Search

Your search keyword '"Wu, Chi-Rei"' showing total 268 results
Start Over Author "Wu, Chi-Rei"
268 results on '"Wu, Chi-Rei"'

2. Exploring the Neuroprotective Potential of Desmodium Species: Insights into Radical Scavenging Capacity and Mechanisms against 6-OHDA-Induced Neurotoxicity.

Author

Chang, Hung-Chi, Lien, Jin-Cherng, Hsueh, Min-Chung, and Wu, Chi-Rei

Subjects
MONOAMINE oxidase, PARKINSON'S disease, RADICALS (Chemistry), HYDROGEN peroxide, DESMODIUM
Abstract

In this study, we collected seven prevalent Taiwanese Desmodium plants, including three species with synonymous characteristics, in order to assess their antioxidant phytoconstituents and radical scavenging capacities. Additionally, we compared their inhibitory activities on monoamine oxidase (MAO) and 6-hydroxydopamine (6-OHDA) auto-oxidation. Subsequently, we evaluated the neuroprotective potential of D. pulchellum on 6-OHDA-induced nerve damage in SH-SY5Y cells and delved into the underlying neuroprotective mechanisms. Among the seven Desmodium species, D. pulchellum exhibited the most robust ABTS radical scavenging capacity and relative reducing power; correspondingly, it had the highest total phenolic and phenylpropanoid contents. Meanwhile, D. motorium showcased the best hydrogen peroxide scavenging capacity and, notably, D. sequax demonstrated remarkable prowess in DPPH radical and superoxide scavenging capacity, along with selective inhibitory activity against MAO-B. Of the aforementioned species, D. pulchellum emerged as the frontrunner in inhibiting 6-OHDA auto-oxidation and conferring neuroprotection against 6-OHDA-induced neuronal damage in the SH-SY5Y cells. Furthermore, D. pulchellum effectively mitigated the increase in intracellular ROS and MDA levels through restoring the activities of the intracellular antioxidant defense system. Therefore, we suggest that D. pulchellum possesses neuroprotective effects against 6-OHDA-induced neurotoxicity due to the radical scavenging capacity of its antioxidant phytoconstituents and its ability to restore intracellular antioxidant activities. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Poria cocos Lanostane Triterpenoids Extract Promotes Collagen and Hyaluronic Acid Production in D-Galactose-Induced Aging Rats.

Author

Chao, Chien-Liang, Kuo, Han-Peng, Huang, Hsin-Wen, Cheng, Maw-Yeun, Chao, Hsin-Fan, Lu, Shih-Min, Lin, Hang-Ching, Wang, Chao-Jih, Chang, Tsu-Chung, and Wu, Chi-Rei

Subjects
GALACTOSE, HYALURONIC acid, COLLAGEN, TRITERPENOIDS, OLDER people, SKIN aging, AGING
Abstract

The global aging population is expanding at an increasingly rapid pace, with approximately one-fourth of the world's population expected to be composed of elderly individuals by 2050. Aging skin is one of the major characteristics expressed in the elderly. The study comprehensively utilizes both cell and animal experiments to confirm the skin anti-aging effects of Poria cocos (P. cocos), which is one of the most important traditional Chinese medicines classified as tonic Chinese medicine, commonly used to treat physical weakness and aging-associated diseases. We demonstrate in this study that P. cocos lanostane triterpenoids extract (Lipucan®) ameliorates aging skin and promotes collagen accumulation and hyaluronic acid production in galactose-induced aging rats. Purified lanostane triterpenoids were initially identified as active components in P. cocos, which significantly increased collagen and hyaluronic acid levels in cultured human skin cells. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

17. Antioxidant and antiproliferative activities of desmodium triflorum (L.) DC

Author

Lai, Shang-Chih, Ho, Yu-Ling, Huang, Shun-Chieh, Huang, Tai-Hung, Lai, Zhen-Rung, Wu, Chi-Rei, Lian, Kuo-Yuan, and Chang, Yuan-Shiun

Subjects
Antioxidants -- Usage, Antioxidants -- Health aspects, Materia medica, Vegetable -- Usage, Materia medica, Vegetable -- Health aspects, Plant extracts -- Usage, Plant extracts -- Health aspects, Bioflavonoids -- Usage, Bioflavonoids -- Health aspects, Flavones -- Usage, Flavones -- Health aspects, Flavonoids -- Usage, Flavonoids -- Health aspects, Medicine, Chinese -- Usage, Medicine, Chinese -- Health aspects, Free radicals (Chemistry) -- Research, Free radicals (Chemistry) -- Physiological aspects, Health
Published
2010

18. The ameliorating effects of luteolin on beta-amyloid-induced impairment of water maze performance and passive avoidance in rats

Author

Tsai, Fan-Shiu, Cheng, Hao-Yuan, Hsieh, Ming-Tsuen, Wu, Chi-Rei, Lin, Ying-Chih, and Peng, Wen-Huang

Subjects
Rats -- Research, Rats -- Physiological aspects, Rattus -- Research, Rattus -- Physiological aspects, Glutathione -- Research, Glutathione -- Physiological aspects, Bioflavonoids -- Physiological aspects, Bioflavonoids -- Research, Flavones -- Physiological aspects, Flavones -- Research, Flavonoids -- Physiological aspects, Flavonoids -- Research, Health
Published
2010

23. Differential change in cortical and hippocampal monoamines, and behavioral patterns in streptozotocin-induced type 1 diabetic rats

Author

Lin, Li-Wei, Tsai, Fan-Shiu, Yang, Wen-Ta, Lai, Shang-Chih, Shih, Chun-Chuan, Lee, Sheng-Chi, and Wu, Chi-Rei

Subjects
Memory and learning tests, Mice, endocrine system diseases, Biogenic amines, nutritional and metabolic diseases, Original Article, Cerebral cortex, Hippocampus, Oral glucose tolerance test Type 1 diabetes mellitus
Abstract

Objective(s): Diabetes mellitus (DM) is a widespread metabolic disorder worldwide. Clinical physicians have found diabetic patients have mild to middle cognitive dysfunction and an alteration of brain monoaminergic function. This study explored the change in various patterns of behavioral models and brain monoamine function under streptozotocin (STZ)-induced type 1 diabetes. Materials and Methods: We established a type 1 DM model via intravenous injection with STZ (65 mg/kg) in rats. Three weeks after the STZ injection, various behavioral measurements including the inhibitory avoidance test, active avoidance test and Morris water maze were conducted. Finally, all rats were dissected and the concentrations of monoamines and their metabolites in cortex and hippocampus were measured by high performance liquid chromatography with electrochemical detection. Results: We found that STZ induced type 1 diabetes (hyperglycemia and lack of insulin) in rats. STZ-induced diabetic rats had cognitive impairment in acquisition sessions and long-term retention of the active avoidance test. STZ-induced diabetic rats also had cognitive impairment in spatial learning, reference and working memory of the Morris water maze. STZ significantly reduced concentrations of norepinephrine (NE) in the cortex and dopamine (DA) in the hippocampus, but increased concentrations of DA and serotonin (5-HT) in the cortex 35 days after injection. The concentration of 5-HT in the hippocampus was also significantly increased. Conclusion: The data suggested that this cognitive impairment after a short-term period of STZ injection might be related to cortical NE dysfunction, differential alteration of cortical and hippocampal DA function, and brain 5-HT hyperfunction.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results