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In this work, a series of indole‐containing pyrazole‐carbohydrazide derivatives A1‐A25 were synthesized, and their biological activity on tubulin polymerization inhibition and mitotic catastrophe was evaluated. For introducing indole group to CA‐4 pattern, the carbohydrazide linker was used for the first time. As the top hit, A18 suggested notable antiproliferation efficacy and tubulin polymerization inhibitory activity. Inferring comparable antitubulin effect with the positive control Colchicine, A18 indicated obviously lower cyto‐toxicity. The cell scratch test showed that A18 could block the cell migration, while the confocal imaging depicted that A18 could induce the mitotic catastrophe via a Colchicine‐like approach. The docking simulation visualized the probable binding pattern of A18. With the information in this work, some new hints on modification might be involved in further tubulin‐related investigations. [ABSTRACT FROM AUTHOR]

To explore catalysts combining highly accessible specific surface areas with low recombination of the photo-induced electron–hole pairs, a novel SiO2@PDA@BiOBr composite photocatalyst with a hierarchical core–shell structure was prepared by a facile solvothermal method. The catalyst shows a superior performance on photodegradation of Rhodamine B under visible light irradiation, especially for SiO2@PDA-2@BiOBr with the reactant kinetics constant (k = 0.0487 min−1). The enhanced photocatalytic performance of SiO2@PDA-2@BiOBr was ascribed to the decreased band-gap, higher surface area, and effectively photo-generated electron–hole pairs by the introduction of polydopamine (PDA). In addition, the photocatalytic degradation is initiated by ṖO2− derived from dye photosensitization and h+ from the BiOBr. Cyclic experiments also indicate that the SiO2@PDA-2@BiOBr is reusable during the photodegradation process. The hierarchical core–shell SiO2@PDA@BiOBr photocatalyst will provide a theoretical model for the development of physical chemistry and structural properties of BiOBr-based composites to enhance the photocatalytic performances. [ABSTRACT FROM AUTHOR]

Nanorods-composed yolk–shell bimetallic-organic frameworks microspheres are successfully synthesized by a one-step solvothermal method in the absence of any template or surfactant. Furthermore, hierarchical double-shelled NiO/ZnO hollow spheres are obtained by calcination of the bimetallic organic frameworks in air. The NiO/ZnO hollow spheres, as supercapacitor electrodes, exhibit high capacitance of 497 F g−1 at the current density of 1.3 A g−1 and present a superior cycling stability. The superior electrochemical performance is believed to come from the unique double-shelled NiO/ZnO hollow structures, which offer free space to accommodate the volume change during the ion insertion and desertion processes, as well as provide rich electroactive sites for the electrochemical reactions. [ABSTRACT FROM AUTHOR]

Metal–organic frameworks (MOFs) are considered as suitable materials for various applications in the area of photocatalysis. On the other hand, 2D BiOBr materials are efficient for the photodegradation of organic dyes under visible light illumination. In this work, BiOBr/NH2-MIL-125(Ti) composite photocatalysts with different NH2-MIL-125(Ti) content were prepared by incorporating NH2-MIL-125(Ti) with BiOBr using a co-precipitation method. A series of characterizations confirmed the strong synergistic effect between BiOBr and NH2-MIL-125(Ti). In rhodamine B (RhB) degradation experiments, the composite photocatalyst with a mass percent of 7 wt% NH2-MIL-125(Ti) exhibited an improved photocatalytic activity compared to pristine BiOBr and NH2-MIL-125(Ti). Furthermore, the enhanced photocatalytic performance under visible light illumination could be attributed to the Ti3+–Ti4+ intervalence electron transfer and synergistic effect between NH2-MIL-125(Ti) and BiOBr, and also resulted in a separation efficiency of photo-generated electron–hole pairs during the photocatalytic reaction. This study can open up numerous opportunities for the development of various MOF-based visible light photocatalysts when combined with 2D bismuth oxyhalide materials for applications in environmental cleaning. [ABSTRACT FROM AUTHOR]

A hexagonal nanosheet LDH@ZIF-8 composite was fabricated by in situ growth of ZIF-8 on Zn–Al LDH without adding any zinc precursor, and exhibited a CO2 adsorption capacity of 1.0 mmol g−1 at room temperature and 1 bar, which was significantly higher than that of pure Zn–Al LDH or ZIF-8, indicating a synergy between ZIF-8 and Zn–Al LDH. [ABSTRACT FROM AUTHOR]

Background: Vasculogenic Mimicry (VM) can reduce the efficacy of anti-angiogenesis and promote distant metastasis in hepatocellular carcinoma (HCC). Our previous studies have found that Celastrus orbiculatus extract (COE) can inhibit the VM formation in HCC by reducing EphA2 expression. However the underlying mechanism related to EphA2 in VM formation is unclear., Purpose: This study aimed to confirm that EphA2 is one of the potential targets of COE, and to explore the effect of EphA2 in VM formation in hypoxia context in HCC., Methods: TCM Systems Pharmacology database and proteomics analysis were used to explore the key targets of COE in HCC treatment. CD31-PAS double staining and VE-CAD staining were used to indicate vasculogenic mimicry. The localization of EphA2 and VE-CAD was examined through fluorescent microscopy. CCK8 assay, cell invasion assay, and tube formation assay were used to indicate the formation of VM under hypoxic conditions. The regulatory relationship of EphA2 upstream and downstream molecules were evaluated through COIP and Western Blot. The nude mouse xenograft tumor models were used to observe the VM formation after knocking down or overexpressing EphA2., Results: EphA2 is identified to the target of COE, and the driving gene of HCC. In HCC surgical specimens, EphA2 expression is closely associated with the VM formation of HCC. COE-regulated EphA2 is involved in hypoxia-induced VM formation in HCC cells in vitro. EphA2 is regulated by HIF directly or indirectly by C-MYC. Overexpression of EphA2 can promote the VM formation of HCC in nude mice, while knocking down EphA2 can inhibit the VM formation., Conclusion: EphA2, as a target of COE, plays a crucial regulatory role in the formation of vasculogenic mimicry in HCC, involving upstream HIF/MYC transcriptional promotion and downstream PI3K/FAK/VE-CAD expression regulation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Chen, Dai, Wu, Wu, Yu, Liu, Chang and Liu.)

To explore catalysts combining highly accessible specific surface areas with low recombination of the photo-induced electron-hole pairs, a novel SiO 2 @PDA@BiOBr composite photocatalyst with a hierarchical core-shell structure was prepared by a facile solvothermal method. The catalyst shows a superior performance on photodegradation of Rhodamine B under visible light irradiation, especially for SiO 2 @PDA-2@BiOBr with the reactant kinetics constant (k = 0.0487 min -1 ). The enhanced photocatalytic performance of SiO 2 @PDA-2@BiOBr was ascribed to the decreased band-gap, higher surface area, and effectively photo-generated electron-hole pairs by the introduction of polydopamine (PDA). In addition, the photocatalytic degradation is initiated by ˙O 2 - derived from dye photosensitization and h + from the BiOBr. Cyclic experiments also indicate that the SiO 2 @PDA-2@BiOBr is reusable during the photodegradation process. The hierarchical core-shell SiO 2 @PDA@BiOBr photocatalyst will provide a theoretical model for the development of physical chemistry and structural properties of BiOBr-based composites to enhance the photocatalytic performances.

Metal-organic frameworks (MOFs) are considered as suitable materials for various applications in the area of photocatalysis. On the other hand, 2D BiOBr materials are efficient for the photodegradation of organic dyes under visible light illumination. In this work, BiOBr/NH 2 -MIL-125(Ti) composite photocatalysts with different NH 2 -MIL-125(Ti) content were prepared by incorporating NH 2 -MIL-125(Ti) with BiOBr using a co-precipitation method. A series of characterizations confirmed the strong synergistic effect between BiOBr and NH 2 -MIL-125(Ti). In rhodamine B (RhB) degradation experiments, the composite photocatalyst with a mass percent of 7 wt% NH 2 -MIL-125(Ti) exhibited an improved photocatalytic activity compared to pristine BiOBr and NH 2 -MIL-125(Ti). Furthermore, the enhanced photocatalytic performance under visible light illumination could be attributed to the Ti 3+ -Ti 4+ intervalence electron transfer and synergistic effect between NH 2 -MIL-125(Ti) and BiOBr, and also resulted in a separation efficiency of photo-generated electron-hole pairs during the photocatalytic reaction. This study can open up numerous opportunities for the development of various MOF-based visible light photocatalysts when combined with 2D bismuth oxyhalide materials for applications in environmental cleaning.