Search

Your search keyword '"Wood, Robyn"' showing total 40 results
Start Over Author "Wood, Robyn"
40 results on '"Wood, Robyn"'

4. Fosciclopirox clinical proof of concept in patients with nonmuscle invasive and muscle-invasive bladder cancer.

Author

Weir, Scott James, primary, Kessler, Elizabeth R, additional, Kukreja, Janet Baack, additional, Falchook, Gerald Steven, additional, Bupathi, Manojkumar, additional, Parikh, Rahul Atul, additional, Wulff-Burchfield, Elizabeth Marie, additional, Wood, Robyn, additional, Lee, Eugene K., additional, Ham, Tammy, additional, Dandawate, Prasad, additional, Anant, Shrikant, additional, Woolbright, Benjamin L., additional, Zhang, Na, additional, Toren, Paul, additional, Dalton, Michael, additional, Zhukova-Harrill, Valentina, additional, Umbreit, Jay Nicholas, additional, McCulloch, William, additional, and Taylor, John A., additional

Published
2022
Full Text
View/download PDF

5. Phase 1B/2A safety, pharmacokinetics, and pharmacodynamics study of fosciclopirox alone and in combination with cytarabine in patients with relapsed/refractory acute myeloid leukemia.

Author

Lin, Tara L., primary, Wood, Robyn, additional, Ham, Tammy, additional, Sullivan, Taegen, additional, Bhattacharyya, Sangita, additional, Dandawate, Prasad, additional, Anant, Shrikant, additional, Santaguida, Marianne T, additional, Zhang, Na, additional, Toren, Paul, additional, Jensen, Roy A., additional, Taylor, John A., additional, Baltezor, Michael Jay, additional, Dalton, Michael, additional, McBride, John, additional, Umbreit, Jay Nicholas, additional, McCulloch, William, additional, Vanderlaag, Kathryn, additional, Wagner, Joseph, additional, and Weir, Scott James, additional

Published
2022
Full Text
View/download PDF

9. Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting notch signaling

Author

Weir, Scott James, Dandawate, Prasad, Ramamoorthy, Prabhu, Ranjarajan, Parthasarathy, Wood, Robyn, Brinker, Amanda, Anant, Shrikant, Tanol, Mehmet, Standing, David, Bhattacharyya, Sangita, Woolbright, Benjamin L., Ham, Tammy, McCulloch, William, Dalton, Michael, Reed, Gregory A., Baltezor, Michael J., Jensen, Roy A., and Tanol, Mehmet

Subjects
Fosciclopirox, Urothelial Cancer
Abstract

AACR Annual Meeting -- JUN 22-24, 2020 -- ELECTR NETWORK WOS:000590059307247 Ciclopirox (CPX) is an FDA-approved topical antifungal agent that has demonstrated preclinical anticancer activity in a number of solid and hematologic malignancies. Its clinical utility as an oral anticancer agent, however, is limited by poor oral bioavailability and gastrointestinal toxicity. Fosciclopirox, the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPXPOM), selectively delivers the active metabolite, CPX, to the entire urinary tract following parenteral administration. We characterized the activity of CPX-POM and its major metabolites in in vitro and in vivo preclinical models of high-grade urothelial cancer. CPX inhibited cell proliferation, clonogenicity and spheroid formation, and increased cell cycle arrest at S and G0/G1 phases. Mechanistically, CPX suppressed activation of Notch signaling. Molecular modeling and cellular thermal shift assays demonstrated CPX binding to γ-secretase complex proteins Presenilin 1 and Nicastrin, which are essential for Notch activation. To establish in vivo preclinical proof of principle, we tested fosciclopirox in the validated N-butyl-N-(4- hydroxybutyl) nitrosamine (BBN) mouse bladder cancer model. Once-daily intraperitoneal administration of CPX-POM for four weeks at doses of 235 mg/kg and 470 mg/kg significantly decreased bladder weight, a surrogate for tumor volume, and resulted in a migration to lower stage tumors in CPX-POM treated animals. This was coupled with a reduction in the proliferation index. Additionally, there was a reduction in Presenilin 1 and Hes-1 expression in the bladder tissues of CPXPOM treated animals. Following the completion of the first-in-human Phase 1 trial (NCT03348514), the pharmacologic activity of fosciclopirox is currently being characterized in a Phase 1 expansion cohort study of muscle-invasive bladder cancer patients scheduled for cystectomy (NCT04608045) as well as a Phase 2 trial of newly diagnosed and recurrent urothelial cancer patients scheduled for transurethral resection of bladder tumors (NCT04525131). Amer Assoc Canc Res

Published
2020

10. Abstract 6405: Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting Notch signaling

Author

Weir, Scott James, primary, Dandawate, Prasad, additional, Ramamoorthy, Prabhu, additional, Ranjarajan, Parthasarathy, additional, Wood, Robyn, additional, Brinker, Amanda, additional, Woolbright, Benjamin, additional, Tanol, Mehmet, additional, Ham, Tammy, additional, McCulloch, William, additional, Dalton, Michael, additional, Baltezor, Michael J., additional, Jensen, Roy A., additional, Taylor, John A., additional, and Anant, Shrikant, additional

Published
2020
Full Text
View/download PDF

11. Window of opportunity trial to characterize the safety, pharmacokinetics, and pharmacodynamics of fosciclopirox (CPX-POM) in cisplatin-ineligible muscle invasive bladder cancer patients.

Author

Taylor, John Arthur, primary, Wood, Robyn, additional, Ham, Tammy, additional, Casey, Crista, additional, Dandawate, Prasad, additional, Reed, Greg, additional, Woolbright, Benjamin L., additional, Baltezor, Michael Jay, additional, Jensen, Roy A., additional, Dalton, Michael, additional, Zhukova-Harrill, Valentina, additional, McCulloch, William, additional, Anant, Shrikant, additional, and Weir, Scott James, additional

Published
2020
Full Text
View/download PDF

12. Safety, dose tolerance, pharmacokinetics, and pharmacodynamics of fosciclopirox (CPX-POM) in patients with advanced solid tumors.

Author

Patel, Manish R., primary, Ulahannan, Susanna Varkey, additional, Weir, Scott James, additional, Wood, Robyn, additional, Ham, Tammy, additional, Casey, Crista, additional, Reed, Greg, additional, Dandawate, Prasad, additional, Ramamoorthy, Prabhu, additional, Baltezor, Michael Jay, additional, Jensen, Roy A., additional, Woolbright, Benjamin L., additional, Taylor, John Arthur, additional, Anant, Shrikant, additional, Dalton, Michael, additional, Zhukova-Harrill, Valentina, additional, McCulloch, William, additional, Jones, Suzanne Fields, additional, Burris, Howard A., additional, and Falchook, Gerald Steven, additional

Published
2020
Full Text
View/download PDF

14. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs

Author

Weir, Scott J., primary, Wood, Robyn, additional, Schorno, Karl, additional, Brinker, Amanda E., additional, Ramamoorthy, Prabhu, additional, Heppert, Kathy, additional, Rajewski, Lian, additional, Tanol, Mehmet, additional, Ham, Tammy, additional, McKenna, Michael J., additional, McCulloch, William, additional, Dalton, Michael, additional, Reed, Gregory A., additional, Jensen, Roy A., additional, Baltezor, Michael J., additional, Anant, Shrikant, additional, and Taylor, John A., additional

Published
2019
Full Text
View/download PDF

15. Pharmacokinetics of ciclopirox prodrug, a novel agent for the treatment of bladder cancer, in animals and humans.

Author

Weir, Scott James, primary, Wood, Robyn, additional, Baltezor, Michael Jay, additional, Reed, Greg, additional, Brinker, Amanda E, additional, Ham, Tammy, additional, Schorno, Karl, additional, Toren, Paul, additional, Ramamoorthy, Prabhu, additional, Zhukova-Harrill, Valentina, additional, Dalton, Michael, additional, McCulloch, William, additional, Patel, Manish R., additional, Ulahannan, Susanna Varkey, additional, Burris, Howard A., additional, Falchook, Gerald Steven, additional, Jensen, Roy A., additional, Anant, Shrikant, additional, and Taylor, John Arthur, additional

Published
2019
Full Text
View/download PDF

16. Isle Of Man Legislative Update - April 2019

Author

Wood, Robyn

Subjects
Brexit -- Economic aspects, Data security -- Laws, regulations and rules, Data security issue, Government regulation, Business, international, Freedom of Information Act, United Kingdom. Data Protection Act 2018, European Union -- Powers and duties
Abstract

European Union and Trade Act 2019 This Act repeals the European Communities (Isle of Man) Act 1973 and makes provisions consequent upon the withdrawal of the UK from the EU [...]

Published
2019

17. Conducting a Pre-Implementation Assessment of Maternal Infant Early Childhood Home Visiting Services for Orange County, North Carolina

Author

Wood, Robyn

Abstract

The Orange County Health Department, along with community partners, has identified a need for programming to support women during the prenatal and early childhood periods. This project describes the creation of an evidence-based pre-implementation assessment for Maternal Infant Early Childhood Home Visiting (MIECHV) programming in Orange County. This assessment was developed using a literature review, study of census data, and the experiences of program administrators, implementation specialists, and research specialists. Findings were disseminated through in-person presentations to key health department staff and community leaders, as well as by electronic distribution of a technical report and short informational videos.

Published
2017
Full Text
View/download PDF

18. Abstract 5882: Bench-to-bedside translation of ciclopirox prodrug for the treatment of non-muscle invasive and muscle-invasive bladder cancer

Author

Weir, Scott J., primary, Ranjarajan, Partha, additional, Wood, Robyn, additional, Schorno, Karl, additional, Ramamoorthy, Prabhu, additional, Rajweski, Lian, additional, Heppert, Kathy, additional, McKenna, Michael J., additional, McCulloch, William, additional, Reed, Greg A., additional, Brinker, Amanda, additional, Baltezor, Michael J., additional, Jensen, Roy A., additional, Taylor, John A., additional, and Anant, Shrikant, additional

Published
2018
Full Text
View/download PDF

19. Safety, dose tolerance, pharmacokinetics and pharmacodynamics study of CPX-POM in patients with advanced solid tumors.

Author

Weir, Scott James, primary, Wood, Robyn, additional, Ham, Tammy, additional, Challenger, Rashida, additional, Ramamoorthy, Prabhu, additional, Reed, Greg, additional, Baltezor, Michael Jay, additional, Jensen, Roy A., additional, Taylor, John Arthur, additional, Anant, Shrikant, additional, Dalton, Michael, additional, McKenna, Michael J, additional, Zhukova-Harrill, Valentina, additional, McCulloch, William, additional, and Burris, Howard A., additional

Published
2018
Full Text
View/download PDF

20. Preclinical development of ciclopirox prodrug for the treatment of non-muscle invasive and muscle invasive bladder cancer.

Author

Weir, Scott James, primary, Wood, Robyn, additional, Ham, Tammy, additional, Ranjarajan, Parthasarathy, additional, Ramamoorthy, Prabhu, additional, Rajewski, Lian, additional, Heppert, Kathy, additional, Haslam, John, additional, Schorno, Karl, additional, Dalton, Michael, additional, McKenna, Michael J, additional, Reed, Greg, additional, Brinker, Amanda E, additional, McCulloch, William, additional, Baltezor, Michael Jay, additional, Jensen, Roy A., additional, Taylor, John Arthur, additional, and Anant, Shrikant, additional

Published
2018
Full Text
View/download PDF

22. Isle Of Man Legislation Updates

Author

Wood, Robyn

Subjects
Antiterrorism measures -- Reports, Money laundering -- Reports, Business, international
Abstract

Anti-Money Laundering and Other Financial Crime (Miscellaneous Amendments) Act 2018 The Act addresses several recommendations made within the MONEYVAL Mutual Evaluation Report of the Isle of Man, as well as [...]

Published
2018

23. Legislation Update

Author

Wood, Robyn

Subjects
Data security -- Laws, regulations and rules, Credit unions -- Laws, regulations and rules, Securities law -- Analysis, Government regulation, Data security issue, Business, international
Abstract

Primary legislation Central Registry Bill 2018: this will provide for the creation of a Central Registry, combining the registry and public records functions of the General Registry with the Companies [...]

Published
2018

25. Phase 1B/2A safety, pharmacokinetics and pharmacodynamics study of fosciclopirox alone and in combination with cytarabine in patients with relapsed/refractory acute myeloid leukemia.

Author

Lin, Tara L., Wood, Robyn, Ham, Tammy, Sullivan, Taegen, Dandawate, Prasad, Anant, Shrikant, Santaguida, Marianne T, Toren, Paul, Jensen, Roy A., Taylor, John A., Baltezor, Michael Jay, Dalton, Michael, Meyer, Fred, McBride, John, Umbreit, Jay Nicholas, McCulloch, William, Vanderlaag, Kathryn, Wagner, Joseph, Weir, Scott James, and Smith, B. Douglas

Published
2023
Full Text
View/download PDF

29. KU-AS-272, a Potential Single-Dose Sterilant for Cats and Dogs, Shows Safety and Ability to Block Spermatogenesis in Testis to Sertoli Cells Only after a Single Subcutaneous Injection in Male Rat.

Author

Gupta, Vijayalaxmi G., primary, Roby, Katherine F., additional, Kern, Brian, additional, Hall, Todd, additional, Jakkaraj, Sudhakar, additional, Chakrasali, Ramappa, additional, Georg, Gunda I., additional, Broward, Melinda, additional, Wood, Robyn, additional, Weir, Scott, additional, and Tash, Joseph S., additional

Published
2012
Full Text
View/download PDF

30. Interaction of Microbiology and Pathology in Women Undergoing Investigations for Infertility

Author

Debattista, Joseph, Gazzard, Caroline, Wood, Robyn, Allan, John, Allan, Janet, Scarman, Anthony, Mortlock, Miranda, Timms, Peter, Knox, Christine, Debattista, Joseph, Gazzard, Caroline, Wood, Robyn, Allan, John, Allan, Janet, Scarman, Anthony, Mortlock, Miranda, Timms, Peter, and Knox, Christine

Abstract

Background: Cases of endometriosis with no tubal damage are associated with infertility, suggesting an immunological rather than mechanical barrier to reproduction. Laparoscopy and falloposcopy results of clinically asymptomatic women undergoing investigation of infertility were correlated with the outcomes of microbiological screening for Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, ureaplasma species, Neisseria gonorrhoeae, Neisseria meningitidis and Chlamydia pneumoniae. Methods: A total of 44 women presenting to a hospital IVF service for laparoscopic or laparoscopic/ falloposcopic investigation of infertility provided endocervical swabs, fallopian tube washings, and peripheral whole blood for analysis. Results: Of these 44 women, 15.9% (7) showed evidence of C. trachomatis infection as detected by either PCR or EIA serology. Of these 7 women, 5 (71%) had no or mild endometriosis and 2 (29%) had moderate or severe endometriosis. Of the remaining 37 women who showed no evidence of chlamydial infection, 15 (40.5%) had no or mild endometriosis. Conclusion: Women with infertility, but without severe endometriosis at laparoscopy, showed a trend towards tubal damage and a higher rate of previous C. trachomatis infection. Although not statistically significant, this trend would suggest that, where moderate to severe tubal damage is found to be the primary cause of infertility, C. trachomatis infection could be a likely cause for such tubal damage.

Published
2004

37. Diagnosis of Helicobacter pyloriInfection in Adults with Intellectual Disability

Author

Wallace, Robyn A., Schluter, Philip J., Forgan-Smith, Ross, Wood, Robyn, and Webb, Penelope M.

Abstract

ABSTRACTHelicobacter pyloriinfection is common among adults with intellectual disability. The acceptabilities and accuracies of different diagnostic tests in this population are unknown. We aimed to determine (i) patient acceptability and (ii) performance characteristics of serology, fecal-antigen, and urea breath tests among adults with intellectual disability. One hundred sixty-eight such adults underwent H. pyloritesting with serology and fecal-antigen tests, and a portion underwent treatment. One year later, the participants were retested with fecal-antigen, serology, and urea breath tests. The numbers of specimens obtained and difficulties in collection reported by caregivers were noted. Test performance characteristics were assessed among participants and 65 of their caregivers, using serology as the reference. All participants provided at least one specimen, despite reported collection difficulties for 23% of fecal and 27% of blood specimens. Only 25% of the participants provided breath specimens; failure to perform this test was associated with lower intellectual ability and higher maladaptive behavior. The sensitivity, specificity, and positive and negative predictive values of the fecal test (baseline and 12 months versus caregivers) were 70 and 63 versus 81, 93 and 95 versus 98, 96 and 92 versus 93, and 53 and 74 versus 93%, respectively; those of the urea breath test (12 months versus caregivers) were 86 versus 100, 88 versus 95, 75 versus 89, and 94 versus 100%, respectively. With assistance, fecal or blood specimens for H. pyloriassessment can be provided by most patients with intellectual disability regardless of their level of function or behavior. Only those with greater ability can perform the urea breath test. Using serology as the reference test, the limitations of performance characteristics of the fecal-antigen and urea breath tests are similar to those among a control group of caregivers.

Published
2003
Full Text
View/download PDF

39. Back to the blackboard for wine industry.

Author

Wheaton, Ashley, Dry, Peter, Weaver, Randy, Wood, Robyn, Bastian, Sue, Colby, Patricia, and Saxton, Valerie

Abstract

The article presents a roundtable discussion among lecturers of the role of education facilities in preparing the wine industry's future leaders. When asked about the important aspects of viticulture/oenology/wine business education, Valerie Saxton says that the need for people skilled in marketing and promotion is increasing. Peter Dry notes that an important feature of the established programs in Australia is the integration of science and technology. The preparation of students into an industry facing economic pressures is also discussed.

Published
2011

40. Food safety under threat from GM crops.

Author

Wood, Robyn

Abstract

The article discusses the Adelaide March Against Monsanto rally organised in Adelaide, Australia as of May 2014 in which people show concern that food safety is under threat as biotechnology company Monsanto attempts to have control on food supply and forces people to eat genetically modified food.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results