1. The effects of ibuprofen on the physiology and survival of patients with sepsis
- Author
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Bernard, Gordon R., Wheeler, Arthur P., Russell, James A., Schein, Roland, Summer, Warren R., Steinberg, Kenneth P., Fulkerson, William J., Wright, Patrick E., Christman, Brian W., Dupont, William D., Higgins, Stanley B., and Swindell, Bridget B.
- Subjects
Septic shock -- Drug therapy ,Ibuprofen -- Evaluation - Abstract
Ibuprofen does not appear to improve survival rates in people with sepsis although it does improve symptoms somewhat. Sepsis is a bacterial infection that spreads into the bloodstream and can cause organ failure. Researchers randomly assigned 455 patients with sepsis to receive intravenous ibuprofen or placebo. Ibuprofen reduced blood levels of inflammatory chemicals and reduced fever but it did not significantly reduce mortality rates. At 30 days, 37% of the ibuprofen group had died compared to 40% of the placebo group. Ibuprofen also did not reduce the incidence of shock or respiratory distress syndrome.
- Published
- 1997