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23. Clonal Analysis of Meningiomas

Author

Wu, Jilian K., primary, Wu, Jilian K., additional, MacGillavry, Melvin, additional, Kessaris, Christos, additional, Verheul, Bas, additional, Adelman, Lester S., additional, and Darras, Basil T., additional

Published
1996
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24. CuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo-Photothermal Therapy

Author

Yuxia Luan, Jilian Wu, Sanjay Garg, Huiyuan Zhang, Guangxi Zhai, Zhonghao Li, Wei Jiang, Jiang, Wei, Zhang, Huiyuan, Wu, Jilian, Zhai, Guangxi, Li, Zhonghao, Luan, Yuxia, and Garg, Sanjay

Subjects
Drug, Male, Materials science, media_common.quotation_subject, Serum albumin, 02 engineering and technology, Sulfides, 010402 general chemistry, Endocytosis, 01 natural sciences, quercetin, Cell Line, chemistry.chemical_compound, Mice, Drug Delivery Systems, negligible side effect, Animals, General Materials Science, Internalization, chemo−photothermal therapy, targeting, MOF, media_common, Mice, Inbred BALB C, biology, Hyperthermia, Induced, Neoplasms, Experimental, Photothermal therapy, Phototherapy, 021001 nanoscience & nanotechnology, Combinatorial chemistry, 0104 chemical sciences, Bioavailability, chemistry, Drug delivery, biology.protein, Quercetin, 0210 nano-technology, ZIF-8, Copper
Abstract

Quercetin (QT) is one promising candidate for the treatment of various cancers with virtually no toxic side effects. However, its anticancer effect is severely restricted by its poor bioavailability, low water solubility, and chemical instability in the neutral and alkaline medium. Herein, zeolitic imidazolate framework-8 (ZIF-8) is first reported as the multifunctional nanoplatform to the codelivery of quercetin asan anticancer agent and CuS nanoparticles as a photothermal therapy (PTT) agent for synergistic combination of chemotherapy and PTT as well as overcoming the drawbacks of quercetin. Moreover, folic acid−bovine serum albumin (FA−BSA) conjugates are applied to stabilize the CuS@ZIF-8-QTto promote the bioavailability of quercetin and realize active-targeting drug delivery. Near-infrared (NIR) fluorescent imaging demonstrated the highly increased drug accumulations of FA−BSA/CuS@ZIF-8-QT in tumors, resulting from efficient internalization via FA-receptors-mediated endocytosis. The results of in vivo and in vitro anticancer experiments demonstrate that quercetin and PTT agent can work together efficiently under NIR irradiation, thus remarkably improving the anticancer effect. Therefore, our newly designed FA−BSA/CuS@ZIF-8-QT multifunctional drug delivery system might be a promising nanoplatform for cancer treatment. Refereed/Peer-reviewed

Published
2018

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