345 results on '"Wynn, James L."'
Search Results
2. The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota
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Stevens, Joseph, Steinmeyer, Shelby, Bonfield, Madeline, Peterson, Laura, Wang, Timothy, Gray, Jerilyn, Lewkowich, Ian, Xu, Yan, Du, Yina, Guo, Minzhe, Wynn, James L, Zacharias, William, Salomonis, Nathan, Miller, Lisa, Chougnet, Claire, O'Connor, Dennis Hartigan, and Deshmukh, Hitesh
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Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Biodefense ,Perinatal Period - Conditions Originating in Perinatal Period ,Preterm ,Low Birth Weight and Health of the Newborn ,Pneumonia & Influenza ,Microbiome ,Emerging Infectious Diseases ,Pediatric ,Pneumonia ,Lung ,Digestive Diseases ,Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Infection ,Good Health and Well Being ,Animals ,Anti-Bacterial Agents ,Dysbiosis ,Female ,Gastrointestinal Microbiome ,Humans ,Immunity ,Macaca mulatta ,Pregnancy ,Proteomics ,Biological Sciences ,Medical and Health Sciences ,Medical biotechnology ,Biomedical engineering - Abstract
Although modern clinical practices such as cesarean sections and perinatal antibiotics have improved infant survival, treatment with broad-spectrum antibiotics alters intestinal microbiota and causes dysbiosis. Infants exposed to perinatal antibiotics have an increased likelihood of life-threatening infections, including pneumonia. Here, we investigated how the gut microbiota sculpt pulmonary immune responses, promoting recovery and resolution of infection in newborn rhesus macaques. Early-life antibiotic exposure interrupted the maturation of intestinal commensal bacteria and disrupted the developmental trajectory of the pulmonary immune system, as assessed by single-cell proteomic and transcriptomic analyses. Early-life antibiotic exposure rendered newborn macaques more susceptible to bacterial pneumonia, concurrent with increases in neutrophil senescence and hyperinflammation, broad inflammatory cytokine signaling, and macrophage dysfunction. This pathogenic reprogramming of pulmonary immunity was further reflected by a hyperinflammatory signature in all pulmonary immune cell subsets coupled with a global loss of tissue-protective, homeostatic pathways in the lungs of dysbiotic newborns. Fecal microbiota transfer was associated with partial correction of the broad immune maladaptations and protection against severe pneumonia. These data demonstrate the importance of intestinal microbiota in programming pulmonary immunity and support the idea that gut microbiota promote the balance between pathways driving tissue repair and inflammatory responses associated with clinical recovery from infection in infants. Our results highlight a potential role for microbial transfer for immune support in these at-risk infants.
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- 2022
3. Neonatal sepsis definitions from randomised clinical trials
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Hayes, Rían, Hartnett, Jack, Semova, Gergana, Murray, Cian, Murphy, Katherine, Carroll, Leah, Plapp, Helena, Hession, Louise, O’Toole, Jonathan, McCollum, Danielle, Roche, Edna, Jenkins, Elinor, Mockler, David, Hurley, Tim, McGovern, Matthew, Allen, John, Meehan, Judith, Plötz, Frans B., Strunk, Tobias, de Boode, Willem P., Polin, Richard, Wynn, James L., Degtyareva, Marina, Küster, Helmut, Janota, Jan, Giannoni, Eric, Schlapbach, Luregn J., Keij, Fleur M., Reiss, Irwin K. M., Bliss, Joseph, Koenig, Joyce M., Turner, Mark A., Gale, Christopher, and Molloy, Eleanor J.
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- 2023
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4. Multisystem inflammatory syndrome in neonates (MIS-N) associated with perinatal SARS CoV-2 infection: Does it exist?
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Lakshminrusimha, Satyan, More, Kiran, Shah, Prakesh S., Wynn, James L., and Sánchez, Pablo J.
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- 2023
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5. Outcomes of interventions in neonatal sepsis: A systematic review of qualitative research
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Taneri, Petek Eylul, primary, Devane, Declan, additional, Kirkham, Jamie, additional, Molloy, Eleanor, additional, Daly, Mandy, additional, Branagan, Aoife, additional, Suguitani, Denise, additional, Wynn, James L., additional, Kissoon, Niranjan, additional, Kawaza, Kondwani, additional, Simons, Sinno H. P., additional, Bonnard, Lívia Nagy, additional, Giannoni, Eric, additional, Strunk, Tobias, additional, Ohaja, Magdalena, additional, Mugabe, Kenneth, additional, Quirke, Fiona, additional, Bazilio, Kateregga, additional, and Biesty, Linda, additional
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- 2024
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6. Limited achievement of NIH research independence by pediatric K award recipients
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Good, Misty, McElroy, Steven J, Berger, Jennifer N, Moore, Daniel J, and Wynn, James L
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Paediatrics ,Biomedical and Clinical Sciences ,Achievement ,Awards and Prizes ,Career Mobility ,Child ,Female ,Humans ,Male ,Mentors ,National Institutes of Health (U.S.) ,Pediatrics ,Physicians ,Research Personnel ,Research Support as Topic ,Translational Research ,Biomedical ,United States ,Paediatrics and Reproductive Medicine ,Public Health and Health Services - Published
- 2018
7. Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials
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Henry, Cían J., Semova, Gergana, Barnes, Ellen, Cotter, Isabel, Devers, Tara, Rafaee, Aisyah, Slavescu, Andreea, Cathain, Niamh O., McCollum, Danielle, Roche, Edna, Mockler, David, Allen, John, Meehan, Judith, Klingenberg, Claus, Latour, Jos M., van den Hoogen, Agnes, Strunk, Tobias, Giannoni, Eric, Schlapbach, Luregn J., Degtyareva, Marina, Plötz, Frans B., de Boode, Willem P., Naver, Lars, Wynn, James L., Küster, Helmut, Janota, Jan, Keij, Fleur M., Reiss, Irwin K. M., Bliss, Joseph M., Polin, Richard, Koenig, Joyce M., Turner, Mark A., Gale, Christopher, and Molloy, Eleanor J.
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- 2022
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8. The frequency and timing of sepsis-associated coagulopathy in the neonatal intensive care unit
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Aziz, Khyzer B., primary, Saxonhouse, Matthew, additional, Mahesh, Divya, additional, Wheeler, Kathryn E., additional, and Wynn, James L., additional
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- 2024
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9. Maximum vasoactive-inotropic score and mortality in extremely premature, extremely low birth weight infants
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Aziz, Khyzer B., Lavilla, Orlyn C., Wynn, James L., Lure, Allison C., Gipson, Daniel, and de la Cruz, Diomel
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- 2021
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10. Criteria for Pediatric Sepsis—A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce
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Menon, Kusum, Schlapbach, Luregn J., Akech, Samuel, Argent, Andrew, Biban, Paolo, Carrol, Enitan D., Chiotos, Kathleen, Jobayer Chisti, Mohammod, Evans, Idris V. R., Inwald, David P., Ishimine, Paul, Kissoon, Niranjan, Lodha, Rakesh, Nadel, Simon, Oliveira, Cláudio Flauzino, Peters, Mark, Sadeghirad, Benham, Scott, Halden F., de Souza, Daniela C., Tissieres, Pierre, Watson, R. Scott, Wiens, Matthew O., Wynn, James L., Zimmerman, Jerry J., and Sorce, Lauren R.
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- 2021
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11. Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)
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Taneri, Petek Eylul, primary, Kirkham, Jamie J., additional, Molloy, Eleanor J., additional, Biesty, Linda, additional, Polin, Richard A., additional, Wynn, James L., additional, Stoll, Barbara J., additional, Kissoon, Niranjan, additional, Kawaza, Kondwani, additional, Daly, Mandy, additional, Branagan, Aoife, additional, Bonnard, Lívia Nagy, additional, Giannoni, Eric, additional, Strunk, Tobias, additional, Ohaja, Magdalena, additional, Mugabe, Kenneth, additional, Suguitani, Denise, additional, Quirke, Fiona, additional, and Devane, Declan, additional
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- 2023
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12. Immunodeficiency Diseases of the Neonate
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Kim-Chang, Julie J., primary, Wynn, James L., additional, Saxonhouse, Matthew A., additional, and Sleasman, John W., additional
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- 2021
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13. A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants
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Wynn, James L. and Polin, Richard A.
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- 2020
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14. Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality
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Wynn, James L, Scumpia, Philip O, Stocks, Blair T, Romano-Keeler, Joann, Alrifai, Mhd Wael, Liu, Jin-Hua, Kim, Annette S, Alford, Catherine E, Matta, Pranathi, Weitkamp, Jörn-Hendrik, and Moore, Daniel J
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Hematology ,Sepsis ,Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Infection ,Inflammatory and immune system ,Good Health and Well Being ,Adoptive Transfer ,Animals ,Antibodies ,Antigens ,CD ,Bone Marrow Cells ,CD11b Antigen ,Endotoxins ,Erythroid Cells ,Female ,Fetal Blood ,Humans ,Male ,Mice ,Mice ,Inbred C57BL ,Receptors ,Transferrin ,Reticulocytes ,Spleen ,Immunology - Abstract
Sepsis is a major cause of neonatal mortality and morbidity worldwide. A recent report suggested that murine neonatal host defense against infection could be compromised by immunosuppressive CD71(+) erythroid splenocytes. We examined the impact of CD71(+) erythroid splenocytes on murine neonatal mortality to endotoxin challenge or polymicrobial sepsis and characterized circulating CD71(+) erythroid (CD235a(+)) cells in human neonates. Adoptive transfer or an Ab-mediated reduction in neonatal CD71(+) erythroid splenocytes did not alter murine neonatal survival to endotoxin challenge or polymicrobial sepsis challenge. Ex vivo immunosuppression of stimulated adult CD11b(+) cells was not limited to neonatal splenocytes; it also occurred with adult and neonatal bone marrow. Animals treated with anti-CD71 Ab showed reduced splenic bacterial load following bacterial challenge compared with isotype-treated mice. However, adoptive transfer of enriched CD71(+) erythroid splenocytes to CD71(+)-reduced animals did not reduce bacterial clearance. Human CD71(+)CD235a(+) cells were common among cord blood mononuclear cells and were shown to be reticulocytes. In summary, a lack of effect on murine survival to polymicrobial sepsis following adoptive transfer or diminution of CD71(+) erythroid splenocytes under these experimental conditions suggests that the impact of these cells on neonatal infection risk and progression may be limited. An unanticipated immune priming effect of anti-CD71 Ab treatment, rather than a reduction in immunosuppressive CD71(+) erythroid splenocytes, was likely responsible for the reported enhanced bacterial clearance. In humans, the well-described rapid decrease in circulating reticulocytes after birth suggests that they may have a limited role in reducing inflammation secondary to microbial colonization.
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- 2015
15. TRIF-Dependent Innate Immune Activation Is Critical for Survival to Neonatal Gram-Negative Sepsis
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Cuenca, Alex G, Joiner, Dallas N, Gentile, Lori F, Cuenca, Angela L, Wynn, James L, Kelly-Scumpia, Kindra M, Scumpia, Philip O, Behrns, Kevin E, Efron, Philip A, Nacionales, Dina, Lui, Chao, Wallet, Shannon M, Reeves, Westley H, Mathews, Clayton E, and Moldawer, Lyle L
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Hematology ,Pediatric ,Vaccine Related ,Infectious Diseases ,Sepsis ,Prevention ,Biodefense ,2.1 Biological and endogenous factors ,Aetiology ,Inflammatory and immune system ,Infection ,Adaptor Proteins ,Vesicular Transport ,Animals ,Animals ,Newborn ,Chemokine CXCL10 ,Chemokines ,Cytokines ,Disease Models ,Animal ,Disease Susceptibility ,Escherichia coli ,Female ,Genetic Predisposition to Disease ,Gram-Negative Bacterial Infections ,Granulocytes ,Immunity ,Innate ,Interferon Type I ,Macrophages ,Peritoneal ,Male ,Mice ,Mice ,Knockout ,Neutrophils ,Phagocytosis ,Reactive Oxygen Species ,Toll-Like Receptors ,Immunology - Abstract
Current evidence suggests that neonatal immunity is functionally distinct from adults. Although TLR signaling through the adaptor protein, MyD88, has been shown to be critical for survival to sepsis in adults, little is known about the role of MyD88 or TRIF in neonatal sepsis. We demonstrate that TRIF(-/-) but not MyD88(-/-) neonates are highly susceptible to Escherichia coli peritonitis and bacteremia. This was associated with decreased innate immune recruitment and function. Importantly, we found that the reverse was true in adults that MyD88(-/-) but not TRIF(-/-) or wild-type adults are susceptible to E. coli peritonitis and bacteremia. In addition, we demonstrate that TRIF but not MyD88 signaling is critical for the TLR4 protective adjuvant effect we have previously demonstrated. These data suggest a differential requirement for the survival of neonates versus adults to Gram-negative infection, and that modulation of TRIF in neonates can be used to augment survival to neonatal sepsis.
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- 2015
16. Contribution of Concurrent Comorbidities to Sepsis-Related Mortality in Preterm Infants ≤32 Weeks of Gestation at an Academic Neonatal Intensive Care Network.
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Barnette, Brian W., Schumacher, Benjamin T., Armenta, Richard F., Wynn, James L., Richardson, Andrew, Bradley, John S., Lazar, Sarah, and Lawrence, Shelley M.
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BACTEREMIA ,NEONATAL necrotizing enterocolitis ,NEONATAL intensive care ,CEREBRAL hemorrhage ,BRAIN diseases ,NEONATAL intensive care units ,RETROSPECTIVE studies ,ACQUISITION of data ,SEPSIS ,MEDICAL records ,DEATH ,INTESTINAL perforation ,COMORBIDITY ,CHILDREN - Abstract
Objective This study sought to identify concurrent major comorbidities in preterm infants ≤32 weeks of gestation that may have contributed to sepsis-related mortality following a diagnosis of bacteremia or blood culture-negative sepsis within the neonatal period (≤28 days of life). Study Design This is a retrospective chart review of infants ≤32 weeks of gestation who were admitted to a single academic network of multiple neonatal intensive care units between January 1, 2012, and December 31, 2015, to determine the primary cause(s) and timing of death in those diagnosed with bacteremia or blood culture-negative sepsis. Direct comparisons between early-onset sepsis (EOS; ≤72 hours) and late-onset sepsis (LOS; >72 hours) were made. Results In our study cohort, of 939 total patients with ≤32 weeks of gestation, 182 infants were diagnosed with 198 episodes of sepsis and 7.7% (14/182) died. Mortality rates did not significantly differ between neonates with bacteremia or blood culture-negative sepsis (7/14 each group), and those diagnosed with EOS compared with LOS (6/14 vs. 8/14). Nearly 80% (11/14) of infants were transitioned to comfort care prior to their death secondary to a coinciding diagnosis of severe grade-3 or -4 intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, and/or intestinal perforation. Conclusion Preexisting comorbidities commonly associated with extreme preterm birth contributed to sepsis-related mortality in our patient cohort. Key Points Concurrent comorbidities contribute to, and may artificially inflate, sepsis-related mortality. Absence of a consensus definition for neonatal sepsis complicates the investigation of infection. Accurate assessment of the incidence of sepsis in very low birth weight infants is vital for future investigations. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Neonates with Early-Onset Infection
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Yeo, Kee Thai, primary, Goh, Guan Lin, additional, Park, Woo Yeon, additional, Wynn, James L., additional, and Aziz, Khyzer B., additional
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- 2023
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18. Neutrophil chemotaxis and transcriptomics in term and preterm neonates
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Raymond, Steven L., Mathias, Brittany J., Murphy, Tyler J., Rincon, Jaimar C., López, María Cecilia, Ungaro, Ricardo, Ellett, Felix, Jorgensen, Julianne, Wynn, James L., Baker, Henry V., Moldawer, Lyle L., Irimia, Daniel, and Larson, Shawn D.
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- 2017
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19. B cells enhance early innate immune responses during bacterial sepsis
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Kelly-Scumpia, Kindra M, Scumpia, Philip O, Weinstein, Jason S, Delano, Matthew J, Cuenca, Alex G, Nacionales, Dina C, Wynn, James L, Lee, Pui Y, Kumagai, Yutaro, Efron, Philip A, Akira, Shizuo, Wasserfall, Clive, Atkinson, Mark A, and Moldawer, Lyle L
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Hematology ,Sepsis ,Infectious Diseases ,1.1 Normal biological development and functioning ,Underpinning research ,2.1 Biological and endogenous factors ,Aetiology ,Infection ,Inflammatory and immune system ,Analysis of Variance ,Animals ,B-Lymphocytes ,Chemokine CXCL10 ,Colony Count ,Microbial ,Flow Cytometry ,Homeodomain Proteins ,Immunity ,Innate ,Mice ,Mice ,Knockout ,Receptor ,Interferon alpha-beta ,Receptors ,Pattern Recognition ,Medical and Health Sciences ,Immunology - Abstract
Microbes activate pattern recognition receptors to initiate adaptive immunity. T cells affect early innate inflammatory responses to viral infection, but both activation and suppression have been demonstrated. We identify a novel role for B cells in the early innate immune response during bacterial sepsis. We demonstrate that Rag1(-/-) mice display deficient early inflammatory responses and reduced survival during sepsis. Interestingly, B cell-deficient or anti-CD20 B cell-depleted mice, but not α/β T cell-deficient mice, display decreased inflammatory cytokine and chemokine production and reduced survival after sepsis. Both treatment of B cell-deficient mice with serum from wild-type (WT) mice and repletion of Rag1(-/-) mice with B cells improves sepsis survival, suggesting antibody-independent and antibody-dependent roles for B cells in the outcome to sepsis. During sepsis, marginal zone and follicular B cells are activated through type I interferon (IFN-I) receptor (IFN-α/β receptor [IFNAR]), and repleting Rag1(-/-) mice with WT, but not IFNAR(-/-), B cells improves IFN-I-dependent and -independent early cytokine responses. Repleting B cell-deficient mice with the IFN-I-dependent chemokine, CXCL10 was also sufficient to improve sepsis survival. This study identifies a novel role for IFN-I-activated B cells in protective early innate immune responses during bacterial sepsis.
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- 2011
20. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10
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Kelly-Scumpia, Kindra M, Scumpia, Philip O, Delano, Matthew J, Weinstein, Jason S, Cuenca, Alex G, Wynn, James L, and Moldawer, Lyle L
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Infectious Diseases ,Hematology ,Sepsis ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Infection ,Good Health and Well Being ,Adaptive Immunity ,Animals ,Cecum ,Chemokine CXCL10 ,Disease Models ,Animal ,Hematopoiesis ,Humans ,Interferon Type I ,Mice ,Neutrophil Infiltration ,Neutrophils ,Phagocytosis ,Receptor ,Interferon alpha-beta ,Signal Transduction ,Medical and Health Sciences ,Immunology - Abstract
Type I interferon (IFN) alpha/beta is critical for host defense. During endotoxicosis or highly lethal bacterial infections where systemic inflammation predominates, mice deficient in IFN-alpha/beta receptor (IFNAR) display decreased systemic inflammation and improved outcome. However, human sepsis mortality often occurs during a prolonged period of immunosuppression and not from exaggerated inflammation. We used a low lethality cecal ligation and puncture (CLP) model of sepsis to determine the role of type I IFNs in host defense during sepsis. Despite increased endotoxin resistance, IFNAR(-/-) and chimeric mice lacking IFNAR in hematopoietic cells display increased mortality to CLP. This was not associated with an altered early systemic inflammatory response, except for decreased CXCL10 production. IFNAR(-/-) mice display persistently elevated peritoneal bacterial counts compared with wild-type mice, reduced peritoneal neutrophil recruitment, and recruitment of neutrophils with poor phagocytic function despite normal to enhanced adaptive immune function during sepsis. Importantly, CXCL10 treatment of IFNAR(-/-) mice improves survival and decreases peritoneal bacterial loads, and CXCL10 increases mouse and human neutrophil phagocytosis. Using a low lethality sepsis model, we identify a critical role of type I IFN-dependent CXCL10 in host defense during polymicrobial sepsis by increasing neutrophil recruitment and function.
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- 2010
21. MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis
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Delano, Matthew J, Scumpia, Philip O, Weinstein, Jason S, Coco, Dominique, Nagaraj, Srinivas, Kelly-Scumpia, Kindra M, O'Malley, Kerri A, Wynn, James L, Antonenko, Svetlana, Al-Quran, Samer Z, Swan, Ryan, Chung, Chun-Shiang, Atkinson, Mark A, Ramphal, Reuben, Gabrilovich, Dmitry I, Reeves, Wesley H, Ayala, Alfred, Phillips, Joseph, LaFace, Drake, Heyworth, Paul G, Clare-Salzler, Michael, and Moldawer, Lyle L
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Sepsis ,Hematology ,Infectious Diseases ,Inflammatory and immune system ,Animals ,CD11b Antigen ,Cell Proliferation ,Colony-Forming Units Assay ,Cytokines ,Flow Cytometry ,Immune Tolerance ,Lymphoid Tissue ,Mice ,Mice ,Inbred C57BL ,Myeloid Differentiation Factor 88 ,Myeloid Progenitor Cells ,Receptors ,Chemokine ,Signal Transduction ,Th2 Cells ,Medical and Health Sciences ,Immunology - Abstract
Polymicrobial sepsis alters the adaptive immune response and induces T cell suppression and Th2 immune polarization. We identify a GR-1(+)CD11b(+) population whose numbers dramatically increase and remain elevated in the spleen, lymph nodes, and bone marrow during polymicrobial sepsis. Phenotypically, these cells are heterogeneous, immature, predominantly myeloid progenitors that express interleukin 10 and several other cytokines and chemokines. Splenic GR-1(+) cells effectively suppress antigen-specific CD8(+) T cell interferon (IFN) gamma production but only modestly suppress antigen-specific and nonspecific CD4(+) T cell proliferation. GR-1(+) cell depletion in vivo prevents both the sepsis-induced augmentation of Th2 cell-dependent and depression of Th1 cell-dependent antibody production. Signaling through MyD88, but not Toll-like receptor 4, TIR domain-containing adaptor-inducing IFN-beta, or the IFN-alpha/beta receptor, is required for complete GR-1(+)CD11b(+) expansion. GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization.
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- 2007
22. Pediatric Sepsis Definition—A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce
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Menon, Kusum, Schlapbach, Luregn J., Akech, Samuel, Argent, Andrew, Chiotos, Kathleen, Chisti, Mohammod Jobayer, Hamid, Jemila, Ishimine, Paul, Kissoon, Niranjan, Lodha, Rakesh, Oliveira, Cláudio Flauzino, Peters, Mark, Tissieres, Pierre, Watson, R. Scott, Wiens, Matthew O., Wynn, James L., and Sorce, Lauren R.
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- 2020
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23. Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis
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Nolan, Lila S., Wynn, James L., and Good, Misty
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- 2020
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24. 6 - Neonatal bacteremia and sepsis
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Lawrence, Shelley M., Wynn, James L., and Gordon, Scott M.
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- 2025
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25. 7 - Meningitis
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Gordon, Scott M., Wynn, James L., and Lawrence, Shelley M.
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- 2025
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26. Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production
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Raymond, Steven L., Hawkins, Russell B., Murphy, Tyler J., Rincon, Jaimar C., Stortz, Julie A., López, María Cecilia, Ungaro, Ricardo, Ellett, Felix, Baker, Henry V., Wynn, James L., Moldawer, Lyle L., Irimia, Daniel, and Larson, Shawn D.
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- 2018
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27. Application of metabolomics to neonatal meningitis
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Wynn, James L.
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- 2020
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28. Sepsis
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Wynn, James L., Hazelzet, Jan A., Shanley, Thomas P., Wong, Hector R., Wheeler, Derek S., Wheeler, Derek S., editor, Wong, Hector R., editor, and Shanley, Thomas P., editor
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- 2014
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29. Frequency of Acute Kidney Injury and Association With Mortality Among Extremely Preterm Infants
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Aziz, Khyzer B., primary, Schles, Eric M., additional, Makker, Kartikeya, additional, and Wynn, James L., additional
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- 2022
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30. Prolonged early antimicrobials in ELBWs: too much for too little
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Wynn, James L.
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- 2019
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31. Contributors
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Abbasi, Soraya, primary, Abbey, James, additional, Adzick, N. Scott, additional, Ahn, Sun-Young, additional, Albertine, Kurt H., additional, Allegaert, Karel, additional, Alper, Seth L., additional, Altit, Gabriel, additional, Altschuler, Steven M., additional, Alvaro, Ruben E., additional, Amorosa, Jennifer M.H., additional, Anbuhl, Kelsey L., additional, Andersen, Claus Yding, additional, Anderson, Richard A., additional, Askenazi, David J., additional, Auten, Richard Lambert, additional, Autmizguine, Julie, additional, Azhibekov, Timur, additional, Back, Stephen A., additional, Badaut, Jérôme, additional, Baker, Peter Russell, additional, Ballard, Philip L., additional, Bancalari, Eduardo H., additional, Barichello, Tatiana, additional, Battaglia, Frederick, additional, Baum, Michel, additional, Beggs, Simon, additional, Bell, Edward F., additional, Benchimol, Corinne, additional, Benders, Manon J.N.L., additional, Bennet, Laura, additional, Bennett, Phillip R., additional, Berger, Melvin, additional, Bernhard, Wolfgang, additional, Bertram, John F., additional, Bhosle, Vikrant K., additional, Bhutani, Vinod K., additional, Black, M. Jane, additional, Bliss, Joseph M., additional, Bolender, David L., additional, Brandenburg, Joline E., additional, Broussard, Delma L., additional, Brown, Laura Davidson, additional, Burrin, Douglas G., additional, Cannon, Barbara, additional, Caplan, Michael, additional, Carlson, Susan E., additional, Carlton, David P., additional, Caruana, Georgina, additional, Cashore, William J., additional, Chaemsaithong, Piya, additional, Chaiyasit, Noppadol, additional, Charlton, Jennifer R., additional, Cheatham, Carol L., additional, Chemtob, Sylvain, additional, Chen, Yi-Yung, additional, Chevalier, Robert L., additional, Chheda, Sadhana, additional, Childs, Andrew J., additional, Christensen, Robert D., additional, Chu, Alison, additional, Chu, David H., additional, Cilio, Maria Roberta, additional, Clark, David A., additional, Cleary-Goldman, Jane, additional, Clemente, Ethel G., additional, Clements, John A., additional, Clyman, Ronald I., additional, Cohen, Susan S., additional, Colombo, John, additional, Cowett, Richard M., additional, Crawford, Peter A., additional, Crowe, James E., additional, Cullen-McEwen, Luise A., additional, Cutfield, Wayne S., additional, D'Alton, Mary E., additional, Danzer, Enrico, additional, Delacourt, Christophe, additional, Devaskar, Sherin U., additional, Diacovo, Thomas G., additional, Docheva, Nikolina, additional, Dormans, John P., additional, Dysart, Kevin, additional, El-Khuffash, Afif, additional, Ellis, Peter James, additional, Empey, Kerry McGarr, additional, Ercal, Baris, additional, Erdős, Melinda, additional, Erickson, Robert P., additional, Fahim, Mohamed A., additional, Faksh, Arij, additional, Frank, Hans-Georg, additional, Friedlich, Philippe S., additional, Friedman, Jed, additional, Gao, Yuansheng, additional, Garland, Marianne, additional, Geddes, Donna, additional, Georgieff, Michael K., additional, Gien, Jason, additional, Giussani, Dino A., additional, Goldman, Armond S., additional, González, Efrén, additional, Good, Misty, additional, Grant, Denis M., additional, Green, Lucy R., additional, Grigoriou, Emmanouil, additional, Grimberg, Adda, additional, Gross, Ian, additional, Grunau, Ruth E., additional, Guignard, Jean-Pierre, additional, Gunn, Alistair Jan, additional, Gurtunca, Nursen, additional, Hadchouel, Alice, additional, Haddad, Gabriel G., additional, Hagberg, Henrik, additional, Hale, Thomas, additional, Hambidge, K. Michael, additional, Hammerman, Cathy, additional, Hansen, Thor Willy Ruud, additional, Hanson, Mark A., additional, Harding, Richard, additional, Harris, Mary Catherine, additional, Hartmann, Peter, additional, Hassiotou, Foteini, additional, Haugen, Guttorm, additional, Hawkes, Colin P., additional, Hay, William W., additional, Hayward, Christina E., additional, Heine, Vivi M., additional, Hellström, Ann, additional, Helmrath, Michael A., additional, Hendricks-Muñoz, Karen D., additional, Herrera, Emilio, additional, Hiatt, Michael J., additional, Hoath, Steven B., additional, Hooper, Stuart B., additional, Huang, Stephen A., additional, Iacobellli, Silvia, additional, Inder, Terrie E., additional, Iruela-Arispe, M. Luisa, additional, Jadcherla, Sudarshan R., additional, Jain, Deepak, additional, Jansson, Thomas, additional, Jefferies, John Lynn, additional, Jetton, Jennifer G., additional, Jobe, Alan H., additional, Johnson, Lois H., additional, Johnston, Richard B., additional, Jones, Rebecca Lee, additional, Jose, Pedro A., additional, Kalhan, Satish C., additional, Kallapur, Suhas G., additional, Kaplan, Michael, additional, Kaplan, Stanley, additional, Karpen, Heidi Eigenrauch, additional, Karpen, Saul J., additional, Karumanchi, S. Ananth, additional, Kaskel, Frederick J., additional, Katheria, Anup C., additional, Katz, Lorraine E. Levitt, additional, Keeney, Susan E., additional, Kern, Steven E., additional, Khanjani, Shirin, additional, Kilpatrick, Laurie E., additional, Kim, Chang-Ryul, additional, Kinsella, John P., additional, Kiserud, Torvid, additional, Koenig, Joyce M., additional, Kollmann, Tobias R., additional, Kolls, Jay K., additional, Krebs, Nancy F., additional, Kulik, Thomas J., additional, Kutikov, Jessica Katz, additional, Lakshminrusimha, Satyan, additional, Lamola, Angelo A., additional, Lasunción, Miguel Angel, additional, Lavoie, Pascal M., additional, LeBien, Tucker W., additional, Lee, Mary M., additional, Lee, Matthew K., additional, Lee, Yvonne K., additional, Leibel, Sandra, additional, Levine, Fred, additional, Levy, Ofer, additional, Liu, Yang, additional, Lobritto, Steven, additional, Loomis, Cynthia A., additional, Lopez, Colleen A., additional, MacIntyre, David A., additional, Mahe, Maxime M., additional, Maheshwari, Akhil, additional, Mankouski, Anastasiya, additional, Mantilla, Carlos B., additional, Marchant, Arnaud, additional, Margolis, Kara Gross, additional, Mariscalco, M. Michele, additional, Maródi, László, additional, Maršál, Karel, additional, Martin, Richard J., additional, Matsell, Douglas G., additional, Matthews, Dwight E., additional, McArdle, Harry J., additional, McManaman, James L., additional, McNamara, Patrick J., additional, McQuillen, Patrick S., additional, McQuinn, Tim C., additional, Mercer, Judith S., additional, Meschia, Giacomo, additional, Miller, Steven P., additional, Minoo, Parviz, additional, Monagle, Paul, additional, Mortola, Jacopo P., additional, Muglia, Louis J., additional, Munshi, Upender K., additional, Namgung, Ran, additional, Narasimhan, Sumana, additional, Nedergaard, Jan, additional, Neu, Josef, additional, Nigam, Sanjay K., additional, Nogee, Lawrence M., additional, Noori, Shahab, additional, O'Brien, Barbara M., additional, Ohls, Robin K., additional, Ortega-Senovilla, Henar, additional, O'Sullivan, Justin M., additional, Owusu, Sarah A., additional, Pal, Abhijeet, additional, Panitch, Howard B., additional, Penn, Anna A., additional, Penn, Raymond B., additional, Pernia, Cameron, additional, Philipps, Anthony F., additional, Picoraro, Joseph A., additional, Pisani, Francesco, additional, Pleasure, David, additional, Pleasure, Jeanette R., additional, Pleasure, Samuel J., additional, Pomeroy, Scott L., additional, Post, Martin, additional, Prakash, Y.S., additional, Prozialeck, Joshua D., additional, Pysher, Theodore J., additional, Quigley, Raymond, additional, Rabinovitch, Marlene, additional, Raffay, Thomas M., additional, Raj, J. Usha, additional, Ramsey, Haley, additional, Rana, Sarosh, additional, Randis, Tara Marie, additional, Ranger, Manon, additional, Ratner, Adam J., additional, Regnault, Timothy R.H., additional, Rigatto, Henrique, additional, Rintoul, Natalie E., additional, Romero, Roberto, additional, Rose, James C., additional, Rosenfeld, Charles R., additional, Ross, A. Catharine, additional, Rozycki, Henry J., additional, Ryan, Thomas D., additional, Sahni, Rakesh, additional, Sajti, Eniko, additional, Sarnat, Harvey B., additional, Satlin, Lisa M., additional, Saugstad, Ola Didrik, additional, Schierding, William, additional, Schmalstieg, Frank C., additional, Schwartz, George J., additional, Schwartz, Jeffrey, additional, Segar, Jeffrey L., additional, Selewski, David T., additional, Seri, Istvan, additional, Shaffer, Thomas H., additional, Shah, Kara N., additional, Shearer, Martin J., additional, Shojaie, Sharareh, additional, Shroyer, Noah F., additional, Sibley, Colin P., additional, Sieck, Gary C., additional, Simmons, Rebecca A., additional, Sivieri, Emidio M., additional, Smith, Francine G., additional, Smith, Lois E.H., additional, Smyth, Ian M., additional, Snarr, Brian S., additional, Snyder, Evan Y., additional, Sola-Visner, Martha, additional, Solhaug, Michael J., additional, Sperling, Mark A., additional, Srinivasan, Lakshmi, additional, Stahl, Andreas, additional, Stanley, Charles A., additional, Steinhorn, Robin H., additional, Stonestreet, Barbara S., additional, Strasburger, Janette F., additional, Styne, Dennis M., additional, Sussel, Lori, additional, Tam, Emily W.Y., additional, Tan, Libo, additional, Thornton, Claire, additional, Tollin, Daniel J., additional, Tóth, Beáta, additional, Towbin, Jeffrey A., additional, Trocle, Ashley, additional, Truog, William E., additional, Tsang, Reginald C., additional, Uhler, Kristin M., additional, Van Den Anker, John N., additional, van Goudoever, Johannes (Hans) B., additional, Vannucci, Susan J., additional, Vickers, Mark H., additional, Virgintino, Daniela, additional, Volpe, Joseph J., additional, Vora, Neeta L., additional, Vyas, Neha V., additional, Wacker-Gussmann, Annette, additional, Wallace, Megan J., additional, Walsh, Brian H., additional, Wang, Alice M., additional, Warburton, David, additional, Ward, Robert M., additional, Watterberg, Kristi L., additional, Werner, Lynne A., additional, Wershil, Barry K., additional, Wert, Susan E., additional, Wessels, Andy, additional, Whitsett, Jeffrey A., additional, Wise, Michael, additional, Wolf, Matthias T., additional, Wolfson, Marla R., additional, Wong, Hector R., additional, Wynn, James L., additional, Yeo, Lami, additional, Yip, Stephen, additional, Yoder, Bradley A, additional, Yoder, Mervin C., additional, Yoshimoto, Momoko, additional, Yuskaitis, Christopher J., additional, Zhou, Dan, additional, and Zovein, Ann, additional
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- 2017
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32. Pathophysiology of Neonatal Sepsis
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Wynn, James L., primary and Wong, Hector R., additional
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- 2017
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33. Reporting of Social Determinants of Health in Pediatric Sepsis Studies.
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Menon, Kusum, Sorce, Lauren R., Argent, Andrew, Bennett, Tellen D., Carrol, Enitan D., Kissoon, Niranjan, Sanchez-Pinto, L. Nelson, Schlapbach, Luregn J., C. de Souza, Daniela, Watson, R. Scott, Wynn, James L., Zimmerman, Jerry J., and Ranjit, Suchitra
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- 2023
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34. Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile sepsis Model
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Atkinson, Sarah J, Varisco, Brian M, Sandquist, Mary, Daly, Meghan N, Klingbeil, Lindsey, Kuethe, Joshua W, Midura, Emily F, Harmon, Kelli, Opoka, Amy, Lahni, Patrick, Piraino, Giovanna, Hake, Paul, Zingarelli, Basilia, Mortensen, Joel E, Wynn, James L, and Wong, Hector R
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- 2016
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35. Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials
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Henry, Cían J, Semova, Gergana, Barnes, Ellen, Cotter, Isabel, Devers, Tara, Rafaee, Aisyah, Slavescu, Andreea, Cathain, Niamh O, McCollum, Danielle, Roche, Edna, Mockler, David, Allen, John, Meehan, Judith, Klingenberg, Claus, Latour, Jos M, van den Hoogen, Agnes, Strunk, Tobias, Giannoni, Eric, Schlapbach, Luregn J, Degtyareva, Marina, Plötz, Frans B, de Boode, Willem P, Naver, Lars, Wynn, James L, Küster, Helmut, Janota, Jan, Keij, Fleur M, Reiss, Irwin K M, Bliss, Joseph M, Polin, Richard, et al, and University of Zurich
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10036 Medical Clinic ,610 Medicine & health ,2735 Pediatrics, Perinatology and Child Health - Published
- 2022
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36. Genome-wide association study of sepsis in extremely premature infants
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Srinivasan, Lakshmi, Page, Grier, Kirpalani, Haresh, Murray, Jeffrey C, Das, Abhik, Higgins, Rosemary D, Carlo, Waldemar A, Bell, Edward F, Goldberg, Ronald N, Schibler, Kurt, Sood, Beena G, Stevenson, David K, Stoll, Barbara J, Van Meurs, Krisa P, Johnson, Karen J, Levy, Joshua, McDonald, Scott A, Zaterka-Baxter, Kristin M, Kennedy, Kathleen A, Sánchez, Pablo J, Duara, Shahnaz, Walsh, Michele C, Shankaran, Seetha, Wynn, James L, Cotten, C Michael, Jobe, Alan H., Fanaroff, Avroy A., Newman, Nancy S., Siner, Bonnie S., Donovan, Edward F., Narendran, Vivek, Alexander, Barbara, Grisby, Cathy, Hessling, Jody, Mincey, Holly L., Auten, Kathy J., Hale, Ellen C., Wright, Linda L., Yaffe, Sumner J., McClure, Elizabeth M., Archer, Stephanie Wilson, Poole, W. Kenneth, Hastings, Betty K., Auman, Jeanette OʼDonnell, Ball, M. Bethany, Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Finer, Neil N., Rasmussen, Maynard R., Kaegi, David, Arnell, Kathy, Demetrio, Clarence, Rich, Wade, Bell, Edward F., Bauer, Charles R., Everett-Thomas, Ruth, Schmidt, Barbara, Korones, Sheldon B., Bada, Henrietta S., Hudson, Tina, Laptook, Abbot R., Salhab, Walid A., Madison, Susie, Miller, Nancy A., Hensley, Gaynelle, Guzman, Alicia, Tyson, Jon E., Kennedy, Kathleen A., Akpa, Esther G., Cluff, Patty A., Franco, Claudia I., Lis, Anna E., McDavid, Georgia E., Tate, Patti Pierce, Konduri, G. Ganesh, Bara, Rebecca, and Muran, Geraldine
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- 2017
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37. Sepsis and Mortality Prediction in Very Low Birth Weight Infants: Analysis of HeRO and nSOFA.
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Zeigler, Angela C., Ainsworth, John E., Fairchild, Karen D., Wynn, James L., and Sullivan, Brynne A.
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BLOOD ,NEONATAL sepsis ,PREDICTIVE tests ,CELL culture ,VERY low birth weight ,RETROSPECTIVE studies ,ACQUISITION of data ,RISK assessment ,MEDICAL records ,RESEARCH funding ,INFANT mortality ,RECEIVER operating characteristic curves ,DISEASE risk factors - Abstract
Objective Scores to predict sepsis or define sepsis severity could improve care for very low birth weight (VLBW) infants. The heart rate characteristics (HRC) index (HeRO score) was developed as an early warning system for late-onset sepsis (LOS), and also rises before necrotizing enterocolitis (NEC). The neonatal sequential organ failure assessment (nSOFA) was developed to predict sepsis-associated mortality using respiratory, hemodynamic, and hematologic data. The aim of this study was to analyze the HRC index and nSOFA near blood cultures in VLBW infants relative to diagnosis and sepsis-associated mortality. Study Design Retrospective, single-center study of VLBW infants from 2011 to 2019. We analyzed HRC index and nSOFA around blood cultures diagnosed as LOS/NEC. In a subgroup of the cohort, we analyzed HRC and nSOFA near the first sepsis-like illness (SLI) or sepsis ruled-out (SRO) compared with LOS/NEC. We compared scores by diagnosis and mortality during treatment. Results We analyzed 179 LOS/NEC, 93 SLI, and 96 SRO blood culture events. In LOS/NEC, the HRC index increased before the blood culture, while nSOFA increased at the time of culture. Both scores were higher in nonsurvivors compared with survivors and in LOS/NEC compared with SRO. The nSOFA 12 hours after the time of blood culture predicted mortality during treatment better than any other time point analyzed (area under the curve 0.91). Conclusion The HRC index provides earlier warning of imminent sepsis, whereas nSOFA after blood culture provides better prediction of mortality. Key Points The HRC index and nSOFA provide complementary information on sepsis risk and sepsis-related mortality risk. This study adds to existing literature evaluating these risk scores independently by analyzing them together and in cases of not only proven but also suspected infections. The impact of combining risk models could be improved outcomes for premature infants. [ABSTRACT FROM AUTHOR]
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- 2023
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38. Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis
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Wynn, James L., Guthrie, Scott O., Wong, Hector R., Lahni, Patrick, Ungaro, Ricardo, Lopez, M. Cecilia, Baker, Henry V., and Moldawer, Lyle L.
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- 2015
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39. Outcomes Following Candiduria in Extremely Low Birth Weight Infants
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The NICHD Neonatal Research Network, Wynn, James L., Tan, Sylvia, Gantz, Marie G., Das, Abhik, Goldberg, Ronald N., Adams-Chapman, Ira, Stoll, Barbara J., Shankaran, Seetha, Walsh, Michele C., Auten, Kathy J., Miller, Nancy A., Sánchez, Pablo J., Higgins, Rosemary D., Cotten, C. Michael, Smith, P. Brian, and Benjamin, Daniel K.
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- 2012
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40. 151 - Pathophysiology of Neonatal Sepsis
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Wynn, James L.
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- 2022
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41. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants with Necrotizing Enterocolitis
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Lewis, Angela N., primary, de la Cruz, Diomel, additional, Wynn, James L., additional, Frazer, Lauren C., additional, Yakah, William, additional, Martin, Camilia R., additional, Yang, Heeju, additional, Itriago, Elena, additional, Unger, Jana, additional, Hair, Amy B., additional, Miele, Jessica, additional, Sullivan, Brynne A., additional, Husain, Ameena, additional, and Good, Misty, additional
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- 2022
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42. Refining the Pediatric Multiple Organ Dysfunction Syndrome
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Weiss, Scott L., primary, Carcillo, Joseph A., additional, Leclerc, Francis, additional, Leteurtre, Stephane, additional, Schlapbach, Luregn J., additional, Tissieres, Pierre, additional, Wynn, James L., additional, and Lacroix, Jacques, additional
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- 2022
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43. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary
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Bembea, Melania M., primary, Agus, Michael, additional, Akcan-Arikan, Ayse, additional, Alexander, Peta, additional, Basu, Rajit, additional, Bennett, Tellen D., additional, Bohn, Desmond, additional, Brandão, Leonardo R., additional, Brown, Ann-Marie, additional, Carcillo, Joseph A., additional, Checchia, Paul, additional, Cholette, Jill, additional, Cheifetz, Ira M., additional, Cornell, Timothy, additional, Doctor, Allan, additional, Eckerle, Michelle, additional, Erickson, Simon, additional, Farris, Reid W.D., additional, Faustino, E. Vincent S., additional, Fitzgerald, Julie C., additional, Fuhrman, Dana Y., additional, Giuliano, John S., additional, Guilliams, Kristin, additional, Gaies, Michael, additional, Gorga, Stephen M., additional, Hall, Mark, additional, Hanson, Sheila J., additional, Hartman, Mary, additional, Hassinger, Amanda B., additional, Irving, Sharon Y., additional, Jeffries, Howard, additional, Jouvet, Philippe, additional, Kannan, Sujatha, additional, Karam, Oliver, additional, Khemani, Robinder G., additional, Kissoon, Niranjan, additional, Lacroix, Jacques, additional, Laussen, Peter, additional, Leclerc, Francis, additional, Lee, Jan Hau, additional, Leteurtre, Stephane, additional, Lobner, Katie, additional, McKiernan, Patrick J., additional, Menon, Kusum, additional, Monagle, Paul, additional, Muszynski, Jennifer A., additional, Odetola, Folafoluwa, additional, Parker, Robert, additional, Pathan, Nazima, additional, Pierce, Richard W., additional, Pineda, Jose, additional, Prince, Jose M., additional, Robinson, Karen A., additional, Rowan, Courtney M., additional, Ryerson, Lindsay M., additional, Sanchez-Pinto, L. Nelson, additional, Schlapbach, Luregn J., additional, Selewski, David T., additional, Shekerdemian, Lara S., additional, Simon, Dennis, additional, Smith, Lincoln S., additional, Squires, James E., additional, Squires, Robert H., additional, Sutherland, Scott M., additional, Ouellette, Yves, additional, Spaeder, Michael C., additional, Srinivasan, Vijay, additional, Steiner, Marie E., additional, Tasker, Robert C., additional, Thiagarajan, Ravi, additional, Thomas, Neal, additional, Tissieres, Pierre, additional, Traube, Chani, additional, Tucci, Marisa, additional, Typpo, Katri V., additional, Wainwright, Mark S., additional, Ward, Shan L., additional, Watson, R. Scott, additional, Weiss, Scott, additional, Whitney, Jane, additional, Willson, Doug, additional, Wynn, James L., additional, Yeyha, Nadir, additional, and Zimmerman, Jerry J., additional
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- 2022
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44. Scoring Systems for Organ Dysfunction and Multiple Organ Dysfunction: The PODIUM Consensus Conference
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Schlapbach, Luregn J., primary, Weiss, Scott L., additional, Bembea, Melania M., additional, Carcillo, Joseph A., additional, Leclerc, Francis, additional, Leteurtre, Stephane, additional, Tissieres, Pierre, additional, Wynn, James L., additional, Zimmerman, Jerry, additional, and Lacroix, Jacques, additional
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- 2022
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45. Hourly Kinetics of Critical Organ Dysfunction in Extremely Preterm Infants
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Lavilla, Orlyn C., primary, Aziz, Khyzer B., additional, Lure, Allison C., additional, Gipson, Daniel, additional, de la Cruz, Diomel, additional, and Wynn, James L., additional
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- 2022
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46. Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce
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Carrol, Enitan D., Ranjit, Suchitra, Menon, Kusum, Bennett, Tellen D., Sanchez-Pinto, L. Nelson, Zimmerman, Jerry J., Souza, Daniela C., Sorce, Lauren R., Randolph, Adrienne G., Ishimine, Paul, Flauzino de Oliveira, Claudio, Lodha, Rakesh, Harmon, Lori, Watson, R. Scott, Schlapbach, Luregn J., Kissoon, Niranjan, Argent, Andrew C., Schlapbach, Luregn J., Watson, R. Scott, Argent, Andrew, Sorce, Lauren R., Akech, Samuel, Alpern, Elizabeth R., Balamuth, Fran, Bennett, Tellen D., Biban, Paolo, Carcillo, Joe, Carrol, Enitan D, Chiotos, Kathleen, Chisti, Mohammod Jobayer, Evans, Idris, Guoping, Lu, Hall, Mark W., Inwald, David, Ishimine, Paul, Levin, Michael, Kissoon, Niranjan Tex, Lodha, Rakesh, Maitland, Kathryn, Nadel, Simon, Nakagawa, Satoshi, Oliveira, Claudio Flauzino, Peters, Mark, Randolph, Adrienne G., Ranjit, Suchitra, Sanchez-Pinto, L. Nelson, Scott, Halden F., Souza, Daniela C., Tissieres, Pierre, Wardenburg, Juliane Bubeck, Weiss, Scott L., Were, Wilson Milton, Wiens, Matthew O., Wynn, James L., and Zimmerman, Jerry J.
- Abstract
Sepsis is a leading cause of global mortality in children, yet definitions for pediatric sepsis are outdated and lack global applicability and validity. In adults, the Sepsis-3 Definition Taskforce queried databases from high-income countries to develop and validate the criteria. The merit of this definition has been widely acknowledged; however, important considerations about less-resourced and more diverse settings pose challenges to its use globally. To improve applicability and relevance globally, the Pediatric Sepsis Definition Taskforce sought to develop a conceptual framework and rationale of the critical aspects and context-specific factors that must be considered for the optimal operationalization of future pediatric sepsis definitions. It is important to address challenges in developing a set of pediatric sepsis criteria which capture manifestations of illnesses with vastly different etiologies and underlying mechanisms. Ideal criteria need to be unambiguous, and capable of adapting to the different contexts in which children with suspected infections are present around the globe. Additionally, criteria need to facilitate early recognition and timely escalation of treatment to prevent progression and limit life-threatening organ dysfunction. To address these challenges, locally adaptable solutions are required, which permit individualized care based on available resources and the pretest probability of sepsis. This should facilitate affordable diagnostics which support risk stratification and prediction of likely treatment responses, and solutions for locally relevant outcome measures. For this purpose, global collaborative databases need to be established, using minimum variable datasets from routinely collected data. In summary, a “Think globally, act locally” approach is required.
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- 2023
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47. Contribution of Concurrent Comorbidities to Sepsis-Related Mortality in Preterm Infants ≤32 Weeks of Gestation at an Academic Neonatal Intensive Care Network
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Barnette, Brian W., additional, Schumacher, Benjamin T., additional, Armenta, Richard F., additional, Wynn, James L., additional, Richardson, Andrew, additional, Bradley, John S., additional, Lazar, Sarah, additional, and Lawrence, Shelley M., additional
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- 2021
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48. Heart rate characteristic index monitoring for bloodstream infection in an NICU: a 3-year experience
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Coggins, Sarah A, Weitkamp, Jörn-Hendrik, Grunwald, Lisa, Stark, Ann R, Reese, Jeff, Walsh, William, and Wynn, James L
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- 2016
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49. Contributors
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Abu-Raya, Bahaa, Ambalavanan, Namasivayam, Archary, Moherndran, Arditi, Moshe, Barnett, Elizabeth D., Bendel, Catherine M., Benjamin, Daniel K., Jr., Bode, Lars, Bradley, John S., Brasil, Patricia, Cassat, James E., Cherry, James D., Coffin, Susan E., D’Angio, Carl T., Darmstadt, Gary L., Darville, Toni, Edwards, Kathryn M., Embree, Joanne E., Freitag, Nancy Elizabeth, Fuller, Trevon L., Gantt, Soren, Garweg, Justus G., Gigliotti, Francis, Gordon, Scott M., Hanekom, Willem A., Hawn, Thomas R., Heininger, Ulrich, Hunstad, David A., Imam, Farhad B., James, Scott H., John, Audrey Ragan Odom, Karnsakul, Wikrom, Kieffer, François, Kim, Jae H., Kimberlin, David W., Klein, Jerome O., Koch, William C., Krogstad, Paul, Krysan, Damian Joseph, Lawrence, Shelley M., Levy, Ofer, Lewis, David B., Liu, George Y., Lucero, Yalda C., Maldonado, Yvonne A., Malley, Richard, Mandelbrot, Laurent, Marshall, Beth C., Mathew, Roshni, McKinney, Jeffrey, Moreira, Alvaro G., Moss, William J., Moujaes, Lea, Nielsen-Saines, Karin, Nieves, Delma J., Nizet, Victor, Ogra, Pearay L., O’Ryan, Miguel L., Permar, Sallie R., Peyron, François, Plotkin, Stanley A., Puopolo, Karen Marie, Ratner, Adam J., Reef, Susan E., Remington, Jack S., Riley, Laura E., Same, Rebecca G., Sammons, Julia Shaklee, Schwarz, Kathleen B., Schwenk, Hayden T., Shapiro, Eugene D., Shetty, Avinash K., Sood, Sunil K., Swamy, Geeta Krishna, Swanson, Elizabeth C., Ulloa, Erlinda R., Velarde, Jorge J., Viscardi, Rose Marie, Wade, Kelly C., Waites, Ken B., Wallon, Martine, Weinberg, Geoffrey A., Weiner, Lukasz D., Weitkamp, Joern-Hendrik, Wright, Terry W., Wynn, James L., and Zaidi, Anita K.M.
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- 2025
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50. Balance between protective and pathogenic immune responses to pneumonia in the neonatal lung enforced by gut microbiota
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Stevens, Joseph, primary, Steinmeyer, Shelby, additional, Bonfield, Madeline, additional, Wang, Timothy, additional, Gray, Jerilyn, additional, Lewkowich, Ian, additional, Xu, Yan, additional, Du, Yina, additional, Guo, Minzhe, additional, Wynn, James L., additional, Zacharias, William, additional, Salomonis, Nathan, additional, Miller, Lisa, additional, Chougnet, Claire, additional, O’Connor, Dennis Hartigan, additional, and Deshmukh, Hitesh, additional
- Published
- 2021
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