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8. IDDF2022-ABS-0013 Comparing diagnostic performance of cantonese-chinese version of rome iv criteria and a short reference standard for functional dyspepsia

Author

Ho, Leonard, primary, Chen, Shuijiao, additional, Ho, Fai-Fai, additional, Wong, Charlene HL, additional, Ching, Jessica YL, additional, Cheong, Pui-Kuan, additional, Wu, Irene XY, additional, Liu, Xiaowei, additional, Leung, Ting-Hung, additional, Wu, Justin CY, additional, and Chung, Vincent CH, additional

Published
2022
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9. Latent tree analysis for the identification and differentiation of evidence-based Traditional Chinese Medicine diagnostic patterns: A primer for clinicians

Author

Ho, Leonard, Zhang, Nevin Lianwen, Xu, Yulong, Ho, Fai Fai, Wu, Irene XY, Chen, Shuijiao, Liu, Xiaowei, Yeung, Wing Fai, Wu, Justin CY, Chung, Vincent CH, Ho, Leonard, Zhang, Nevin Lianwen, Xu, Yulong, Ho, Fai Fai, Wu, Irene XY, Chen, Shuijiao, Liu, Xiaowei, Yeung, Wing Fai, Wu, Justin CY, and Chung, Vincent CH

Abstract

Background: A supplementary chapter on the diagnostic patterns of Traditional Medicine, including Traditional Chinese Medicine (TCM), was introduced into the latest edition of the International Classification of Diseases (ICD-11). However, evidence-based rules are yet to be developed for pattern differentiation in patients with specific conventional medicine diagnoses. Without such standardised rules, the level of diagnostic agreement amongst practitioners is unsatisfactory. This may reduce the reliability of practice and the generalisability of clinical research. Purpose: Using cross-sectional study data from patients with functional dyspepsia, we reviewed and illustrated a quantitative approach that combines TCM expertise and computer algorithmic capacity, namely latent tree analysis (LTA), to establish score-based pattern differentiation rules. Review of methods: LTA consists of six major steps: (i) the development of a TCM clinical feature questionnaire; (ii) statistical pattern discovery; (iii) statistical pattern interpretation; (iv) TCM diagnostic pattern identification; (v) TCM diagnostic pattern quantification; and (vi) TCM diagnostic pattern differentiation. Step (i) involves the development of a comprehensive questionnaire covering all essential TCM clinical features of the disease of interest via a systematic review. Step (ii) to (iv) required input from TCM experts, with the algorithmic capacity provided by Lantern, a dedicated software for TCM LTA. Motivational example to illustrate the methods: LTA is used to quantify the diagnostic importance of various clinical features in each TCM diagnostic pattern in terms of mutual information and cumulative information coverage. LTA is also capable of deriving score-based differentiation rules for each TCM diagnostic pattern, with each clinical feature being provided with a numerical score for its presence. Subsequently, a summative threshold is generated to allow pattern differentiation. If the total score of

Published
2022

16. sj-pdf-1-aim-10.1177_0964528420920299 - Supplemental material for Non-specific effects of acupuncture and sham acupuncture in clinical trials from the patient’s perspective: a systematic review of qualitative evidence

Author

Ho, Robin ST, Wong, Charlene HL, Wu, Justin CY, Wong, Samuel YS, and Chung, Vincent CH

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-1-aim-10.1177_0964528420920299 for Non-specific effects of acupuncture and sham acupuncture in clinical trials from the patient’s perspective: a systematic review of qualitative evidence by Robin ST Ho, Charlene HL Wong, Justin CY Wu, Samuel YS Wong and Vincent CH Chung in Acupuncture in Medicine

Published
2020
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17. Gastrointestinal Problems in Chinese Children with Autism Spectrum Disorder

Author

Lai,Kelly YC, Leung,Patrick WL, Hung,Se Fong, Shea,Caroline KS, Mo,Flora, Che,Kiti KI, Tse,Chun-Yu, Lau,Fanny LF, Ma,Suk Ling, Wu,Justin CY, So,Suzanne, Dadds,Mark R, Lai,Kelly YC, Leung,Patrick WL, Hung,Se Fong, Shea,Caroline KS, Mo,Flora, Che,Kiti KI, Tse,Chun-Yu, Lau,Fanny LF, Ma,Suk Ling, Wu,Justin CY, So,Suzanne, and Dadds,Mark R

Abstract

Kelly YC Lai,1 Patrick WL Leung,2 Se Fong Hung,1 Caroline KS Shea,3 Flora Mo,3 Kiti KI Che,3 Chun-Yu Tse,2 Fanny LF Lau,1 Suk Ling Ma,1 Justin CY Wu,4 Suzanne So,2 Mark R Dadds5 1Department of Psychiatry, Chinese University of Hong Kong, Shatin, Hong Kong; 2Department of Psychology, Chinese University of Hong Kong, Shatin, Hong Kong; 3Department of Psychiatry, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong; 4Department of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong; 5School of Psychology, University of Sydney, Sydney, AustraliaCorrespondence: Kelly YC LaiDepartment of Psychiatry, Chinese University of Hong Kong, Shatin, Hong KongTel +852 26076025Fax +852 26671255Email shwso@psy.cuhk.edu.hkPurpose: Gastrointestinal symptoms in individuals with autism spectrum disorder may constitute a subgroup with complex gut-brain interactions underlying the pathogenesis. This study examined the prevalence of gastrointestinal symptoms in a sample of Chinese children with autism spectrum disorder, as well as the factors related to them.Participants and Methods: The participants included a clinic sample of 107 children with autism spectrum disorder and 249 gender- and age-matched typically developing community children.Results: Results found children with autism spectrum disorder to be twice as likely to suffer from gastrointestinal symptoms, reporting increased rates of constipation, abdominal migraine and aerophagia. Autism spectrum disorder diagnosis remained a significant predictor of gastrointestinal symptoms after taking into account the potential confounders that included comorbid psychopathologies, diets, and parental anxiety and depression.Conclusion: Our results suggest that autism spectrum disorder with gastrointestinal symptoms may constitute a subgroup within the autism spectrum disorder population that warrants further investigation.Keywords: autism spectrum disorder, gastrointestinal symptoms, subgroup, children, Chinese

Published
2020

27. Faecal microbiota transplantation for treatment of recurrent or refractory Clostridioides difficile infection in Hong Kong

Author

Lui, Rashid N, primary, Wong, Sunny H, additional, Lau, Louis HS, additional, Chan, TT, additional, Cheung, Kitty CY, additional, Li, Amy YL, additional, Chin, ML, additional, Tang, Whitney WY, additional, Ching, Jessica YL, additional, Lam, Kelvin LY, additional, Chan, Paul KS, additional, Wu, Justin CY, additional, Sung, Joseph JY, additional, Chan, Francis KL, additional, and Ng, Siew C, additional

Published
2019
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29. Non-specific effects of acupuncture and sham acupuncture in clinical trials from the patient's perspective: a systematic review of qualitative evidence.

Author

Ho, Robin ST, Wong, Charlene HL, Wu, Justin CY, Wong, Samuel YS, and Chung, Vincent CH

Subjects
ACUPUNCTURE, CINAHL database, CLINICAL trials, CONCEPTUAL structures, EMPATHY, MEDICAL information storage & retrieval systems, PSYCHOLOGY information storage & retrieval systems, MEDLINE, SYSTEMATIC reviews, TREATMENT effectiveness, PATIENTS' attitudes, AMED (Information retrieval system)
Abstract

Background: Previous clinical trials have demonstrated that both acupuncture and sham acupuncture exert significant, non-specific effects on treatment outcomes when compared to no-treatment controls. A recently developed framework (mechanisms in orthodox and complementary and alternative medicine—MOCAM) suggests that the non-specific effects of acupuncture originate from multiple domains (e.g. patient characteristics, acupuncturist skill/technique, the patient–acupuncturist relationship, and the acupuncture environment). However, it remains to be determined precisely how these domains influence the non-specific effects of treatment among patients receiving acupuncture and sham acupuncture in clinical trials. Therefore, we conducted a systematic review to synthesize existing qualitative evidence on how trial participants randomized to acupuncture and sham acupuncture groups experience non-specific effects, regardless of the types of medical condition investigated. Methods: This systematic review included primary qualitative studies embedded in randomized controlled trials designed to investigate acupuncture or sham acupuncture interventions. Eligible studies published in English were derived from a search of five international databases. The methodological quality of included studies was evaluated using the Critical Appraisal Skills Programme (CASP) tool. Using a framework synthesis approach, the identified MOCAM framework was adapted based on the synthesis of the available qualitative evidence. Results: A total of 20 studies of high methodological quality were included. Our proposed model indicated that the effects of acupuncture may be increased by maintaining a professional status, applying a holistic treatment approach, practicing empathy, and providing patients with an appropriate explanation of the theory behind acupuncture and sham acupuncture. From the patient's perspective, the efficacy of treatment can be increased by following the lifestyle modification advice provided by acupuncturists, maintaining a positive attitude toward treatment efficacy, actively engaging with acupuncturists during consultation, and making behavioral changes based on experience gained during the trial. Conclusion: The results of this study may provide a basis for improving and standardizing key components of non-specific effects in acupuncture treatment, and for improving the isolation of specific effects in future clinical trials involving acupuncture and sham acupuncture. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Reduced lysosomal clearance of autophagosomes promotes survival and colonization ofHelicobacter pylori

Author

Zhang, Lin, primary, Hu, Wei, additional, Cho, Chi H, additional, Chan, Francis KL, additional, Yu, Jun, additional, Fitzgerald, J Ross, additional, Cheung, Cynthia KY, additional, Xiao, Zhan G, additional, Shen, Jing, additional, Li, Long F, additional, Li, Ming X, additional, Wu, Justin CY, additional, Ling, Thomas KW, additional, Chan, Jason YK, additional, Ko, Ho, additional, Tse, Gary, additional, Ng, Siew C, additional, Yu, Sidney, additional, Wang, Maggie HT, additional, Gin, Tony, additional, Ashktorab, Hassan, additional, Smoot, Duane T, additional, Wong, Sunny H, additional, Chan, Matthew TV, additional, and Wu, William KK, additional

Published
2018
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37. Factors influencing treatment outcome in patients with gastroesophageal reflux disease: outcome of a prospective pragmatic trial in Asian patients

Author

Goh, Khean Lee, primary, Choi, Kee Don, additional, Choi, Myung-Gyu, additional, Hsieh, Tsai-Yuan, additional, Jung, Hwoon-Yong, additional, Lien, Han-Chung, additional, Menon, Jayaram, additional, Mesenas, Steven, additional, Park, Hyojin, additional, Sheu, Bor-Shyang, additional, and Wu, Justin CY, additional

Published
2014
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41. Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole

Author

Tang,Raymond SY, Wu,Justin CY, Tang,Raymond SY, and Wu,Justin CY

Abstract

Raymond SY Tang, Justin CY Wu Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Abstract: Peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) are not uncommon in elderly patients. Clinical presentations of these acid-related disorders may be atypical in the geriatric population. Older individuals are at increased risk for poor outcomes in complicated PUD and for development of GERD complications. Multiple risk factors (eg, Helicobacter pylori [HP], use of nonsteroidal anti-inflammatory drugs [NSAIDs], aspirin) contribute to the development of PUD. Recent data has shown that HP-negative, NSAID-negative idiopathic peptic ulcers are on the rise and carry a higher risk of recurrent ulcer bleeding and mortality. Effective management of PUD in the geriatric population relies on identification and modification of treatable risk factors. Elderly patients with GERD often require long-term acid suppressive therapy. Proton pump inhibitors (PPI) including esomeprazole are effective in the treatment of reflux esophagitis, maintenance of GERD symptomatic control, and management of PUD as well as its complications. Potential safety concerns of long-term PPI use have been reported in the literature. Clinicians should balance the risks and benefits before committing elderly patients to long-term PPI therapy. Keywords: elderly patients, peptic ulcer disease, gastroesophageal reflux disease, proton pump inhibitor, esomeprazole

Published
2013

43. Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn's and Colitis Epidemiology Study

Author

Ng, Siew C., primary, Tang, Whitney, additional, Ching, Jessica Y., additional, Wong, May, additional, Chow, Chung Mo, additional, Hui, A.J., additional, Wong, T.C., additional, Leung, Vincent K., additional, Tsang, Steve W., additional, Yu, Hon Ho, additional, Li, Mo Fong, additional, Ng, Ka Kei, additional, Kamm, Michael A., additional, Studd, Corrie, additional, Bell, Sally, additional, Leong, Rupert, additional, de Silva, H. Janaka, additional, Kasturiratne, Anuradhani, additional, Mufeena, M.N.F., additional, Ling, Khoon Lin, additional, Ooi, Choon Jin, additional, Tan, Poh Seng, additional, Ong, David, additional, Goh, Khean L., additional, Hilmi, Ida, additional, Pisespongsa, Pises, additional, Manatsathit, Sathaporn, additional, Rerknimitr, Rungsun, additional, Aniwan, Satimai, additional, Wang, Yu Fang, additional, Ouyang, Qin, additional, Zeng, Zhirong, additional, Zhu, Zhenhua, additional, Chen, Min Hu, additional, Hu, Pin Jin, additional, Wu, Kaichun, additional, Wang, Xin, additional, Simadibrata, Marcellus, additional, Abdullah, Murdani, additional, Wu, Justin Cy, additional, Sung, Joseph J.Y., additional, and Chan, Francis K.L., additional

Published
2013
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44. Does Acupuncture Therapy Alter Activation of Neural Pathway for Pain Perception in Irritable Bowel Syndrome?: A Comparative Study of True and Sham Acupuncture Using Functional Magnetic Resonance Imaging

Author

Chu, Winnie CW, primary, Wu, Justin CY, additional, Yew, David TW, additional, Zhang, Liang, additional, Shi, Lin, additional, Yeung, David KW, additional, Wang, Defeng, additional, Tong, Raymond KY, additional, Chan, Yawen, additional, Lao, Lixing, additional, Leung, Ping C, additional, Berman, Brian M, additional, and Sung, Joseph JY, additional

Published
2012
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46. Response to Whiting and Ford

Author

Cheng, Chung-Wah, primary, Bian, Zhao-Xiang, additional, Zhu, Li-Xing, additional, Wu, Justin CY, additional, and Sung, Joseph JY, additional

Published
2011
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