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BackgroundMany app-based interventions targeting women with breast cancer have been developed and tested for effectiveness. However, information regarding the evaluation of the usage of these interventions is scarce. A better understanding of usage data is important to determine how women use apps and how these interventions affect health outcomes. ObjectiveThis study aimed to examine the usage duration and login frequency of an app-based intervention, the Breast Cancer e-Support (BCS) program, and to investigate the association between usage data and participants’ demographic and medical characteristics. MethodsThis study is a secondary data analysis of a randomized controlled trial assessing the effectiveness of the BCS program. The BCS program contains four modules: Learning Forum, Discussion Forum, Ask-the-Expert Forum, and Your Story Forum. A total of 57 women in the intervention group accessed the BCS program during their 12-week chemotherapy. The app’s background system tracked the usage duration and login frequency for each forum and the entire BCS program. ResultsThe total usage duration per participant ranged from 0 to 9371 minutes, and the login frequency per participant ranged from 0 to 774 times. The Discussion Forum and the Learning Forum were the most frequently used modules. The general linear model showed that age, education, family monthly income, and employment were associated with BCS usage duration and/or login frequency. Age (F1,45=10.09, P=.003, B=115.34, 95% CI 42.22-188.47) and education level (F1,45=7.22, P=.01, B=1949.63, 95% CI 487.76-3411.50) were positively associated with the usage duration of the entire BCS program. Family monthly income was positively associated with the usage duration of the Learning Forum (F1,45=11.85, P=.001, B=1488.55, 95% CI 617.58-2359.51) and the login frequency of the entire BCS program (F1,45=4.47, P=.04, B=113.68, 95% CI 5.33-222.03). Employment was negatively associated with the usage duration of the Ask-the-expert Forum (F1,45=4.50, P=.04, B=–971.87, 95% CI –1894.66 to –49.07) and the Your Story Forum (F1,45=5.36, P=.03, B=–640.71, 95% CI –1198.30 to –83.11) and positively associated with the login frequency of the entire BCS program (F1,45=10.86, P=.002, B=192.88, 95% CI 75.01-310.74). No statistical differences were found between BCS usage data and cancer stage, BMI, comorbidity, types of surgery, or cycles of chemotherapy. ConclusionsOverall, this study found considerable variability in the usage of app-based interventions. When health care professionals incorporate app-based interventions into their routine care for women with breast cancer, the learning and discussion functions of apps should be strengthened to promote engagement. Additionally, characteristics of women with breast cancer, such as age, level of education, income, and employment status, should be taken in consideration to develop tailored apps that address their particular needs and therefore improve their engagement with the app. Trial RegistrationAustralian New Zealand Clinical Trials Registry ACTRN12616000639426; http://www.ANZCTR.org.au/ACTRN12616000639426.aspx

Objective To investigate the effect of Traditional Chinese Medicine (TCM) umbilical moxibustion combined with diet nursing in the treatment of diarrhea of spleen and stomach Qi deficiency type in children. Methods Totally 72 pediatric patients with diarrhea of spleen and stomach qi deficiency type were divided into the control group(n=36) and study group(n=36) by coin tossing method. All pediatric patients received acupoint application treatment, and those in the study group were given TCM umbilical moxibustion combined with diet nursing. The effect of interventions was evaluated. The scores of main symptoms (stool characters and defecation frequency), secondary symptoms (bloated stomach after eating, loss of appetite, physical and mental fatigue) and negative conversion ratio of abnormal index (fat globules) of microscopy of two groups were compared. Results The total effective rate in the study group was higher than that in the control group (94. 44% vs. 72. 22%, P＜0. 05). The scores of main symptoms (Stool characters and defecation frequency )in the study group were lower than those in the control group after treatment(P0. 05). Conclusion The TCM umbilical moxibustion combined with diet nursing is effective to relive the clinical symptoms of pediatric patients with diarrhea of spleen and stomach qi deficiency type (目的 探讨中医脐灸联合饮食调护辅助治疗小儿脾胃气虚型泄泻的效果。方法 选取2020年2月—2022年11月医院收治的72例小儿脾胃气虚型泄泻患儿为研究对象, 采用投掷硬币法分成对照组(n=36)和研究组(n=36)。对照组接受穴位贴敷治疗, 研究组在对照组基础上增加中医脐灸联合基于辨证的饮食调护。评价治疗效果, 对比两组中医主症分级量化表积分(粪便性状积分、大便次数积分)、中医次症分级量化表积分(食后腹胀、食欲不振、倦怠乏力、神疲懒言)、粪便镜检中异常理化指标(脂肪球)的转阴率。结果 研究组总有效率94. 44%(34/36), 高于对照组的72. 22%(26/36), 差异有统计学意义(P0. 05)。结论 中医脐灸联合饮食调护辅助治疗小儿脾胃气虚型泄泻效果明确, 能有效改善患儿临床症状, 促进康复。)

Objective To investigate the effect of different radiation doses on the accuracy of iodine quantification and CT value of virtual monochromatic image with a muti-spectral CT iodine phantom using second-generation dual-layer detector spectral CT (DLCT). Methods The second-generation DLCT scan abdominal phantom was used, which consisted of six different concentrations of iodine rods at 4, 8 and 12 g/L. The scan parameters were set at 100, 120 and 140 kVp tube voltages, and six radiation exposure sequences were scanned at each tube voltage: 5, 10, 15, 20, 25 and 30 mGy. Measure the iodine concentration value and the CT value at the single level of 50, 70 and 100 keV, and calculate the absolute error value of iodine concentration and CT value under different radiation exposure. SPSS 22.0 software single factor analysis of variance was used to compare the difference between the iodine concentration and the absolute error of CT value under different Radiation exposure, and LSD method was used to compare the two groups. Results The absolute error of CT value of 4 g/L iodine rod with 10~30 mGy scanning at 100 keV energy level was significantly higher than that of 12 g/L and 8 g/L(P＜0.05), and the absolute error of iodine concentration measurement of other iodine rods with different concentrations at different Radiation exposure had no statistical difference. Conclusions The second-generation double-layer detector spectral CT has high measurement stability for iodine concentration quantification and CT value accuracy under conditions of radiation dose greater than 5 mGy.

Isoflurane, a commonly used inhaled anesthetic, has been found to have a cardioprotective effect. However, the precise mechanisms have not been fully elucidated. Here, we found that isoflurane preconditioning enhanced OGD/R‐induced upregulation of miR‐210, a hypoxia‐responsive miRNA, in AC16 human myocardial cells. To further test the roles of miR‐210 in regulating the effects of isoflurane preconditioning on OGD/R‐induced cardiomyocyte injury, AC16 cells were transfected with anti‐miR‐210 or control anti‐miRNA. Results showed that isoflurane preconditioning attenuated OGD/R‐induced cardiomyocyte cytotoxicity (as assessed by cell viability, LDH and CK‐MB levels), which could be reversed by anti‐miR‐210. Isoflurane preconditioning also prevented OGD/R‐induced increase in apoptotic rate, caspase‐3 and caspase‐9 activities, and Bax level and decrease in Bcl‐2 expression level, while anti‐miR‐210 blocked these effects. We also found that anti‐miR‐210 prevented the inhibitory effects of isoflurane preconditioning on OGD/R‐induced decrease in adenosine triphosphate content; mitochondrial volume; citrate synthase activity; complex I, II, and IV activities; and p‐DRP1 and MFN2 expression. Besides, the expression of BNIP3, a reported direct target of miR‐210, was significantly decreased under hypoxia condition and could be regulated by isoflurane preconditioning. In addition, BNIP3 knockdown attenuated the effects of miR‐210 silencing on the cytoprotection of isoflurane preconditioning. These findings suggested that isoflurane preconditioning exerted protective effects against OGD/R‐induced cardiac cytotoxicity by regulating the miR‐210/BNIP3 axis. Isoflurane preconditioning elicited cardioprotection against OGD/R‐induced cardiomyocyte injury via maintaining mitochondrial function by regulating the miR‐210/BNIP3 axis. Our study provided new evidence for the underlying molecular mechanisms of protective effects of isoflurane preconditioning against OGD/R‐induced injury in cardiomyocytes. [ABSTRACT FROM AUTHOR]

N2 electroreduction reaction (NRR) enables an eco‐friendly NH3 synthesis under mild conditions, which is regarded as a carbon‐neutral alternative technology to the traditional Haber–Bosch process. However, its practical applications are seriously impeded by the difficulty in N2 adsorption and activation over catalysts, as well as the competing hydrogen evolution reaction (HER). In this work, a novel bismuth molybdate nanocatalyst with sufficient oxygen vacancies and high Biconcentration (41.9 at%), BiMoO‐OVs, is synthesized and demonstrated as an excellent NRR electrocatalyst. Benefiting from synergistic effect of the adequate Bi active centers with inert HER activity provided by the high concentration of Bi, and the reinforced N2 adsorption and activation ability of oxygen vacancies, the as‐synthesized BiMoO‐OVs presents a high Faradaic efficiency of 16.38% with a NH3 yield rate of 3.65 µg h−1 cm−2 at −0.4 V (vs RHE) in neutral electrolyte, which outperforms those of most Bi‐based NRR nanocatalysts. Noticeably, it also presents excellent electrochemical durability for at least 24 h. The present work provides a simple and effective strategy for designing low‐cost and high‐performance Bi‐based catalysts. [ABSTRACT FROM AUTHOR]

Objective: Polo‐like kinase 1 (PLK1), a serine/threonine‐protein kinase, functions as a potent oncogene in the initiation and progression of tumor. The aim of this study is to assess potential correlations between PLK1 expression and immune infiltration in breast cancer (BRCA) and construct a PLK1‐based immune risk model applicable for prognosis and treatment response prediction in BRCA. Methods: We collected data on PLK1 gene expression in BRCA patients from The Cancer Genome Atlas (TCGA) database. Thereafter, we analyzed the associations of PLK1 expression with immune cell infiltration and immunomodulators, and established a prognostic risk model based on seven PLK1‐associated immunomodulator genes and a nomogram for survival prediction. Results: BRCA prognosis, clinical stage progression, and tumor classification were all shown to be substantially correlated with PLK1 expression. The PLK1 gene was significantly enriched in T cell and B cell receptors and molecules of the chemokine signaling pathways. Specifically, PLK1 expression was positively correlated with the CD8+ T cell and regulatory T cell (Tregs) activation and negatively correlated with M2 macrophage infiltration. The seven‐genes‐based risk model could serve as an independent prognostic factor of BRCA. The risk model was markedly correlated with the expression of programmed cell death protein 1/programmed cell death ligand 1 (PD‐1/PD‐L1; both p < 0.001) immune checkpoints, and tumor mutation burden (TMB). High‐ and low‐risk BRCA patients identified by the risk model responded differently to anti‐PD‐1 and/or anti‐CTLA4 therapy, as well as common chemotherapy drugs, like cisplatin, paclitaxel, and gemcitabine. Conclusion: This PLK1‐based immune risk model can effectively predict the prognosis and tumor progression of BRCA, identify gene mutations, and evaluate patient's response toward immunotherapy and chemotherapy regimens. [ABSTRACT FROM AUTHOR]

The pollution of ammonia-nitrogen in water became more serious with the development of the industry. In this paper, hydroxyapatite (HAP) was prepared from waste fish scales; the XRD, FTIR, SEM, TEM and Raman were used to characterize the prepared samples, and the prepared HAP samples were studied as degradation photocatalyst and adsorbing material for the removal of ammonia-nitrogen. The ammonia-nitrogen removal efficiency (ANRE, Removal Rate = (Initial Concentration–Current Concentration)/Initial Concentration × 100%) of the samples was also discussed. The results showed that the HAP sample, which was calcinated at 800 °C for 2 h, had the best ANRE, which was 41%. The UV-Vis, EIS, and PL were used to analyze the reason for the different ANRE. The reason for the high ANRE was attributed to the samples' superior adsorption capability resulting from their large specific surface area, as well as their superior properties for photocatalytic degradation. This was a meaningful work to explore a treatment of ammonia-nitrogen by HAP. [ABSTRACT FROM AUTHOR]