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Oral probiotics have significant potential for preventing and treating many diseases. Yet, their efficacy is often hindered by challenges related to survival and colonization within the gastrointestinal tract. Nanoparticles emerge as a transformative solution, offering robust protection and enhancing the stability and bioavailability of these probiotics. This review explores the innovative application of nanoparticle-armored engineered probiotics for precise disease treatment, specifically addressing the physiological barriers associated with oral administration. A comprehensive evaluation of various nano-armor probiotics and encapsulation methods is provided, carefully analyzing their respective merits and limitations, alongside strategies to enhance probiotic survival and achieve targeted delivery and colonization within the gastrointestinal tract. Furthermore, the review explores the potential clinical applications of nano-armored probiotics in precision therapeutics, critically addressing safety and regulatory considerations, and proposing the innovative concept of 'probiotic intestinal colonization with nano armor' for brain-targeted therapies. Ultimately, this review aspires to guide the advancement of nano-armored probiotic therapies, driving progress in precision medicine and paving the way for groundbreaking treatment modalities. [ABSTRACT FROM AUTHOR]

In this paper, we propose a self-synchronization algorithm for audio watermarking to facilitate assured audio data transmission. The synchronization codes are embedded into audio with the informative data, thus the embedded data have the self-synchronization ability. To achieve robustness, we embed the synchronization codes and the hidden informative data into the low frequency coefficients in DWT (discrete wavelet transform) domain. By exploiting the time-frequency localization characteristics of DWT, the computational load in searching synchronization codes has been dramatically reduced, thus resolving the contending requirements between robustness of hidden data and efficiency of synchronization codes searching. The performance of the proposed scheme in terms of SNR (signal to noise ratio) and BER (bit error rate) is analyzed. An estimation formula that connects SNR with embedding strength has been provided to ensure the transparency of embedded data. BER under Gaussian noise corruption has been estimated to evaluate the performance of the proposed scheme. The experimental results are presented to demonstrate that the embedded data are robust against most common signal processing and attacks, such as Gaussian noise corruption, resampling, requantization, cropping, and MP3 compression. Index Terms--Audio watermarking, audio data transmission, cropping, robustness, self-synchronization, wavelet.

We theoretically study the properties of the ground state of the parallel-coupled double quantum dot embedded in a mesoscopic ring in the Kondo regime by means of the two-impurity Anderson Hamiltonian. The Hamiltonian is solved by means of the slave-boson mean-field theory. Our results that when the system goes into the strong coupling regime, two parallel dots can are coupled coherently, which leads to an enhanced Kondo effect and a giant persistent current emerging in this system. This double quantum dot device might be a possible candidate for future device applications. [Copyright &y& Elsevier]