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The experiment aimed to investigate the protective effects of Lycium barbarum polysaccharides (LBP) on aspirin (ASA) -induced intestinal injury in mice. The twenty-four 7-week-old male Kunming mice were randomly divided into a control group, aspirin model group (ASA group), and Lycium barbarum polysaccharide group (LBP group) after seven days of adaptive feeding, with eight mice in each group. The experimental period was 12 days. In the first six days of the experiment, the control group was gavage 200 mg/kg normal saline, and the ASA group and the LBP group were gavage the same amount of aspirin. On the last six days of the experiment, the LBP group was gavage 75 mg/kg LBP, and the control group and ASA group were gavage the same amount of normal saline. The results showed that compared with the control group, the jejunal villus height (VH) of the ASA group was significantly decreased ( P<0.05) and villus height/crypt depth (VH/CD) was extremely decreased (P<0.01), the activity of superoxide dismutase (SOD) in the ileum was extremely decreased (P<0.01), the content of malondialdehyde (MDA) in the jejunum and ileum was extremely increased (P<0.01). Compared with the ASA group, the LBP group significantly decreased kidney index (P<0.05), extremely increased VH/CD in jejunum and SOD activity in jejunum and ileum (P<0.01), and extremely decreased MDA content in jejunum and ileum (P<0.01). The study indicates that LBP can enhance the antioxidant capacity of jejunum and ileum in ASA-induced intestinal injury in mice, improve intestinal morphology, and alleviate intestinal injury in mice. [ABSTRACT FROM AUTHOR]