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Hypermetropic anisometropia is often accompanied by visual fatigue, and the higher hyperopia is prone to form amblyopia. To avoid Wear glasses fatigue, the higher hyperopia is often under corrected and regulative spasm. Pseudomyopia may occur in the early stage after refractive surgery. In this case, autologous corneal stromal lenticule transplantation was used to correct hyperopia. After standard visual cognitive training, the Uncorrected Distance Visual Acuity was rapidly improved, and the binocular vision was normal.远视性屈光参差，往往伴视疲劳，度数较高眼易于形成弱视。为了避免屈光参差配镜后出现不适，往往会选择远视眼欠矫，使其长期处于调节紧张状态，屈光术后早期可出现假性近视。本例20岁女性患者采用自体角膜基质透镜移植矫正远视，术后经过规范的训练，在短期内左眼视功能改善，裸眼视力快速提高，双眼视功能恢复正常。.

Physical review / B 106(7), 075132 (2022). doi:10.1103/PhysRevB.106.075132, We have synthesized YbPdAs with the hexagonal ZrNiAl-type structure in which the Yb atoms form a distorted kagome sublattice in the hexagonal-basal plane. Magnetic, transport, and thermodynamic measurements indicate that YbPdAs is a low-carrier Kondo lattice compound with an antiferromagnetic transition at $T_N$ = 6.6 K, which is slightly suppressed in applied magnetic fields up to 9 T. The magnetic entropy at $T_N$ recovers only 33% of Rln2, the full entropy of the ground-state doublet of the Yb-ions. The resistivity displays a −lnT dependence between 30 and 15 K, followed by a broad maximum at $T_{coh}$ = 12 K upon cooling. Below $T_{coh}$, the magnetoresistance changes from negative to positive, suggesting a crossover from single-ion Kondo scattering processes at intermediate temperatures to coherent Kondo lattice behaviors at low temperatures. Both the Hall resistivity measurements and band-structure calculations indicate a relatively low carrier concentration in YbPdAs. Our results suggest that YbPdAs could provide an opportunity for examining the interplay of Kondo physics and magnetic frustration in low carrier systems., Published by Inst., Woodbury, NY

Two new Cd(II)-containing coordination polymers, namely [Cd(H2O)2(L1)2](NO3)2(1, L1 = 1,3-bis-(imidazol-1-yl)-5-methyl-benzene) and [Cd2(L2)(H2O)6](DMF)3(2, H4L2 = 5,5′-(p-xylylenediamino)-1,1′,3,3′-(benzene-tetra-carboxylic acid), are successfully prepared under the solvothermal conditions using different donor ligands. Complex 1 is a 2D layered structure whose network could be considered as a sql uninodal topological network, while complex 2 reveals a 3D supramolecular structure via H bond interactions between the adjacent 2D layers. Furthermore, the anticancer activity of the two complexes is studied via the CCK-8 assay against the MGC-803 gastric cancer cell lines, which reveals that compound 1 exhibits a significantly stronger activity than compound 2.

Редколлегия журнала отзывает данную статью. После публикации были высказаны опасения по поводу использования явно нерелевантных ссылок и очень похожих изображений в ряде статей из разных групп, которые находились на рассмотрении в аналогичные сроки. В частности, изображения, представленные на рис. 3, очень похожи на рис. 3 Ma et al. 2020 [1], рис. 4c Cui et al. 2020 [2] и рис. S5 Jiang et al. 2020 [3] среди прочих. Кроме того, авторы использовали клетки MGC-803, которые, как известно, частично контаминированы клетками HeLa и поэтому являются непригодной моделью рака желудка.

Little is known about the disease burden of chronic obstructive pulmonary disease (COPD) and asthma in southern China.We calculated the mortality, disability-adjusted life-years (DALY), years lived with disability (YLD) and years of life lost (YLL) for COPD and asthma in Guangdong province between 2005 and 2015. We examined the significance of trends of mortality, DALY, YLD and YLL rates for COPD and asthma with the Cochran-Armitage trend test. We also analyzed their association with sociodemographic factors by negative binomial models.The age-standardized mortality, DALY, YLD and YLL rates of COPD and asthma decreased significantly in Guangdong, except for an increase of 11.3% in the age-standardized YLD rate of COPD between 2005 and 2015 (all P 0.05). Compared with females, the respective adjusted mortality rate ratio of males was 2.11 for COPD, and 0.74 for asthma. Compared with other regions, the richest region, Pearl River Delta, had the lowest mortality, DALY, YLD and YLL rate ratios (RR) of COPD and asthma (all P 0.05). COPD and asthma mortality, DALY, YLD and YLL rates increased substantially with age. Specifically, when compared with the 25-49 years age group, the respective adjusted DALY RR of asthma was 1.91, 2.02 and 22.21 for 0-24, 50-74 and ≥75 years age group; the respective adjusted YLD RR was 2.27, 1.33 and 7.17 for 0-24, 50-74 and ≥75 years age group.Disease burden of COPD and asthma decreased in Guangdong province in southern China between 2005 and 2015; however, a disproportionate burden of COPD and asthma in terms of age, sex and regions was observed. The relatively high disease burden and high rate of impaired public health from the less developed regions highlight the need for focused policy making to address the problem.

Two new Cd(II)-containing coordination polymers, namely [Cd(H2O)2(L1)2](NO3)2 (1, L1 = 1,3-bis­(imidazol-1-yl)-5-methyl­benzene) and [Cd2(L2)(H2O)6](DMF)3 (2, H4L2 = 5,5'-(p-xylylenediamino)-1,1',3,3'-(benzene-tetra-carboxylic acid), are successfully prepared under the solvothermal conditions using different donor ligands. Complex 1 is a 2D layered structure whose network could be considered as a sql uninodal topological network, while complex 2 reveals a 3D supramolecular structure via H bond interactions between the adjacent 2D layers. Furthermore, the anticancer activity of the two complexes is studied via the CCK8 assay against the MGC-803 gastric cancer cell lines, which reveals that compound 1 exhibits a significantly stronger activity than compound 2.

Summary Aims The purpose of this study was to examine the effectiveness of beinaglutide on body weight, glycated haemoglobin (HbA1c), blood pressure and lipid profiles in patients with type 2 diabetes mellitus (T2DM) in a real‐world setting in China. Materials and methods This was a multicentre, observational, retrospective, open‐label study conducted in China. Data were collected from T2DM patients who started treatment with beinaglutide between 2017 and 2018. Results A total of 314 patients were included in the study. After 3 months of treatment with beinaglutide, there were significant reductions in body weight (−10.05 kg [95% confidence interval −9.29 to −10.80]), HbA1c (−2.87% [−2.62 to −3.11]), 2‐h postprandial plasma glucose (−5.46 mmol L−1 [−4.96 to −5.95]) and fasting plasma glucose (−3.04 mmol L−1 [−2.78 to −3.31]) (all p < 0.0001). In addition, 84.96% and 72.18% of the patients achieved weight loss of ≥5% and ≥10%, respectively. Subgroup analyses showed that weight loss was significantly greater in patients with ≥28 kg m−2 of baseline body mass index and 0.60 mg of beinaglutide doses (p = 0.007 and p < 0.0001, respectively). HbA1c reductions were significantly greater in patients with ≥9.0% baseline HbA1c and in those administered 0.40–0.48 mg of beinaglutide doses (all p < 0.0001). Weight loss at 3 months was positively correlated with baseline BMI and the dose of beinaglutide. Positive determinants for HbA1c reduction after 3 months were baseline HbA1c and the dose of beinaglutide. Conclusions These observational results confirmed the benefits of beinaglutide in weight loss and glycaemic control and support the use of beinaglutide as an effective treatment for T2DM.

目的 了解血液科碳青霉烯耐药革兰阴性菌（CRO）感染的分布及耐药情况，分析影响CRO感染患者预后的危险因素，为临床CRO感染患者的治疗和预后判断提供依据。 方法 回顾性分析2018年1月至2020年6月血液科确诊的CRO感染患者181例，收集患者的临床和实验室检查等资料，分析影响患者30 d死亡的危险因素。在碳青霉烯类耐药肠杆菌科细菌（CRE）亚组中进一步评价CRE主动筛查的临床意义。 结果 分离出的181株CRO中CRE占47.2％，铜绿假单胞菌占37.0％，肺炎克雷伯菌占32.6％，对碳青霉烯类药物高度耐药，对亚胺培南耐药最低抑菌浓度（MIC）≥16 µg/ml的占76.8％（139/181）。菌株标本来源主要是血样和痰液。CRO和CRE感染患者30 d的全因死亡率分别为（41.4±3.7）％、（44.7±5.4）％。Cox多因素回归分析结果显示：降钙素原水平>0.2 ng/ml及亚胺培南耐药的MIC≥16 µg/ml是CRO感染30 d死亡的独立危险因素。CRE亚组分析结果显示，亚胺培南耐药的MIC≥16 µg/ml为CRE感染30 d死亡的独立危险因素。CRE主动筛查患者的30 d累积生存率高于未筛查患者［（68.0±9.3）％对（50.0±6.5）％，P＝0.21］。 结论 高亚胺培南耐药MIC值的致病菌严重影响血液科CRO感染患者预后，病死率高。开展CRE主动筛查有助于早期预防、早期诊断和早期治疗高危患者。

Physical review / B 104(17), 174425 (2021). doi:10.1103/PhysRevB.104.174425, We report the observation of multiple magnetic transitions in single crystals of EuPtAs using magnetization, transport, and thermodynamic measurements. EuPtAs crystallizes in the noncentrosymmetric tetragonal LaPtSi-type structure (space group I41md) and undergoes a second-order antiferromagnetic (AFM) transition at 14.8 K, which is followed by a first-order transition at about 7.5 K. Both transitions are suppressed by magnetic fields applied parallel and perpendicular to the c axis, and multiple field-induced transitions are observed for both field directions, leading to complex temperature-field diagrams with a domelike magnetic phase for fields parallel to the c axis. Moreover, the dependence of the low-temperature resistivity on the application of a training field, together with a lack of remanent magnetization, suggests the presence of multiple AFM domains in zero field., Published by Inst., Woodbury, NY

Liver fibrosis, liver cirrhosis and hepatocellular carcinoma caused by chronic hepatitis B are still the main diseases that seriously affect the health of Chinese population. Notably, even if serum HBV-DNA cannot be detected after treatment, many patients will still develop liver disease. Therefore, in addition to the quantitative analysis of HBV-DNA and HBsAg, other new serological markers should be sought to facilitate the selection of CHB antiviral drugs and methods, monitoring efficacy and follow-up, efficacy prediction, and the risks of viral rebound after drug withdrawal. This article focuses on three new serological markers, namely HBcrAg, HBV-RNA and anti-HBc, with a view to applying them in clinical practice.在我国，慢性乙型肝炎（CHB）及其所导致的纤维化、肝硬化和肝细胞癌仍是严重影响人群健康的重大疾病。很多患者经治疗虽然检测不到血清HBV DNA，但也会出现肝脏疾病的进展，因此，应该寻找除HBV DNA、HBsAg定量之外的新型血清学标志物，有利于CHB抗病毒药物及方式的选择、疗效监测随访、疗效预测以及预测停药后病毒学反弹风险等。现重点阐述HBV核心相关抗原、HBV RNA、抗-HBc这三种新型有望应用于临床实践的血清学标志物。.

Stochastic multiresonance in a time-delayed asymmetric bistable system modulated by periodic rectangular signal and colored noises was investigated. By using the small time delay method and two-state theory, we have obtained the expression of its signal-to-noise ratio (SNR). The numerical results indicate the SNR exhibits stochastic multiresonance as a function of intensity of multiplicative noise, the intensity of additive noise, self-correlation time of multiplicative noise, self-correlation time of additive noise and delay time. In addition, when the SNR is a function of intensity of additive noise and delay time, the corresponding curves of SNR have four peaks.

Self-assemblies of the flexible ferrocenyl block 2-chloro-4-ferrocenylbenzoate with Cd2+ cations in the presence of N-containing auxiliary ligand result in two coordination complexes, namely, &{[Cd(η2 -OOCClH3C6Fc)2(Mbbz)(CH3OH)] · (H2O)0.5} n (I) and [Cd(η2 -OOCClH3C6Fc)2(Bbbm)] n (II) {Fc = (η5- C5H4)Fe(η5-C5H4), Mbbz = 1,1'-methyl benzimidazole, Bbbm = 1,4-bis(benzimidazol-1-ylmethyl)-benzene}. Their structure has been determined by single-crystal X-ray diffraction analyses (CIF files nos. 1529095 (I), 1529096 (II)) and further characterized by elemental analyses, IR spectra, and thermogravimetric analyses. Crystallographic characterization shows that both I and II are 1D chain structures. Notably, various C–H···π interactions and C–H···Cl interactions are discovered in I and II, and they have significant contributions to self-assembly, which extend 1D complex to infinite 3D supramolecular networks. Moreover, the electrochemical studies of I and II in DMF solution display irreversible redox waves and indicate that the half-wave potentials of the ferrocenyl moieties in I and II are shifted to positive potential compared with that of free 2-chloro-4-ferrocenylbenzoate.

Although platinum-based chemotherapies have long been used as standard treatment in ovarian cancer, cisplatin resistance is a major problem that restricts its use. Herein, we investigate the biological function of SLC27A2 and its underlying mechanisms in regulating chemo-resistance in ovarian cancer. The findings show that SLC27A2 down-regulation in primary ovarian cancer tissues correlates with chemo-resistance and poor patient survival in our patient cohort. Significantly, we demonstrate that up-regulation of SLC27A2 by lentivirus-mediated p-SLC27A2 sensitizes ovarian cancer cells to cisplatin in vitro and in vivo via apoptosis. Mechanistic investigation reveals that miR-411 is the most strikingly over-expressed gene in response to ectopic expression of SLC27A2, but under-expressed in recurrent ovarian cancer tissues. Lower miR-411 expression contributes to ovarian cancer chemo-resistance in vitro and in vivo. Furthermore, SLC27A2 directly binds specific sites in the miR-411 promoter region and promoter activity decreases after mutation of putative SLC27A2-binding sites. This indicates that SLC27A2 is required for the transcriptional induction of miR-411. The luciferase assays also confirm that miR-411 directly targets ABCG2 in ovarian cancer, and overall findings establish the SLC27A2-miR-411-ABCG2 pathway in the regulation of ovarian cancer chemo-resistance with potential therapeutic applications.

Identifying the causes of human diseases requires deconvolution of abnormal molecular phenotypes spanning DNA accessibility, gene expression and protein abundance

Magnetic skyrmions are topologically protected spin textures with promising prospects for applications in data storage. They can form a lattice state due to competing magnetic interactions and are commonly found in a small region of the temperature—magnetic field phase diagram. Recent work has demonstrated that these magnetic quasi-particles fluctuate at the μeV energy scale. Here, we use a coherent x-ray correlation method at an x-ray free-electron laser to investigate these fluctuations in a magnetic phase coexistence region near a first-order transition boundary where fluctuations are not expected to play a major role. Surprisingly, we find that the relaxation of the intermediate scattering function at this transition differs significantly compared to that deep in the skyrmion lattice phase. The observation of a compressed exponential behavior suggests solid-like dynamics, often associated with jamming. We assign this behavior to disorder and the phase coexistence observed in a narrow field-window near the transition, which can cause fluctuations that lead to glassy behavior.

To analyze the application value of high-frequency ultrasound in the muscles, bones and the thoracodorsal artery in the subscapular region and summarize the characteristics of ultrasound.Subscapularis muscle, bone and thoracodorsal artery of 72 healthy subjects were examined using high-frequency ultrasound, the initial segment diameter of the thoracodorsal artery and peak systolic blood flow velocity were recorded, and the ultrasonographic characteristics of subscapularis muscle, bone and thoracodorsal artery were summarized.The spinous processes of 7th thoracic vertebrae, 9th thoracic vertebrae and 11th thoracic vertebrae all showed strong echoes with posterior acoustic shadow. The vertebral plates of 8th thoracic vertebrae, 10th thoracic vertebrae and 11th thoracic vertebrae showed a strong linear echo on both sides of the spinous process, and the lateral side was connected with the transverse processes of 8th thoracic vertebrae, 10th thoracic vertebrae, and 11th thoracic vertebrae. The inferior scapular artery was launched from the axillary artery, along with the deep side of the inferior scapular muscle, the latissimus dorsi and teres major muscle, and then it went inferior and backward which was then divided into arteriae dorsalis scapulae and thoracodorsal artery, showing a tubular structure with no echo. Color Doppler Flow Imaging (CDFI) showed the endovascular blood flow signal of the inferior scapular artery and its branches. The internal diameter of the initial segment of the thoracodorsal artery of the male subjects was bigger than that of the female subjects, and the difference was statistically significant (p0.05).High-frequency ultrasound can provide a reliable reference for the anatomical structure and adjacent relationship of subscapular muscles, bones and thoracodorsal artery, and is worthy of being promoted as a non-invasive and reliable mean of examination.

The life cycle monitoring of long distance diversion tunnel acts as an important foundation of the process control, maintenance, assessment and safety warning for tunnel rock engineering. Given the advanced technologies of internet of things, such as mobile computing, near field communication (NFC) and context computing, a new architecture with NFC context-awareness is proposed for the life cycle monitoring of long distance diversion tunnel. Based on it, efficient support for acquiring, interpreting, and accessing diversion tunnel contexts is provided. Focusing on the practical problems occurred in the life cycle monitoring of long distance diversion tunnel, the critical issues in this monitoring framework have been researched. The description model for monitoring data and critical processes are analysed and designed. In addition, an end-to-end platform has been developed for the life cycle monitoring of long distance diversion tunnel. The test results validate the feasibility of the monitoring system. The achievements of this paper could provide references for the Life cycle monitoring of long distance diversion tunnel or similar rock engineering. Technical support and scientific basis are also provided for its process control, safety warning, later inspection and maintenance.

To investigate the effects of the recent upper respiratory tract infections (URI) on the incidence of perioperative respiratory adverse events in children scheduled to undergo general anesthesia and elective surgery.In the study, 232 children undergoing general anesthesia with laryngeal mask airway (LMA) for elective ophthalmic surgeries at Peking University First Hospital, Beijing, China, from Nov. 1, 2015 to May 10, 2016 were enrolled. On the day of the surgery, the parents of the children were preoperatively asked to fill out a questionnaire regarding the baseline characteristics and medical history of the children, including gender, age, height, weight, history of URI within the last 2 weeks before anesthesia, history of premature, long-term passive smoking exposure, habitual sleep snoring, and history of asthma. In addition, all adverse respiratory events throughout the perioperative periods (oxygen desaturation, cough, copious secretions, laryngospasm and bronchospasm) as well as peri-operative variables (number of attempts to insert the LMA successfully, anesthesia duration and so on) were recorded. Multivariate Logistic regression analysis was applied to identify independent risk factors of perioperative respiratory adverse events.Among the 232 children included in the study, 28.0% (65/232) presented with a history of a recent URI within the last 2 weeks before anesthesia. The presence of the recent URI increased the incidence of oxygen desaturation (23.1% vs.12.0%, P=0.034), copious secretions (15.4% vs. 6.6%, P=0.036) and any of all the adverse respiratory events (32.3% vs. 18.6%, P=0.024). Multivariate Logistic regression analysis identified two independent risk factors of perioperative adverse respiratory events: a history of URI within the last 2 weeks before general anesthesia (OR=2.021, 95%CI: 1.023-3.994, P=0.043) and habitual sleep snoring (OR=3.660, 95%CI: 1.517-8.832, P=0.004).A history of a recent URI within 2 weeks before general anesthesia was associated with a higher incidence of oxygen desaturation, copious secretions and the overall respiratory adverse events. For the children with recent URI, we recommend the general anesthesia and elective surgery should be postponed for at least 2 weeks after the URI.