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241 results on '"Wu, Chia-Chin"'

1. A randomized, non-comparative phase 2 study of neoadjuvant immune-checkpoint blockade in retroperitoneal dedifferentiated liposarcoma and extremity/truncal undifferentiated pleomorphic sarcoma

Author

Roland, Christina L., Nassif Haddad, Elise F., Keung, Emily Z., Wang, Wei-Lien, Lazar, Alexander J., Lin, Heather, Chelvanambi, Manoj, Parra, Edwin R., Wani, Khalida, Guadagnolo, B. Ashleigh, Bishop, Andrew J., Burton, Elizabeth M., Hunt, Kelly K., Torres, Keila E., Feig, Barry W., Scally, Christopher P., Lewis, Valerae O., Bird, Justin E., Ratan, Ravin, Araujo, Dejka, Zarzour, M. Alexandra, Patel, Shreyaskumar, Benjamin, Robert, Conley, Anthony P., Livingston, J. Andrew, Ravi, Vinod, Tawbi, Hussein A., Lin, Patrick P., Moon, Bryan S., Satcher, Robert L., Mujtaba, Bilal, Witt, Russell G., Traweek, Raymond S., Cope, Brandon, Lazcano, Rossana, Wu, Chia-Chin, Zhou, Xiao, Mohammad, Mohammad M., Chu, Randy A., Zhang, Jianhua, Damania, Ashish, Sahasrabhojane, Pranoti, Tate, Taylor, Callahan, Kate, Nguyen, Sa, Ingram, Davis, Morey, Rohini, Crosby, Shadarra, Mathew, Grace, Duncan, Sheila, Lima, Cibelle F., Blay, Jean-Yves, Fridman, Wolf Herman, Shaw, Kenna, Wistuba, Ignacio, Futreal, Andrew, Ajami, Nadim, Wargo, Jennifer A., and Somaiah, Neeta

Published
2024
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5. Complete loss of TP53 and RB1 is associated with complex genome and low immune infiltrate in pleomorphic rhabdomyosarcoma

Author

Beird, Hannah C., Wu, Chia-Chin, Nakazawa, Michael, Ingram, Davis, Daniele, Joseph R., Lazcano, Rossana, Little, Latasha, Davies, Christopher, Daw, Najat C., Wani, Khalida, Wang, Wei-Lien, Song, Xingzhi, Gumbs, Curtis, Zhang, Jianhua, Rubin, Brian, Conley, Anthony, Flanagan, Adrienne M., Lazar, Alexander J., and Futreal, P. Andrew

Published
2023
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6. Loss of the DNA Repair Gene RNase H2 Identifies a Unique Subset of DDR-Deficient Leiomyosarcomas

Author

Nakazawa, Michael S., primary, Silverman, Ian M., additional, Rimkunas, Victoria, additional, Veloso, Artur, additional, Glodzik, Dominik, additional, Johnson, Adrienne, additional, Ohsumi, Toshiro K., additional, Patel, Shreyaskumar R., additional, Conley, Anthony P., additional, Roland, Christina L., additional, Soliman, Pamela T., additional, Beird, Hannah C., additional, Wu, Chia-Chin, additional, Ingram, Davis R., additional, Lazcano, Rossana, additional, Song, Dawon, additional, Wani, Khalida M., additional, Lazar, Alexander J., additional, Yap, Timothy A., additional, Wang, Wei-Lien, additional, and Livingston, J. Andrew, additional

Published
2024
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9. The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma

Author

Lamhamedi-Cherradi, Salah-Eddine, Maitituoheti, Mayinuer, Menegaz, Brian A., Krishnan, Sandhya, Vetter, Amelia M., Camacho, Pamela, Wu, Chia-Chin, Beird, Hannah C., Porter, Robert W., Ingram, Davis R., Ramamoorthy, Vandhana, Mohiuddin, Sana, McCall, David, Truong, Danh D., Cuglievan, Branko, Futreal, P. Andrew, Velasco, Alejandra Ruiz, Anvar, Nazanin Esmaeili, Utama, Budi, Titus, Mark, Lazar, Alexander J., Wang, Wei-Lien, Rodriguez-Aguayo, Cristian, Ratan, Ravin, Livingston, J. Andrew, Rai, Kunal, MacLeod, A. Robert, Daw, Najat C., Hayes-Jordan, Andrea, and Ludwig, Joseph A.

Published
2022
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11. Genomics and the Immune Landscape of Osteosarcoma

Author

Wu, Chia-Chin, Livingston, J. Andrew, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Kleinerman, Eugenie S., editor, and Gorlick, Richard, editor

Published
2020
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12. Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state

Author

Kochat, Veena, Raman, Ayush T., Landers, Sharon M., Tang, Ming, Schulz, Jonathan, Terranova, Christopher, Landry, Jace P., Bhalla, Angela D., Beird, Hannah C., Wu, Chia-Chin, Jiang, Yingda, Mao, Xizeng, Lazcano, Rossana, Gite, Swati, Ingram, Davis R., Yi, Min, Zhang, Jianhua, Keung, Emily Z., Scally, Christopher P., Roland, Christina L., Hunt, Kelly K., Feig, Barry W., Futreal, P. Andrew, Hwu, Patrick, Wang, Wei-Lien, Lazar, Alexander J., Slopis, John M., Wilson-Robles, Heather, Wiener, Dominique J., McCutcheon, Ian E., Wustefeld-Janssens, Brandan, Rai, Kunal, and Torres, Keila E.

Published
2021
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13. Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

Author

Farshidfar, Farshad, Zheng, Siyuan, Gingras, Marie-Claude, Newton, Yulia, Shih, Juliann, Robertson, A Gordon, Hinoue, Toshinori, Hoadley, Katherine A, Gibb, Ewan A, Roszik, Jason, Covington, Kyle R, Wu, Chia-Chin, Shinbrot, Eve, Stransky, Nicolas, Hegde, Apurva, Yang, Ju Dong, Reznik, Ed, Sadeghi, Sara, Pedamallu, Chandra Sekhar, Ojesina, Akinyemi I, Hess, Julian M, Auman, J Todd, Rhie, Suhn K, Bowlby, Reanne, Borad, Mitesh J, Network, The Cancer Genome Atlas, Akbani, Rehan, Allotey, Loretta K, Ally, Adrian, Alvaro, Domenico, Andersen, Jesper B, Appelbaum, Elizabeth L, Arora, Arshi, Balasundaram, Miruna, Balu, Saianand, Bardeesy, Nabeel, Bathe, Oliver F, Baylin, Stephen B, Beroukhim, Rameen, Berrios, Mario, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S, Bowen, Jay, Bragazzi, Maria Consiglia, Brooks, Denise, Cardinale, Vincenzo, Carlsen, Rebecca, Carpino, Guido, Carvalho, Andre L, Chaiteerakij, Roongruedee, Chandan, Vishal C, Cherniack, Andrew D, Chin, Lynda, Cho, Juok, Choe, Gina, Chuah, Eric, Chudamani, Sudha, Cibulskis, Carrie, Cordes, Matthew G, Crain, Daniel, Curley, Erin, De Rose, Agostino Maria, Defreitas, Timothy, Demchok, John A, Deshpande, Vikram, Dhalla, Noreen, Ding, Li, Evason, Kimberley, Felau, Ina, Ferguson, Martin L, Foo, Wai Chin, Franchitto, Antonio, Frazer, Scott, Fronick, Catrina C, Fulton, Lucinda A, Fulton, Robert S, Gabriel, Stacey B, Gardner, Johanna, Gastier-Foster, Julie M, Gaudio, Eugenio, Gehlenborg, Nils, Genovese, Giannicola, Gerken, Mark, Getz, Gad, Giama, Nasra H, Gibbs, Richard A, Giuliante, Felice, Grazi, Gian Luca, Hayes, D Neil, Hegde, Apurva M, and Heiman, David I

Subjects
Liver Cancer, Digestive Diseases, Liver Disease, Biotechnology, Human Genome, Genetics, Cancer, Rare Diseases, Digestive Diseases - (Gallbladder), Adult, Aged, Aged, 80 and over, Bile Duct Neoplasms, Cholangiocarcinoma, Chromatin, DNA Methylation, DNA-Binding Proteins, Female, Gene Expression Regulation, Neoplastic, Genomics, Humans, Isocitrate Dehydrogenase, Liver, Liver Neoplasms, Male, Middle Aged, Mitochondria, Mutation, Nuclear Proteins, Pancreatic Neoplasms, Promoter Regions, Genetic, RNA, Long Noncoding, RNA, Messenger, Transcription Factors, Cancer Genome Atlas Network, ARID1A, DNA methylation, IDH, RNA sequencing, TCGA, cholangiocarcinoma, integrative genomics, lncRNAs, multi-omics, whole exome, Biochemistry and Cell Biology, Medical Physiology
Abstract

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. We identified an IDH mutant-enriched subtype with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number. Leveraging the multi-platform data, we observed that ARID1A exhibited DNA hypermethylation and decreased expression in the IDH mutant subtype. More broadly, we found that IDH mutations are associated with an expanded histological spectrum of liver tumors with molecular features that stratify with CCA. Our studies reveal insights into the molecular pathogenesis and heterogeneity of cholangiocarcinoma and provide classification information of potential therapeutic significance.

Published
2017

14. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Author

Dey, Prasenjit, Baddour, Joelle, Muller, Florian, Wu, Chia Chin, Wang, Huamin, Liao, Wen-Ting, Lan, Zangdao, Chen, Alina, Gutschner, Tony, Kang, Yaan, Fleming, Jason, Satani, Nikunj, Zhao, Di, Achreja, Abhinav, Yang, Lifeng, Lee, Jiyoon, Chang, Edward, Genovese, Giannicola, Viale, Andrea, Ying, Haoqiang, Draetta, Giulio, Maitra, Anirban, Wang, Y Alan, Nagrath, Deepak, and DePinho, Ronald A

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Rare Diseases, Cancer, Pancreatic Cancer, Digestive Diseases, Biotechnology, Ovarian Cancer, Development of treatments and therapeutic interventions, Aetiology, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, AMP-Activated Protein Kinases, Amino Acids, Branched-Chain, Animals, Biocatalysis, Carcinoma, Pancreatic Ductal, Gene Deletion, Humans, Ketoglutaric Acids, Malate Dehydrogenase, Male, Mice, Minor Histocompatibility Antigens, Mitochondria, NADP, Pancreatic Neoplasms, Pregnancy Proteins, Reactive Oxygen Species, Sterol Regulatory Element Binding Protein 1, Transaminases, General Science & Technology
Abstract

The genome of pancreatic ductal adenocarcinoma (PDAC) frequently contains deletions of tumour suppressor gene loci, most notably SMAD4, which is homozygously deleted in nearly one-third of cases. As loss of neighbouring housekeeping genes can confer collateral lethality, we sought to determine whether loss of the metabolic gene malic enzyme 2 (ME2) in the SMAD4 locus would create cancer-specific metabolic vulnerability upon targeting of its paralogous isoform ME3. The mitochondrial malic enzymes (ME2 and ME3) are oxidative decarboxylases that catalyse the conversion of malate to pyruvate and are essential for NADPH regeneration and reactive oxygen species homeostasis. Here we show that ME3 depletion selectively kills ME2-null PDAC cells in a manner consistent with an essential function for ME3 in ME2-null cancer cells. Mechanistically, integrated metabolomic and molecular investigation of cells deficient in mitochondrial malic enzymes revealed diminished NADPH production and consequent high levels of reactive oxygen species. These changes activate AMP activated protein kinase (AMPK), which in turn directly suppresses sterol regulatory element-binding protein 1 (SREBP1)-directed transcription of its direct targets including the BCAT2 branched-chain amino acid transaminase 2) gene. BCAT2 catalyses the transfer of the amino group from branched-chain amino acids to α-ketoglutarate (α-KG) thereby regenerating glutamate, which functions in part to support de novo nucleotide synthesis. Thus, mitochondrial malic enzyme deficiency, which results in impaired NADPH production, provides a prime 'collateral lethality' therapeutic strategy for the treatment of a substantial fraction of patients diagnosed with this intractable disease.

Published
2017

15. Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

Author

Roberts, Lewis R, Farshidfar, Farshad, Zheng, Siyuan, Gingras, Marie-Claude, Newton, Yulia, Shih, Juliann, Robertson, A Gordon, Hinoue, Toshinori, Hoadley, Katherine A, Gibbs, Richard, Roszik, Jason, Covington, Kyle, Wu, Chia-Chin, Shinbrot, Eve, Stransky, Nicolas, Hegde, Apurva M, Yang, Ju Dong, Reznik, Ed, Sadeghi, Sara, Pedamallu, Chandra Sekhar, Ojesina, Akinyemi I, Hess, Julian, Auman, J Todd, Rhie, Suhn K, Bowlby, Reanne, Borad, Mitesh J, Stuart, Josh, Sander, Chris, Akbani, Rehan, Cherniack, Andrew D, Laird, Peter W, Deshpande, Vikram, Mounajjed, Taofic, Foo, Wai Chin, Torbenson, Michael, Kleiner, David E, Wheeler, David A, Mcree, Autumn J, Bathe, Oliver F, Andersen, Jesper B, Bardeesy, Nabeel, and Kwong, Lawrence N

Subjects
Gastroenterology & Hepatology, Medical Biochemistry and Metabolomics, Clinical Sciences, Immunology
Published
2016

18. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Author

Özdemir, Berna C, Pentcheva-Hoang, Tsvetelina, Carstens, Julienne L, Zheng, Xiaofeng, Wu, Chia-Chin, Simpson, Tyler R, Laklai, Hanane, Sugimoto, Hikaru, Kahlert, Christoph, Novitskiy, Sergey V, De Jesus-Acosta, Ana, Sharma, Padmanee, Heidari, Pedram, Mahmood, Umar, Chin, Lynda, Moses, Harold L, Weaver, Valerie M, Maitra, Anirban, Allison, James P, LeBleu, Valerie S, and Kalluri, Raghu

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Rare Diseases, Digestive Diseases, Pancreatic Cancer, Cancer, 2.1 Biological and endogenous factors, Aetiology, Animals, Carcinoma, Pancreatic Ductal, Disease Models, Animal, Fibroblasts, Fibrosis, Humans, Immune Tolerance, Mice, Mice, Transgenic, Pancreatic Neoplasms, Survival Analysis, Neurosciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the ability to delete αSMA(+) myofibroblasts in pancreatic cancer were generated. Depletion starting at either noninvasive precursor (pancreatic intraepithelial neoplasia) or the PDAC stage led to invasive, undifferentiated tumors with enhanced hypoxia, epithelial-to-mesenchymal transition, and cancer stem cells, with diminished animal survival. In PDAC patients, fewer myofibroblasts in their tumors also correlated with reduced survival. Suppressed immune surveillance with increased CD4(+)Foxp3(+) Tregs was observed in myofibroblast-depleted mouse tumors. Although myofibroblast-depleted tumors did not respond to gemcitabine, anti-CTLA4 immunotherapy reversed disease acceleration and prolonged animal survival. This study underscores the need for caution in targeting carcinoma-associated fibroblasts in PDAC.

Published
2014

20. Static and dynamic analyses of mountain bikes and their riders

Author

Wu, Chia-Chin

Subjects
629.227, Q Science (General), QA76 Computer software, TA Engineering (General). Civil engineering (General)
Abstract

Mountain biking is a globally popular sport, in which the rider uses a mountain bike to ride on off-road terrain. A mountain bike has either a front suspension system only or a full-suspension system to decrease the external vibration resulting from the terrain irregularities and to increase riding comfort. Despite the added comfort of full-suspension of mountain bikes, there are some disadvantages because the chain-suspension interaction and bobbing effect absorb some of the rider's pedalling power and lead to the reduction of pedalling efficiency. In this study, a technique for evaluating the pedalling efficiency of a bike rider in seated cycling by using engineering mechanics is developed. This method is also found to be useful for determining the correct crank angle for the beginning of the downstroke and that of the upstroke during each pedalling cycle. Next, five mathematical models of rider-bike systems are developed in Simulink and SimMechanics, including one hard-tail (HT) bike, and four full-suspension (FS) bikes [single pivot, four-bar-linkage horst link, four-bar-linkage faux bar, and virtual pivot point (VPP)]. In each of the five rider-bike systems, a PID controller is applied on the rider's elbow to prevent his upper body from falling down due to gravity. A pedalling controller is also developed in Simulink, which is based on the previous theory for evaluating the rider's pedalling efficiency written in Matlab. Another PID controller is used for the pedalling control by sensing the real-time moving speed and applying a suitable pedalling force to achieve a desired speed. The dynamic responses for each of the five rider-bike systems moving on a flat road surface (without bumps) and rough terrain (with bumps) are investigated. The values determined include the pedalling force, pedalling torque and power, forward velocity, contact forces of front and rear wheels, compressions of front suspension (front fork) and rear suspension (rear shock absorber), sprocket distance, chain tension force, and vertical accelerations of handlebar and seats. The numerical results reveal that, while moving on flat road surface, the pedalling efficiency of hard-tail bike is highest, and the bobbing effect of the VPP bike is most serious. However, while moving on rough terrain, the riding conditions for each of the four full-suspension bikes are more stable than the hard-tail bike.

Published
2013

21. Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

Author

Lee, Won-Chul, Reuben, Alexandre, Hu, Xin, McGranahan, Nicholas, Chen, Runzhe, Jalali, Ali, Negrao, Marcelo V., Hubert, Shawna M., Tang, Chad, Wu, Chia-Chin, Lucas, Anthony San, Roh, Whijae, Suda, Kenichi, Kim, Jihye, Tan, Aik-Choon, Peng, David H., Lu, Wei, Tang, Ximing, Chow, Chi-Wan, Fujimoto, Junya, Behrens, Carmen, Kalhor, Neda, Fukumura, Kazutaka, Coyle, Marcus, Thornton, Rebecca, Gumbs, Curtis, Li, Jun, Wu, Chang-Jiun, Little, Latasha, Roarty, Emily, Song, Xingzhi, Lee, J. Jack, Sulman, Erik P., Rao, Ganesh, Swisher, Stephen, Diao, Lixia, Wang, Jing, Heymach, John V., Huse, Jason T., Scheet, Paul, Wistuba, Ignacio I., Gibbons, Don L., Futreal, P. Andrew, Zhang, Jianhua, Gomez, Daniel, and Zhang, Jianjun

Published
2020
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22. Abstract 1196: The epigenetic impact and therapeutic opportunity of AR-directed therapy for DSRCT

Author

Truong, Danh, primary, Lamhamedi-Cherradi, Salah-Eddine, additional, Maitituoheti, Mayinuer, additional, Beird, Hannah C., additional, Arslan, Emre, additional, Wu, Chia-Chin, additional, Krishnan, Sandhya, additional, Ingram, Davis, additional, Futreal, P Andrew, additional, Titus, Mark, additional, Rai, Kunal, additional, Lazar, Alexander, additional, MacLeod, A Robert, additional, Ratan, Ravin, additional, Livingston, John Andrew, additional, Daw, Najat, additional, Hayes-Dixon, Andrea, additional, and Ludwig, Joseph, additional

Published
2023
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23. Abstract 6558: Defining differentiation States in well-differentiated and de-differentiated liposarcoma

Author

Truong, Danh, primary, Beird, Hannah C., additional, Wu, Chia-Chin, additional, Krishnan, Sandhya, additional, Ingram, Davis, additional, Lazar, Alexander, additional, Keung, Emily, additional, Roland, Christina, additional, Yao, Wantong, additional, Benjamin, Robert, additional, Somaiah, Neeta, additional, Feig, Barry W., additional, and Ludwig, Joseph A., additional

Published
2023
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24. Data from Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer

Author

McAndrews, Kathleen M., primary, Chen, Yang, primary, Darpolor, J. Kebbeh, primary, Zheng, Xiaofeng, primary, Yang, Sujuan, primary, Carstens, Julienne L., primary, Li, Bingrui, primary, Wang, Huamin, primary, Miyake, Toru, primary, Correa de Sampaio, Pedro, primary, Kirtley, Michelle L., primary, Natale, Mariangela, primary, Wu, Chia-Chin, primary, Sugimoto, Hikaru, primary, LeBleu, Valerie S., primary, and Kalluri, Raghu, primary

Published
2023
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25. Supplementary Data from Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer

Author

McAndrews, Kathleen M., primary, Chen, Yang, primary, Darpolor, J. Kebbeh, primary, Zheng, Xiaofeng, primary, Yang, Sujuan, primary, Carstens, Julienne L., primary, Li, Bingrui, primary, Wang, Huamin, primary, Miyake, Toru, primary, Correa de Sampaio, Pedro, primary, Kirtley, Michelle L., primary, Natale, Mariangela, primary, Wu, Chia-Chin, primary, Sugimoto, Hikaru, primary, LeBleu, Valerie S., primary, and Kalluri, Raghu, primary

Published
2023
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26. Data from Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

Author

Wang, Guocan, primary, Lu, Xin, primary, Dey, Prasenjit, primary, Deng, Pingna, primary, Wu, Chia Chin, primary, Jiang, Shan, primary, Fang, Zhuangna, primary, Zhao, Kun, primary, Konaparthi, Ramakrishna, primary, Hua, Sujun, primary, Zhang, Jianhua, primary, Li-Ning-Tapia, Elsa M., primary, Kapoor, Avnish, primary, Wu, Chang-Jiun, primary, Patel, Neelay Bhaskar, primary, Guo, Zhenglin, primary, Ramamoorthy, Vandhana, primary, Tieu, Trang N., primary, Heffernan, Tim, primary, Zhao, Di, primary, Shang, Xiaoying, primary, Khadka, Sunada, primary, Hou, Pingping, primary, Hu, Baoli, primary, Jin, Eun-Jung, primary, Yao, Wantong, primary, Pan, Xiaolu, primary, Ding, Zhihu, primary, Shi, Yanxia, primary, Li, Liren, primary, Chang, Qing, primary, Troncoso, Patricia, primary, Logothetis, Christopher J., primary, McArthur, Mark J., primary, Chin, Lynda, primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary

Published
2023
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27. Supplementary Methods, Figure Legends, Figures S1 - S7 from Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

Author

Wang, Guocan, primary, Lu, Xin, primary, Dey, Prasenjit, primary, Deng, Pingna, primary, Wu, Chia Chin, primary, Jiang, Shan, primary, Fang, Zhuangna, primary, Zhao, Kun, primary, Konaparthi, Ramakrishna, primary, Hua, Sujun, primary, Zhang, Jianhua, primary, Li-Ning-Tapia, Elsa M., primary, Kapoor, Avnish, primary, Wu, Chang-Jiun, primary, Patel, Neelay Bhaskar, primary, Guo, Zhenglin, primary, Ramamoorthy, Vandhana, primary, Tieu, Trang N., primary, Heffernan, Tim, primary, Zhao, Di, primary, Shang, Xiaoying, primary, Khadka, Sunada, primary, Hou, Pingping, primary, Hu, Baoli, primary, Jin, Eun-Jung, primary, Yao, Wantong, primary, Pan, Xiaolu, primary, Ding, Zhihu, primary, Shi, Yanxia, primary, Li, Liren, primary, Chang, Qing, primary, Troncoso, Patricia, primary, Logothetis, Christopher J., primary, McArthur, Mark J., primary, Chin, Lynda, primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary

Published
2023
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28. Supplementary Table S7 from Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

Author

Wang, Guocan, primary, Lu, Xin, primary, Dey, Prasenjit, primary, Deng, Pingna, primary, Wu, Chia Chin, primary, Jiang, Shan, primary, Fang, Zhuangna, primary, Zhao, Kun, primary, Konaparthi, Ramakrishna, primary, Hua, Sujun, primary, Zhang, Jianhua, primary, Li-Ning-Tapia, Elsa M., primary, Kapoor, Avnish, primary, Wu, Chang-Jiun, primary, Patel, Neelay Bhaskar, primary, Guo, Zhenglin, primary, Ramamoorthy, Vandhana, primary, Tieu, Trang N., primary, Heffernan, Tim, primary, Zhao, Di, primary, Shang, Xiaoying, primary, Khadka, Sunada, primary, Hou, Pingping, primary, Hu, Baoli, primary, Jin, Eun-Jung, primary, Yao, Wantong, primary, Pan, Xiaolu, primary, Ding, Zhihu, primary, Shi, Yanxia, primary, Li, Liren, primary, Chang, Qing, primary, Troncoso, Patricia, primary, Logothetis, Christopher J., primary, McArthur, Mark J., primary, Chin, Lynda, primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary

Published
2023
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29. Immuno-genomic landscape of osteosarcoma

Author

Wu, Chia-Chin, Beird, Hannah C., Andrew Livingston, J., Advani, Shailesh, Mitra, Akash, Cao, Shaolong, Reuben, Alexandre, Ingram, Davis, Wang, Wei-Lien, Ju, Zhenlin, Hong Leung, Cheuk, Lin, Heather, Zheng, Youyun, Roszik, Jason, Wang, Wenyi, Patel, Shreyaskumar, Benjamin, Robert S., Somaiah, Neeta, Conley, Anthony P., Mills, Gordon B., Hwu, Patrick, Gorlick, Richard, Lazar, Alexander, Daw, Najat C., Lewis, Valerae, and Futreal, P. Andrew

Published
2020
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30. Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

Author

Lissanu Deribe, Yonathan, Sun, Yuting, Terranova, Christopher, Khan, Fatima, Martinez-Ledesma, Juan, Gay, Jason, Gao, Guang, Mullinax, Robert A., Khor, Tin, Feng, Ningping, Lin, Yu-Hsi, Wu, Chia-Chin, Reyes, Claudia, Peng, Qian, Robinson, Frederick, Inoue, Akira, Kochat, Veena, Liu, Chang-Gong, Asara, John M., Moran, Cesar, Muller, Florian, Wang, Jing, Fang, Bingliang, Papadimitrakopoulou, Vali, Wistuba, Ignacio I., Rai, Kunal, Marszalek, Joseph, and Futreal, P. Andrew

Published
2018
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34. 590 Metagenomic sequencing reveals unique gut microbial features associated with tertiary lymphoid structures in response to immune checkpoint blockade in solid cancers

Author

Chelvanambi, Manoj, primary, Deboever, Nathaniel, additional, Nassif, Elise, additional, Damania, Ashish, additional, Chen, Lili, additional, Leung, Cheuk, additional, Keung, Emily, additional, Wu, Chia-Chin, additional, Witt, Russell, additional, White, Michael, additional, Johnson, Sarah, additional, Wong, Matthew, additional, Mishra, Aditya, additional, Lastrapes, Matthew, additional, Somaiah, Neeta, additional, Kadara, Humam, additional, Basu, Sreyashi, additional, Allison, James, additional, Sharma, Padmanee, additional, McBride, Kevin, additional, Fridman, Wolf, additional, Heymach, John, additional, Sepesi, Boris, additional, Ajami, Nadim, additional, Roland, Christina, additional, Wargo, Jennifer, additional, and Cascone, Tina, additional

Published
2022
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35. Abstract PR002: Antigen presentation and processing pathway is associated with early relapse after neoadjuvant immune checkpoint blockade (ICB) in dedifferentiated liposarcomas (DDLPS)

Author

Nassif, Elise F., primary, Wu, Chia-Chin, additional, Akdemir, Kadir, additional, Witt, Russell G., additional, Traweek, Raymond, additional, Cope, Brandon, additional, Thirasastr, Prapassorn, additional, Tate, Taylor, additional, Mathew, Grace, additional, Crosby, Shadarra, additional, Chu, Randy, additional, Mohammad, Mohammad, additional, Shaw, Kenna, additional, Davis, Ingram, additional, Wani, Khalida, additional, Lazar, Alexander J., additional, Wang, Wei-Lien, additional, Duncan, Sheila, additional, Guadagnolo, Ashleigh B., additional, Bishop, Andrew J., additional, Lewis, Valerae, additional, Bird, Justin E., additional, Torres, Keila E., additional, Hunt, Kelly K., additional, Feig, Barry W., additional, Scally, Christopher P., additional, Ratan, Ravin, additional, Patel, Shreyaskumar, additional, Benjamin, Robert S., additional, Satcher, Robert, additional, McBride, Kevin, additional, Fridman, Wolf H., additional, Wistuba, Ignacio, additional, Futreal, Andrew, additional, Wargo, Jennifer A., additional, Somaiah, Neeta, additional, Roland, Christina L., additional, and Keung, Emily Z., additional

Published
2022
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37. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

Author

Zheng, Xiaofeng, Carstens, Julienne L., Kim, Jiha, Scheible, Matthew, Kaye, Judith, Sugimoto, Hikaru, Wu, Chia-Chin, LeBleu, Valerie S., and Kalluri, Raghu

Subjects
Cancer cells -- Analysis, Pancreatic cancer -- Diagnosis -- Prognosis -- Care and treatment, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal prognosis despite current best therapies; therefore new treatment strategies are urgently required. Numerous studies have suggested that epithelial-to-mesenchymal transition [...]

Published
2015

38. Identifying gut microbial signatures associated with B cells and tertiary lymphoid structures (TLS) in the tumor microenvironment (TME) in response to immune checkpoint blockade (ICB).

Author

Nassif, Elise F, primary, Chelvanambi, Manoj, additional, Chen, Lili, additional, Wu, Chia-Chin, additional, Damania, Ashish, additional, Keung, Emily Zhi-Yun, additional, Witt, Russell G., additional, White, Michael, additional, Ajami, Nadim J., additional, Wong, Matthew C., additional, Somaiah, Neeta, additional, Sepesi, Boris, additional, Basu, Sreyashi, additional, Allison, James Patrick, additional, Sharma, Padmanee, additional, McBride, Kevin, additional, Fridman, Wolf-Hervé, additional, Wargo, Jennifer Ann, additional, Cascone, Tina, additional, and Roland, Christina Lynn, additional

Published
2022
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39. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Author

Genovese, Giannicola, Carugo, Alessandro, Tepper, James, Robinson, Frederick Scott, Li, Liren, Svelto, Maria, Nezi, Luigi, Corti, Denise, Minelli, Rosalba, Pettazzoni, Piergiorgio, Gutschner, Tony, Wu, Chia-Chin, Seth, Sahil, Akdemir, Kadir Caner, Leo, Elisabetta, Amin, Samirkumar, Molin, Marco Dal, Ying, Haoqiang, Kwong, Lawrence N., Colla, Simona, Takahashi, Koichi, Ghosh, Papia, Giuliani, Virginia, Muller, Florian, Dey, Prasenjit, Jiang, Shan, Garvey, Jill, Liu, Chang-Gong, Zhang, Jianhua, Heffernan, Timothy P., Toniatti, Carlo, Fleming, Jason B., Goggins, Michael G., Wood, Laura D., Sgambato, Alessandro, Agaimy, Abbas, Maitra, Anirban, Roberts, Charles W. M., Wang, Huamin, Viale, Andrea, DePinho, Ronald A., Draetta, Giulio F., and Chin, Lynda

Published
2017
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40. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

Author

Lovisa, Sara, LeBleu, Valerie S., Tampe, Bjorn, Sugimoto, Hikaru, Vadnagara, Komal, Carstens, Julienne L., Wu, Chia-Chin, Hagos, Yohannes, Burckhardt, Birgitta C., Pentcheva-Hoang, Tsvetelina, Nischal, Hersharan, Allison, James P., Zeisberg, Michael, and Kalluri, Raghu

Subjects
Fibrosis, Cell differentiation, Biological sciences, Health
Abstract

Kidney fibrosis is marked by an epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells (TECs). Here we find that, during renal fibrosis, TECs acquire a partial EMT program during which they remain associated with their basement membrane and express markers of both epithelial and mesenchymal cells. The functional consequence of the EMT program during fibrotic injury is an arrest in the G2 phase of the cell cycle and lower expression of several solute and solvent transporters in TECs. We also found that transgenic expression of either Twist1 (encoding twist family bHLH transcription factor 1, known as Twist) or Snail (encoding snail family zinc finger 1, known as Snail) expression is sufficient to promote prolonged TGF-β1-induced G2 arrest of TECs, limiting the cells' potential for repair and regeneration. In mouse models of experimentally induced renal fibrosis, conditional deletion of Twist1 or Snail in proximal TECs resulted in inhibition of the EMT program and the maintenance of TEC integrity, while also restoring cell proliferation, dedifferentiation-associated repair and regeneration of the kidney parenchyma and attenuating interstitial fibrosis. Thus, inhibition of the EMT program in TECs during chronic renal injury represents a potential anti-fibrosis therapy., Kidney fibrosis is associated with a reduction in the functional renal parenchyma, leading to compromised kidney functions and eventual organ death (1). There is no effective treatment for renal fibrosis [...]

Published
2015
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41. Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer

Author

McAndrews, Kathleen M., primary, Chen, Yang, additional, Darpolor, J. Kebbeh, additional, Zheng, Xiaofeng, additional, Yang, Sujuan, additional, Carstens, Julienne L., additional, Li, Bingrui, additional, Wang, Huamin, additional, Miyake, Toru, additional, Correa de Sampaio, Pedro, additional, Kirtley, Michelle L., additional, Natale, Mariangela, additional, Wu, Chia-Chin, additional, Sugimoto, Hikaru, additional, LeBleu, Valerie S., additional, and Kalluri, Raghu, additional

Published
2022
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42. The Androgen Receptor: A Therapeutic Target in Desmoplastic Small Round Cell Sarcoma

Author

Lamhamedi-Cherradi, Salah-Eddine, primary, Maitituoheti, Mayinuer, additional, Menegaz, Brian A., additional, Krishnan, Sandhya, additional, Vetter, Amelia M., additional, Camacho, Pamela, additional, Wu, Chia-Chin, additional, Beird, Hannah C., additional, Porter, Robert W., additional, Ingram, Davis R., additional, Ramamoorthy, Vandhana, additional, Mohiuddin, Sana, additional, McCall, David, additional, Truong, Danh D., additional, Cuglievan, Branko, additional, Futreal, P. Andrew, additional, Velasco, Alejandra Ruiz, additional, Anvar, Nazanin Esmaeili, additional, Utama, Budi, additional, Titus, Mark, additional, Lazar, Alexander J., additional, Wang, Wei-Lien, additional, Rodriguez-Aguayo, Cristian, additional, Ratan, Ravin, additional, Livingston, John A., additional, Rai, Kunal, additional, MacLeod, A. Robert, additional, Daw, Najat C., additional, Hayes-Jordan, Andrea, additional, and Ludwig, Joseph A., additional

Published
2022
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44. Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer

Author

Zhou, Xunian, primary, Kurywchak, Paul, additional, Wolf-Dennen, Kerri, additional, Che, Sara P.Y., additional, Sulakhe, Dinanath, additional, D’Souza, Mark, additional, Xie, Bingqing, additional, Maltsev, Natalia, additional, Gilliam, T. Conrad, additional, Wu, Chia-Chin, additional, McAndrews, Kathleen M., additional, LeBleu, Valerie S., additional, McConkey, David J., additional, Volpert, Olga V., additional, Pretzsch, Shanna M., additional, Czerniak, Bogdan A., additional, Dinney, Colin P., additional, and Kalluri, Raghu, additional

Published
2021
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47. Genomic assessment distinguishes intrapulmonary metastases from synchronous primary lung cancers

Author

Corsini, Erin M., primary, Wang, Jinliang, additional, Wu, Chia-Chin, additional, Fujimoto, Junya, additional, Negrao, Marcelo V., additional, Chen, Runzhe, additional, Quek, Kelly, additional, Mitchell, Kyle G., additional, Chow, Chi-Wan B., additional, Little, Latasha, additional, Gumbs, Curtis, additional, Song, Xingzhi, additional, Behrens, Carmen, additional, Correa, Arlene M., additional, Antonoff, Mara B., additional, Swisher, Stephen G., additional, Heymach, John V., additional, Zhang, Jianhua, additional, Wistuba, Ignacio I., additional, Futreal, P. Andrew, additional, Sepesi, Boris, additional, and Zhang, Jianjun, additional

Published
2020
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50. Abstract A108: Identification of distinct fibroblast populations with unique roles in PDAC progression and tumor immunity

Author

Darpolor, J. Kebbeh, primary, Zheng, Xiaofeng, additional, Yang, Sujuan, additional, McAndrews, Kathleen M., additional, Carstens, Julienne L., additional, Phillips, Patricia E., additional, Sugimoto, Hikaru, additional, De Sampaio, Pedro Correa, additional, Wu, Chia-Chin, additional, LeBleu, Valerie S., additional, and Kalluri, Raghu, additional

Published
2020
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