based spectroscopic redshifts obtained with the Atacama Large Millimeter/submillimeter Array (ALMA) and the Atacama Pathfinder Experiment (APEX). We detect all sources with known redshifts in either CO J=1-0 or J=2-1. Twelve sources are detected in the 7-mm continuum. The derived CO luminosities imply gas masses in the range (0.5-11)x10^{10} M_sun and gas depletion timescales <200 Myr, using a CO to gas mass conversion factor alpha_CO=0.8 M_sun (K km/s pc^2)^{-1}. Combining the CO luminosities and dust masses, along with a fixed gas-to-dust ratio, we derive alpha_CO factors in the range 0.4-1.8, similar to what is found in other starbursting systems. We find small scatter in alpha_CO values within the sample, even though inherent variations in the spatial distribution of dust and gas in individual cases could bias the dust-based alpha_CO estimates. We find that lensing magnification factors based on the CO linewidth to luminosity relation (mu_CO) are highly unreliable, but particularly when mu<5. Finally, comparison of the gas and dynamical masses suggest that the average molecular gas fraction stays relatively constant at z=2-5 in the SPT DSFG sample., Comment: Accepted for publication in MNRAS
- Published
- 2016
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44. Implementation of Tidbinbilla 70-m On-The-Fly mapping and Hydrogen radio recombination line early results
- Author
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Wong, G. F., Horiuchi, S., Green, J. A., Tothill, N. F. H., Sugimoto, K., and Filipovic, M. D.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
On-the-fly mapping of cm-wave spectral lines has been implemented at the the Tidbinbilla 70-m radio antenna. We describe the implementation and data reduction procedure and present new H92$\alpha$ radio recombination line maps towards Orion A and Sagittarius A. Comparison of the Orion~A map to previous observations suggests that the lines arise largely from gas with electron density of 100--200\,cm$^{-3}$. On-the-fly mapping is very efficient at generating large maps of bright lines (such as radio recombination lines), but will still yield strong efficiency gains for smaller maps of fainter lines, such as the ammonia inversion lines at the 1.3\,cm wavelength., Comment: 8 pages, 3 tables, 8 Figures. Accepted for Publication in the Monthly Notices of the Royal Astronomical Society Journal
- Published
- 2016
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45. C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance
- Author
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Lei, Xia, Seldin, Marcus M, Little, Hannah C, Choy, Nicholas, Klonisch, Thomas, and Wong, G William
- Subjects
Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Nutrition ,Obesity ,Diabetes ,Biotechnology ,Aetiology ,2.1 Biological and endogenous factors ,Cardiovascular ,Metabolic and endocrine ,3T3-L1 Cells ,Adipokines ,Adipose Tissue ,Animals ,Cells ,Cultured ,Collagen ,Disease Models ,Animal ,Humans ,Inflammation ,Insulin Resistance ,Male ,Mice ,Mice ,Inbred C57BL ,Mice ,Knockout ,Mice ,Obese ,RAW 264.7 Cells ,adipose tissue ,inflammation ,insulin resistance ,macrophage ,obesity ,Chemical Sciences ,Medical and Health Sciences ,Biochemistry & Molecular Biology ,Biological sciences ,Biomedical and clinical sciences ,Chemical sciences - Abstract
Obesity is associated with chronic low-grade inflammation, and metabolic regulators linking obesity to inflammation have therefore received much attention. Secreted C1q/TNF-related proteins (CTRPs) are one such group of regulators that regulate glucose and fat metabolism in peripheral tissues and modulate inflammation in adipose tissue. We have previously shown that expression of CTRP6 is up-regulated in leptin-deficient mice and, conversely, down-regulated by the anti-diabetic drug rosiglitazone. Here, we provide evidence for a novel role of CTRP6 in modulating both inflammation and insulin sensitivity. We found that in obese and diabetic humans and mouse models, CTRP6 expression was markedly up-regulated in adipose tissue and that stromal vascular cells, such as macrophages, are a major CTRP6 source. Overexpressing mouse or human CTRP6 impaired glucose disposal in peripheral tissues in response to glucose and insulin challenge in wild-type mice. Conversely, Ctrp6 gene deletion improved insulin action and increased metabolic rate and energy expenditure in diet-induced obese mice. Mechanistically, CTRP6 regulates local inflammation and glucose metabolism by targeting macrophages and adipocytes, respectively. In cultured macrophages, recombinant CTRP6 dose-dependently up-regulated the expression and production of TNF-α. Conversely, CTRP6 deficiency reduced circulating inflammatory cytokines and pro-inflammatory macrophages in adipose tissue. CTRP6-overexpressing mice or CTRP6-treated adipocytes had reduced insulin-stimulated Akt phosphorylation and glucose uptake. In contrast, loss of CTRP6 enhanced insulin-stimulated Akt activation in adipose tissue. Together, these results establish CTRP6 as a novel metabolic/immune regulator linking obesity to adipose tissue inflammation and insulin resistance.
- Published
- 2017
46. Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.
- Author
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Lopez, Pablo Hh, Aja, Susan, Aoki, Kazuhiro, Seldin, Marcus M, Lei, Xia, Ronnett, Gabriele V, Wong, G William, and Schnaar, Ronald L
- Subjects
Adipose Tissue ,Animals ,Mice ,Knockout ,Humans ,Mice ,Insulin Resistance ,Obesity ,Disease Models ,Animal ,N-Acetylneuraminic Acid ,Sialyltransferases ,Gangliosides ,Galactose ,Glucose Tolerance Test ,Lipid Metabolism ,Insulin Receptor Substrate Proteins ,beta-Galactoside alpha-2 ,3-Sialyltransferase ,adipose tissue ,ganglioside ,hyperglycemia ,metabolism ,sialic acid ,Diabetes ,Nutrition ,Biotechnology ,Digestive Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Metabolic and endocrine ,Biological Sciences ,Medical and Health Sciences ,Biochemistry & Molecular Biology - Abstract
Sialyltransferases are a family of 20 gene products in mice and humans that transfer sialic acid from its activated precursor, CMP-sialic acid, to the terminus of glycoprotein and glycolipid acceptors. ST3Gal-II (coded by the St3gal2 gene) transfers sialic acid preferentially to the three positions of galactose on the Galβ1-3GalNAc terminus of gangliosides GM1 and GD1b to synthesize GD1a and GT1b, respectively. Mice with a targeted disruption of St3gal2 unexpectedly displayed late-onset obesity and insulin resistance. At 3 months of age, St3gal2-null mice were the same weight as their wild type (WT) counterparts, but by 13 months on standard chow they were visibly obese, 22% heavier and with 37% greater fat/lean ratio than WT mice. St3gal2-null mice became hyperglycemic and displayed impaired glucose tolerance by 9 months of age. They had sharply reduced insulin responsiveness despite equivalent pancreatic islet morphology. Analyses of insulin receptor (IR) tyrosine kinase substrate IRS-1 and downstream target Akt revealed decreased insulin-induced phosphorylation in adipose tissue but not liver or skeletal muscle of St3gal2-null mice. Thin-layer chromatography and mass spectrometry revealed altered ganglioside profiles in the adipose tissue of St3gal2-null mice compared to WT littermates. Metabolically, St3gal2-null mice display a reduced respiratory exchange ratio compared to WT mice, indicating a preference for lipid oxidation as an energy source. Despite their altered metabolism, St3gal2-null mice were hyperactive. We conclude that altered ganglioside expression in adipose tissue results in diminished IR sensitivity and late-onset obesity.
- Published
- 2017
47. Abstract 10252: Differences in the Transcriptomic Profile of Visceral Fat in Persons With Metabolically “Healthy” versus Metabolically “Unhealthy” Obesity
- Author
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Meddeb, Mariam, Wolf, Risa, Wallace, Amelia S, Chu, Xin, Florido, Roberta, Echouffo Tcheugui, Justin B, Matsushita, Kuni, Kass, David A, Gerstenblith, Gary, Kim, Sangwon, Ahima, Rexford, Wood, G, Coresh, Josef, Benotti, Peter, Wong, G William, and Ndumele, Chiadi E
- Published
- 2022
- Full Text
- View/download PDF
48. Sub-kiloparsec Imaging of Cool Molecular Gas in Two Strongly Lensed Dusty, Star-Forming Galaxies
- Author
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Spilker, J. S., Aravena, M., Marrone, D. P., Bethermin, M., Bothwell, M. S., Carlstrom, J. E., Chapman, S. C., Collier, J. D., de Breuck, C., Fassnacht, C. D., Galvin, T., Gonzalez, A. H., Gonzalez-Lopez, J., Grieve, K., Hezaveh, Y., Ma, J., Malkan, M., O'Brien, A., Rotermund, K. M., Strandet, M., Vieira, J. D., Weiss, A., and Wong, G. F.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We present spatially-resolved imaging obtained with the Australia Telescope Compact Array (ATCA) of three CO lines in two high-redshift gravitationally lensed dusty star-forming galaxies, discovered by the South Pole Telescope. Strong lensing allows us to probe the structure and dynamics of the molecular gas in these two objects, at z=2.78 and z=5.66, with effective source-plane resolution of less than 1kpc. We model the lensed emission from multiple CO transitions and the dust continuum in a consistent manner, finding that the cold molecular gas as traced by low-J CO always has a larger half-light radius than the 870um dust continuum emission. This size difference leads to up to 50% differences in the magnification factor for the cold gas compared to dust. In the z=2.78 galaxy, these CO observations confirm that the background source is undergoing a major merger, while the velocity field of the other source is more complex. We use the ATCA CO observations and comparable resolution Atacama Large Millimeter/submillimeter Array dust continuum imaging of the same objects to constrain the CO-H_2 conversion factor with three different procedures, finding good agreement between the methods and values consistent with those found for rapidly star-forming systems. We discuss these galaxies in the context of the star formation - gas mass surface density relation, noting that the change in emitting area with observed CO transition must be accounted for when comparing high-redshift galaxies to their lower redshift counterparts., Comment: 14 pages, 7 figures; accepted for publication in ApJ
- Published
- 2015
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49. The Spectral Variability of the GHz-Peaked Spectrum Radio Source PKS 1718-649 and a Comparison of Absorption Models
- Author
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Tingay, S. J., Macquart, J. -P., Collier, J. D., Rees, G., Callingham, J. R., Stevens, J., Carretti, E., Wayth, R. B., Wong, G. F., Trott, C. M., McKinley, B., Bernardi, G., Bowman, J. D., Briggs, F., Cappallo, R. J., Corey, B. E., Deshpande, A. A., Emrich, D., Gaensler, B. M., Goeke, R., Greenhill, L. J., Hazelton, B. J., Johnston-Hollitt, M., Kaplan, D. L., Kasper, J. C., Kratzenberg, E., Lonsdale, C. J., Lynch, M. J., McWhirter, S. R., Mitchell, D. A., Morales, M. F., Morgan, E., Oberoi, D., Ord, S. M., Prabu, T., Rogers, A. E. E., Roshi, A., Shankar, N. Udaya, Srivani, K. S., Subrahmanyan, R., Waterson, M., Webster, R. L., Whitney, A. R., Williams, A., and Williams, C. L.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Using the new wideband capabilities of the Australia Telescope Compact Array (ATCA), we obtain spectra for PKS 1718-649, a well-known gigahertz-peaked spectrum radio source. The observations, between approximately 1 and 10 GHz over three epochs spanning approximately 21 months, reveal variability both above the spectral peak at ~3 GHz and below the peak. The combination of the low and high frequency variability cannot be easily explained using a single absorption mechanism, such as free-free absorption or synchrotron self-absorption. We find that the PKS 1718-649 spectrum and its variability are best explained by variations in the free-free optical depth on our line-of-sight to the radio source at low frequencies (below the spectral peak) and the adiabatic expansion of the radio source itself at high frequencies (above the spectral peak). The optical depth variations are found to be plausible when X-ray continuum absorption variability seen in samples of Active Galactic Nuclei is considered. We find that the cause of the peaked spectrum in PKS 1718-649 is most likely due to free-free absorption. In agreement with previous studies, we find that the spectrum at each epoch of observation is best fit by a free-free absorption model characterised by a power-law distribution of free-free absorbing clouds. This agreement is extended to frequencies below the 1 GHz lower limit of the ATCA by considering new observations with Parkes at 725 MHz and 199 MHz observations with the newly operational Murchison Widefield Array. These lower frequency observations argue against families of absorption models (both free-free and synchrotron self-absorption) that are based on simple homogenous structures., Comment: Accepted for publication in The Astronomical Journal
- Published
- 2014
- Full Text
- View/download PDF
50. Energy stacking efficiency of a novel low-frequency spring-like piezoelectric energy harvester.
- Author
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Wong, G S, Lee, K Q, Eileen Lee, M S, Kang, H S, and Wong, K Y
- Published
- 2024
- Full Text
- View/download PDF
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