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19 results on '"Wu, Debin"'

15. Meta-analysis of the efficacy and safety of the application of adjuvant material in the repair of anterior vaginal wall prolapsed

Author

Cheng Yanxiang, Chen Lu, Ding Wenjuan, Zhang Xiaohong, Wu Wenying, Liu Qian, Li Bingshu, Hong Shasha, Sun Qing, Guo Wenjun, Liu Yuling, Chen Jianhua, Wu Debin, Min Jie, Hong Li, Zhu Xuejiao, and Hu Min

Subjects
Adult, Reoperation, medicine.medical_specialty, Time Factors, Adolescent, medicine.medical_treatment, Treatment outcome, Blood Loss, Surgical, Transplants, Urinary incontinence, Vaginal wall, Postoperative Complications, Blood loss, Recurrence, Uterine Prolapse, medicine, Humans, Anterior vaginal wall prolapse, Aged, Randomized Controlled Trials as Topic, Pain, Postoperative, business.industry, Obstetrics and Gynecology, General Medicine, Middle Aged, Surgical Mesh, Surgery, Surgical mesh, Dyspareunia, Treatment Outcome, Urinary Incontinence, Female, medicine.symptom, business, Adjuvant
Abstract

This study is a meta-analysis of the efficacy and safety of the application of adjuvant material in the repair of anterior vaginal wall prolapse and a sub-category analysis of the use of nonabsorbable synthetic mesh, biological graft and absorbable synthetic mesh.Pubmed, Embase and Ovid databases were searched for published randomized controlled trials from 1980 to February 2012 on the treatment of anterior vaginal wall prolapse with adjuvant materials. A comprehensive meta-analysis applying Revman5.1 analysis software was performed.A total of 20 randomized controlled trials including 2,313 participants were recognized. The result showed that repair with adjuvant materials was better and more effective; nevertheless, use of adjuvant materials resulted in longer duration of surgery and more peri-operative bleeding when compared with the control group, but no significant differences were observed between the two groups regarding visceral injury, postoperative pain, urinary tract infection rate, new stress incontinence and new dyspareunia.Adjuvant material is worthy of clinical popularization, especially the biological graft type because of its lower anatomy failure rate and no difference in safety compared with the control group. However, exposure to adjuvant materials and erosion rate are high, which are the most important aspects to be improved.

Published
2012

18. TSLC1 gene silencing in cutaneous melanoma

Author

You, Yan, primary, Ma, Liangjuan, additional, You, Min, additional, Li, Xiaomei, additional, Wang, Shuhai, additional, Li, Hongli, additional, Wu, Debin, additional, Yang, Huimin, additional, and Li, Zhen Yu, additional

Published
2010
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19. [Effect of mechanical stress on human parametrial ligament fibroblasts apoptosis].

Author

Ding W, Hong L, Wu D, Hong S, Li B, Guo W, Min J, Fang G, and Zhang X

Subjects
Cells, Cultured, Female, Flow Cytometry, Humans, Hysterectomy, Ligaments, Apoptosis physiology, Fibroblasts physiology, Pelvic Organ Prolapse pathology, Stress, Mechanical
Abstract

Objective: To explore the possible mechanism of mechanical factors in the pathogenesis of pelvic organ prolapse (POP)., Methods: The experiment material were uterosacral ligament and cardinal ligament- derived fibroblast from 10 patients who received total hysterectomy due to benign disease except POP. Fibroblast were cultured after collagenase digestion and identified by morphology and immocytochemical methods. Fibroblasts of 4-8 generations were stretched by four-point bending system for 0µ (0 mm), 1 333 µ (1 mm), 2 666 µ (2 mm), 5 333 µ (4 mm) strain, using 0 mm strain as the control group. Parameters was set to a frequency of 0.1 Hz, 4 hours. Cell apoptosis was tested by flow cytometry., Results: Mechanical strain increased cell apoptosis [0 µ: (7.4 ± 1.5)%, 1 333 µ: (8.7 ± 2.2)%, 2 666 µ: (19.4 ± 3.4)%, 5333 µ: (50.9 ± 6.6)%, respectively]. Cell apoptosis rate was significantly higher under strong mechanical strain (2 666 µ and 5 333 µ versus 0 µ, all P < 0.05)., Conclusion: Increased mechanical stress loading on human parametrial ligament fibroblasts could raise the rate of apoptosis.

Published
2014

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