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25 results on '"Wu, Wangbin"'

1. GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior

Author

Bhat, Aaqib M., Mohapatra, Bhopal C., Luan, Haitao, Mushtaq, Insha, Chakraborty, Sukanya, Kumar, Siddhartha, Wu, Wangbin, Nolan, Ben, Dutta, Samikshan, Storck, Matthew D., Schott, Micah, Meza, Jane L., Lele, Subodh M., Lin, Ming-Fong, Cook, Leah M., Corey, Eva, Morrissey, Colm, Coulter, Donald W., Rowley, M. Jordan, Natarajan, Amarnath, Datta, Kaustubh, Band, Vimla, and Band, Hamid

Published
2024
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17. Catalytic asymmetric Meerwein–Ponndorf–Verley reduction of glyoxylates induced by a chiral N,N′-dioxide/Y(OTf)3 complex.

Author

Wu, Wangbin, Zou, Sijia, Lin, Lili, Ji, Jie, Zhang, Yuheng, Ma, Baiwei, Liu, Xiaohua, and Feng, Xiaoming

Subjects
*MOLECULAR sieves, *NITROGEN dioxide analysis
Abstract

An asymmetric Meerwein–Ponndorf–Verley (MPV) reduction of glyoxylates was for the first time accomplished via an N,N′-dioxide/Y(OTf)3 complex with aluminium alkoxide and molecular sieves (MSs) as crucial additives. A variety of optically active α-hydroxyesters were obtained with excellent results. A possible reaction mechanism was proposed based on the experiments. [ABSTRACT FROM AUTHOR]

Published
2017
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20. Chiral N,N′-dioxide–FeCl3 complex-catalyzed asymmetric intramolecular Cannizzaro reaction.

Author

Wu, Wangbin, Liu, Xiaohua, Zhang, Yuheng, Ji, Jie, Huang, Tianyu, Lin, Lili, and Feng, Xiaoming

Subjects
*IRON compound synthesis, *IRON chlorides, *CANNIZZARO reaction, *DEUTERIUM, *ASYMMETRIC synthesis, *INTRAMOLECULAR catalysis
Abstract

An environmentally benign catalyst, the N,N′-dioxide–FeCl3 complex, has been developed for the asymmetric intramolecular Cannizzaro reaction. Aryl and alkyl glyoxal monohydrates were applied to obtain α-hydroxy acid esters with excellent results. Deuterium-label and control experiments shed light on the reaction mechanism. [ABSTRACT FROM AUTHOR]

Published
2015
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21. Kinetic Resolution of Racemic Mandelic Acid Esters by N, N′-Dioxide-Scandium-Complex-Catalyzed Enantiomer-Selective Acylation.

Author

Zhang, Yuheng, Liu, Xiaohua, Zhou, Lin, Wu, Wangbin, Huang, Tianyu, Liao, Yuting, Lin, Lili, and Feng, Xiaoming

Subjects
ESTERS, DEACYLATION, CHEMICAL reactions, ENANTIOSELECTIVE catalysis, KINETIC resolution
Abstract

A simple and efficient acylative kinetic resolution of racemic mandelic acid esters was accomplished with a chiral N, N'-dioxide-scandium(III) complex under mild and base-free reaction conditions. A variety of mandelic acid esters performed well in the reaction, obtaining both acylated products (up to 49% yield, 97% ee) and recovered substrates (up to 49% yield, 95% ee) in high enantioselectivities with perfect selectivity factors (up to 247). The enantioselective recognition and catalytic models were also proposed for the catalytic KR reaction. [ABSTRACT FROM AUTHOR]

Published
2014
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23. GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior.

Author

Bhat AM, Mohapatra BC, Luan H, Mushtaq I, Chakraborty S, Kumar S, Wu W, Nolan B, Dutta S, Stock MD, Schott M, Meza JL, Lele SM, Lin MF, Cook LM, Corey E, Morrissey C, Coulter DW, Rowley J, Natarajan A, Datta K, Band V, and Band H

Abstract

While better management of loco-regional prostate cancer (PC) has greatly improved survival, advanced PC remains a major cause of cancer deaths. Identification of novel targetable pathways that contribute to tumor progression in PC could open new therapeutic options. The di-ganglioside GD2 is a target of FDA-approved antibody therapies in neuroblastoma, but the role of GD2 in PC is unexplored. Here, we show that GD2 is expressed in a small subpopulation of PC cells in a subset of patients and a higher proportion of metastatic tumors. Variable levels of cell surface GD2 expression were seen on many PC cell lines, and the expression was highly upregulated by experimental induction of lineage progression or enzalutamide resistance in CRPC cell models. GD2high cell fraction was enriched upon growth of PC cells as tumorspheres and GD2high fraction was enriched in tumorsphere-forming ability. CRISPR-Cas9 knockout (KO) of the rate-limiting GD2 biosynthetic enzyme GD3 Synthase (GD3S) in GD2high CRPC cell models markedly impaired the in vitro oncogenic traits and growth as bone-implanted xenograft tumors and reduced the cancer stem cell (CSC) and epithelial-mesenchymal transition (EMT) marker expression. Our results support the potential role of GD3S and its product GD2 in promoting PC tumorigenesis by maintaining cancer stem cells and suggest the potential for GD2 targeting in advanced PC.

Published
2024
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24. Enantioselective Radical-Polar Crossover Reactions of Indanonecarboxamides with Alkenes.

Author

Zhang X, Wu W, Cao W, Yu H, Xu X, Liu X, and Feng X

Abstract

Highly efficient asymmetric intermolecular radical-polar crossover reactions were realized by combining a chiral N,N'-dioxide/Ni II complex catalyst with Ag 2 O under mild reaction conditions. Various terminal alkenes and indanonecarboxamides/esters underwent radical addition/cyclization reactions to afford spiro-iminolactones and spirolactones with good to excellent yields (up to 99 %) and enantioselectivities (up to 97 % ee). Furthermore, a range of different radical-mediated oxidation/elimination or epoxide ring-opening products were obtained under mild reaction conditions. The Lewis acid catalysts exhibited excellent performance and precluded the strong background reaction., (© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2020
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25. Kinetic resolution of racemic mandelic acid esters by N,N'-dioxide-scandium-complex-catalyzed enantiomer-selective acylation.

Author

Zhang Y, Liu X, Zhou L, Wu W, Huang T, Liao Y, Lin L, and Feng X

Subjects
Catalysis, Esters, Kinetics, Molecular Structure, Stereoisomerism, Mandelic Acids chemistry, Organometallic Compounds chemistry, Scandium chemistry
Abstract

A simple and efficient acylative kinetic resolution of racemic mandelic acid esters was accomplished with a chiral N,N'-dioxide-scandium(III) complex under mild and base-free reaction conditions. A variety of mandelic acid esters performed well in the reaction, obtaining both acylated products (up to 49% yield, 97% ee) and recovered substrates (up to 49% yield, 95% ee) in high enantioselectivities with perfect selectivity factors (up to 247). The enantioselective recognition and catalytic models were also proposed for the catalytic KR reaction., (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2014
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