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Objective To explore a mixed teaching method that can effectively improve the clinical capacity of students in the department of imaging and residence training. Methods Sixty-six students were enrolled in the First Hospital of Shanxi Medical University in past recent 2 years and were randomly divided into traditional group, modern group and comprehensive group. Each group adopted corresponding teaching methods. Recording the OSCE scores before and after the standardized training and teaching work, and using questionnaires to obtain students' satisfaction with teaching work and self-evaluation. Results The results of the three groups before and after the standardized training were statistically different (P＜0.05). There was no significant difference in OSCE scores among the three groups before standardized training. After the standardized training of the three groups of students, there was a statistical difference between the OSCE performance groups(P＜0.05),and the comprehensive group was better than the traditional group and the modern group. The comprehensive teaching group had the highest average satisfaction (AS) scores with the teaching mode(4.36). The effective use of time AS scores (4.23 and 4.27) in traditional education group and comprehensive education group were higher than those in modern education group (3.55). The AS scores (3.64 and 3.78) of the traditional group in the application of self-learning ability and clinical skills were lower than those of the modern group and the comprehensive group. Conclusions The quadruple mixed teaching method can effectively improve the clinical knowledge and skills of resident trainees in the imaging department in the residential training.

Background: The most visible sign of facial aging is often seen in the periocular area. However, periocular rejuvenation remains challenging due to the particularity of periocular anatomic locations. Aims: We aimed to evaluate the efficacy and safety of the fractional‐ablative CO2 laser‐facilitated recombinant human collagen permeation in periocular rejuvenation. Patients/Methods: This 3‐month prospective single‐blinded and self‐controlled trial enrolled 26 patients with periocular aging who underwent the treatments of fractional‐ablative CO2 laser along with laser‐facilitated recombinant human collagen permeation. Following the treatments, the patients were quantitatively assessed by various periocular skin aging indices before and after the treatment and monitored for any related adverse events. Results: The patients showed significant improvements with the periocular skin aging indices 3 months after the treatments, which were detailed with a 47.3% decrease in lower eyelid skin rhytids, a 41.4% decrease in the lower eyelid skin texture, a 35.0% decrease in the static crow's feet, a 29.3% decrease in the amount of upper eyelid laxity, and a 20.2% increase in the MRD1 as compared with baseline (p < 0.05). Moreover, total skin thickness under ultrasound was increased in both upper and lower eyelids (5.6% and 3.3%, p < 0.05, respectively). Moreover, six patients (23.1%, 6/26) had erythema for 2 weeks, and two (2/26, 7.7%) had mild hyperpigmentation for 3 months. Conclusions: Fractional‐ablative CO2 laser combined with laser‐facilitated recombinant human collagen permeation can be a safe and effective treatment for periocular rejuvenation. [ABSTRACT FROM AUTHOR]

Byline: Di-Qing. Luo, Juan-Hua. Liu, Rashmi. Sarkar, Yu-Kun. Zhao, Fang. Wang, Hui-Hui. Wu Sir, Almost everyone, especially people with longer hair, have experienced minor reversible tangling of scalp hair.[1] Because [...]

Promoted by K2 CO3 (2.0 equiv), the 1,3-dipolar [3+3] cy-cloaddition between 1, 4-benzodiazepinone-based nitrones and α-halohydroxamates processed smoothly under the mild reaction conditions and delivered structurally novel and complex cis - or trans -configured d -edge heterocycle-fused 1,4-benzodiazepinones in up to >99% isolated yield with >20:1 dr. The relative configuration of the title chemical entities was clearly identified with the use of single-crystal X-ray structure analysis. The reaction mechanism was assumed to interpret the diastereoselective production of the obtained cis - or trans -configured d -edge heterocycle-fused 1,4-benzodiazepinones. [ABSTRACT FROM AUTHOR]

In the presence of Na2 CO3 , conjugate addition of α-halo hydrazones to nitroso compounds proceeded readily to give polyfunctionalized nitrones in reasonable chemical yields and excellent stereoselectivities. The chemical structure and the stereochemical configuration of the products were unambiguously identified by an X-ray single-crystal structural analysis. [ABSTRACT FROM AUTHOR]

Under the catalysis of PhCO2 H, the 1,3-dipolar [3+2] cyclo-addition between pyrazolone-based olefins and N , N ′-cyclic azomethine imines proceeded readily, thus delivering structurally novel spiropyrazolones with up to 98% yield and >20:1 dr. The relative stereochemical configuration of the obtained spiropyrazolones was unambiguously -assigned by X-ray single-crystal structure analysis. The diastereoselective formation of the title spiropyrazolones was interpreted by the hypothesized reaction mechanism. [ABSTRACT FROM AUTHOR]

In the presence of Pd2 (dba)3 ·CHCl3 (2.5 mol%), PPh3 (10 mol%), and 60% NaH (1.5 equiv), the formal [5+3] cycloaddition between isatin-based α-(trifluoromethyl)imines and vinyloxiranes proceeded readily in 1,2-DCE at 40 ℃ and afforded cis -configured medium-heterocycle-fused spirooxindoles in the reasonable chemical yields with >20:1 dr. The relative stereochemical configuration of the title products was identified by X-ray diffraction analysis. [ABSTRACT FROM AUTHOR]

The formal [5+2] cycloaddition of vinyloxiranes with oxazol‐5‐(4H)‐ones proceeds readily at room temperature in THF in the presence of Pd2(dba)3·CHCl3, dppp, and K2CO3, thus furnishing the desired seven‐membered lactones in 67–96 % yield. The chemical structure of the title compounds was confirmed by X‐ray diffraction analysis. [ABSTRACT FROM AUTHOR]