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15 results on '"Wu, LuYin"'

9. Environmentally relevant concentrations of F–53B induce eye development disorders-mediated locomotor behavior in zebrafish larvae

Author

Wu, Luyin, primary, Zeeshan, Mohammed, additional, Dang, Yao, additional, Liang, Li-Ya, additional, Gong, Yan-Chen, additional, Li, Qing-Qing, additional, Tan, Ya-Wen, additional, Fan, Yuan-Yuan, additional, Lin, Li-Zi, additional, Zhou, Yang, additional, Liu, Ru-Qing, additional, Hu, Li-Wen, additional, Yang, Bo-Yi, additional, Zeng, Xiao-Wen, additional, Yu, Yunjiang, additional, and Dong, Guang-Hui, additional

Published
2022
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10. Perfluorooctane sulfonates induces neurobehavioral changes and increases dopamine neurotransmitter levels in zebrafish larvae

Author

Wu, Luyin, primary, Dang, Yao, additional, Liang, Li-Xia, additional, Gong, Yan-Chen, additional, Zeeshan, Mohammed, additional, Qian, Zhengmin, additional, Geiger, Sarah Dee, additional, Vaughn, Michael G., additional, Zhou, Yang, additional, Li, Qing-Qing, additional, Chu, Chu, additional, Tan, Ya-Wen, additional, Lin, Li-Zi, additional, Liu, Ru-Qing, additional, Hu, Li-Wen, additional, Yang, Bo-Yi, additional, Zeng, Xiao-Wen, additional, Yu, Yunjiang, additional, and Dong, Guang-Hui, additional

Published
2022
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11. Thyroid-Disrupting Effects of Cadmium and Mercury in Zebrafish Embryos/Larvae.

Author

Zhong, Liqiao, Zhang, He, Wu, Luyin, Ru, Huijun, Wei, Nian, Yao, Fan, Ni, Zhaohui, Duan, Xinbin, and Li, Yunfeng

Subjects
MERCURY, BRACHYDANIO, CADMIUM, MERCURY vapor, FISH larvae, EMBRYOS, URIDINE diphosphate, LARVAE, THYROID hormone receptors
Abstract

Cadmium (Cd2+) and mercury (Hg2+) are two kinds of non-essential heavy metals. Cd2+ and Hg2+ can cause thyroid disruption, but very few researchers have investigated the thyroid-disrupting effects of these metals on fish, specifically during their early developmental transition stage from embryos to larvae. In this study, wild-type zebrafish embryos were exposed to varying concentrations (contents) of Cd2+ (0, 10, 100, and 1000 μg/L) and Hg2+ (0, 0.1, 1, and 10 μg/L) for 120 h. Thereafter, the thyroid hormone contents and transcriptional changes in the genes, including thyroid stimulating hormone-β (tshβ), thyroglobulin (tg), sodium-iodide symporter (nis), thyroid peroxidase (tpo), transthyretin (ttr), thyroid hormone receptor-α and -β (thrα, thrβ), types I and II iodothyronine deiodinase (dio1, dio2), and uridine diphosphate glucuronosyltransferase 1 family a, b (ugt1ab) associated with the hypothalamic-pituitary-thyroid (HPT) axis were measured. Results showed that zebrafish embryos/larvae malformation rates were significantly higher in the Cd2+ and Hg2+ groups. A significant increase in the thyroxine (T4) concentration and a decrease in the triiodothyronine (T3) concentration were observed in the Cd2+-exposed zebrafish embryos/larvae. On the other hand, the T4 and T3 concentrations were observed to be significantly increased after Hg2+ exposure. Additionally, changes were noted in the expression patterns of the HPT axis-linked genes after Cd2+ and Hg2+ exposure. Based on the results of the principal component analysis (PCA), it was concluded that Cd2+ exposure significantly affected the thyroid endocrine system at a concentration of 100 μg/L, whereas Hg2+ exposure led to a thyroid disruption at a low concentration of 0.1 μg/L. Thus, this study demonstrated that exposure to Cd2+ and Hg2+ metal ions induced developmental toxicity and led to thyroid disruption in zebrafish embryos/larvae. [ABSTRACT FROM AUTHOR]

Published
2023
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