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11 results on '"Xenophon Giannakopoulos"'

1. Curcumin Acts as a Chemosensitizer for Leiomyosarcoma Cells In Vitro But Fails to Mediate Antioxidant Enzyme Activity in Cisplatin-Induced Experimental Nephrotoxicity in Rats

Author

Irida Dhima MSc, PhD, Stelios Zerikiotis MSc, PhD, Panagiotis Lekkas MSc, PhD, Yannis V. Simos MSc (MedSci), PhD, Maria Gkiouli MSc, PhD, Patra Vezyraki MD, PhD, Evangelia Dounousi MD, PhD, Vasilios Ragos MD, PhD, Xenophon Giannakopoulos MD, PhD, Dimitrios Baltogiannis MD, PhD, Vasiliki Kalfakakou MD, PhD, Angelos Evangelou MD, PhD, Dimitrios Peschos MD, PhD, and Spyridon Karkabounas PhD

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background. Cisplatin (cis-diamminedichloroplatinum) is a widely used chemotherapeutic agent for the treatment of various cancers. Although it represents an effective regimen, its application is accompanied by side effects to normal tissues, especially to the kidneys. Cisplatin generates free radicals and impairs the function of antioxidant enzymes. Modulation of cisplatin-induced oxidative stress by specific antioxidant molecules represents an attractive approach to minimize side effects. Methods. We studied the ability of curcumin to sensitize leiomyosarcoma (LMS) cells to cisplatin. Assays for cell proliferation, mitochondrial function, induction of apoptosis, and cell cycle arrest were performed using various concentrations of cisplatin and a concentration of curcumin that caused a nonsignificant reduction in cell viability. Moreover, the effect of curcumin was examined against cisplatin-induced experimental nephrotoxicity. Renal injury was assessed by measuring serum creatinine, blood urea nitrogen (BUN), and the kidney’s relative weight. Oxidative stress was measured by means of enzymatic activities of superoxide dismutase and glutathione peroxidase in the rats’ blood and malondialdehyde levels in rats’ urine. Results. In our study, we found that curcumin sensitizes LMS cells to cisplatin by enhancing apoptosis and impairing mitochondrial function. In an in vivo model of cisplatin-induced experimental nephrotoxicity, intraperitoneal administration of curcumin failed to preserve blood’s antioxidant enzyme activity and decrease lipid peroxidation. Nevertheless, curcumin was able to protect nephrons’ histology from cisplatin’s toxic effect. Conclusion. Our results showed that curcumin can act as chemosensitizer, but its role as an adjunctive cisplatin-induced oxidative stress inhibitor requires further dose-finding studies to maximize the effectiveness of chemotherapy.

Published
2019
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2. Safety, Efficacy and Impact on Patients’ Quality of Life of a Long–Term Treatment with the α1–Blocker Alfuzosin in Symptomatic Patients with BPH

Author

P. Carretero, Urs E. Studer, Norio Nonomura, Satoshi Hamano, G. Mürtz, Stephan Madersbacher, Jacques Aubert, Henry Botto, Katsuyuki Aozasa, Matteo Surace, J. Llopis, M.J. Ribal, Jacques Irani, W. Dorschner, Thomas M. Stulnig, Isin Kilicaslan, Annette Kassen, M. Frank, Hiroshi Tazaki, Anne-Catherine Baglin, Hervé Baumert, Yasuyuki Kojima, Tsuneharu Miki, Véronique Becette, Enrico Colli, Sebastian Wille, Theodor Senge, Faruk Özcan, Yoshifumi Narumi, I.T. Köksal, Gianni Origgi, Hironobu Nakamura, Lambertus A. Kiemeney, Sensuke Konno, Tarık Esen, Teoman Cem Kadioglu, Robert D. Mills, Yannis Alamanos, Fabio Parazzini, Murat Tunc, Masaru Shin, Massimiliano Bianchi, M.A. Barranco, Toshihiko Inoue, Thierry Lebret, Xenophon Giannakopoulos, A. Verbaeys, Kyou Tsuda, Philippe Barré, Tomonori Yamanishi, Walter Artibani, Michael Marberger, J.M. Corral, Thomas Lang, A. Rodriguez, R. Griebenow, A. Alcaraz, Annie Gentille, P.J. Ventura, Tatsuo Igarashi, Haruo Ito, Bart L.H. Bemelmans, Yutaka Yasunaga, Richard Berges, Dan M. Milanesa, M. Solé, Takayuki Nose, Z. Belahnech, Bob Djavan, F. Wieners, J.U. Stolzenburg, Vincent Molinié, W.A. De Sy, Ioanna Bouba, Camille Mallouh, Shino Murakami, Ioannis Georgiou, Remigio Vela-Navarette, M. Halaska, Dimitrios Lolis, Georg Schatzl, G. Schubert, Jean-Marie Hervé, Ioannis F. Filiadis, Frans M.J. Debruyne, A. Lachkar, Pierre-Marie Lugagne, Muhammad S. Choudhury, Guido Benzi, A. Benchekroun, and Akihiko Okuyama

Subjects
medicine.medical_specialty, Long term treatment, Quality of life, business.industry, Urology, Internal medicine, medicine, urologic and male genital diseases, business, Alfuzosin, Treatment period, α1 blocker, medicine.drug
Abstract

Objective: The aim of this study was to assess the impact of a 12–month treatment period with alfuzosin, 2.5 mg t.i.d, on symptomatic patients with BPH (n = 355) by means of the Int

Published
2000
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3. Glutathione S–Transferase Null Genotypes in Transitional Cell Bladder Cancer

Author

Ioannis F. Filiadis, Xenophon Giannakopoulos, Ioannis Georgiou, Yannis Alamanos, Ioanna Bouba, and Dimitrios Lolis

Subjects
medicine.medical_specialty, education.field_of_study, Urinary bladder, Bladder cancer, integumentary system, biology, business.industry, Urology, Population, Null (mathematics), Odds ratio, medicine.disease, Endocrinology, medicine.anatomical_structure, Glutathione S-transferase, Transitional cell carcinoma, Internal medicine, Genotype, medicine, biology.protein, Cancer research, education, business, neoplasms
Abstract

Results: The GSTM1 null genotype was strongly associated with bladder cancer. The odds ratio, attributable and population attributable risks were est

Published
2000
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4. GENOTYPES OF N-ACETYLTRANSFERASE-2 AND RISK OF BLADDER CANCER: A CASE-CONTROL STUDY

Author

Vasilis Kranas, Dimitrios Lolis, Yannis Alamanos, Ioannis F. Filiadis, Xenophon Giannakopoulos, and Ioannis Georgiou

Subjects
Adult, Male, medicine.medical_specialty, Genotype, Arylamine N-Acetyltransferase, Urology, Population, Disease, Gastroenterology, law.invention, Risk Factors, law, Internal medicine, Humans, Medicine, Risk factor, education, Polymerase chain reaction, Aged, Aged, 80 and over, Carcinoma, Transitional Cell, education.field_of_study, Urinary bladder, Bladder cancer, business.industry, Case-control study, Arylamine N-Acetyltransferase/*genetics, Middle Aged, medicine.disease, medicine.anatomical_structure, Urinary Bladder Neoplasms, Case-Control Studies, Immunology, Female, Urinary Bladder Neoplasms/*enzymology/*genetics, Carcinoma, Transitional Cell/*enzymology/*genetics, business
Abstract

PURPOSE: This study was conducted to examine whether certain slow N-acetylation genotypes could be risk factors for bladder cancer, and the possible association between specific genotypes and the severity of the disease at first diagnosis. MATERIALS AND METHODS: This case-control study included 89 patients with transitional cell bladder cancer (diagnosed over a period of 21 months) and 147 controls. N-acetyltransferase-2 (NAT-2) genotypes were identified by allele specific polymerase chain reaction (PCR) on peripheral blood DNA samples. The x2 test was used for statistical evaluation to compare the differences observed between patients and controls and the different genotypes with tumor grading and local staging at presentation. Relative, attributable and population attributable risks were estimated for the genotypes found to present a significantly increased frequency for bladder cancer. RESULTS: A statistically significant difference in the frequency of genotypes was found between the two groups. The patient group had the higher frequency of slow acetylation genotypes (p = 0.0016). Among slow acetylators, homozygotes 341C/341C and compound heterozygotes 341C/857A had the most excessive risk for bladder cancer (p = 0.0041 and 0.0031, respectively). The 341C/341C genotype was found to be associated with more aggressive disease, in terms of tumor grading at presentation (p

Published
1999
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5. Infertility and Multiple Urogenital Abnormalities in a Male with Mosaic 46,XY/45,XO/47,XXY Karyotype and Mixed Phenotype

Author

Ioannis Georgiou, Xenophon Giannakopoulos, Maria C. Bai, Gerasimos N. Pagoulatos, Ioannis F. Filiadis, and Maria Syrrou

Subjects
Male, Infertility, medicine.medical_specialty, Pathology, Urology, Aneuploidy, Biology, Genetic determinism, Cell Line, Klinefelter Syndrome, Internal medicine, medicine, Humans, Abnormalities, Multiple, XO Gonadal Dysgenesis, In Situ Hybridization, Fluorescence, Infertility, Male, Sex Chromosome Aberrations, Gonadal Dysgenesis, 46,XY, Sex Chromosomes, Mosaicism, Noonan Syndrome, Urogenital Abnormality, Urography, Karyotype, Middle Aged, medicine.disease, Phenotype, Endocrinology, Karyotyping, Urogenital Abnormalities, Urinary Calculi, Klinefelter syndrome, Follow-Up Studies
Abstract

We hereby present a rare case of a 46,XY/45,XO/47,XXY mosaic male patient with a predominance of the XY cell line. The patient, who exhibited phenotypic stigmata of both XO gonadal dysgenesis and Klinefelter syndromes, suffered from infertility and multiple urogenital abnormalities, as our investigation revealed.

Published
1998
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6. Quality of life survey in patients with advanced prostate cancer

Author

Xenophon, Giannakopoulos, Konstantinos, Charalabopoulos, Alexandros, Charalabopoulos, Christos, Golias, Dimitrios, Peschos, and Nikolaos, Sofikitis

Subjects
Male, Surveys and Questionnaires, Quality of Life, Humans, Prostatic Neoplasms
Abstract

Prostate cancer is a major health concern for Western patients who are facing important decisions, alongside with the physicians, concerning their treatment. Additionally, the physician has to take into account the potential side effects of the disease and the treatment itself. Treatment for advanced prostate cancer produces problematic physical and psychosocial side effects. The patient should be asked by the physician for information concerning daily life activities, overall satisfaction voiding ability, and sexual activity in a standardized questionnaire assessing the quality of life (QoL) of the patient. Many such questionnaires and studies have been evaluated or are still in progress. Modern QoL questionnaires are considered to be more than a necessity nowadays for the improvement of the treatment administered from the physician and the performance and functional status of the patient.

Published
2005

7. The role of lymphadenectomy in renal cancer surgery. An update

Author

Xenophon, Giannakopoulos, Konstantinos, Charalabopoulos, Alexandros, Charalabopoulos, Christos, Golias, Dimitrios, Baltogiannis, and Nikolaos, Sofikitis

Subjects
Humans, Lymph Node Excision, Prognosis, Carcinoma, Renal Cell, Kidney Neoplasms, Neoplasm Staging
Abstract

In the present review the role of lymph node dissection in association to the prognosis of renal cell carcinoma is discussed in some details. The distribution of lymph node metastases, the extend of the lymph node dissection as well as the relation between histologic type and the incidence of nodal metastases are the points that must be well investigated. Nowdays, it seems that the complete lymph node dissection does not demonstrate any survival benefit over the radical nephrectomy alone.

Published
2005

8. Monotherapy in advanced prostate cancer: an overview

Author

Dimitrios, Baltogiannis, Xenophon, Giannakopoulos, Kostas, Charalabopoulos, and Nikolaos, Sofikitis

Subjects
Male, Antineoplastic Agents, Hormonal, Progesterone Congeners, Palliative Care, Prostatic Neoplasms, Androgen Antagonists, Dihydrotestosterone, Estrogens, Adenocarcinoma, Imidazolidines, Combined Modality Therapy, Flutamide, Gonadotropin-Releasing Hormone, Tosyl Compounds, Nitriles, Humans, Anilides, Testosterone, Cyproterone Acetate, Orchiectomy, Randomized Controlled Trials as Topic
Abstract

Prostate cancer is the second leading malignancy in men associated with an enormous research interest in all aspects of the disease. It is well recognized that the regulation of prostatic growth is a complicated biological process. Further more the androgenic dependence of the advanced prostate cancer is well know and in the last 50 years significant progresses regarding the principle of deprivation of androgens for the treatment of the disease occured. Prostate cancer is now diagnosed in earlier stages and treatment results in increased potential for cure or extension of overall survival. Unfortunately, every treatment for prostate cancer has adverse effects with negative impact in health-related quality of life. Surgical or pharmacological castration has a significant negative impact on quality of life in patients with prostate cancer (loss of sexuality, osteoporosis, and loss of muscle mass, e.g.). Antiandrogen monotherapy is considered to be a treatment in well-informed patients who wish to remain sexually active, can be administered orally, and is well tolerated by patients with prostate cancer. This review is focused on antiandrogen monotherapy in the treatment of advanced prostate cancer.

Published
2004

9. Meiosis and Klinefelter's syndrome

Author

I. Miyagawa, Stavros Tsabalas, M. Schradr, Y. Yamamoto, A. Tasos, D. Yianakis, Ioannis Georgiou, Anthoula Chatzikyriakidou, Nikolaos Sofikitis, D. Baltoyiannis, and Xenophon Giannakopoulos

Subjects
Genetics, S syndrome, Reproductive Medicine, Meiosis, Rehabilitation, Obstetrics and Gynecology, Biology
Published
2002
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10. Subject Index Vol. 37, 2000

Author

Georg Schatzl, Satoshi Hamano, Walter Artibani, J.M. Corral, J.U. Stolzenburg, G. Mürtz, Dan M. Milanesa, Bart L.H. Bemelmans, Teoman Cem Kadioglu, Richard Berges, Michael Marberger, R. Griebenow, Yutaka Yasunaga, Takayuki Nose, Véronique Becette, M. Solé, Masaru Shin, Hervé Baumert, Tomonori Yamanishi, G. Schubert, Isin Kilicaslan, Stephan Madersbacher, Ioannis F. Filiadis, I.T. Köksal, Thomas Lang, A. Rodriguez, Annette Kassen, Bob Djavan, Jean-Marie Hervé, Sensuke Konno, Gianni Origgi, Robert D. Mills, Hironobu Nakamura, Tsuneharu Miki, F. Wieners, P. Carretero, Tatsuo Igarashi, Sebastian Wille, M.A. Barranco, Frans M.J. Debruyne, Urs E. Studer, Vincent Molinié, Shino Murakami, Jacques Irani, Camille Mallouh, W. Dorschner, Enrico Colli, Matteo Surace, Murat Tunc, Katsuyuki Aozasa, A. Alcaraz, M.J. Ribal, Z. Belahnech, Yasuyuki Kojima, Anne-Catherine Baglin, W.A. De Sy, M. Frank, J. Llopis, Guido Benzi, Philippe Barré, Lambertus A. Kiemeney, Henry Botto, Muhammad Choudhury, Thomas M. Stulnig, Haruo Ito, Theodor Senge, M. Halaska, Yoshifumi Narumi, Aubert J, Xenophon Giannakopoulos, Tarık Esen, Remigio Vela-Navarette, Pierre-Marie Lugagne, Yannis Alamanos, Thierry Lebret, Toshihiko Inoue, Massimiliano Bianchi, Norio Nonomura, Dimitrios Lolis, Hiroshi Tazaki, Annie Gentille, Ioanna Bouba, P.J. Ventura, A. Lachkar, A. Benchekroun, Akihiko Okuyama, Ioannis Georgiou, Faruk Özcan, Fabio Parazzini, Kyou Tsuda, and A. Verbaeys

Subjects
Gynecology, medicine.medical_specialty, Index (economics), business.industry, Urology, Medicine, Subject (documents), Medical physics, business
Published
2000
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11. Contents Vol. 37, 2000

Author

Véronique Becette, Murat Tunc, A. Verbaeys, W.A. De Sy, Jean-Marie Hervé, Ioannis Georgiou, Sensuke Konno, Yasuyuki Kojima, Remigio Vela-Navarette, Teoman Cem Kadioglu, Sebastian Wille, Tomonori Yamanishi, Muhammad Choudhury, Dan M. Milanesa, Takayuki Nose, Xenophon Giannakopoulos, Guido Benzi, Aubert J, Enrico Colli, Norio Nonomura, Massimiliano Bianchi, Camille Mallouh, Bob Djavan, F. Wieners, J.U. Stolzenburg, Yoshifumi Narumi, Vincent Molinié, Philippe Barré, Lambertus A. Kiemeney, Pierre-Marie Lugagne, Hiroshi Tazaki, Annette Kassen, J.M. Corral, Jacques Irani, Shino Murakami, Tsuneharu Miki, Richard Berges, Bart L.H. Bemelmans, Dimitrios Lolis, W. Dorschner, Yutaka Yasunaga, Robert D. Mills, G. Schubert, M. Solé, Theodor Senge, M.A. Barranco, Georg Schatzl, Matteo Surace, Tarık Esen, Yannis Alamanos, P. Carretero, Gianni Origgi, Hironobu Nakamura, I.T. Köksal, A. Benchekroun, Toshihiko Inoue, Akihiko Okuyama, Urs E. Studer, Anne-Catherine Baglin, A. Alcaraz, Frans M.J. Debruyne, M. Frank, Thierry Lebret, Thomas Lang, A. Rodriguez, Ioanna Bouba, Henry Botto, Tatsuo Igarashi, Kyou Tsuda, M.J. Ribal, Haruo Ito, Thomas M. Stulnig, Faruk Özcan, Walter Artibani, A. Lachkar, Satoshi Hamano, G. Mürtz, Fabio Parazzini, Ioannis F. Filiadis, Stephan Madersbacher, Isin Kilicaslan, Annie Gentille, P.J. Ventura, Z. Belahnech, Hervé Baumert, Katsuyuki Aozasa, M. Halaska, Masaru Shin, J. Llopis, Michael Marberger, and R. Griebenow

Subjects
medicine.medical_specialty, business.industry, Urology, General surgery, medicine, business
Published
2000
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