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Summary: Background: Pre‐operative tissue diagnosis for suspected malignant biliary strictures remains challenging. Aim: To develop evidence‐based consensus statements on endoscopic tissue acquisition for biliary strictures. Methods: The initial draft of statements was prepared following a systematic literature review. A committee of 20 experts from Asia‐Pacific region then reviewed, discussed, and modified the statements. Two rounds of independent voting were conducted to reach a final version. Consensus was considered to be achieved when 80% or more of voting members voted “agree completely” or “agree with some reservation.” Results: Eleven statements achieved consensus. The choice of tissue sampling modalities for biliary strictures depends on the clinical setting, the location of lesion, and availability of expertise. Detailed radiological and endoscopic evaluation is useful to guide the selection of appropriate tissue acquisition technique. Standard intraductal biliary brushing and/or forceps biopsy is the first option when endoscopic biliary drainage is required with an overall (range) sensitivity and specificity of 45% (26%‐72%) and 99% (98%‐100%), and 48% (15%‐100%) and 99% (97%‐100%), respectively, in diagnosing malignant biliary strictures. Probe‐based confocal laser endomicroscopy and fluorescence in situ hybridisation using 4 fluorescent‐labelled probes targeting chromosomes 3, 7, 17 and 9p21 locus may be added to improve the diagnostic yield. Cholangioscopy‐guided biopsy and EUS‐guided tissue acquisition can be considered after prior negative conventional tissue sampling with an overall (range) sensitivity and specificity of 60% (38%‐88%) and 98% (83%‐100%), and 80% (46%‐100%) and 97% (92%‐100%), respectively, in diagnosing malignant biliary strictures. Conclusion: These consensus statements provide evidence‐based recommendations for endoscopic tissue acquisition of biliary strictures. [ABSTRACT FROM AUTHOR]