1. Application of The Method of Elastic Maps In Analysis of Genetic Texts
- Author
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Gorban, Alexander N., Zinovyev, Andrey Yu., and Wunsch, Donald C.
- Subjects
Computer Science: Statistical Models ,Computer Science: Artificial Intelligence ,Biology: Theoretical Biology ,Statistical Models ,Artificial Intelligence ,Theoretical Biology - Abstract
Method of elastic maps ( http://cogprints.ecs.soton.ac.uk/archive/00003088/ and http://cogprints.ecs.soton.ac.uk/archive/00003919/ ) allows us to construct efficiently 1D, 2D and 3D non-linear approximations to the principal manifolds with different topology (piece of plane, sphere, torus etc.) and to project data onto it. We describe the idea of the method and demonstrate its applications in analysis of genetic sequences. The animated 3D-scatters are available on our web-site: http://www.ihes.fr/~zinovyev/7clusters/ We found the universal cluster structure of genetic sequences, and demonstrated the thin structure of these clusters for coding regions. This thin structure is related to different translational efficiency.
- Published
- 2003