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2. Intraventricular 4D flow cardiovascular magnetic resonance for assessing patients with heart failure with preserved ejection fraction: a pilot study

Author

Kwan, Chi Ting, Ching, On Hang Samuel, Yap, Pui Min, Fung, Sau Yung, Tang, Hok Shing, Tse, Wan Wai Vivian, Kwan, Cheuk Nam Felix, Chow, Yin Hay Phoebe, Yiu, Nga Ching, Lee, Yung Pok, Lau, Jessica Wing Ka, Fong, Ambrose Ho Tung, Ren, Qing-Wen, Wu, Mei-Zhen, Wan, Eric Yuk Fai, Lee, Ka Chun Kevin, Leung, Chun Yu, Li, Andrew, Montero, David, Vardhanabhuti, Varut, Hai, Jojo Siu Han, Siu, Chung-Wah, Tse, Hung-Fat, Zingan, Valentin, Zhao, Xiaoxi, Wang, Haonan, Pennell, Dudley John, Mohiaddin, Raad, Senior, Roxy, Yiu, Kai-Hang, and Ng, Ming-Yen

Published
2023
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10. Target organ damage in untreated hypertensive patients with primary aldosteronism

Author

Li, Shi‐Min, primary, Huang, Jia‐Yi, additional, Zhu, Ching‐Yan, additional, Ng, Ming‐Yen, additional, Lin, Qing‐Shan, additional, Wu, Min, additional, Liu, Ming‐Ya, additional, Wang, Run, additional, Cao, Gao‐Zhen, additional, Chen, Cong, additional, Wu, Mei‐Zhen, additional, Ren, Qing‐Wen, additional, Tse, Hung‐Fat, additional, and Yiu, Kai‐Hang, additional

Published
2024
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11. Prediabetes is associated with increased cardiac events in patients with cancer who are prescribed anthracyclines

Author

Cheang, Iokfai, primary, Zhu, Xu, additional, Huang, Jia‐Yi, additional, Tse, Yi‐Kei, additional, Li, Hang‐Long, additional, Ren, Qing‐Wen, additional, Wu, Mei‐Zhen, additional, Chan, Yap‐Hang, additional, Xu, Xin, additional, Tse, Hung‐Fat, additional, Gue, Ying, additional, Lip, Gregory Y. H., additional, Li, Xinli, additional, and Yiu, Kai‐Hang, additional

Published
2024
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14. Statin Therapy Is Associated With a Lower Risk of Heart Failure in Patients With Atrial Fibrillation: A Population‐Based Study

Author

Huang, Jia‐Yi, primary, Chan, Yap‐Hang, additional, Tse, Yi‐Kei, additional, Yu, Si‐Yeung, additional, Li, Hang‐Long, additional, Chen, Cong, additional, Zhao, Chun‐Ting, additional, Liu, Ming‐Ya, additional, Wu, Mei‐Zhen, additional, Ren, Qing‐Wen, additional, Leung, Ka‐Lam, additional, Hung, Denise, additional, Li, Xin‐Li, additional, Tse, Hung‐Fat, additional, Lip, Gregory Y. H., additional, and Yiu, Kai‐Hang, additional

Published
2023
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15. Risk of hyperkalaemia in patients with type 2 diabetes mellitus prescribed with SGLT2 versus DPP-4 inhibitors

Author

Wu, Mei-zhen, primary, Teng, Tiew-Hwa Katherine, additional, Tsang, Christopher Tze-Wei, additional, Chan, Yap-Hang, additional, Lee, Chi-Ho, additional, Ren, Qing-wen, additional, Huang, Jia-Yi, additional, Cheang, Iok-fai, additional, Tse, Yi-Kei, additional, Li, Xin-li, additional, Xu, Xin, additional, Tse, Hung-Fat, additional, Lam, Carolyn S P, additional, and Yiu, Kai-Hang, additional

Published
2023
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17. Diagnostic Performance of Cardiovascular Magnetic Resonance Phase Contrast Analysis to Identify Heart Failure With Preserved Ejection Fraction.

Author

Lin, Lu, Kwan, Chi Ting, Yap, Pui Min, Fung, Sau Yung, Tang, Hok Shing, Tse, Wan Wai Vivian, Kwan, Cheuk Nam Felix, Chow, Yin Hay Phoebe, Yiu, Nga Ching, Lee, Yung Pok, Fong, Ambrose Ho Tung, Ren, Qing-Wen, Wu, Mei-Zhen, Lee, Ka Chun Kevin, Leung, Chun Yu, Li, Andrew, Montero, David, Vardhanabhuti, Varut, Hai, JoJo, and Siu, Chung-Wah

Published
2024
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22. Low-dose aspirin and incidence of lung carcinoma in patients with chronic obstructive pulmonary disease in Hong Kong: A cohort study

Author

Yu, Si-Yeung, Ip, Mary Sau-Man, Li, Xue, Cheung, Ka-Shing, Ren, Qing-Wen, Wu, Mei-Zhen, Li, Hang-Long, Wong, Pui-Fai, Tse, Hung-Fat, and Yiu, Kai-Hang

Subjects
Aspirin -- Dosage and administration -- Complications and side effects, Lung diseases, Obstructive -- Risk factors -- Drug therapy, Lung cancer -- Drug therapy -- Complications and side effects, Biological sciences
Abstract

Background Evidence suggests that chronic obstructive pulmonary disease (COPD) is associated with a higher risk of lung carcinoma. Using a territory-wide clinical electronic medical records system, we investigated the association between low-dose aspirin use ([less than or equal to]160 mg) among patients with COPD and incidence of lung carcinoma and the corresponding risk of bleeding. Methods and findings This is a retrospective cohort study conducted utilizing Clinical Data Analysis Reporting System (CDARS), a territory-wide database developed by the Hong Kong Hospital Authority. Inverse probability of treatment weighting (IPTW) was used to balance baseline covariates between aspirin nonusers (35,049 patients) with new aspirin users (7,679 patients) among all eligible COPD patients from 2005 to 2018 attending any public hospitals. The median age of the cohort was 75.7 years (SD = 11.5), and 80.3% were male. Competing risk regression with Cox proportional hazards model were performed to estimate the subdistribution hazard ratio (SHR) of lung carcinoma with low-dose aspirin and the associated bleeding events. Of all eligible patients, 1,779 (4.2%, 1,526 and 253 among nonusers and users) were diagnosed with lung carcinoma over a median follow-up period of 2.6 years (interquartile range [IQR]: 1.4 to 4.8). Aspirin use was associated with a 25% lower risk of lung carcinoma (SHR = 0.75, 95% confidence interval [CI] 0.65 to 0.87, p = Conclusions In this study, we observed that low-dose aspirin use was associated with a lower risk of lung carcinoma and lung carcinoma-related mortality among COPD patients. While aspirin was not associated with an increased risk of UGIB, the risk of hemoptysis was elevated., Author(s): Si-Yeung Yu 1,2, Mary Sau-Man Ip 2, Xue Li 2, Ka-Shing Cheung 2, Qing-Wen Ren 2, Mei-Zhen Wu 2, Hang-Long Li 2, Pui-Fai Wong 2, Hung-Fat Tse 2, Kai-Hang [...]

Published
2022
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25. Diagnostic Accuracy of Cardiovascular Magnetic Resonance Strain Analysis and Atrial Size to Identify Heart Failure with Preserved Ejection Fraction

Author

Ng, Ming-Yen, primary, Kwan, Chi Ting, additional, Yap, Pui Min, additional, Fung, Sau Yung, additional, Tang, Hok Shing, additional, Tse, Wan Wai Vivian, additional, Kwan, Cheuk Nam Felix, additional, Chow, Yin Hay Phoebe, additional, Yiu, Nga Ching, additional, Lee, Yung Pok, additional, Fong, Ambrose Ho Tung, additional, Hwang, Subin, additional, Fong, Zachary Fai Wang, additional, Ren, Qing-Wen, additional, Wu, Mei-Zhen, additional, Wan, Eric Yuk Fai, additional, Lee, Ka Chun Kevin, additional, Leung, Chun Yu, additional, Li, Andrew, additional, Montero, David, additional, Vardhanabhuti, Varut, additional, Hai, Jojo Siu Han, additional, Siu, Chung-Wah, additional, Tse, Hung-Fat, additional, Pennell, Dudley John, additional, Mohiaddin, Raad, additional, Senior, Roxy, additional, and Yiu, Kai-Hang, additional

Published
2023
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29. Comparison of Serum Ketone Levels and Cardiometabolic Efficacy of Dapagliflozin versus Sitagliptin among Insulin-Treated Chinese Patients with Type 2 Diabetes Mellitus

Author

Lee, Chi-Ho, primary, Wu, Mei-Zhen, additional, Lui, David Tak-Wai, additional, Chan, Darren Shing-Hei, additional, Fong, Carol Ho-Yi, additional, Shiu, Sammy Wing-Ming, additional, Wong, Ying, additional, Lee, Alan Chun-Hong, additional, Lam, Joanne King-Yan, additional, Woo, Yu-Cho, additional, Lam, Karen Siu-Ling, additional, Yiu, Kelvin Kai-Hang, additional, and Tan, Kathryn Choon-Beng, additional

Published
2022
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30. Chronic kidney disease begets heart failure and vice versa: temporal associations between heart failure events in relation to incident chronic kidney disease in type 2 diabetes

Author

Wu, Mei‐zhen, primary, Teng, Tiew‐Hwa Katherine, additional, Tay, Wan‐Ting, additional, Ren, Qing‐wen, additional, Tromp, Jasper, additional, Ouwerkerk, Wouter, additional, Chandramouli, Chanchal, additional, Huang, Jia‐Yi, additional, Chan, Yap‐Hang, additional, Teramoto, Kanako, additional, Yu, Si‐Yeung, additional, Lawson, Claire, additional, Li, Hang‐Long, additional, Tse, Yi‐Kei, additional, Li, Xin‐li, additional, Hung, Denise, additional, Tse, Hung‐Fat, additional, Lam, Carolyn S. P., additional, and Yiu, Kai‐Hang, additional

Published
2022
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32. Prediabetes Is Associated With Increased Risk of Heart Failure Among Patients With Atrial Fibrillation

Author

Huang, Jia-Yi, primary, Tse, Yi-Kei, additional, Li, Hang-Long, additional, Chen, Cong, additional, Zhao, Chun-Ting, additional, Liu, Ming-Ya, additional, Wu, Mei-Zhen, additional, Ren, Qing-Wen, additional, Yu, Si-Yeung, additional, Hung, Denise, additional, Li, Xin-Li, additional, Tse, Hung-Fat, additional, Lip, Gregory Y.H., additional, and Yiu, Kai-Hang, additional

Published
2022
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33. Epidemiology and Characteristics of Surgical Intervention for Infective Endocarditis: A Population-Based Study in the Past Two Decades (2000 – 2019) in Hong Kong

Author

Li, Hang-Long, primary, Tse, Yi-Kei, additional, Chen, Cong, additional, Cai, Si-Dong, additional, Su, Meng-Qi, additional, Wu, Mei-Zhen, additional, Ren, Qing-Wen, additional, Huang, Jia-Yi, additional, Yu, Si-Yeung, additional, Chan, Yap-Hang, additional, Tse, Hung-Fat, additional, and Yiu, Kai-Hang, additional

Published
2022
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35. Prognostic value of right ventricular remodelling in patients undergoing concomitant aortic and mitral valve surgery.

Author

Tse, Yi-Kei, Li, Hang-Long, Yu, Si-Yeung, Wu, Mei-Zhen, Ren, Qing-Wen, Huang, Jiayi, Tse, Hung-Fat, Bax, Jeroen J, and Yiu, Kai-Hang

Subjects
AORTIC valve surgery, MITRAL valve surgery, MITRAL valve insufficiency, LEFT heart ventricle, ECHOCARDIOGRAPHY, HEART valve prosthesis implantation, VENTRICULAR remodeling, RIGHT heart ventricle, AORTIC stenosis, TREATMENT effectiveness, PSYCHOLOGICAL tests, COMPARATIVE studies, PROSTHETIC heart valves, RIGHT ventricular dysfunction, DECISION making, DESCRIPTIVE statistics, CHI-squared test, RESEARCH funding, STROKE volume (Cardiac output), HEART physiology, LONGITUDINAL method, HEART failure, ALGORITHMS
Abstract

Aims Long-term risk stratification and surgical timing remain suboptimal in concomitant aortic and mitral (double) valve surgery. This study sought to examine the predictors, changes, and prognostic implications of right ventricular (RV) remodelling in patients undergoing double-valve surgery. Methods and results In 152 patients undergoing double-valve surgery, four RV remodelling patterns were characterized using transthoracic echocardiography: normal RV size and systolic function (Pattern 1); dilated RV (tricuspid annulus diameter >35 mm) with normal systolic function (Pattern 2); normal RV size with systolic dysfunction (percentage RV fractional area change <35%; Pattern 3); and dilated RV with systolic dysfunction (Pattern 4). The primary endpoint was the composite of heart failure hospitalization and all-cause mortality. Patterns 1, 2, 3, and 4 RV remodelling were present in 41, 20, 23, and 16% of patients, respectively. Patients with Stage 4 RV remodelling had worse renal function, higher EuroSCORE II, and impaired left ventricular ejection fraction. During a 3.7-year median follow up, 45 adverse events occurred. Patterns 3 and 4 RV remodelling were associated with significantly higher adverse event rates compared with Pattern 1 (37 and 75% vs. 11%, P < 0.01) and had incremental prognostic value when added to clinical parameters and EuroSCORE II (χ2 increased from 30 to 66, P < 0.01). At 1 year after surgery (n = 100), Patterns 3 and 4 RV remodelling had a higher risk of adverse events compared with Pattern 1. Conclusion Right ventricular remodelling was strongly related to adverse outcomes and deserves consideration as part of the risk and decision-making algorithms in double-valve surgery. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Concomitant Hepatorenal Dysfunction and Malnutrition in Valvular Heart Surgery: Long‐Term Prognostic Implications for Death and Heart Failure

Author

Tse, Yi‐Kei, primary, Chandramouli, Chanchal, additional, Li, Hang‐Long, additional, Yu, Si‐Yeung, additional, Wu, Mei‐Zhen, additional, Ren, Qing‐Wen, additional, Chen, Yan, additional, Wong, Pui‐Fai, additional, Sit, Ko‐Yung, additional, Chan, Daniel Tai‐Leung, additional, Ho, Cally Ka‐Lai, additional, Au, Wing‐Kuk, additional, Li, Xin‐Li, additional, Tse, Hung‐Fat, additional, Lam, Carolyn S. P., additional, and Yiu, Kai‐Hang, additional

Published
2022
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38. Incidence, Clinical Correlates, and Prognostic Impact of Dementia in Heart Failure: A Population-Based Cohort Study

Author

Ren, Qing-wen, Katherine Teng, Tiew-Hwa, Tse, Yi-Kei, Tay, Wan Ting, Li, Hang-Long, Tromp, Jasper, Yu, Si-Yeung, Hung, Denise, Wu, Mei-Zhen, Chen, Christopher, Yuk Yuen, Jacqueline Kwan, Huang, Jia-Yi, Ouwerkerk, Wouter, Li, Xin-Li, Teramoto, Kanako, Chandramouli, Chanchal, Tse, Hung-Fat, Lam, Carolyn S. P., Yiu, Kai-Hang, Epidemiology and Data Science, AII - Cancer immunology, CCA - Cancer Treatment and Quality of Life, CCA - Cancer biology and immunology, and CCA - Imaging and biomarkers

Subjects
heart failure, clinical correlates, sex differ, mortality, dementia
Abstract

Background: Heart failure (HF) may increase the risk of dementia via shared risk factors. Objectives: The authors investigated the incidence, types, clinical correlates, and prognostic impact of dementia in a population-based cohort of patients with index HF. Methods: The previously territory-wide database was interrogated to identify eligible patients with HF (N = 202,121) from 1995 to 2018. Clinical correlates of incident dementia and their associations with all-cause mortality were assessed using multivariable Cox/competing risk regression models where appropriate. Results: Among a total cohort aged ≥18 years with HF (mean age 75.3 ± 13.0 years, 51.3% women, median follow-up 4.1 [IQR: 1.2-10.2] years), new-onset dementia occurred in 22,145 (11.0%), with age-standardized incidence rate of 1,297 (95% CI: 1,276-1,318) per 10,000 in women and 744 (723-765) per 10,000 in men. Types of dementia were Alzheimer's disease (26.8%), vascular dementia (18.1%), and unspecified dementia (55.1%). Independent predictors of dementia included: older age (≥75 years, subdistribution hazard ratio [SHR]: 2.22), female sex (SHR: 1.31), Parkinson's disease (SHR: 1.28), peripheral vascular disease (SHR: 1.46), stroke (SHR: 1.24), anemia (SHR: 1.11), and hypertension (SHR: 1.21). The population attributable risk was highest for age ≥75 years (17.4%) and female sex (10.2%). New-onset dementia was independently associated with increased risk of all-cause mortality (adjusted SHR: 4.51; P < 0.001). Conclusions: New-onset dementia affected more than 1 in 10 patients with index HF over the follow-up, and portended a worse prognosis in these patients. Older women were at highest risk and should be targeted for screening and preventive strategies.

Published
2022

39. Chronic kidney disease begets heart failure and vice versa: temporal associations between heart failure events in relation to incident chronic kidney disease in type 2 diabetes.

Author

Wu, Mei‐zhen, Teng, Tiew‐Hwa Katherine, Tay, Wan‐Ting, Ren, Qing‐wen, Tromp, Jasper, Ouwerkerk, Wouter, Chandramouli, Chanchal, Huang, Jia‐Yi, Chan, Yap‐Hang, Teramoto, Kanako, Yu, Si‐Yeung, Lawson, Claire, Li, Hang‐Long, Tse, Yi‐Kei, Li, Xin‐li, Hung, Denise, Tse, Hung‐Fat, Lam, Carolyn S. P., and Yiu, Kai‐Hang

Subjects
*CHRONIC kidney failure, *TYPE 2 diabetes, *HEART failure, *CARDIO-renal syndrome, *KIDNEY diseases
Abstract

Aim: To investigate the interplay of incident chronic kidney disease (CKD) and/or heart failure (HF) and their associations with prognosis in a large, population‐based cohort with type 2 diabetes (T2DM). Methods: Patients aged ≥18 years with new‐onset T2DM, without renal disease or HF at baseline, were identified from the territory‐wide Clinical Data Analysis Reporting System between 2000 and 2015. Patients were followed up until December 31, 2020 for incident CKD and/or HF and all‐cause mortality. Results: Among 102 488 patients (median age 66 years, 45.7% women, median follow‐up 7.5 years), new‐onset CKD occurred in 14 798 patients (14.4%), in whom 21.7% had HF. In contrast, among 9258 patients (9.0%) with new‐onset HF, 34.6% had CKD. The median time from baseline to incident CKD or HF (4.4 vs. 4.1 years) did not differ. However, the median (interquartile range) time until incident HF after CKD diagnosis was 1.7 (0.5‐3.6) years and was 1.2 (0.2‐3.4) years for incident CKD after HF diagnosis (P < 0.001). The crude incidence of CKD was higher than that of HF: 17.6 (95% confidence interval [CI] 17.3‐17.9) vs. 10.6 (95% CI 10.4‐10.9)/1000 person‐years, respectively, but incident HF was associated with a higher adjusted‐mortality than incident CKD. The presence of either condition (vs. CKD/HF‐free status) was associated with a three‐fold hazard of death, whereas concomitant HF and CKD conferred a six to seven‐fold adjusted hazard of mortality. Conclusion: Cardiorenal complications are common and are associated with high mortality risk among patients with new‐onset T2DM. Close surveillance of these dual complications is crucial to reduce the burden of disease. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Prediabetes Is Associated With Increased Risk of Heart Failure Among Patients With Atrial Fibrillation.

Author

Huang, Jia-Yi, Tse, Yi-Kei, Li, Hang-Long, Chen, Cong, Zhao, Chun-Ting, Liu, Ming-Ya, Wu, Mei-Zhen, Ren, Qing-Wen, Yu, Si-Yeung, Hung, Denise, Li, Xin-Li, Tse, Hung-Fat, Lip, Gregory Y.H., and Yiu, Kai-Hang

Subjects
HEART failure patients, ATRIAL fibrillation, PREDIABETIC state, TYPE 2 diabetes
Abstract

OBJECTIVE: To evaluate the association between prediabetes and heart failure (HF) and the association of HF with changes in glycemic status. RESEARCH DESIGN AND METHODS: Patients newly diagnosed with atrial fibrillation (AF) between 2015 and 2018 were divided into three groups (normoglycemia, prediabetes, and type 2 diabetes) according to their baseline glycemic status. The primary outcome was incident HF. The Fine and Gray competing risks model was applied, with death defined as the competing event. RESULTS: Among 17,943 patients with AF (mean age 75.5 years, 47% female), 3,711 (20.7%) had prediabetes, and 10,127 (56.4%) had diabetes at baseline. Over a median follow-up of 4.7 years, HF developed in 518 (14%) patients with normoglycemia, 646 (15.7%) with prediabetes, and 1,795 (17.7%) with diabetes. Prediabetes was associated with an increased risk of HF compared with normoglycemia (subdistribution hazard ratio [SHR] 1.12, 95% CI 1.03–1.22). In patients with prediabetes at baseline, 403 (11.1%) progressed to diabetes, and 311 (8.6%) reversed to normoglycemia at 2 years. Compared with remaining prediabetic, progression to diabetes was associated with an increased risk of HF (SHR 1.50, 95% CI 1.13–1.97), whereas reversion to normoglycemia was associated with a decreased risk (SHR 0.61, 95% CI 0.42–0.94). CONCLUSIONS: Prediabetes was associated with an increased risk of HF in patients with AF. Compared with patients who remained prediabetic, those who progressed to diabetes at 2 years experienced an increased risk of HF, whereas those who reversed to normoglycemia incurred a lower risk of HF. [ABSTRACT FROM AUTHOR]

Published
2023
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41. CLINICAL IMPORTANCE OF GLOBAL ISCHEMIA ASSESSMENT IN STABLE CORONARY ARTERY DISEASE BASED ON A NOVEL ANGIOGRAPHY-BASED INDEX

Author

Leung, Ka Lam Calvin, primary, Lam, Lok Yee, additional, Li, Kwan Yu, additional, Yu, Shuk Yin, additional, Wu, Mei Zhen, additional, Ren, Qing Wen, additional, Wong, Pui Fai, additional, Tse, Yi Kei, additional, Yu, Si Yeung, additional, Li, Hang Long, additional, Feng, Yundi, additional, Huo, Yunlong, additional, Tse, Hung-Fat, additional, and Yiu, Kai Hang, additional

Published
2022
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46. Prevalence and Prognostic Importance of Massive Tricuspid Regurgitation in Patients Undergoing Tricuspid Annuloplasty With Concomitant Left-Sided Valve Surgery: A Study on Rheumatic Valvular Heart Disease

Author

Chen, Yan, primary, Chan, Yap-Hang, additional, Wu, Mei-Zhen, additional, Yu, Yu-Juan, additional, Lam, Yui-Ming, additional, Sit, Ko-Yung, additional, Chan, Daniel Tai-Leung, additional, Ho, Cally Ka-Lai, additional, Ho, Lai-Ming, additional, Lau, Chu-Pak, additional, Au, Wing-Kuk, additional, Tse, Hung-Fat, additional, and Yiu, Kai-Hang, additional

Published
2022
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47. Statin is Associated with a Lower Risk of Incident Dementia in Heart Failure Patients: A Territory-Wide Cohort Study in Hong Kong

Author

Ren, Qing-wen, primary, Tse, Yi-Kei, additional, Li, Hang Long, additional, Teng, Tiew-Hwa Katherine, additional, Yu, Si-Yeung, additional, Wu, Mei-zhen, additional, Li, Xin-Li, additional, Hung, Denise, additional, Chen, Cong, additional, Liu, Ming-ya, additional, Tse, Hung-Fat Tse, additional, Lam, Carolyn S.P., additional, and Yiu, Kai-Hang, additional

Published
2022
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48. Abstract 12130: Statin Use is Associated With Lower Risk of New Onset Dementia in Patients With Heart Failure: A Population-Based Study

Author

Qingwen Ren, Tse Yi Kei Stephanie, Si-Yeung Yu, Hang Long Li, Wong Pui Fai, Wu mei zhen, and Kai Hang Yiu

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Introduction: Increasing number of heart failure (HF) patients diagnosed with dementia due to improved treatment and aging population. Data relating to the association of statin use on the risk of dementia incidence among patients with HF are sparse. Hypothesis: The use of statin is associated with lower risk of new- onset dementia in HF population. Methods: Using a previously validated territory-wide clinical information registry, statin use was ascertained among all eligible patients with HF (N=241,995) from 1996 to 2019. Propensity score matching was used to balance baseline covariates between statin nonusers (167,738 patients) with statin users (74,257 patients). Competing risk regression with Cox proportional-hazard models was performed to estimate the risk of incident dementia associated with statin use. Results: Of all eligible subjects, the mean age was 76.5±13.0 years, 115,371(47.7%) was male. Over a median follow-up of 2.7 years (interquartile range [IQR]: 0.6 to 6.7), 13,482 (5.6%) patients were diagnosed with dementia including Alzheimer's disease (N=5,253), senile dementia uncomplicated (N=4,273), arteriosclerotic dementia (N=3,262), and others (N=694). Statin use (vs. none) was associated with a 58% lower risk of dementia incidence (multivariable-adjusted sub-distribution hazard ratio [SHR]=0.42; 95% Confidence Interval [CI], 0.38 to 0.46) after accounting for death as a competing risk. Moreover, the male gender was associated with a 51% lower risk of dementia incidence (multivariable-adjusted SHR=0.59; 95%CI (0.54-0.65) compared with females. Conclusions: Our study suggests that there is substantial sex difference in the incidence of dementia among HF patients. Moreover, statin use is associated with a significantly lower risk of incident dementia in HF.

Published
2021

49. Abstract 12454: Prognostic Value of Computational Pressure-Flow Dynamics Derived Fractional Flow Reserve in Non-Culprit Vessels Among Patients Presenting With Acute Coronary Syndrome and Multivessel Disease

Author

Leung, Ka Lam Calvin, primary, Lam, Lok Yee, additional, LI, Kwan Yu, additional, Yu, Shuk Yin, additional, Wu, Mei Zhen, additional, Ren, Qing Wen, additional, Wong, Pui Fai, additional, Tse, Yi Kei, additional, Yu, Si Yeung, additional, Li, Hang Long, additional, Feng, Yundi, additional, Huo, Yunlong, additional, Tse, Hung Fat, additional, and Yiu, Kai Hang, additional

Published
2021
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50. Abstract 10967: Prognostic Value of a Novel Index: Computational Pressure-Flow Dynamics Derived Fractional Flow Reserve in Stable Coronary Artery Disease Patients with Nonischemic Lesions

Author

LI, Kwan Yu, primary, Lam, Lok Yee Jane, additional, Leung, Ka Lam Calvin, additional, Wu, Mei Zhen, additional, Ren, Qingwen, additional, Li, Hang Long, additional, Yu, Si-Yeung, additional, Tse, Yi Kei Stephanie, additional, Yu, Shuk Yin, additional, Wong, Pui Fai, additional, Feng, Yundi, additional, Huo, Yunlong, additional, and Yiu, Kai Hang, additional

Published
2021
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