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14. Supplementary Tables, 1-5, Figure 1 from Stage 2 Combination Testing of Rapamycin with Cytotoxic Agents by the Pediatric Preclinical Testing Program

Author

Houghton, Peter J., primary, Morton, Christopher L., primary, Gorlick, Richard, primary, Lock, Richard B., primary, Carol, Hernan, primary, Reynolds, C. Patrick, primary, Kang, Min H., primary, Maris, John M., primary, Keir, Stephen T., primary, Kolb, E. Anders, primary, Wu, Jianrong, primary, Wozniak, Amy W., primary, Billups, Catherine A., primary, Rubinstein, Larry, primary, and Smith, Malcolm A., primary

Published
2023
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27. The Effect of Obesity on Pediatric Tibia Fractures

Author

McGregor, Patrick Cole, Lyons, Madeline M., Wozniak, Amy, Linko, Kristina, Fishman, Felicity, and Cappello, Teresa

Subjects
Tibial Fractures, Pediatric Obesity, Thinness, Tibia, Humans, Overweight, Child, Pediatrics, Retrospective Studies
Abstract

BACKGROUND: Childhood obesity affects nearly one fifth of all children in the United States. Understanding the unique injury characteristics and treatment of tibia fractures in this population has become increasingly important. This study aims to explore the different injury characteristics between tibia fractures in obese and non-obese children. METHODS: 215 skeletally immature children aged 2-18 who sustained tibia fractures between 2007.2019 were retrospectively reviewed. Patients were analyzed by weight group: underweight, normal weight, overweight, and obese as defined by body mass index (BMI) percentile based upon age. Analyses were performed on dichotomized groups: underweight and normal weight versus overweight and obese. Chi-square or Fisher’s exact test was used to compare differences in categorical outcome between the 2-category BMI class variables; Wilcoxon test was used to compare continuous outcomes. A multivariate logistic regression model was used to evaluate BMI associations while controlling for age, sex, race, and mechanism of injury. RESULTS: Distribution of BMI in the cohort included 6.5% underweight, 45.6% normal weight, 16.7% overweight and 31.2% obese. Overweight and obese children sustained fractures from low energy mechanisms at more than double the rate of normal and underweight children (20.5% versus 9.7%, p=0.028). Overweight and obese children sustained physeal fractures at a rate of 54.4% in comparison with 28.6% in their normal and underweight peers (p

Published
2022

33. COVID ‐19 Thromboembolism Incidence, Risk Factors and Anticoagulation Practices from a Chicago Metropolitan US Population

Author

Berg, Stephanie, primary, Kim, Seo‐Hyun, additional, Wozniak, Amy, additional, Odetola, Oluwatobi, additional, Arain, Saad, additional, Aleem, Ahmed, additional, Coggan, James, additional, Dave, Ami, additional, Elliott, Elizabeth, additional, Guerrettaz, Ryan, additional, Dalal, Hina, additional, Lee, Raymond, additional, Kodali, Abhigna, additional, Moore, Patrick, additional, Patel, Sonam, additional, Rajakumar, Priya, additional, Qin, Shuai, additional, Ramos, Glenda Delgado, additional, Schwartz, Candice, additional, Esmail, Fatema, additional, Feltman Frank, Rebecca, additional, Murchie, Ellen, additional, Pax, Laura, additional, Yun, Nicole, additional, Zhang, Yanyu, additional, Barton, Kevin, additional, Hagen, Patrick, additional, Hossain, Nasheed, additional, Larson, Melissa L., additional, Mai, Hanh, additional, Nand, Sucha, additional, Phelan, Kathleen, additional, Venugopal, Parameswawran, additional, Stiff, Patrick, additional, and Saraf, Santosh, additional

Published
2022
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37. Nucleated red blood cells as a potential biomarker for predicting spontaneous intestinal perforation in premature infants.

Author

O’Neill, Michaela, Katebian, Roia, Shutter, Mollie, Wozniak, Amy, DeChristopher, Phillip J., Glynn, Loretto, Weiss, Marc G., and Muraskas, Jonathan K.

Subjects
ERYTHROCYTES, BIOMARKERS, PREMATURE infants, HYPOXEMIA, KRUSKAL-Wallis Test
Abstract

Background: The specific etiology of spontaneous intestinal perforation (SIP) and necrotizing enterocolitis (NEC) remains elusive. Both can present acutely without antecedent signs and can be difficult to differentiate. Neonatal nucleated red blood cell (NRBC) counts are part of the routine admission and serial CBCs drawn on premature neonates. Elevated NRBC counts could represent relative intrauterine hypoxemia, a possible risk factor for the development of SIP or NEC. Methods: We compared premature neonates with SIP to premature neonates with NEC and controls, matched gestational age (GA) and birth weight (BW). Kruskal-Wallis, Chi-Square, or Fisher's exact tests and univariate and multivariate nominal logistic regression models were used to estimate the association of baseline NRBC. Median times to SIP and NEC were calculated using the Kaplan-Meier method. All analyses were performed with SAS 9.4. Results: Male sex (72.5%), lower GA [Median (Q1, Q3): 25.1 (23.8, 28)], and lower BW [Median (Q1, Q3): 690 g (585, 1072)] had the highest incidence of SIP compared to NEC or controls. Increased baseline NRBC was associated with lower odds of developing NEC compared to controls [Median (Q1, Q3): 9 (5, 29) vs 19 (10, 51); OR (CI) 0.70 (0.55, 0.89), pvalue = 0.0033]. Increased baseline NRBC was associated with higher odds of developing SIP compared to NEC [Median (Q1, Q3): 9 (5, 29) vs 19 (10, 51); OR (CI) 1.61 (1.18, 2.20) p-value = 0.0027]. There were no significant differences between intrauterine growth restriction (IUGR), maternal hypertension, chorioamnionitis, multiple births, or depressed APGAR scores in all three groups. NRBC for SIP neonates remained significantly higher at the day of life (DOL) 1-3 compared to other groups [Median (Q1, Q3): 23 (6, 93), p-value = 0.0020]. The percentage of patients with NRBC >4, remained elevated for patients with SIP as late as week three (p = 0.0023). Conclusion: ELBW, male sex, and elevated baseline NRBC were significantly associated with the risk of developing SIP compared to NEC or controls. NRBC remained significantly elevated on DOL 1-3, compared to NEC or controls. Between the groups, there were no significant differences in perinatal stressors. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Economic Impact of Diagnostic Imaging in the Workup of Uncomplicated Bell's Palsy.

Author

Kazemian, Elycia, Schaffer, Hollie Marie, Wozniak, Amy, and Leonetti, John P.

Subjects
BELL'S palsy, DIAGNOSTIC imaging, ECONOMIC impact, MAGNETIC resonance imaging, TERTIARY care
Abstract

Objective  Our primary objective is to identify the costs associated with imaging in the diagnostic workup of uncomplicated Bell's palsy. Our secondary objective is to identify a dollar amount spent on extraneous diagnostic testing on a state and national level. Design and Setting  Retrospective chart analysis was performed at our tertiary care medical center between 2007 and 2018. International Statistical Classification of Diseases-10 code G51.0 was used to identify patients with Bell's palsy seen by the senior author. A total of 163 patients were divided into two groups: those having received imaging and those diagnosed without imaging. The imaging group was then further subdivided by imaging modality: computed tomography (CT) only, magnetic resonance imaging (MRI) only, or both. There was a total of 138 scans in 115 patients. To quantify the amount spent by insurance companies or patients on these scans, net expected pay (NEP) for each modality was used as a representation of cost. The NEP for a CT was $618. The NEP for an MRI was $1,119. The NEP for both scans was $1,737. We extrapolated our results to a state and national level. Main Outcome Measurements  Cost of workup; state and national economic burden. Results  Extrapolating our data, we forecast that in Illinois and in the United States, over $2 million and $53 million, respectively, are spent on unnecessary imaging. Conclusion  By highlighting an unnecessary financial burden, our study provides concrete evidence to support the American Academy of Otolaryngology's recommendation that clinicians should not perform routine imaging studies when diagnosing uncomplicated Bell's palsy. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Relationship of Stress Test Findings to Anatomic or Functional Extent of Coronary Artery Disease Assessed by Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve

Author

Doukas, Demetrios, primary, Allen, Sorcha, additional, Wozniak, Amy, additional, Kunchakarra, Siri, additional, Verma, Rina, additional, Marot, Jessica, additional, Lopez, John J., additional, Nieman, Koen, additional, Pontone, Gianluca, additional, Leipsic, Jonathon, additional, Bax, Jeroen, additional, and Rabbat, Mark G., additional

Published
2021
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48. Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer

Author

Carol, Hernan, Boehm, Ingrid, Reynolds, C. Patrick, Kang, Min H., Maris, John M., Morton, Christopher L., Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Wu, Jianrong, Wozniak, Amy E., Yang, Yu, Manfredi, Mark, Ecsedy, Jeffrey, Wang, Jianmin, Neale, Geoffrey, Houghton, Peter J., Smith, Malcolm A., and Lock, Richard B.

Published
2011
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