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111 results on '"Wu, Jun-Jun"'

7. An Adjustable Adjuvant STINGsome for Tailoring the Potent and Broad Immunity Against SARS‐CoV‐2 and Monkeypox Virus via STING and Necroptosis

Author

Wu, Jun‐Jun, primary, Chen, Guan‐Jie, additional, Fan, Chen‐Yuan, additional, Shen, Fan, additional, Yang, Yi, additional, Pang, Wei, additional, Zhao, Zhen‐Nan, additional, Guan, Hong‐Xin, additional, Wu, Huan, additional, Lu, Ying, additional, Fu, Ya‐Juan, additional, Chen, Qi, additional, Zheng, Yong‐Tang, additional, and Ouyang, Songying, additional

Published
2023
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9. CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination

Author

Wu, Jun-Jun, primary, Chen, Fang-Yuan, additional, Han, Bei-Bei, additional, Zhang, Hong-Qing, additional, Zhao, Lang, additional, Zhang, Zhe-Rui, additional, Li, Juan-Juan, additional, Zhang, Bo-Dou, additional, Zhang, Ya-Nan, additional, Yue, Yu-Xin, additional, Hu, Hong-Guo, additional, Li, Wen-Hao, additional, Zhang, Bo, additional, Chen, Yong-Xiang, additional, Guo, Dong-Sheng, additional, and Li, Yan-Mei, additional

Published
2023
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15. Overcoming STING Agonists Barriers: Peptide, Protein, and Biomembrane‐based Biocompatible Delivery Strategies.

Author

Zheng, Yong‐Fang and Wu, Jun‐Jun

Subjects
*PEPTIDES, *PATTERN perception receptors, *PROTEINS, *VISUAL fields
Abstract

After development for more than ten years, stimulator of interferon genes (STING), a representative of pattern recognition receptors (PRRs), is now entering the stage of widespread applications. Along with the evolution of STING agonists of cyclic dinucleotides (CDNs) and non‐nucleotide molecules, the stability of agonists has been improved. However, their poor performance in clinical trials triggers urgent demands for highly effective delivery strategies to further improve the cellular permeability, tissue targetability and retention. In this review, we summarized the recent progress of STING agonists applications and delivery strategies with a focus on the biocompatible platforms of peptide, protein and biomembrane, providing a novel vision for the STING field and future direction. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Agonists and inhibitors of the STING pathway: Potential agents for immunotherapy.

Author

Wu, Jun‐Jun, Zhao, Lang, Hu, Hong‐Guo, Li, Wen‐Hao, and Li, Yan‐Mei

Subjects
TYPE I interferons, IMMUNOTHERAPY, DINUCLEOTIDES, AUTOIMMUNE diseases, THERAPEUTICS
Abstract

Since being discovered in 2008, the STING (stimulator of interferon genes) pathway has gradually been recognized as a central and promising target for immunotherapy. The STING pathway can be stimulated by cyclic dinucleotides (CDNs), leading to the type I interferons (IFN) production for immunotherapy for cancer or other diseases. However, the negative charges, hydrophilicity, and instability of CDNs have hindered their further applications. In addition, chronic activation of the STING pathway has been found to be involved in autoimmune diseases as IFN overproduction. Thus, research and development of STING agonists and inhibitors has been a hot field for the treatment of several diseases. The past several years, especially 2018, has seen increasingly rapid advances in this field. Here, this review summarizes the synthesis and modification of CDNs, the identification of nonnucleotide agonists, the recent progress in delivery systems and the medical applications, such as personalized vaccine adjuvants, in detail. In addition, in this review, we summarize the STING inhibitors' advances from two aspects, covalent, and noncovalent inhibitors. [ABSTRACT FROM AUTHOR]

Published
2020
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31. A Trusted Portable Computing Device

Author

Wu Jun-jun, Zhang Xin-fang, Fang Ming-wei, and Yu Peng-fei

Subjects
Cloud computing security, Computer science, authencification, trusted computing, Covert channel, Data security, Trusted Computing, Physics and Astronomy(all), Computer security model, Computer security, computer.software_genre, Security service, Trusted computing base, mobile storage, Trusted Platform Module, dynamic ecryption, computer
Abstract

A trusted portable computing device and its security mechanism were presented to solve the security issues, such as the attack of virus and Trojan horse, the lost and stolen of storage device, in mobile office. It used smart card to build a trusted portable security base, virtualization to create a secure virtual execution environment, two-factor authentication mechanism to identify legitimate users, and dynamic encryption to protect data privacy. The security environment described in this paper is characteristic of portability, security and reliability. It can meet the security requirement of mobile office.

Published
2012

34. Fully Synthetic Invariant NKT Cell-Dependent Self-Adjuvanting Antitumor Vaccines Eliciting Potent Immune Response in Mice

Author

Chen, Pu-Guang, Hu, Hong-Guo, Sun, Zhan-Yi, Li, Qian-Qian, Zhang, Bo-Dou, Wu, Jun-Jun, Li, Wen-Hao, Zhao, Yu-Fen, Chen, Yong-Xiang, and Li, Yan-Mei

Abstract

Constructing an effective therapeutic cancer vaccine is very attractive and promising for cancer immunotherapy. However, the poor immunogenicity of tumor antigens and suppression of the immune system in the tumor microenvironment are two major obstacles for developing effective cancer vaccines. Invariant NKT cells (iNKT cells), which are essential bridges between the innate and adaptive immune systems, can be rapidly activated by their agonists and, consequently, evoke whole immune systems. Herein, we conjugated a potent agonist of the iNKT cell, α-galactosylceramide (α-GalCer), with the tumor-associated MUC1 glycopeptide antigens as novel self-adjuvanting cancer vaccines through click chemistry. Immunological studies revealed that the mouse immune system was potently evoked and that high levels of tumor-specific IgG antibodies were elicited by vaccine conjugates without an external adjuvant. The produced antibodies could specifically recognize and bind to antigen-expressing cancer cells and, subsequently, induce cytotoxicity through complement-dependent cytotoxicity. Thus, the insertion of α-GalCer significantly improved the immunogenicity of the MUC1 glycopeptide and induced strong antigen-specific antitumor responses, indicating that α-GalCer is an effective built-in adjuvant for constructing potent chemical synthetic antitumor vaccines.

Published
2020
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35. Pam3CSK4-CDGSFAugments Antitumor Immunotherapy by Synergistically Activating TLR1/2 and STING

Author

Hu, Hong-Guo, Wu, Jun-Jun, Zhang, Bo-Dou, Li, Wen-Hao, and Li, Yan-Mei

Abstract

Cyclic dinucleotides (CDNs), agonists of stimulator of interferon genes (STING), are promising agents for immunotherapy. However, the application of CDNs has been limited by their instability and low transmembrane efficiency. Here, we introduced a conjugated adjuvant of STING and TLR1/2, Pam3CSK4-CDGSF. Conjugating CDGSFwith Pam3CSK4increased the stability and intracellular delivery. In addition, by synergistically activating the STING and TLR pathways, Pam3CSK4-CDGSFwas able to enhance immune activation. Both humoral and cellular immune responses were triggered by Pam3CSK4-CDGSFplus OVA (V4), and tumor growth was significantly inhibited after V4 administration. More importantly, V4 can also boost the antigen-specific CD8+ T cell response for cancer cell killing. Thus, the conjugated STING and TLR1/2 agonist Pam3CSK4-CDGSFcan serve as a potent adjuvant for vaccine construction to augment antitumor immunotherapy.

Published
2020
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38. Design of channel coding in digital video broadcasting system based on FPGA

Author

Shao Jia-lin, Meng Ming-chuan, and Wu Jun-jun

Subjects
Channel code, Computer science, business.industry, Concatenated error correction code, Reliability (computer networking), Data_CODINGANDINFORMATIONTHEORY, Digital Video Broadcasting, Code (cryptography), Electronic engineering, Forward error correction, Low-density parity-check code, Field-programmable gate array, business, Computer hardware
Abstract

This paper introduces the structure of digital video broadcasting system. A channel coding program is proposed that irregular LDPC code and series regular LDPC code are used to be a serially concatenated code. Use FPGA to implement the channel coding program. It can effectively improve the reliability of communications.

Published
2011

39. An indoor location-based access control system by RFID

Author

Fang Ming-wei, Zhang Xin-fang, and Wu Jun-jun

Subjects
Engineering, Spoofing attack, business.industry, Data security, Access control, Computer security, computer.software_genre, Cellular network, Wireless, Confidentiality, business, Replay attack, computer, Anonymity, Computer network
Abstract

With the rapid development of wireless and mobile network, traditional access control mechanisms face the new security risk that access data at any place may lead the leakage of the confidential data or bring new attack to the server. Location based access control is proposed to authorize user by consideration the location information of the user. In this paper, a novel indoor access control system is presented to protect the data security in mobile storage device. An Active tag is embedded into the storage device to implement location based access control. We make use of the limited penetration of RF signal to build the security zone, and get user's location information from the tag and the reader. In order to protect the system and carry out authorization, an authenticate protocol is proposed. The protocol can ensure the anonymity of the tag, and protect the confidential of the data to prevent spoofing attack and replay attack. More important, our system can authorize the user according to user's location information.

Published
2011

40. A Secure Software Download Framework Based on Mobile Trusted Computing

Author

Wu Jun-jun, Fang Ming-wei, Yu Peng-fei, and Zhang Xin-fang

Subjects
Authentication, business.industry, Computer science, Mobile computing, Cryptography, Trusted Computing, computer.software_genre, Computer security, Software framework, Software, Mobile telephony, business, computer, Mobile device, Computer network
Abstract

The number of software deployed on mobile terminals is dramatically increasing. However, this leads the mobile terminal facing a serious of security threats. In order to resolve these threat issues, several security requirements are proposed. Also, this paper introduces a secure software download framework and corresponding download protocol based on mobile trusted computing, designed to handle a collection of activities in software download. Such activities include authentication, download and installation of the software. The core part of the framework is a discretionary engine--Device Management Engine (DME), which provides entity authentication, integrity protection and remote attestation for the mobile device. By the introduction of software description file, we provide a mechanism to transfer Reference Integrity Metric (RIM), which makes up for the shortage of the specification.

Published
2009

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