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1. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Author

Aisenberg, Javier, Akkurt, Ilker, Abdul-Latif, Hussein, Al-Abdullah, Anees, Barak, Lubomir, Van Den Bergh, Joop, Bertrand, Anne-Marie, Bizzarri, Carla, Bonfanti, Riccardo, Bruel, Henri, Burrows, Anthony, Cadario, Francesco, Cameron, Fergus J., Carson, Dennis, Cartigny, Maryse, Cauvin, Vittoria, Cave, Helene, Chakera, Ali, Chetan, Ravi, Chiari, Giovanni, Couch, Bob, Coutant, Régis, Cummings, Elizabeth, Dankovcikova, Adriana, Davis, Liz, Deiss, Dorothee, Delvecchio, Maurizio, Faleschini, Elena, Fauret, Anne-Laure, Finn, Roisin, Ford, Tamsin, Franco, Elisa De, Gallen, Bastian De, Gasperíková, Daniela, Guntamukkala, Padma, Hakeem, Vaseem, Hasegawa, Shinji, Hathout, Eba H., Heffernan, Emmeline, Hill, David, Ho, Josephine, Hoarau, Marie, Holl, Reinhard, Hoddinott, Rebecca, Houghton, Jane, Howard, Neville, Hughes, Natalie, Hunter, Ian, Høgåsen, Anne Kirsti, Kuulasmaa, Helena, Ioacara, Sorin, Iotova, Violeta, Irgens, Henrik, Jaap, Alan, Jones, Kenneth, Kapellen, Thomas, Kaufman, Ellen, Klinge, Andreas, Klupa, Tomasz, Krishnaswamy, Ramaiyer, Lafferty, Tony, LeGault, Laurent, Lambert, Paul, Malecki, Maciej T, Malievsky, Olag, Mathew, Revi, Mathews, Frances, McVie, Robert, Menzel, Ulrike, Metz, Chantale, Meulen, John Van Der, Modgil, Gita, Mul, Dick, Muther, Silvia, Nuboer, Roos, O'Connell, Susan M., O'Riordan, Stephen, Palko, Miroslav, Patel, Kashyap Amratlal, Pesavento, Roberta, Piccinno, Elvira, Pillai, Janani Kumaraguru, Pruhova, Stephanka, Punthakee, Zubin, Rabbone, Ivana, Raile, Klemens, Rincon, Marielisa, Rose, Danette, Sanchez, Janine, Sandereson, Susan, Saxena, Vinay, Schebek, Martin, Schmidt, Dorothee, Shehadeh, Naim, Shiels, Julian P.H., Silva, Jose M. C. L, Stanik, Juraj, Tinklin, Tracy, Tjora, Erling, Tumini, Stefano, Tuomi, Tiinamaija, Uehara, Akiko, Velde, Robert Van der, Vermeulen, Guido, Visser, Uma, Voorhoeve, Paul, Walker, Jan, Weill, Jaques, Weisner, Tobias, Werner, Andrea, Williams, Toni, Woodhead, Helen, øddegård, Rønnaug, Bowman, Pamela, Sulen, Åsta, Barbetti, Fabrizio, Beltrand, Jacques, Svalastoga, Pernille, Codner, Ethel, Tessmann, Ellen H, Juliusson, Petur B, Skrivarhaug, Torild, Pearson, Ewan R, Flanagan, Sarah E, Babiker, Tarig, Thomas, Nicholas J, Shepherd, Maggie H, Ellard, Sian, Klimes, Iwar, Szopa, Magdalena, Polak, Michel, Iafusco, Dario, Hattersley, Andrew T, and Njølstad, Pål R

Published
2018
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2. Improved local diagnosis of focal hyperinsulinism in the COVID‐19 era by interstate radiopharmaceutical transport

Author

Vanderniet, Joel, primary, Neville, Kristen A, additional, Conwell, Louise S, additional, Wegner, Eva A, additional, Craig, Maria E, additional, Adams, Susan, additional, Gifford, Andrew J, additional, Koutsiofi, Melissa, additional, Calabria, Frances M, additional, Maguire, Gemma, additional, Thomas, Paul, additional, Campbell, Louise, additional, and Woodhead, Helen J, additional

Published
2022
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11. Early determinants of fractures in Rett syndrome

Author

Downs, Jennepher, Bebbington, Ami, Woodhead, Helen, Jacoby, Peter, Jian, Le, Jefferson, Amanda, and Leonard, Helen

Subjects
Rett syndrome -- Complications and side effects, Fractures -- Risk factors, Fractures -- Research
Published
2008

12. Improved local diagnosis of focal hyperinsulinism in the COVID‐19 era by interstate radiopharmaceutical transport.

Author

Vanderniet, Joel, Neville, Kristen A, Conwell, Louise S, Wegner, Eva A, Craig, Maria E, Adams, Susan, Gifford, Andrew J, Koutsiofi, Melissa, Calabria, Frances M, Maguire, Gemma, Thomas, Paul, Campbell, Louise, and Woodhead, Helen J

Subjects
COVID-19 pandemic, HYPERINSULINISM, RADIOPHARMACEUTICALS, VON Hippel-Lindau disease, ICHTHYOSIS
Abstract

Improved local diagnosis of focal hyperinsulinism in the COVID-19 era by interstate radiopharmaceutical transport 2013; 98: E1786 - 9. 7 States LJ, Davis JC, Hamel SM, Becker SA, Zhuang H. 18F-6-Fluoro-l-Dopa PET/CT imaging of congenital hyperinsulinism. Interstate transport of SP 18 sp F-DOPA, rather than the infant, resulted in improved patient safety, reduced cost and shorter time to definitive treatment for an infant with focal congenital hyperinsulinism, but is primarily limited by its 8-h expiry window and requires a close collaborative and multidisciplinary approach. [Extracted from the article]

Published
2023
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25. Sydney Diabetes centre's experience of the Australian Government's roll out of subsidised continuous glucose monitoring for children with type 1 diabetes mellitus

Author

Sandy, Jessica L, primary, Nyunt, Ohn, additional, Woodhead, Helen J, additional, Youde, Lesley S, additional, Ramjan, Kim A, additional, Jack, Michelle M, additional, Lim, Lena, additional, Shepherd, Margaret, additional, Marshall, Ailsa, additional, Townsend, Nicky, additional, Wilson, Suzi, additional, Duke, Sally‐Anne, additional, Slavich, Eve, additional, and Hameed, Shihab, additional

Published
2018
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26. Researching Effective Strategies to Improve Insulin Sensitivity in Children and Teenagers - RESIST. A randomised control trial investigating the effects of two different diets on insulin sensitivity in young people with insulin resistance and/or pre-diabetes.

Author

De Sukanya, Parker Robert, Broderick Carolyn R, Chisholm Kerryn, Burrell Susie, Woodhead Helen J, Steinbeck Katharine, Noakes Manny, Baur Louise A, Garnett Sarah P, Shrinivasan Shubha, Hopley Lori, Hendrie Gilly, Ambler Geoffrey R, Kohn Michael R, and Cowell Chris T

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Concomitant with the rise in childhood obesity there has been a significant increase in the number of adolescents with clinical features of insulin resistance and prediabetes. Clinical insulin resistance and prediabetes are likely to progress to type 2 diabetes and early atherosclerosis if not targeted for early intervention. There are no efficacy trials of lifestyle intervention in this group to inform clinical practice. The primary aim of this randomised control trial (RCT) is to determine the efficacy and effectiveness of two different structured lifestyle interventions differing in diet composition on insulin sensitivity, in adolescents with clinical insulin resistance and/or prediabetes treated with metformin. Methods/design This study protocol describes the design of an ongoing RCT. We are recruiting 108 (54 each treatment arm) 10 to 17 year olds with clinical features of insulin resistance and/or prediabetes, through physician referral, into a multi-centred RCT. All participants are prescribed metformin and participate in a diet and exercise program. The lifestyle program is the same for all participants except for diet composition. The diets are a high carbohydrate, low fat diet and a moderate carbohydrate, increased protein diet. The program commences with an intensive 3 month dietary intervention, implemented by trained dietitians, followed by a 3 month intensive gym and home based exercise program, supervised by certified physical trainers. To measure the longer term effectiveness, after the intensive intervention trial participants are managed by either their usual physician or study physician and followed up by the study dietitians for an additional 6 months. The primary outcome measure, change in insulin sensitivity, is measured at 3, 6 and 12 months. Discussion Clinical insulin resistance and prediabetes in the paediatric population are rapidly emerging clinical problems with serious health outcomes. With appropriate management these conditions are potentially reversible or at least their progression can be delayed. This research study is the first trial designed to provide much needed data on the effective dietary management for this cohort. This study will inform clinical practice guidelines for adolescents with clinical insulin resistance and may assist in preventing metabolic complications, type 2 diabetes and early cardiovascular disease. Trial registration Australian and New Zealand Clinical Trials Registration Number ACTRN12608000416392

Published
2010
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27. Global consensus on nutritional rickets: Implications for Australia.

Author

Siafarikas, Aris, Simm, Peter, Zacharin, Margaret, Jefferies, Craig, Lafferty, Antony R, Wheeler, Benjamin J, Tham, Elaine, Brown, Justin, Biggin, Andrew, Hofman, Paul, Woodhead, Helen, Rodda, Christine, Jensen, Diane, Brookes, Denise, Munns, Craig F, and APEG Bone and Mineral Working Group

Subjects
RICKETS, VITAMIN D deficiency, VITAMIN D, DIET therapy, SUPPORT groups
Abstract

In 2016, a global consensus on the prevention, diagnosis and management of nutritional rickets was published. The bone and mineral working group of the Australasian Paediatric Endocrine Group provides a summary and highlights differences to previous Australian and New Zealand (ANZ) guidelines on vitamin D deficiency and their implications for clinicians. Key points are: (i) The International Consensus document is focused on nutritional rickets, whereas the ANZ guidelines were focused on vitamin D deficiency. (ii) Definitions for the interpretation of 25-hydroxy vitamin D (25OHD) levels do not differ between statements. (iii) The global consensus recommends that routine 25OHD screening should not be performed in healthy children and recommendations for vitamin D supplementation are not based solely on 25OHD levels. The Australasian Paediatric Endocrine Group bone and mineral working group supports that screening for vitamin D deficiency should be restricted to populations at risk. (iv) Recommendations from the global consensus for vitamin D dosages for the therapy of nutritional rickets (diagnosed based on history, physical examination, biochemical testing and a confirmation by X-rays) are higher than in ANZ publications. (v) The global consensus recommends the implementation of public health strategies such as universal supplementation with vitamin D from birth to 1 year of age and food fortification. We conclude that updated global recommendations for therapy of nutritional rickets complement previously published position statements for Australia and New Zealand. Screening, management and the implementation of public health strategies need to be further explored for Australia. [ABSTRACT FROM AUTHOR]

Published
2020
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28. Sydney Diabetes centre's experience of the Australian Government's roll out of subsidised continuous glucose monitoring for children with type 1 diabetes mellitus.

Author

Sandy, Jessica L, Nyunt, Ohn, Woodhead, Helen J, Youde, Lesley S, Ramjan, Kim A, Jack, Michelle M, Lim, Lena, Shepherd, Margaret, Marshall, Ailsa, Townsend, Nicky, Wilson, Suzi, Duke, Sally‐Anne, Slavich, Eve, Hameed, Shihab, and Duke, Sally-Anne

Subjects
TYPE 1 diabetes, BLOOD sugar monitoring, DIABETES in children, SATISFACTION, TREATMENT effectiveness, TIME, GOVERNMENT programs
Abstract

Aim: To determine patient/carer expectations of continuous glucose monitoring (CGM) and short-term satisfaction, to assess the efficacy of CGM in improving: fear of hypoglycaemia and glycaemic control (HbA1c , ketosis, hypoglycaemia) and to determine time requirements of diabetes clinic staff in commencing and administering CGM.Methods: We assessed CGM-naïve patients starting on CGM at a Sydney Diabetes Centre following the introduction of a nationwide government subsidy for CGM. A standardised questionnaire was administered collecting demographic and glycaemic information in addition to Likert scale assessment of expectations and satisfaction. Clinic staff reported time dedicated to CGM education, commencement and follow-up.Results: A total of 55 patients or parents/carers completed baseline questionnaires, with 37 completing a 3-month follow-up questionnaire. There were high expectations of CGM prior to commencement and high satisfaction ratings on follow-up. CGM improved fear of hypoglycaemia, and total daily insulin dose increased after commencement of CGM. There was a trend towards lower HbA1c that was not statistically significant and no statistically significant reduction in ketosis or hypoglycaemia. Comments were mostly positive, with some concern raised regarding technical issues and a lack of subsidy after 21 years of age. Staff time requirements were substantial, with an estimated average of 7.7 h per patient per year.Conclusions: Patients and families have high expectations of CGM, and satisfaction levels are high in the short term. Total insulin delivery increased after CGM commencement. Time requirements by staff are substantial but are worthwhile if families' overall satisfaction levels are high. [ABSTRACT FROM AUTHOR]

Published
2019
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29. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Author

Bowman, Pamela, primary, Sulen, Åsta, additional, Barbetti, Fabrizio, additional, Beltrand, Jacques, additional, Svalastoga, Pernille, additional, Codner, Ethel, additional, Tessmann, Ellen H, additional, Juliusson, Petur B, additional, Skrivarhaug, Torild, additional, Pearson, Ewan R, additional, Flanagan, Sarah E, additional, Babiker, Tarig, additional, Thomas, Nicholas J, additional, Shepherd, Maggie H, additional, Ellard, Sian, additional, Klimes, Iwar, additional, Szopa, Magdalena, additional, Polak, Michel, additional, Iafusco, Dario, additional, Hattersley, Andrew T, additional, Njølstad, Pål R, additional, Aisenberg, Javier, additional, Akkurt, Ilker, additional, Abdul-Latif, Hussein, additional, Al-Abdullah, Anees, additional, Barak, Lubomir, additional, Van Den Bergh, Joop, additional, Bertrand, Anne-Marie, additional, Bizzarri, Carla, additional, Bonfanti, Riccardo, additional, Bruel, Henri, additional, Burrows, Anthony, additional, Cadario, Francesco, additional, Cameron, Fergus J., additional, Carson, Dennis, additional, Cartigny, Maryse, additional, Cauvin, Vittoria, additional, Cave, Helene, additional, Chakera, Ali, additional, Chetan, Ravi, additional, Chiari, Giovanni, additional, Couch, Bob, additional, Coutant, Régis, additional, Cummings, Elizabeth, additional, Dankovcikova, Adriana, additional, Davis, Liz, additional, Deiss, Dorothee, additional, Delvecchio, Maurizio, additional, Faleschini, Elena, additional, Fauret, Anne-Laure, additional, Finn, Roisin, additional, Ford, Tamsin, additional, Franco, Elisa De, additional, Gallen, Bastian De, additional, Gasperíková, Daniela, additional, Guntamukkala, Padma, additional, Hakeem, Vaseem, additional, Hasegawa, Shinji, additional, Hathout, Eba H., additional, Heffernan, Emmeline, additional, Hill, David, additional, Ho, Josephine, additional, Hoarau, Marie, additional, Holl, Reinhard, additional, Hoddinott, Rebecca, additional, Houghton, Jane, additional, Howard, Neville, additional, Hughes, Natalie, additional, Hunter, Ian, additional, Høgåsen, Anne Kirsti, additional, Kuulasmaa, Helena, additional, Ioacara, Sorin, additional, Iotova, Violeta, additional, Irgens, Henrik, additional, Jaap, Alan, additional, Jones, Kenneth, additional, Kapellen, Thomas, additional, Kaufman, Ellen, additional, Klinge, Andreas, additional, Klupa, Tomasz, additional, Krishnaswamy, Ramaiyer, additional, Lafferty, Tony, additional, LeGault, Laurent, additional, Lambert, Paul, additional, Malecki, Maciej T, additional, Malievsky, Olag, additional, Mathew, Revi, additional, Mathews, Frances, additional, McVie, Robert, additional, Menzel, Ulrike, additional, Metz, Chantale, additional, Meulen, John Van Der, additional, Modgil, Gita, additional, Mul, Dick, additional, Muther, Silvia, additional, Nuboer, Roos, additional, O'Connell, Susan M., additional, O'Riordan, Stephen, additional, Palko, Miroslav, additional, Patel, Kashyap Amratlal, additional, Pesavento, Roberta, additional, Piccinno, Elvira, additional, Pillai, Janani Kumaraguru, additional, Pruhova, Stephanka, additional, Punthakee, Zubin, additional, Rabbone, Ivana, additional, Raile, Klemens, additional, Rincon, Marielisa, additional, Rose, Danette, additional, Sanchez, Janine, additional, Sandereson, Susan, additional, Saxena, Vinay, additional, Schebek, Martin, additional, Schmidt, Dorothee, additional, Shehadeh, Naim, additional, Shiels, Julian P.H., additional, Silva, Jose M. C. L, additional, Stanik, Juraj, additional, Tinklin, Tracy, additional, Tjora, Erling, additional, Tumini, Stefano, additional, Tuomi, Tiinamaija, additional, Uehara, Akiko, additional, Velde, Robert Van der, additional, Vermeulen, Guido, additional, Visser, Uma, additional, Voorhoeve, Paul, additional, Walker, Jan, additional, Weill, Jaques, additional, Weisner, Tobias, additional, Werner, Andrea, additional, Williams, Toni, additional, Woodhead, Helen, additional, and øddegård, Rønnaug, additional

Published
2018
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30. Bone and Muscle Geometry in Female Adolescent Middle-Distance Runners.

Author

Greene, David A., Naughton, Geraldine A., Briody, Julie N., Kemp, Allan, Woodhead, Helen, and Farpour-Lambert, Nathalie

Subjects
WOMEN runners, MINERALS in the body, TIBIA, MUSCLES, TEENAGERS
Abstract

This study compared tibial bone and muscle geometry and total body and regional bone mineral content (BMC) in elite female adolescent middle-distance runners (n = 20, age: 16 ± 1.7 years) and age- and sex-matched controls (n = 20, 16 ± 1.8 years) using magnetic resonance imaging and dual-energy X-ray absorptiometry. Significant advantages were found in athletes compared with controls in bone and muscle geometric values for distal tibial cortical, medullary cavity, distal tibial total muscle and dorsi flexor muscle compartment cross-sectional area, and regional BMC. Results imply mechanical loads associated with middle-distance running might be beneficial to musculoskeletal health in adolescent females. [ABSTRACT FROM AUTHOR]

Published
2005
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31. Correlates and Determinants of Bone Mineral Density in Prepubertal Girls.

Author

Wiebe, Peter N., Blimkie, Cameron J.R., Farpour-Lambert, Nathalie, Briody, Julie, Woodhead, Helen, Cowell, Chris, and Howman-Giles, Robert

Subjects
BONE densitometry, MINERALS in the body, PEDIATRIC physiology
Abstract

The correlates and determinants of total body (TB), femoral neck (FN), greater trochanter (GT) and leg areal bone mineral density (aBMD), and FN volumetric (vol) BMD were investigated in 42 healthy 6-10-year-old girls. Predictor variables included age, height, weight, lean tissue mass (LTM), fat mass, percent body fat, physical activity level, calcium intake, isokinetic knee flexion and extension strength and endocrine (E[sub 2]) status. Bone density and body composition were determined by dual energy-x-ray absorptiometry (DEXA), and pubertal status was self-determined. LTM, weight, age, knee extensor strength and fat mass were significantly correlated (Pearson correlation coefficients; 0.36 ≤ r ≥ 0.62) with TBaBMD. These same variables with the addition of height and knee flexor strength were significantly correlated (0.33 ≤ r ≥ 0.77) with leg aBMD. Only LTM correlated significantly with FNaBMD and none of the independent variables correlated with FNvolBMD or GTaBMD. Only LTM entered as a significant predictor in multiple linear regression analysis (R² = 46.7%) for TBaBMD. In conclusion, estradiol status, dietary calcium intake and physical activity level appeared not to be important predictors of B MD in this population, whereas LTM was consistently correlated with most BMD measures and was the single significant determinant of TBaBMD in this study. [ABSTRACT FROM AUTHOR]

Published
2002

33. Clinical Guidelines for Management of Bone Health in Rett Syndrome Based on Expert Consensus and Available Evidence

Author

Jefferson, Amanda, primary, Leonard, Helen, additional, Siafarikas, Aris, additional, Woodhead, Helen, additional, Fyfe, Sue, additional, Ward, Leanne M., additional, Munns, Craig, additional, Motil, Kathleen, additional, Tarquinio, Daniel, additional, Shapiro, Jay R., additional, Brismar, Torkel, additional, Ben-Zeev, Bruria, additional, Bisgaard, Anne-Marie, additional, Coppola, Giangennaro, additional, Ellaway, Carolyn, additional, Freilinger, Michael, additional, Geerts, Suzanne, additional, Humphreys, Peter, additional, Jones, Mary, additional, Lane, Jane, additional, Larsson, Gunilla, additional, Lotan, Meir, additional, Percy, Alan, additional, Pineda, Mercedes, additional, Skinner, Steven, additional, Syhler, Birgit, additional, Thompson, Sue, additional, Weiss, Batia, additional, Witt Engerström, Ingegerd, additional, and Downs, Jenny, additional

Published
2016
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34. Single High-Dose Oral Vitamin D3 Therapy (Stoss)

Author

Shepherd, Darren, primary, Day, Andrew S., additional, Leach, Steven T., additional, Lopez, Robert, additional, Messenger, Rachel, additional, Woodhead, Helen J., additional, Ledder, Oren, additional, and Lemberg, Daniel A., additional

Published
2015
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37. Improved insulin sensitivity and body composition, irrespective of macronutrient intake, after a 12 month intervention in adolescents with pre-diabetes; RESIST a randomised control trial

Author

Garnett, Sarah P, primary, Gow, Megan, additional, Ho, Mandy, additional, Baur, Louise A, additional, Noakes, Manny, additional, Woodhead, Helen J, additional, Broderick, Carolyn R, additional, Chisholm, Kerryn, additional, Briody, Julie, additional, De, Sukanya, additional, Steinbeck, Katherine, additional, Srinivasan, Shubha, additional, Ambler, Geoffrey R, additional, and Cowell, Chris T, additional

Published
2014
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39. Skeletal adaptations to intense exercise in pre-pubertal athletes and normal children

Author

Woodhead, Helen Jaye

Subjects
Musculoskeletal system, Exercise -- Physiological aspects, Exercise for children
Abstract

This thesis describes two complementary fields of research in bone health and osteoporosis: the non-invasive assessment of bone strength and the effects of exercise on bone strength acquisition. The aims of this work were to develop and validate new techniques for the longitudinal assessment of bone geometry in childhood and to apply these techniques (and others) in the study of bone strength in young boy and girl geometry (bone strength index: 21.3%) and perhaps also at the arm. Adaptation at the FN was largely at the periosteal surface implying increased resistance to torsional, bending and axial compressive forces, while adaptation at the endocortical surface remains unknown. In contrast, weight-supported exercise was associated with no benefit in any skeletal variable, except perhaps FN totalvBMD (6.0%). No advantage was observed in material properties in either group. Adaptation suggested by differences in bone mineral content (BMC) and areal bone density (aBMD) at other sites in this and previous studies, was largely accounted for by adjustment for age and size. Increased muscle action was a likely mediator of adaptation at both sites, as was serum IGFl at the FN. athletes participating in exercise with different mechanical loading characteristics and healthy control children. Novel techniques for assessing bone geometry at the mid-femur, using Magnetic Resonance Imaging (MRI) and Dual Energy X-ray Absorptiometry (DXA) and the repeatability and accuracy of these and previously described DXA methods were examined. MRI measures of geometric parameters at this site were highly accurate and repeatable in individuals with and without osteoporosis. Both MRI and DXA techniques had limited value in determining cortical width. This study confirmed MRI as a valuable tool in the assessment of surface—specific bone accrual and resorption. The cross-sectional study of 84 pre-pubertal children, 60 boys and 24 girls, is unique in that skeletal adaptation to exercise has been investigated within and between sexes in populations precisely matched for factors known to influence bone strength outcomes. The study of pre—pubertal boys, 20 intensely training in tennis, 20 in swimming and 20 controls, constitutes the first study where the bone mineral, geometry, biomechanical and material property characteristics of bone in children participating in wei t-bearing and weight-supported exercise have been compared. Weight-bearing exercise in pre-pubertal males confers only small, though significant, benefits mainly at the femoral neck (FN) in total volumetric density (FN totalvBMD) (7.2%) and bone

Published
2003

40. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11mutations: an international cohort study

Author

Bowman, Pamela, Sulen, Åsta, Barbetti, Fabrizio, Beltrand, Jacques, Svalastoga, Pernille, Codner, Ethel, Tessmann, Ellen H, Juliusson, Petur B, Skrivarhaug, Torild, Pearson, Ewan R, Flanagan, Sarah E, Babiker, Tarig, Thomas, Nicholas J, Shepherd, Maggie H, Ellard, Sian, Klimes, Iwar, Szopa, Magdalena, Polak, Michel, Iafusco, Dario, Hattersley, Andrew T, Njølstad, Pål R, Aisenberg, Javier, Akkurt, Ilker, Abdul-Latif, Hussein, Al-Abdullah, Anees, Barak, Lubomir, Van Den Bergh, Joop, Bertrand, Anne-Marie, Bizzarri, Carla, Bonfanti, Riccardo, Bruel, Henri, Burrows, Anthony, Cadario, Francesco, Cameron, Fergus J., Carson, Dennis, Cartigny, Maryse, Cauvin, Vittoria, Cave, Helene, Chakera, Ali, Chetan, Ravi, Chiari, Giovanni, Couch, Bob, Coutant, Régis, Cummings, Elizabeth, Dankovcikova, Adriana, Davis, Liz, Deiss, Dorothee, Delvecchio, Maurizio, Faleschini, Elena, Fauret, Anne-Laure, Finn, Roisin, Ford, Tamsin, Franco, Elisa De, Gallen, Bastian De, Gasperíková, Daniela, Guntamukkala, Padma, Hakeem, Vaseem, Hasegawa, Shinji, Hathout, Eba H., Heffernan, Emmeline, Hill, David, Ho, Josephine, Hoarau, Marie, Holl, Reinhard, Hoddinott, Rebecca, Houghton, Jane, Howard, Neville, Hughes, Natalie, Hunter, Ian, Høgåsen, Anne Kirsti, Kuulasmaa, Helena, Ioacara, Sorin, Iotova, Violeta, Irgens, Henrik, Jaap, Alan, Jones, Kenneth, Kapellen, Thomas, Kaufman, Ellen, Klinge, Andreas, Klupa, Tomasz, Krishnaswamy, Ramaiyer, Lafferty, Tony, LeGault, Laurent, Lambert, Paul, Malecki, Maciej T, Malievsky, Olag, Mathew, Revi, Mathews, Frances, McVie, Robert, Menzel, Ulrike, Metz, Chantale, Meulen, John Van Der, Modgil, Gita, Mul, Dick, Muther, Silvia, Nuboer, Roos, O'Connell, Susan M., O'Riordan, Stephen, Palko, Miroslav, Patel, Kashyap Amratlal, Pesavento, Roberta, Piccinno, Elvira, Pillai, Janani Kumaraguru, Pruhova, Stephanka, Punthakee, Zubin, Rabbone, Ivana, Raile, Klemens, Rincon, Marielisa, Rose, Danette, Sanchez, Janine, Sandereson, Susan, Saxena, Vinay, Schebek, Martin, Schmidt, Dorothee, Shehadeh, Naim, Shiels, Julian P.H., Silva, Jose M. C. L, Stanik, Juraj, Tinklin, Tracy, Tjora, Erling, Tumini, Stefano, Tuomi, Tiinamaija, Uehara, Akiko, Velde, Robert Van der, Vermeulen, Guido, Visser, Uma, Voorhoeve, Paul, Walker, Jan, Weill, Jaques, Weisner, Tobias, Werner, Andrea, Williams, Toni, Woodhead, Helen, and øddegård, Rønnaug

Abstract

KCNJ11mutations cause permanent neonatal diabetes through pancreatic ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to oral sulfonylureas with excellent initial glycaemic control; however, whether this control is maintained in the long term is unclear. Sulfonylurea failure is seen in about 44% of people with type 2 diabetes after 5 years of treatment. Therefore, we did a 10-year multicentre follow-up study of a large international cohort of patients with KCNJ11permanent neonatal diabetes to address the key questions relating to long-term efficacy and safety of sulfonylureas in these patients.

Published
2018
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45. Once daily insulin detemir in cystic fibrosis with insulin deficiency

Author

Hameed, Shihab, primary, Morton, John R, additional, Field, Penny I, additional, Belessis, Yvonne, additional, Yoong, Terence, additional, Katz, Tamarah, additional, Woodhead, Helen J, additional, Walker, Jan L, additional, Neville, Kristen A, additional, Campbell, Thomas A, additional, Jaffé, Adam, additional, and Verge, Charles F, additional

Published
2011
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47. Researching Effective Strategies to Improve Insulin Sensitivity in Children and Teenagers - RESIST. A randomised control trial investigating the effects of two different diets on insulin sensitivity in young people with insulin resistance and/or pre-diabetes.

Author

Garnett, Sarah P, primary, Baur, Louise A, additional, Noakes, Manny, additional, Steinbeck, Katharine, additional, Woodhead, Helen J, additional, Burrell, Susie, additional, Chisholm, Kerryn, additional, Broderick, Carolyn R, additional, Parker, Robert, additional, De, Sukanya, additional, Shrinivasan, Shubha, additional, Hopley, Lori, additional, Hendrie, Gilly, additional, Ambler, Geoffrey R, additional, Kohn, Michael R, additional, and Cowell, Chris T, additional

Published
2010
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