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2. A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption

Author

Allard, Sabine D., De Keersmaecker, Brenda, de Goede, Anna L., Verschuren, Esther J., Koetsveld, Jeanette, Reedijk, Mariska L., Wylock, Carolien, De Bel, Annelies V., Vandeloo, Judith, Pistoor, Frank, Heirman, Carlo, Beyer, Walter E.P., Eilers, Paul H.C., Corthals, Jurgen, Padmos, Iman, Thielemans, Kris, Osterhaus, Albert D.M.E., Lacor, Patrick, der Ende, Marchina E. van, Aerts, Joeri L., van Baalen, Carel A., and Gruters, Rob A.

Published
2012
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3. Corrigendum to ‘A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption’ [Clin. Immunol. 142 (2012) 252–268]

Author

Allard, Sabine D., primary, De Keersmaecker, Brenda, additional, de Goede, Anna L., additional, Verschuren, Esther J., additional, Koetsveld, Jeanette, additional, Reedijk, Mariska L., additional, Wylock, Carolien, additional, De Bel, Annelies V., additional, Vandeloo, Judith, additional, Pistoor, Frank, additional, Heirman, Carlo, additional, Beyer, Walter E.P., additional, Eilers, Paul H.C., additional, Corthals, Jurgen, additional, Padmos, Iman, additional, Thielemans, Kris, additional, Osterhaus, Albert D.M.E., additional, Lacor, Patrick, additional, van der Ende, Marchina E., additional, Aerts, Joeri L., additional, van Baalen, Carel A., additional, and Gruters, Rob A., additional

Published
2014
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5. Prospective relationship between hemispheric lateralisation and CD4+ T cells in human immunodeficiency virus type 1.

Author

Sumner RC, Nowicky AV, Parton A, Wylock C, Cserjesi R, Fischler B, Lacor P, and Gidron Y

Subjects
Adult, Analysis of Variance, Antiretroviral Therapy, Highly Active methods, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes virology, Female, Follow-Up Studies, HIV Infections drug therapy, Humans, Male, Middle Aged, Prospective Studies, Statistics as Topic, CD4-Positive T-Lymphocytes pathology, Functional Laterality physiology, HIV Infections pathology, HIV Infections physiopathology
Abstract

Objectives: Neuromodulation of the immune system has been proposed to be influenced by hemispheric lateralisation (HL). The present study tested whether HL predicted CD4+ levels, statistically controlling for confounders., Methods: Employing two assessments of HL, 68 human immunodeficiency virus (HIV)-1+ patients were followed prospectively. Numerous exclusion criteria and confounder assessments were employed (e.g. age/medication)., Results: Left HL significantly positively predicted CD4+ levels at follow-up, and this was qualified by medication (HAART) status: only in HAART-naïve patients did HL predict CD4 levels. Furthermore, HL significantly predicted whether patients had clinically significantly high/low CD4+ counts., Conclusions: Using a more rigorous methodology than a previous study, the present work partly corroborated the theory of HL influences on immunity, extended it to HIV immunity and identified a possible moderator: HAART medication. Implications for future research and treatments are provided., (© 2013 S. Karger AG, Basel.)

Published
2014
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