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Your search keyword '"Wu, Minying"' showing total 21 results
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21 results on '"Wu, Minying"'

19. Liquid metal-tailored gluten network for protein-based e-skin

Author

Chen, Bin, primary, Cao, Yudong, additional, Yan, Zhuo, additional, Liu, Rui, additional, Zhao, Yunjiao, additional, Zhang, Xiang, additional, Wu, Minying, additional, Qin, Yixiu, additional, Sun, Chang, additional, Yao, Wei, additional, Cao, Ziyi, additional, Ajayan, Pulickel, additional, Chee, Mason, additional, Dong, Pei, additional, Li, Zhaofen, additional, Shen, Jianfeng, additional, and Ye, Mingxin, additional

Published
2021
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20. Efficient Drug Delivery of Ti3C2TxMXenes for Synergistic Treatment of Human Hypopharyngeal Squamous Cell Carcinoma

Author

Wu, Minying, Yang, Jianqiang, Ye, Tong, Wang, Baoxin, Tang, Yi, and Ying, Xinjiang

Abstract

Ti3C2TxMXene is a versatile two-dimensional material that exhibits exceptional properties, such as an abundance of surface functional groups that facilitate modifications. Additionally, Ti3C2TxMXene possesses remarkable photothermal effects. In this study, ultrathin Ti3C2Txnanosheets with dimensions (∼200 nm) suitable for biological applications were prepared by ultrasonication of larger pieces of Ti3C2TxMXene with a cell pulverizer operating at a specific power. The ultrathin nanosheets exhibited a significant photothermal conversion efficiency (47.1%) under an 808 nm infrared laser irradiation. In addition, they showed an excellent mass extinction coefficient of 15.7 L g–1cm–1. By exploiting the intermolecular force between these ultrathin nanosheets and doxorubicin (DOX), a drug loading efficiency of 72.8% was achieved. Through layer-by-layer surface modification of a sulfhydryl-modified polymethacrylic acid (PMAsh) shell and a transferrin (Tf) layer with targeting function, a multifunctional nanomedicine platform (Ti3C2Tx-DOX-PMAsh-Tf) was constructed. Experiments executed in vitro with cells and in vivo to inhibit tumors manifested that Ti3C2Txis biocompatible. Furthermore, the results showed that the drug release behavior of Ti3C2Tx-DOX-PMAsh-Tf is responsive to glutathione (GSH) stimulation. The synergistic treatment of photothermal therapy and the anticancer drug DOX effectively achieved the inhibition of human hypopharyngeal squamous cell carcinoma.

Published
2023
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21. Efficient Drug Delivery of Ti 3 C 2 T x MXenes for Synergistic Treatment of Human Hypopharyngeal Squamous Cell Carcinoma.

Author

Wu M, Yang J, Ye T, Wang B, Tang Y, and Ying X

Subjects
Humans, Squamous Cell Carcinoma of Head and Neck, Drug Delivery Systems, Doxorubicin pharmacology, Titanium pharmacology, Head and Neck Neoplasms
Abstract

Ti 3 C 2 T x MXene is a versatile two-dimensional material that exhibits exceptional properties, such as an abundance of surface functional groups that facilitate modifications. Additionally, Ti 3 C 2 T x MXene possesses remarkable photothermal effects. In this study, ultrathin Ti 3 C 2 T x nanosheets with dimensions (∼200 nm) suitable for biological applications were prepared by ultrasonication of larger pieces of Ti 3 C 2 T x MXene with a cell pulverizer operating at a specific power. The ultrathin nanosheets exhibited a significant photothermal conversion efficiency (47.1%) under an 808 nm infrared laser irradiation. In addition, they showed an excellent mass extinction coefficient of 15.7 L g -1 cm -1 . By exploiting the intermolecular force between these ultrathin nanosheets and doxorubicin (DOX), a drug loading efficiency of 72.8% was achieved. Through layer-by-layer surface modification of a sulfhydryl-modified polymethacrylic acid (PMAsh) shell and a transferrin (Tf) layer with targeting function, a multifunctional nanomedicine platform (Ti 3 C 2 T x -DOX-PMAsh-Tf) was constructed. Experiments executed in vitro with cells and in vivo to inhibit tumors manifested that Ti 3 C 2 T x is biocompatible. Furthermore, the results showed that the drug release behavior of Ti 3 C 2 T x -DOX-PMAsh-Tf is responsive to glutathione (GSH) stimulation. The synergistic treatment of photothermal therapy and the anticancer drug DOX effectively achieved the inhibition of human hypopharyngeal squamous cell carcinoma.

Published
2023
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