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Based on the daily meteorological data of seven stations in Altay region, China, this study investigated the temporal ( seasonal, inter-annual and decadal) and spatial variations of drought by using composite index of meteorological drought, as well as trend analysis, M-K abrupt analysis, wavelet analysis and interpolation tools in ArcGIS. The results indicated that the composite index of meteorological drought could reflect the drought condition in Altay region well. Although the frequency and the covered area of both inter-annual and seasonal droughts presented decreasing trends in the recent 52 a, the drought was still serious when considering the annual drought. The frequencies of inter-annual and spring droughts had no abrupt changes, whereas the frequencies of inter-summer, autumn and winter droughts had abrupt changes during the past 52 a. A significant periodic trend was also observed for the frequencies of inter-annual and seasonal droughts. The distribution of frequency and covered area suggested that the conditions of drought were heavily serious in Qinghe County, moderately serious in Altay City, Fuyun County, Buerjin County and Fuhai County, and slightly serious in Habahe County and Jimunai County. [ABSTRACT FROM AUTHOR]

Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34+ cells in vitro. On semisolid medium, CD34+ cells derived from cord blood were incubated with thalassemic serum, and colony-forming units were counted after 10 days of culture. After incubation with serum-specific panel reactive antibody, profound decreases were found in the numbers of CFU-GM, CFU-GEMM and BFU-E compared with controls. The results indicated that serum-specific panel reactive antibody might have an apparent inhibition effect on proliferation and differentiation of cord blood CD34+ cells. [ABSTRACT FROM AUTHOR]

Based on the daily meteorological data of seven stations in Altay region, China, this study investigated the temporal ( seasonal, inter-annual and decadal) and spatial variations of drought by using composite index of meteorological drought, as well as trend analysis, M-K abrupt analysis, wavelet analysis and interpolation tools in ArcGIS. The results indicated that the composite index of meteorological drought could reflect the drought condition in Altay region well. Although the frequency and the covered area of both inter-annual and seasonal droughts presented decreasing trends in the recent 52 a, the drought was still serious when considering the annual drought. The frequencies of inter-annual and spring droughts had no abrupt changes, whereas the frequencies of inter-summer, autumn and winter droughts had abrupt changes during the past 52 a. A significant periodic trend was also observed for the frequencies of inter-annual and seasonal droughts. The distribution of frequency and covered area suggested that the conditions of drought were heavily serious in Qinghe County, moderately serious in Altay City, Fuyun County, Buerjin County and Fuhai County, and slightly serious in Habahe County and Jimunai County.

Aim: To conduct a meta-analysis to estimate the determinants of the association between erosive esophagitis (EE) and body mass index (BMI)., Methods: We identified the studies using PubMed. Studies were selected for analysis based on certain inclusion and exclusion criteria. Data were extracted from each study on the basis of predefined items. Meta-analyses were performed to verify the risk factors, such as obesity and gender., Results: Twenty-one studies were included in this systematic review. These studies demonstrated an association between increasing BMI and the presence of EE [95% confidence interval (CI): 1.35-1.88, overweight, odds ratio (OR) = 1.60, P value homogeneity = 0.003, 95% CI: 1.65-2.55, obese, OR = 2.05, P < 0.01]. The heterogeneity disappeared by stratifying for gender. No publication bias was observed in this meta-analysis by the Egger method., Conclusion: This analysis demonstrates a positive association between BMI and the presence of EE, especially in males. The risk seems to progressively increase with increasing weight.

This study was aimed to investigate the expression level of perforin in cord blood NK cells and the relation of perforin expression after IL-2, IL-15 stimulation to cytotoxicity of NK cells. NK cells were isolated from cord blood MNC by depleting CD3(+) cells and then enriching CD56(+) cells using immunomagnetic separation (CD3 and CD56 cell isolation kit, autoMACS, miltenyi). The purity was analysed by flow cytometry. According to the different combination of cytokines, there were two groups: group A (IL-2) and group B (IL-2 + IL-15). The cytotoxicity and perforin expression rate of fresh and different cultured CB-NK cells against K562/Jurkat cell lines were estimated by LDH release test (cytotoxic 96 non-radioactive cytotoxicity assay). The results showed that the purity of NK cells after separation was more than 90%. The cytotoxicity towards both tumor lines in group B was higher than that in group A (p < 0.05), and cytotoxicity in group A was higher than that of fresh NK cells (p < 0.05). Perforin expression rate of group A (84.55%) was higher than that of fresh NK cells (67.21%) (p < 0.05), and there was no significant difference between group A and B (84.55% versus 87.22%) Cytotoxic activity of CB-NK cells was positively correlated with perforin expression rate (r = 0.886, p < 0.05). It is concluded that IL-2 can enhance cytotoxicity of CB/BM-NK cells by increasing the perforin expression.