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34. Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway.

Author

Shan-Qing Zheng, Xiao-Bing Huang, Ti-Kun Xing, Ai-Jun Ding, Gui-Sheng Wu, Huai-Rong Luo, Zheng, Shan-Qing, Huang, Xiao-Bing, Xing, Ti-Kun, Ding, Ai-Jun, Wu, Gui-Sheng, and Luo, Huai-Rong

Subjects
CHLOROGENIC acid, CAENORHABDITIS elegans, INSULIN, CARDIOVASCULAR diseases, ANTIOXIDANTS, YEAST
Abstract

Coffee and tea, two of the most popular drinks around the world, share many in common from chemical components to beneficial effects on human health. One of their shared components, the polyphenols, most notably chlorogenic acid (CGA), was supposed to account for many of the beneficial effects on ameliorating diseases occurred accompanying people aging, such as the antioxidant effect and against diabetes and cardiovascular disease. CGA is also present in many traditional Chinese medicines. However, the mechanism of these effects was vague. The aging signaling pathways were conservative from yeast and worms to mammals. So, we tested if CGA had an effect on aging in Caenorhabditis elegans. We found that CGA could extend the lifespan of C. elegans by up to 20.1%, delay the age-related decline of body movement, and improve stress resistance. We conducted genetic analysis with a series of worm mutants and found that CGA could extend the lifespan of the mutants of eat-2, glp-1, and isp-1, but not of daf-2, pdk-1, akt-1, akt-2, sgk-1, and clk-1. CGA could activate the FOXO transcription factors DAF-16, HSF-1, SKN-1, and HIF-1, but not SIR-2.1. Taken together, CGA might extend the lifespan of C. elegans mainly via DAF-16 in insulin/IGF-1 signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2017
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37. Association of PDE11A global haplotype with major depression and antidepressant drug response

Author

Luo, Huai-Rong, Wu, Gui-Sheng, Dong, Chuanhui, Arcos-Burgos, Mauricio, Ribeiro, L., Licinio, Julio, Wong, Ma-Li, Luo, Huai-Rong, Wu, Gui-Sheng, Dong, Chuanhui, Arcos-Burgos, Mauricio, Ribeiro, L., Licinio, Julio, and Wong, Ma-Li

Abstract

Cyclic nucleotide phosphodiesterases (PDEs) hydrolyze the intracellular second messengers cAMP and cGMP to their corresponding monophosphates. PDEs play an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. We have previously shown that the individual haplotype GAACC in the PDE11A gene was associated with major depressive disorder (MDD) based on block-by-block analysis. There are two PDE genes, PDE11A and PDE1A, located in chromosome 2q31-q32. In this study, we have further explored whether the whole region 2q31-q32 contribute to MDD or antidepressant response 278 depressed Mexican-American participants and 321 matched healthy controls. Although there is no significant interaction between the two genes, the remission rate of individual carrying the combination genotype at rs1880916 (AG/AA) and rs1549870 (GG) is significantly increased. We analyzed the global haplotype by examining 16 single-nucleotide polymorphisms (SNPs) in PDE11A and six SNPs in PDE1A. None of the haplotypes consisting of six SNPs in the PDE1A have a significant difference between depressed and control groups. Among haplotypes consisting of 16 SNPs across 440 kb in the PDE11A gene, 18 common haplotypes (with frequency higher than 0.8%) have been found in the studied population. Six haplotypes showed significantly different frequencies between the MDD group and the control group. The phylogenetic network result for the 16 SNPs showed that several historic recombination events have happened in the PDE11A gene. The frequency of one haplotype is significantly lower in the remitter group than in the nonremitter group for the depressed participants treated with either desipramine or fluoxetine. Thus, our data suggest that the PDE11A global haplotype is associated with both MDD and antidepressant drug response.

Published
2009

38. Association of PDE11A global haplotype with major depression and antidepressant drug response

Author

Luo,Huai-Rong, Wu,Gui-Sheng, Dong,Chuanhui, Arcos-Burgos,Mauricio, Ribeiro,Luciana, Licinio,Julio, Wong,Ma Li, Luo,Huai-Rong, Wu,Gui-Sheng, Dong,Chuanhui, Arcos-Burgos,Mauricio, Ribeiro,Luciana, Licinio,Julio, and Wong,Ma Li

Abstract

Huai-Rong Luo, Gui-Sheng Wu, Chuanhui Dong, Mauricio Arcos-Burgos, Luciana Ribeiro, Julio Licinio, Ma-Li WongCenter on Pharmacogenomics, Department of Psychiatry and Behavioral Science, University of Miami Miller School of Medicine, Miami, FL, USAAbstract: Cyclic nucleotide phosphodiesterases (PDEs) hydrolyze the intracellular second messengers cAMP and cGMP to their corresponding monophosphates. PDEs play an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. We have previously shown that the individual haplotype GAACC in the PDE11A gene was associated with major depressive disorder (MDD) based on block-by-block analysis. There are two PDE genes, PDE11A and PDE1A, located in chromosome 2q31–q32. In this study, we have further explored whether the whole region 2q31–q32 contribute to MDD or antidepressant response 278 depressed Mexican-American participants and 321 matched healthy controls. Although there is no significant interaction between the two genes, the remission rate of individual carrying the combination genotype at rs1880916 (AG/AA) and rs1549870 (GG) is significantly increased. We analyzed the global haplotype by examining 16 single-nucleotide polymorphisms (SNPs) in PDE11A and six SNPs in PDE1A. None of the haplotypes consisting of six SNPs in the PDE1A have a significant difference between depressed and control groups. Among haplotypes consisting of 16 SNPs across 440 kb in the PDE11A gene, 18 common haplotypes (with frequency higher than 0.8%) have been found in the studied population. Six haplotypes showed significantly different frequencies between the MDD group and the control group. The phylogenetic network result for the 16 SNPs showed that several historic recombination events have happened in the PDE11A gene. The frequency of one haplotype is significantly lower in the remitter group than in the nonremitter group for the depressed participants treated with either desipram

Published
2009

50. Multiple maternal origins of chickens: Out of the Asian jungles

Author

Liu, Yi-Ping, primary, Wu, Gui-Sheng, additional, Yao, Yong-Gang, additional, Miao, Yong-Wang, additional, Luikart, Gordon, additional, Baig, Mumtaz, additional, Beja-Pereira, Albano, additional, Ding, Zhao-Li, additional, Palanichamy, Malliya Gounder, additional, and Zhang, Ya-Ping, additional

Published
2006
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