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Objective: To explore the microbial correlation between oral tongue coating (TC) and gastric mucosa (GM) in patients with gastric intestinal metaplasia (GIM). Methods: The present study recruited 1360 volunteers for upper gastrointestinal cancer screening. The microbiota in TC and GM were profiled by long-read sequencing of full-length 16S rRNA gene. The microbial diversity, community structure, and linear discriminant analysis effect size (LEfSe) were analyzed by the software Visual Genomics. SparCC correlation analysis was used to construct the commensal network and the graphical display was conducted by R software. Results: The population included 44 patients with precancerous GIM, and 28 matched controls with negative rapid urease test (RUT) and non-symptomatic chronic superficial gastritis (CSG). No significant difference in diversity was observed between GIM patients and controls in TC or GM microbiota (P > 0.05). Patients had a higher percentage of 41 – 60 co-occurring operational taxonomic units (OTUs) between TC and GM than controls (34.1 % vs. 25.0 %) (P < 0.05). The LEfSe showed that TC Prevotella melaninogenica and three gastric Helicobacter species (i.e., Helicobacter pylori, Helicobacter pylori XZ274, and Helicobacter pylori 83) were enriched in patients with GIM. Furthermore, GIM patients with positive RUT had a lower percentage of co-occurring OTUs over 20 (P < 0.05), and lower abundances of gastric Veillonella, Pseudonocardia, and Mesorhizobium than those with negative RUT (P < 0.05). The commensal network between TC and GM was more complex in GIM patients than in controls. GIM patients with positive RUT demonstrated more bacterial correlations between TC and GM than those with negative RUT. Finally, the serum ratio of PG-I/II was negatively correlated with three gastric Helicobacter species (Helicobacter pylori, Helicobacter pylori XZ274, and Helicobacter pylori 83) in patients with negative RUT (P < 0.05), and negatively correlated with two TC species (Fusobacterium nucleatum subsp. nucleatum and Campylobacter showae) in patients with positive RUT (P < 0.05). Conclusion: The development of GIM potentiated the commensal network between oral TC and GM, providing microbial evidence of the correlation between TC and the stomach.

Objective To evaluate the clinical efficacy of comprehensive treatment for synchronous primary advanced gastric and esophageal cancer by propensity score matching (PSM). Methods A total of 2 551 patients with advanced gastric cancer admitted to Jiangsu Province Hospital of Chinese Medicine from January 2013 to December 2022 were retrospectively analyzed. Among them, 45 patients with synchronous primary esophageal cancer were distributed to the observation group, and 2 506 patients without esophageal cancer were distributed to the control group. Through the PSM method, the control group was matched with the observation group and the equilibrium samples of covariates between two groups were obtained. The overall survival(OS) between the two groups were compared. Results Both observation and control group contained 45 patients in this study. According to the treatment regimen, the patients in the observation group was divided into radical resection treatment subgroup (n=22) and chemoradiotherapy (CRT) subgroup (n=23). In the radical resection subgroup, 4 patients underwent the simultaneous surgical resection of gastric and esophageal tumors through proximal gastrectomy with the Ivor Lewis operation. Eighteen patients underwent endoscopic submucosal dissection(ESD) of their esophageal tumors and gastric cancer radical resection. Radical resection of gastric cancer combined with preoperative chemoradiotherapy of esophageal cancer was performed in the CRT subgroup. Survival analysis showed that OS in the observation group was significantly shorter than that in the control group (P=0.042) and there was no significant difference in OS between the radical resection subgroup and the control group (P=0.799). The 1 -, 3 -, and 5-year survival rates of the patients in the CRT subgroup were significantly lower than those of the control group (P=0.003). While the 1 -, 3 -, and 5-year survival rates of the patients in the radical resection subgroup were not statistically significant, compared to those of the CRT subgroup (P=0.071).Conclusions Multidisciplinary and comprehensive treatment can significantly improve the prognosis of patients with synchronous primary advanced gastric and esophageal cancer. Radical resection of gastric cancer combined with ESD of esophageal cancer is an optional treatment for patients with gastric cancer complicated with early esophageal cancer. Radical resection of gastric cancer combined with CRT of esophageal cancer can improve the prognosis of patients with advanced gastric cancer complicated with unresectable esophageal cancer.

Let σ = { σ i | i ∈ I } be some partition of the set of all primes P , G a finite group and σ (G) = { σ i | σ i ∩ π (G) ≠ ∅ } . A set H of subgroups of G is said to be a complete Hall σ-set of G if every nonidentity member of H is a Hall σi-subgroup of G for some i and H contains exactly one Hall σi-subgroup of G for every σ i ∈ σ (G) . Let H be a complete Hall σ-set of G. A subgroup H of G is said to be H -permutable if HA = AH for every member A ∈ H ; m- H -permutable if H = 〈 A , B 〉 for some modular subgroup A and H -permutable subgroup B of G; weakly m- H -permutable in G if there exists a σ-subnormal subgroup T of G such that G = HT and H ∩ T ≤ S ≤ H for some m- H -permutable subgroup S of G. In this paper, we study the structure of finite groups G by assuming that some σ-primary subgroups are weakly m- H -permutable in G. Some recent results are generalized and unified. [ABSTRACT FROM AUTHOR]

The aerodynamic performance of a high-speed train is intimately linked to its head shape. In order to reduce the aerodynamic drag during the operation of high-speed trains, five distinct head types with varying parameters are developed for double-arch trains and numerical calculation models for high-speed trains are established by modifying the cab height and front window transition shape of the double-arch high-speed train. The three-dimensional, steady, incompressible N-S equation and RNS method are used to simulate the flow field of five models running at a constant speed in open air, the influence of train cab height and front window transition shape on resistance characteristics of the double-arch train in the stable operation of the open air is comparatively analyzed. The following conclusions are drawn: under the same running conditions, the pressure difference in the flow field around the train mainly occurs in the transition area at the front window of the driver's cab and above, and the external geometric parameters of the driver significantly affect the aerodynamic drag of double-arch high-speed trains. The aerodynamic drag coefficient decreases as the height of the design position of the curvature transition of the front window of the train head increases, the maximum difference is 14.5%, and the distribution range of high pressure in the head car is reduced. The design inclination of the front window of the cab is reduced and the maximum pressure on the front window of the cab is lowered, resulting in a 13.4% decrease in the train's aerodynamic drag coefficient. When the plane is chosen to replace the curved surface as the transition surface of the train cab's front window, the positive pressure at the front window of the cab can be reduced, but the negative pressure above the cab will be intensified, and the aerodynamic drag coefficient of the train is decreased by only 3%. To achieve optimal drag reduction, it is recommended to raise the driver's cab height within a reasonable range and decrease the inclination of the front window surface on double-arch high-speed trains. [ABSTRACT FROM AUTHOR]