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Haiyan Lan, Weifeng Shan, Yini Wu, Qiaomin Xu, Xiaoli Dong, Peiyi Mei, Gongchen Duan, Minji You, Linfei Jin, Jimin Wu Department of Anesthesiology, Lishui City People’s Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, People’s Republic of ChinaCorrespondence: Jimin Wu, Department of Anesthesiology, Lishui City People’s Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, No. 15, Dazhong Street, Lishui, Zhejiang Province, 323000, People’s Republic of China, Email wujimin2022@163.comObjective: To compare the efficacy and safety of ciprofol and propofol for sedation during hysteroscopy.Methods: A total of 149 patients undergoing hysteroscopy were randomly assigned to a ciprofol (Group C) or propofol group (Group P). All cases received intravenous sufentanil 0.1 μg/kg for analgesic preconditioning. Group C received an induction dose of ciprofol 0.4 mg/kg and a maintenance dosage of 0.6– 1.2 mg/kg/h to maintain BIS value between 40– 60. In Group P, propofol was started at 2.0 mg/kg and then maintained at 3.0– 6.0 mg/kg/h. The primary outcome was the successful rate of hysteroscopy. Secondary outcomes included the change of hemodynamic, respiratory adverse events, injection pain, body movement, recovery time, anesthetist’s satisfaction, time of disappearance of the eyelash reflex and the incidence of nausea and vomiting.Results: The success rate of hysteroscopy in each group was 100%. After drug administration, the incidence of hypotension in Group C was much lower than that in Group P (P< 0.05). The incidence of respiratory adverse events in Group C (4.0%) was much lower than that in Group P (31.1%) (P< 0.05). The incidence of injection pain and body movement in Group C was significantly lower than that in Group P (P< 0.05). The mean eyelash reflex disappearance time was less than 3 minutes in both groups. There was no statistically significant difference between the two groups in awakening times, anesthetist’s satisfaction and the incidence of nausea and vomiting. No serious adverse events occurred in any patients.Conclusion: Ciprofol proved to be a safer alternative to propofol for anesthesia during hysteroscopy. In comparison to propofol, ciprofol does not cause injection pain, exerts less impact on hemodynamics, and results in less respiratory depression.Keywords: ciprofol, propofol, sedation, anesthesia, hysteroscopy

Because of measurement environment and its own performance defect, the poor stability of nuclear radiation detector used on portable nuclear instrument leads to spectrum drift and decrease of energy resolution, which causes reduction of the detect efficiency. This results in lower measurement precision and accuracy of the system. Generally, the stabilization method based on hardware and software was applied. It is difficult to solve the problem about Spectrum drift caused by multiple factors. To slove the nonlinear problems caused by interference source, Multi-sensor Data Fusion Technique is adopt to design the intelligent nuclear detector with the Self-compensation Technique. It shows that the results of the project can improve the stability and reliability of the fieldwork measurement in system of the nuclear instruments. Except that it will improve the adaptive ability of the nuclear instruments to measuring environment.