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416 results on '"Wu, Zeming"'

1. GPU-Accelerated Optimization-Based Collision Avoidance

Author

Wu, Zeming, Wang, Zhuping, and Zhang, Hao

Subjects
Computer Science - Robotics
Abstract

This paper proposes a GPU-accelerated optimization framework for collision avoidance problems where the controlled objects and the obstacles can be modeled as the finite union of convex polyhedra. A novel collision avoidance constraint is proposed based on scale-based collision detection and the strong duality of convex optimization. Under this constraint, the high-dimensional non-convex optimization problems of collision avoidance can be decomposed into several low-dimensional quadratic programmings (QPs) following the paradigm of alternating direction method of multipliers (ADMM). Furthermore, these low-dimensional QPs can be solved parallel with GPUs, significantly reducing computational time. High-fidelity simulations are conducted to validate the proposed method's effectiveness and practicality.

Published
2024

4. Collective flow and the fluid behavior in p/d/$^3$He+Au collisions at $\sqrt{s_{NN}} = 200$ GeV

Author

Wu, Zeming, Fu, Baochi, Zhao, Shujun, Liu, Runsheng, and Song, Huichao

Subjects
Nuclear Theory, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

By varying the intrinsic initial geometry, the p/d/$^3$He+Au collisions at the Relativistic Heavy Ion Collider (RHIC) provide a unique opportunity to understand the collective behavior and probe the possible sub-nucleon fluctuations in small systems. In this paper, we employ the hybrid model iEBE-VISHNU with Trento initial conditions to study the collective flow and the fluid behavior in p/d/$^3$He+Au collisions. With fine-tuned parameters, iEBE-VISHNU can describe the $v_2(p_T)$ and $v_3(p_T)$ data from the PHENIX and STAR collaborations. However, for some certain parameter sets with initial sub-nucleon fluctuation, the hydrodynamic simulations have already beyond their limits with the average Knudsen number $\langle K_n \rangle$ obviously larger than one. Our calculations demonstrate that, for a meaningful evaluation of the fluid behavior in the small systems, model simulations should also pay attention to the validity range of hydrodynamics.

Published
2023

6. CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord

Author

Sun, Shuhui, Li, Jiaming, Wang, Si, Li, Jingyi, Ren, Jie, Bao, Zhaoshi, Sun, Le, Ma, Xibo, Zheng, Fangshuo, Ma, Shuai, Sun, Liang, Wang, Min, Yu, Yan, Ma, Miyang, Wang, Qiaoran, Chen, Zhiyuan, Ma, He, Wang, Xuebao, Wu, Zeming, Zhang, Hui, Yan, Kaowen, Yang, Yuanhan, Zhang, Yixin, Zhang, Sheng, Lei, Jinghui, Teng, Zhao-Qian, Liu, Chang-Mei, Bai, Ge, Wang, Yan-Jiang, Li, Jian, Wang, Xiaoqun, Zhao, Guoguang, Jiang, Tao, Belmonte, Juan Carlos Izpisua, Qu, Jing, Zhang, Weiqi, and Liu, Guang-Hui

Published
2023
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14. Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

Author

Zhang, Hui, Li, Jiaming, Yu, Yang, Ren, Jie, Liu, Qiang, Bao, Zhaoshi, Sun, Shuhui, Liu, Xiaoqian, Ma, Shuai, Liu, Zunpeng, Yan, Kaowen, Wu, Zeming, Fan, Yanling, Sun, Xiaoyan, Zhang, Yixin, Ji, Qianzhao, Cheng, Fang, Wei, Peng-Hu, Ma, Xibo, Zhang, Shiqiang, Xie, Zhengwei, Niu, Yuyu, Wang, Yan-Jiang, Han, Jing-Dong J., Jiang, Tao, Zhao, Guoguang, Ji, Weizhi, Izpisua Belmonte, Juan Carlos, Wang, Si, Qu, Jing, Zhang, Weiqi, and Liu, Guang-Hui

Published
2023
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15. FTO stabilizes MIS12 and counteracts senescence

Author

Zhang, Sheng, Wu, Zeming, Shi, Yue, Wang, Si, Ren, Jie, Yu, Zihui, Huang, Daoyuan, Yan, Kaowen, He, Yifang, Liu, Xiaoqian, Ji, Qianzhao, Liu, Beibei, Liu, Zunpeng, Qu, Jing, Liu, Guang-Hui, Ci, Weimin, Wang, Xiaoqun, and Zhang, Weiqi

Published
2022
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16. Resurrection of endogenous retroviruses during aging reinforces senescence

Author

Liu, Xiaoqian, Liu, Zunpeng, Wu, Zeming, Ren, Jie, Fan, Yanling, Sun, Liang, Cao, Gang, Niu, Yuyu, Zhang, Baohu, Ji, Qianzhao, Jiang, Xiaoyu, Wang, Cui, Wang, Qiaoran, Ji, Zhejun, Li, Lanzhu, Esteban, Concepcion Rodriguez, Yan, Kaowen, Li, Wei, Cai, Yusheng, Wang, Si, Zheng, Aihua, Zhang, Yong E., Tan, Shengjun, Cai, Yingao, Song, Moshi, Lu, Falong, Tang, Fuchou, Ji, Weizhi, Zhou, Qi, Belmonte, Juan Carlos Izpisua, Zhang, Weiqi, Qu, Jing, and Liu, Guang-Hui

Published
2023
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20. Universal scaling of the sigma field and net-protons from Langevin dynamics of model A

Author

Wu, Shanjin, Wu, Zeming, and Song, Huichao

Subjects
Nuclear Theory
Abstract

In this paper, we investigate the Kibble-Zurek scaling of the sigma field and net-protons within the framework of Langevin dynamics of model A. After determining the characteristic scales $\tau_{kz},l_{kz}$ and $\theta_{kz}$ and properly rescaling the traditional cumulants, we construct universal functions for the sigma field and approximate universal functions for net-protons in the critical regime, which are insensitive to the relaxation time and the chosen evolving trajectory. Besides, the oscillating behavior for the higher order cumulants of net-protons near the critical point is also drastically suppressed, which converge into approximate universal curves with these constructed Kibble-Zurek functions.

Published
2018
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21. Applications of deep learning to relativistic hydrodynamics

Author

Huang, Hengfeng, Xiao, Bowen, Xiong, Huixin, Wu, Zeming, Mu, Yadong, and Song, Huichao

Subjects
Nuclear Theory, Condensed Matter - Disordered Systems and Neural Networks, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

In this proceeding, we will briefly review our recent progress on implementing deep learning to relativistic hydrodynamics. We will demonstrate that a successfully designed and trained deep neural network, called {\tt stacked U-net}, can capture the main features of the non-linear evolution of hydrodynamics, which could also rapidly predict the final profiles for various testing initial conditions., Comment: QM2018 proceeding, 4 pages, 4 figures

Published
2018
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24. Destabilizing heterochromatin by APOE mediates senescence

Author

Zhao, Hongkai, Ji, Qianzhao, Wu, Zeming, Wang, Si, Ren, Jie, Yan, Kaowen, Wang, Zehua, Hu, Jianli, Chu, Qun, Hu, Huifang, Cai, Yusheng, Wang, Qiaoran, Huang, Daoyuan, Ji, Zhejun, Li, Jingyi, Belmonte, Juan Carlos Izpisua, Song, Moshi, Zhang, Weiqi, Qu, Jing, and Liu, Guang-Hui

Published
2022
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25. Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

Author

Liu, Zunpeng, Ji, Qianzhao, Ren, Jie, Yan, Pengze, Wu, Zeming, Wang, Si, Sun, Liang, Wang, Zehua, Li, Jiaming, Sun, Guoqiang, Liang, Chuqian, Sun, Run, Jiang, Xiaoyu, Hu, Jianli, Ding, Yingjie, Wang, Qiaoran, Bi, Shijia, Wei, Gang, Cao, Gang, Zhao, Guoguang, Wang, Hongmei, Zhou, Qi, Belmonte, Juan Carlos Izpisua, Qu, Jing, Zhang, Weiqi, and Liu, Guang-Hui

Published
2022
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28. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming

Author

Wang, Yongtao, Chen, Yixin, Guan, Lihuan, Zhang, Huizheng, Huang, Yaoyao, Johnson, Caroline H, Wu, Zeming, Gonzalez, Frank J, Yu, Aiming, Huang, Peng, Wang, Ying, Yang, Shouhui, Chen, Pan, Fan, Xiaomei, Huang, Min, and Bi, Huichang

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Medical Biochemistry and Metabolomics, Oncology and Carcinogenesis, Cancer, Genetics, Rare Diseases, Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Animals, Carnitine O-Palmitoyltransferase, Cell Line, Tumor, Cellular Senescence, Humans, Mice, Mice, Nude, Mitochondria, Neoplasms, Experimental, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Cellular senescence is a fundamental biological process that has profound implications in cancer development and therapeutics, but the underlying mechanisms remain elusive. Here we show that carnitine palmitoyltransferase 1C (CPT1C), an enzyme that catalyzes carnitinylation of fatty acids for transport into mitochondria for β-oxidation, plays a major role in the regulation of cancer cell senescence through mitochondria-associated metabolic reprograming. Metabolomics analysis suggested alterations in mitochondria activity, as revealed by the marked decrease in acylcarnitines in senescent human pancreatic carcinoma PANC-1 cells, indicating low CPT1C activity. Direct analyses of mRNA and protein show that CPT1C is significantly reduced in senescent cells. Furthermore, abnormal mitochondrial function was observed in senescent PANC-1 cells, leading to lower cell survival under metabolic stress and suppressed tumorigenesis in a mouse xenograft model. Knock-down of CPT1C in PANC-1 cells induced mitochondrial dysfunction, caused senescence-like growth suppression and cellular senescence, suppressed cell survival under metabolic stress, and inhibited tumorigenesis in vivo. Further, CPT1C knock-down suppressed xenograft tumor growth in situ. Silencing of CPT1C in five other tumor cell lines also caused cellular senescence. On the contrary, gain-of-function of CPT1C reversed PANC-1 cell senescence and enhanced mitochondrial function. This study identifies CPT1C as a novel biomarker and key regulator of cancer cell senescence through mitochondria-associated metabolic reprograming, and suggests that inhibition of CPT1C may represent a new therapeutic strategy for cancer treatment through induction of tumor senescence.

Published
2018

30. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Author

Liu, Zunpeng, Li, Wei, Geng, Lingling, Sun, Liang, Wang, Qiaoran, Yu, Yang, Yan, Pengze, Liang, Chuqian, Ren, Jie, Song, Moshi, Zhao, Qian, Lei, Jinghui, Cai, Yusheng, Li, Jiaming, Yan, Kaowen, Wu, Zeming, Chu, Qun, Li, Jingyi, Wang, Si, Li, Chunyi, Han, Jing-Dong J., Hernandez-Benitez, Reyna, Shyh-Chang, Ng, Belmonte, Juan Carlos Izpisua, Zhang, Weiqi, Qu, Jing, and Liu, Guang-Hui

Published
2022
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33. Kinematic Calibration for Industrial Robot Using a Telescoping Ballbar

Author

Wu, Zeming, Guo, Peng, Zhang, Yang, Zhu, Limin, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Chan, Chee Seng, editor, Liu, Hong, editor, Zhu, Xiangyang, editor, Lim, Chern Hong, editor, Liu, Xinjun, editor, Liu, Lianqing, editor, and Goh, Kam Meng, editor

Published
2020
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36. Single-cell transcriptomic atlas of primate cardiopulmonary aging

Author

Ma, Shuai, Sun, Shuhui, Li, Jiaming, Fan, Yanling, Qu, Jing, Sun, Liang, Wang, Si, Zhang, Yiyuan, Yang, Shanshan, Liu, Zunpeng, Wu, Zeming, Zhang, Sheng, Wang, Qiaoran, Zheng, Aihua, Duo, Shuguang, Yu, Yang, Belmonte, Juan Carlos Izpisua, Chan, Piu, Zhou, Qi, Song, Moshi, Zhang, Weiqi, and Liu, Guang-Hui

Published
2021
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37. Experimental Study on the Shear Strength of Different Interfaces of Fine-Grained-Tailing-Filled Geotextile Tubes.

Author

Liu, Xiaowen, Wu, Zeming, and Guo, Feiyang

Subjects
SHEAR strength, INTERFACIAL friction, GEOTEXTILES, TUBES, SLURRY
Abstract

As damming material, fine-grained tailings present challenges such as low dam strength and poor stability. To address these issues, this study employs geotextile tube technology to mix water with fine-grained tailings, forming a tailing slurry with a concentration of 60%, which is filled into a geotextile bag to form a geotextile tube, so as to improve the stability of fine-grained tailings. The shear strength characteristics of each interface under different consolidation times and different filling degrees were studied via an indoor shear experiment, including the shear strength of tailing particles, that between tailings and geotextiles, and that within geotextile tubes themselves. The results show that the shear strength of each interface conforms to the Mohr–Coulomb strength criterion, and that the interface cohesion is greatly affected by the consolidation time, while the interface friction angle is mainly affected by the filling degree. Moreover, the shear strength comparison, based on the comprehensive friction angle concept, indicates a substantial increase in shear strength at the interfaces between geotextile tubes compared to both that of the tailings themselves and the interface between tailings and geotextiles, highlighting the reinforcing effect of the geotextile tube filling technology on tailings' shear strength. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells

Author

Yu, Tao, Wang, Yongtao, Zhang, Huizhen, Johnson, Caroline H, Jiang, Yiming, Li, Xiangjun, Wu, Zeming, Liu, Tian, Krausz, Kristopher W, Yu, Aiming, Gonzalez, Frank J, Huang, Min, and Bi, Huichang

Subjects
Analytical Chemistry, Chemical Sciences, Digestive Diseases, Rare Diseases, Cancer, Aetiology, 2.1 Biological and endogenous factors, Arginine, Cell Culture Techniques, Cell Line, Tumor, Chromatography, Liquid, Humans, Mass Spectrometry, Metabolomics, Mycoplasma, Purines, Mycoplasma contamination, Cellular metabolism, PANC-1 cells, Cell culture, Biological Sciences, Engineering, Biological sciences, Chemical sciences
Abstract

Mycoplasma contamination is a common problem in cell culture and can alter cellular functions. Since cell metabolism is either directly or indirectly involved in every aspect of cell function, it is important to detect changes to the cellular metabolome after mycoplasma infection. In this study, liquid chromatography mass spectrometry (LC/MS)-based metabolomics was used to investigate the effect of mycoplasma contamination on the cellular metabolism of human pancreatic carcinoma cells (PANC-1). Multivariate analysis demonstrated that mycoplasma contamination induced significant metabolic changes in PANC-1 cells. Twenty-three metabolites were identified and found to be involved in arginine and purine metabolism and energy supply. This study demonstrates that mycoplasma contamination significantly alters cellular metabolite levels, confirming the compelling need for routine checking of cell cultures for mycoplasma contamination, particularly when used for metabolomics studies. Graphical abstract Metabolomics reveals mycoplasma contamination changes the metabolome of PANC-1 cells.

Published
2016

48. An Experimental Study Focusing on the Filling Process and Consolidation Characteristics of Geotextile Tubes Filled with Fine-Grained Tungsten Tailings.

Author

Liu, Xiaowen, Wu, Zeming, He, Haisong, and Xu, Qing

Abstract

With advancements in mineral processing technology, the disposal of fine-grained tailings has increasingly become a significant challenge. The geotextile tube method, characterized by its use of a permeable fabric and its cost-effectiveness, has gradually been applied in dam construction and other engineering projects involving tailings. This method offers a novel approach to addressing the storage issues of fine-grained tailings and promotes sustainable utilization. In this paper, the fine tailings that remained after the cyclone classification of Ganzhou tungsten ore were taken as the research object. Specifically, this research endeavored to evaluate the effects of various filling heights and concentrations on the geotextile tube-filling and consolidation process. The results revealed that the filling concentration had a significant impact on the filling benefit of the geotextile tubes, while the filling height had a minimal effect. During the consolidation drainage stage, the dry density, internal friction angle, cohesion, and compression modulus of the tailings in the bags increased with an increasing consolidation time and filling concentration. However, the physical and mechanical properties of the tailings in the geotextile tubes decreased with an increased filling height. Ultimately, this research developed a hyperbolic equation that makes it possible to forecast the ultimate settlement value at various filling heights and concentrations, better representing how the settlement of geotextile tubes changes over the consolidation time. [ABSTRACT FROM AUTHOR]

Published
2024
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