Search

Your search keyword '"Wu, T.-C."' showing total 1,970 results
Start Over Author "Wu, T.-C."
1,970 results on '"Wu, T.-C."'

1. Ultrafast terahertz field control of the emergent magnetic and electronic interactions at oxide interfaces

Author

Derrico, A. M., Basini, M., Unikandanunni, V., Paudel, J. R., Kareev, M., Terilli, M., Wu, T. -C., Alostaz, A., Klewe, C., Shafer, P., Gloskovskii, A., Schlueter, C., Schneider, C. M., Chakhalian, J., Bonetti, S., and Gray, A. X.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

Ultrafast electric-field control of emergent electronic and magnetic states at oxide interfaces offers exciting prospects for the development of new generations of energy-efficient devices. Here, we demonstrate that the electronic structure and emergent ferromagnetic interfacial state in epitaxial LaNiO3/CaMnO3 superlattices can be effectively controlled using intense single-cycle THz electric-field pulses. We employ a combination of polarization-dependent X-ray absorption spectroscopy with magnetic circular dichroism and X-ray resonant magnetic reflectivity to measure a detailed magneto-optical profile and thickness of the ferromagnetic interfacial layer. Then, we use time-resolved and temperature-dependent magneto-optical Kerr effect, along with transient optical reflectivity and transmissivity measurements, to disentangle multiple correlated electronic and magnetic processes driven by ultrafast high-field (~1 MV/cm) THz pulses. These processes include an initial sub-picosecond electronic response, consistent with non-equilibrium Joule heating; a rapid (~270 fs) demagnetization of the ferromagnetic interfacial layer, driven by THz-field-induced nonequilibrium spin-polarized currents; and subsequent multi-picosecond dynamics, possibly indicative of a change in the magnetic state of the superlattice due to the transfer of spin angular momentum to the lattice. Our findings shed light on the intricate interplay of electronic and magnetic phenomena in this strongly correlated material system, suggesting a promising avenue for efficient control of two-dimensional ferromagnetic states at oxide interfaces using ultrafast electric-field pulses.

Published
2024

5. Direct experimental evidence of tunable charge transfer at the $LaNiO_{3}/CaMnO_{3}$ ferromagnetic interface

Author

Paudel, J. R., Terilli, M., Wu, T. -C., Grassi, J. D., Derrico, A. M., Sah, R. K., Kareev, M., Klewe, C., Shafer, P., Gloskovskii, A., Schlueter, C., Strocov, V. N., Chakhalian, J., and Gray, A. X.

Subjects
Condensed Matter - Materials Science
Abstract

Interfacial charge transfer in oxide heterostructures gives rise to a rich variety of electronic and magnetic phenomena. Designing heterostructures where one of the thin-film components exhibits a metal-insulator transition opens a promising avenue for controlling such phenomena both statically and dynamically. In this letter, we utilize a combination of depth-resolved soft X-ray standing-wave and hard X-ray photoelectron spectroscopies in conjunction with polarization-dependent X-ray absorption spectroscopy to investigate the effects of the metal-insulator transition in $LaNiO_{3}$ on the electronic and magnetic states at the $LaNiO_{3}/CaMnO_{3}$ interface. We report on a direct observation of the reduced effective valence state of the interfacial Mn cations in the metallic superlattice with an above-critical $LaNiO_{3}$ thickness (6 u.c.) due to the leakage of itinerant Ni 3d $e_{g}$ electrons into the interfacial $CaMnO_{3}$ layer. Conversely, in an insulating superlattice with a below-critical $LaNiO_{3}$ thickness of 2 u.c., a homogeneous effective valence state of Mn is observed throughout the $CaMnO_{3}$ layers due to the blockage of charge transfer across the interface. The ability to switch and tune interfacial charge transfer enables precise control of the emergent ferromagnetic state at the $LaNiO_{3}/CaMnO_{3}$ interface and, thus, has far-reaching consequences on the future strategies for the design of next-generation spintronic devices.

Published
2023

6. Direct experimental evidence of tunable charge transfer at the LaNiO3/CaMnO3 ferromagnetic interface

Author

Paudel, JR, Terilli, M, Wu, T-C, Grassi, JD, Derrico, AM, Sah, RK, Kareev, M, Wen, F, Klewe, C, Shafer, P, Gloskovskii, A, Schlueter, C, Strocov, VN, Chakhalian, J, and Gray, AX

Subjects
Engineering, Physical Sciences, Condensed Matter Physics, Chemical sciences, Physical sciences
Abstract

Interfacial charge transfer in oxide heterostructures gives rise to a rich variety of electronic and magnetic phenomena. Designing heterostructures where one of the thin-film components exhibits a metal-insulator transition opens a promising avenue for controlling such phenomena both statically and dynamically. In this work, we utilize a combination of depth-resolved soft x-ray standing-wave and hard x-ray photoelectron spectroscopies in conjunction with polarization-dependent x-ray absorption spectroscopy to investigate the effects of the metal-insulator transition in LaNiO3 on the electronic and magnetic states at the LaNiO3/CaMnO3 interface. We report a direct observation of the reduced effective valence state of the interfacial Mn cations in the metallic superlattice with an above-critical LaNiO3 thickness (6 unit cells, u.c.) facilitated by the charge transfer of itinerant Ni3deg electrons into the interfacial CaMnO3 layer. Conversely, in an insulating superlattice with a below-critical LaNiO3 thickness of 2u.c., a homogeneous effective valence state of Mn is observed throughout the CaMnO3 layers due to the blockage of charge transfer across the interface. The ability to switch and tune interfacial charge transfer enables precise control of the emergent ferromagnetic state at the LaNiO3/CaMnO3 interface and, thus, has far-reaching consequences on the future strategies for the design of next-generation spintronic devices.

Published
2023

8. In situ vaccination via tissue-targeted cDC1 expansion enhances the immunogenicity of chemoradiation and immunotherapy

Author

Lam, Brandon, Kung, Yu Jui, Lin, John, Tseng, Ssu-Hsueh, Tu, Hsin-Fang, Huang, Claire, Lee, Brandon, Velarde, Esteban, Tsai, Ya Chea, Villasmil, Rafael, Park, Sung Taek, Xing, Deyin, Hung, Chien-Fu, and Wu, T.- C.

Subjects
Chemotherapy -- Patient outcomes, Tumor antigens -- Testing, Apoptosis -- Health aspects, Cancer vaccines -- Dosage and administration, Cancer -- Chemotherapy, Radiotherapy -- Patient outcomes, Health care industry
Abstract

Even with the prolific clinical use of next-generation cancer therapeutics, many tumors remain unresponsive or become refractory to therapy, creating a medical need. In cancer, DCs are indispensable for T cell activation, so there is a restriction on cytotoxic T cell immunity if DCs are not present in sufficient numbers in the tumor and draining lymph nodes to take up and present relevant cancer antigens. To address this bottleneck, we developed a therapeutic based on albumin fused with FMS-related tyrosine kinase 3 ligand (Alb-Flt3L) that demonstrated superior pharmacokinetic properties compared with Flt3L, including significantly longer half-life, accumulation in tumors and lymph nodes, and cross-presenting-DC expansion following a single injection. We demonstrated that Alb-Flt3L, in combination with standard-of-care chemotherapy and radiation therapy, serves as an in situ vaccination strategy capable of engendering polyclonal tumor neoantigen- specific immunity spontaneously. In addition, Alb-Flt3L-mediated tumor control synergized with immune checkpoint blockade delivered as anti-PD-L1. The mechanism of action of Alb-Flt3L treatment revealed a dependency on Batf3, type I IFNs, and plasmacytoid DCs. Finally, the ability of Alb-Flt3L to expand human DCs was explored in humanized mice. We observed significant expansion of human cross-presenting-DC subsets, supporting the notion that Alb-Flt3L could be used clinically to modulate human DC populations in future cancer therapeutic regimens., Introduction The ability to engender potent neoantigen- or tumor-associated antigen-specific [CD8.sup.+] cytotoxic T cell immunity is indispensable to the long-term therapeutic efficacy of essentially all cancer treatment strategies. Classical methods [...]

Published
2024
Full Text
View/download PDF

18. Immune responses, therapeutic anti-tumor effects, and tolerability upon therapeutic HPV16/18 E6/E7 DNA vaccination via needle-free biojector

Author

Peng, Shiwen, primary, Tu, Hsin-Fang, additional, Cheng, Michelle, additional, Hu, Ming-Hung, additional, Tsai, Hua-Ling, additional, Tsai, Ya-Chea, additional, Koenig, Chelsea, additional, Brayton, Cory, additional, Wang, Hao, additional, Chang, Yung-Nien, additional, Arend, Rebecca C., additional, Levinson, Kimberly, additional, Roden, Richard B. S., additional, Wu, T. C., additional, and Hung, Chien-Fu, additional

Published
2023
Full Text
View/download PDF

27. Figure S1 from Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics

Author

Xing, Deyin, primary, Zheng, Gang, primary, Pallavajjala, Aparna, primary, Schoolmeester, J. Kenneth, primary, Liu, Yuehua, primary, Haley, Lisa, primary, Hu, Yan, primary, Liu, Li, primary, Logan, Lisa, primary, Lin, Yuan, primary, Pearce, Kathryn E., primary, Sattler, Christopher A., primary, Tsai, Ya Chea, primary, Vang, Russell, primary, Hung, Chien-Fu, primary, Wu, T.-C., primary, and Ronnett, Brigitte M., primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figure 1 from Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell–Mediated Tumor Control in the Genital Tract

Author

Sun, Yun-Yan, primary, Peng, Shiwen, primary, Han, Liping, primary, Qiu, Jin, primary, Song, Liwen, primary, Tsai, Yachea, primary, Yang, Benjamin, primary, Roden, Richard B.S., primary, Trimble, Cornelia L., primary, Hung, Chien-Fu, primary, and Wu, T.-C., primary

Published
2023
Full Text
View/download PDF

31. Supplementary Figure 2 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8+ T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ

Author

Soong, Ruey-Shyang, primary, Song, Liwen, primary, Trieu, Janson, primary, Knoff, Jayne, primary, He, Liangmei, primary, Tsai, Ya-Chea, primary, Huh, Warner, primary, Chang, Yung-Nien, primary, Cheng, Wen-Fang, primary, Roden, Richard B.S., primary, Wu, T.-C., primary, Trimble, Cornelia L., primary, and Hung, Chien-Fu, primary

Published
2023
Full Text
View/download PDF

32. Supplementary Figure 4 from Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell–Mediated Tumor Control in the Genital Tract

Author

Sun, Yun-Yan, primary, Peng, Shiwen, primary, Han, Liping, primary, Qiu, Jin, primary, Song, Liwen, primary, Tsai, Yachea, primary, Yang, Benjamin, primary, Roden, Richard B.S., primary, Trimble, Cornelia L., primary, Hung, Chien-Fu, primary, and Wu, T.-C., primary

Published
2023
Full Text
View/download PDF

33. Table S1 from Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics

Author

Xing, Deyin, primary, Zheng, Gang, primary, Pallavajjala, Aparna, primary, Schoolmeester, J. Kenneth, primary, Liu, Yuehua, primary, Haley, Lisa, primary, Hu, Yan, primary, Liu, Li, primary, Logan, Lisa, primary, Lin, Yuan, primary, Pearce, Kathryn E., primary, Sattler, Christopher A., primary, Tsai, Ya Chea, primary, Vang, Russell, primary, Hung, Chien-Fu, primary, Wu, T.-C., primary, and Ronnett, Brigitte M., primary

Published
2023
Full Text
View/download PDF

34. Supplementary Figure Legends from Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell–Mediated Tumor Control in the Genital Tract

Author

Sun, Yun-Yan, primary, Peng, Shiwen, primary, Han, Liping, primary, Qiu, Jin, primary, Song, Liwen, primary, Tsai, Yachea, primary, Yang, Benjamin, primary, Roden, Richard B.S., primary, Trimble, Cornelia L., primary, Hung, Chien-Fu, primary, and Wu, T.-C., primary

Published
2023
Full Text
View/download PDF

35. Data from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8+ T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ

Author

Soong, Ruey-Shyang, primary, Song, Liwen, primary, Trieu, Janson, primary, Knoff, Jayne, primary, He, Liangmei, primary, Tsai, Ya-Chea, primary, Huh, Warner, primary, Chang, Yung-Nien, primary, Cheng, Wen-Fang, primary, Roden, Richard B.S., primary, Wu, T.-C., primary, Trimble, Cornelia L., primary, and Hung, Chien-Fu, primary

Published
2023
Full Text
View/download PDF

36. SSupplementary Figure 1 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8+ T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ

Author

Soong, Ruey-Shyang, primary, Song, Liwen, primary, Trieu, Janson, primary, Knoff, Jayne, primary, He, Liangmei, primary, Tsai, Ya-Chea, primary, Huh, Warner, primary, Chang, Yung-Nien, primary, Cheng, Wen-Fang, primary, Roden, Richard B.S., primary, Wu, T.-C., primary, Trimble, Cornelia L., primary, and Hung, Chien-Fu, primary

Published
2023
Full Text
View/download PDF

41. Supplementary Data from Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics

Author

Xing, Deyin, primary, Zheng, Gang, primary, Pallavajjala, Aparna, primary, Schoolmeester, J. Kenneth, primary, Liu, Yuehua, primary, Haley, Lisa, primary, Hu, Yan, primary, Liu, Li, primary, Logan, Lisa, primary, Lin, Yuan, primary, Pearce, Kathryn E., primary, Sattler, Christopher A., primary, Tsai, Ya Chea, primary, Vang, Russell, primary, Hung, Chien-Fu, primary, Wu, T.-C., primary, and Ronnett, Brigitte M., primary

Published
2023
Full Text
View/download PDF

45. Supplementary Figure Legends from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8+ T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ

Author

Soong, Ruey-Shyang, primary, Song, Liwen, primary, Trieu, Janson, primary, Knoff, Jayne, primary, He, Liangmei, primary, Tsai, Ya-Chea, primary, Huh, Warner, primary, Chang, Yung-Nien, primary, Cheng, Wen-Fang, primary, Roden, Richard B.S., primary, Wu, T.-C., primary, Trimble, Cornelia L., primary, and Hung, Chien-Fu, primary

Published
2023
Full Text
View/download PDF

48. Supplementary Figure 2 from Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell–Mediated Tumor Control in the Genital Tract

Author

Sun, Yun-Yan, primary, Peng, Shiwen, primary, Han, Liping, primary, Qiu, Jin, primary, Song, Liwen, primary, Tsai, Yachea, primary, Yang, Benjamin, primary, Roden, Richard B.S., primary, Trimble, Cornelia L., primary, Hung, Chien-Fu, primary, and Wu, T.-C., primary

Published
2023
Full Text
View/download PDF

49. Supplementary Figure 6 from Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell–Mediated Tumor Control in the Genital Tract

Author

Sun, Yun-Yan, primary, Peng, Shiwen, primary, Han, Liping, primary, Qiu, Jin, primary, Song, Liwen, primary, Tsai, Yachea, primary, Yang, Benjamin, primary, Roden, Richard B.S., primary, Trimble, Cornelia L., primary, Hung, Chien-Fu, primary, and Wu, T.-C., primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results