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146 results on '"Wright, E. R."'

3. Click It or Ticket, But Don't Admit It? How Unrestrained Drivers and Passengers Take Us for a Ride.

Author

Wright, E. R.

Subjects
*COVID-19 pandemic, *PUBLIC health, *SOCIAL distancing, *VACCINATION, *GOVERNMENT policy
Abstract

While the COVID-19 crisis has forced societies and governments to confront new challenges and answer new questions, it has also renewed and reignited longstanding debates about the extent of individuals' obligations to each other.1 In particular, the American body politic is once again embroiled in conflict over the reach of an individual's personal choices and the extent to which consideration of the potentially harmful effects of our choices on others should shape individual behaviors.2 Today, this fight centers on public health measures intended to reduce the spread and severity of COVID-19, such as masking, distancing, and vaccination.3 Debates rage over where the freedom of individual choice--a nearly-sacred tenant of the gospel of American exceptionalism--intersects with and must yield to the interests of others. Governments at all levels have largely responded to the current crisis with ad hoc improvisation and strained efforts to balance public health imperatives against real and imagined threats to individual liberty. [ABSTRACT FROM AUTHOR]

Published
2022

14. Capturing Enveloped Viruses on Affinity Grids for Downstream Cryo- Electron Microscopy Applications

Author

Kiss, G., Chen, X. M., Brindley, M. A., Campbell, P., Afonso, C. L., Ke, Z. L., Holl, J. M., Guerrero-Ferreira, R. C., Byrd-Leotis, L. A., Steel, J., Steinhauer, D. A., Plemper, R. K., Kelly, Deborah F., Spearman, P. W., Wright, E. R., Kiss, G., Chen, X. M., Brindley, M. A., Campbell, P., Afonso, C. L., Ke, Z. L., Holl, J. M., Guerrero-Ferreira, R. C., Byrd-Leotis, L. A., Steel, J., Steinhauer, D. A., Plemper, R. K., Kelly, Deborah F., Spearman, P. W., and Wright, E. R.

Abstract

Electron microscopy (EM), cryo-electron microscopy (cryo-EM), and cryo-electron tomography (cryo-ET) are essential techniques used for characterizing basic virus morphology and determining the three-dimensional structure of viruses. Enveloped viruses, which contain an outer lipoprotein coat, constitute the largest group of pathogenic viruses to humans. The purification of enveloped viruses from cell culture presents certain challenges. Specifically, the inclusion of host-membrane-derived vesicles, the complete destruction of the viruses, and the disruption of the internal architecture of individual virus particles. Here, we present a strategy for capturing enveloped viruses on affinity grids (AG) for use in both conventional EM and cryo-EM/ET applications. We examined the utility of AG for the selective capture of human immunodeficiency virus virus-like particles, influenza A, and measles virus. We applied nickel-nitrilotriacetic acid lipid layers in combination with molecular adaptors to selectively adhere the viruses to the AG surface. This further development of the AG method may prove essential for the gentle and selective purification of enveloped viruses directly onto EM grids for ultrastructural analyses.

Published
2014
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15. Blueberry blight caused by Bipolaris cynodontis in Argentina

Author

Sisterna, Marina Noemí, Pérez, B. A., Divo de Sesar, M., and Wright, E. R.

Subjects
Cultivos Agrícolas, Ciencias Agrarias
Abstract

Blueberry (Vaccinium corymbosum) production in Argentina has grown remarkably in the last 8 years due to the high demand worldwide in the off-season fresh market. Since it is a new crop in Argentina, diseases are just starting to become problematic for farmers. Surveys have been conducted since 2000 to detect new pathogenic associations and to evaluate their distribution, incidence and severity in different blueberry varieties and localities., Facultad de Ciencias Agrarias y Forestales

Published
2009

50. Fiscal outcomes of the closing of Central State Hospital: an analysis of the costs to state government.

Author

Wright, Eric R. and Wright, E R

Subjects
*STATE hospitals, *MENTAL health services, *HOSPITAL closures, *MENTAL illness, *DEINSTITUTIONALIZATION, *PUBLIC hospitals, *MEDICAL care cost statistics, *COST effectiveness, *ECONOMIC aspects of diseases, *LONGITUDINAL method, *MEDICAL care costs, *MULTIVARIATE analysis, *PSYCHIATRIC hospitals, *REGRESSION analysis, *RESEARCH funding, *STATE governments, *COST analysis, *ECONOMICS
Abstract

This study reports estimates of the preclosure and postclosure costs of mental health services for patients directly affected by the closing of Central State Hospital. The data come from state budget documents and from the billing records of the community mental health centers serving the discharged clients. On average, it cost Indiana approximately $68,347 (in 1995 dollars) to provide 12 months of state hospital care for this client cohort in fiscal year 1993. In contrast, during the first year following the closure, the average per patient cost to the state was $55,417. When clients were served exclusively in community care settings, the average annual per patient cost was $40,618. The analyses suggest that the closing reduced the costs of caring for this cohort of patients by approximately 18.9%. A significant portion of the cost savings to the state mental health budget was achieved by shifting some of the direct patient care costs to Medicaid/Medicare. [ABSTRACT FROM AUTHOR]

Published
1999
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