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1. Respiratory eukaryotic virome expansion and bacteriophage deficiency characterize childhood asthma

Author

Megremis, S. (Spyridon), Constantinides, B. (Bede), Xepapadaki, P. (Paraskevi), Yap, C. F. (Chuan Fu), Sotiropoulos, A. G. (Alexandros G.), Bachert, C. (Claus), Finotto, S. (Susetta), Jartti, T. (Tuomas), Tapinos, A. (Avraam), Vuorinen, T. (Tytti), Andreakos, E. (Evangelos), Robertson, D. L. (David L.), Papadopoulos, N. G. (Nikolaos G.), Megremis, S. (Spyridon), Constantinides, B. (Bede), Xepapadaki, P. (Paraskevi), Yap, C. F. (Chuan Fu), Sotiropoulos, A. G. (Alexandros G.), Bachert, C. (Claus), Finotto, S. (Susetta), Jartti, T. (Tuomas), Tapinos, A. (Avraam), Vuorinen, T. (Tytti), Andreakos, E. (Evangelos), Robertson, D. L. (David L.), and Papadopoulos, N. G. (Nikolaos G.)

Abstract

Asthma development and exacerbation is linked to respiratory virus infections. There is limited information regarding the presence of viruses during non-exacerbation/infection periods. We investigated the nasopharyngeal/nasal virome during a period of asymptomatic state, in a subset of 21 healthy and 35 asthmatic preschool children from the Predicta cohort. Using metagenomics, we described the virome ecology and the cross-species interactions within the microbiome. The virome was dominated by eukaryotic viruses, while prokaryotic viruses (bacteriophages) were independently observed with low abundance. Rhinovirus B species consistently dominated the virome in asthma. Anelloviridae were the most abundant and rich family in both health and asthma. However, their richness and alpha diversity were increased in asthma, along with the co-occurrence of different Anellovirus genera. Bacteriophages were richer and more diverse in healthy individuals. Unsupervised clustering identified three virome profiles that were correlated to asthma severity and control and were independent of treatment, suggesting a link between the respiratory virome and asthma. Finally, we observed different cross-species ecological associations in the healthy versus the asthmatic virus-bacterial interactome, and an expanded interactome of eukaryotic viruses in asthma. Upper respiratory virome “dysbiosis” appears to be a novel feature of pre-school asthma during asymptomatic/non-infectious states and merits further investigation.

Published
2023

2. Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers

Author

Maurer, D. J. (Debbie J.), Liu, C. (Chengyao), Xepapadaki, P. (Paraskevi), Stanic, B. (Barbara), Bachert, C. (Claus), Finotto, S. (Susetta), Gao, Y.-D. (Ya-Dong), Graser, A. (Anna), Jartti, T. (Tuomas), Kistler, W. (Walter), Kowalski, M. (Marek), Lukkarinen, H. (Heikki), Pasioti, M. (Maria), Tan, G. (Ge), Villiger, M. (Michael), Zhang, L. (Luo), Zhang, N. (Nan), Akdis, M. (Mübeccel), Papadopoulos, N. G. (Nikolaos G.), Akdis, C. A. (Cezmi A.), Maurer, D. J. (Debbie J.), Liu, C. (Chengyao), Xepapadaki, P. (Paraskevi), Stanic, B. (Barbara), Bachert, C. (Claus), Finotto, S. (Susetta), Gao, Y.-D. (Ya-Dong), Graser, A. (Anna), Jartti, T. (Tuomas), Kistler, W. (Walter), Kowalski, M. (Marek), Lukkarinen, H. (Heikki), Pasioti, M. (Maria), Tan, G. (Ge), Villiger, M. (Michael), Zhang, L. (Luo), Zhang, N. (Nan), Akdis, M. (Mübeccel), Papadopoulos, N. G. (Nikolaos G.), and Akdis, C. A. (Cezmi A.)

Abstract

Background: The impact of physical activity on immune response is a hot topic in exercise immunology, but studies involving asthmatic children are scarce. Our aims were to examine whether there were any differences in the level of physical activity and daily TV attendance, to assess its role on asthma control and immune responses to various immune stimulants. Methods: Weekly physical activity and daily television attendance were obtained from questionnaires at inclusion of the PreDicta study. PBMC cultures were stimulated with phytohemagglutinin (PHA), R848, poly I:C, and zymosan. A panel of cytokines was measured and quantified in cell culture supernatants using luminometric multiplex immunofluorescence beads-based assay. Results: Asthmatic preschoolers showed significantly more TV attendance than their healthy peers (58.6% vs. 41.5% 1–3 h daily and only 25.7% vs. 47.2% ≤1 h daily) and poor asthma control was associated with less frequent physical activity (PA) (75% no or occasional activity in uncontrolled vs. 20% in controlled asthma; 25% ≥3 times weekly vs. 62%). Asthmatics with increased PA exhibited elevated cytokine levels in response to polyclonal stimulants, suggesting a readiness of circulating immune cells for type 1, 2, and 17 cytokine release compared to subjects with low PA and high TV attendance. This may also represent a proinflammatory state in high PA asthmatic children. Low physical activity and high TV attendance were associated with a decrease in proinflammatory cytokines. Proinflammatory cytokines were correlating with each other in in vitro immune responses of asthmatic children, but not healthy controls, this correlation was more pronounced in children with sedentary behavior. Conclusion: Asthmatic children show more sedentary behavior than healthy subjects, while poor asthma control is associated with a substantial decrease in physical activity. Our results suggest that asthmatic children may profit from regular exercise, as elevate

Published
2022

3. Childhood asthma outcomes during the COVID-19 pandemic:findings from the PeARL multinational cohort

Author

Papadopoulos, N. G. (Nikolaos G.), Mathioudakis, A. G. (Alexander G.), Custovic, A. (Adnan), Deschildre, A. (Antoine), Phipatanakul, W. (Wanda), Wong, G. (Gary), Xepapadaki, P. (Paraskevi), Abou-Taam, R. (Rola), Agache, I. (Ioana), Castro-Rodriguez, J. A. (Jose A.), Chen, Z. (Zhimin), Cros, P. (Pierrick), Dubus, J.-C. (Jean-Christophe), El-Sayed, Z. A. (Zeinab Awad), El-Owaidy, R. (Rasha), Feleszko, W. (Wojciech), Fierro, V. (Vincenzo), Fiocchi, A. (Alessandro), Garcia-Marcos, L. (Luis), Goh, A. (Anne), Hossny, E. M. (Elham M.), Huerta Villalobos, Y. R. (Yunuen R.), Jartti, T. (Tuomas), Le Roux, P. (Pascal), Levina, J. (Julia), Lopez Garcia, A. I. (Aida Ines), Ramos, A. M. (Angel Mazon), Morais-Almeida, M. (Mario), Murray, C. (Clare), Nagaraju, K. (Karthik), Nagaraju, M. K. (Major K.), Navarrete Rodriguez, E. M. (Elsy Maureen), Namazova-Baranova, L. (Leyla), Nieto Garcia, A. (Antonio), Pozo Beltran, C. F. (Cesar Fireth), Ratchataswan, T. (Thanaporn), Rivero Yeverino, D. (Daniela), Rodriguez Zagal, E. (Erendira), Schweitzer, C. E. (Cyril E.), Tulkki, M. (Marleena), Wasilczuk, K. (Katarzyna), and Xu, D. (Dan)

Subjects
immune system diseases, childhood asthma, coronavirus, COVID-19, respiratory tract diseases
Abstract

Background: The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes. Methods: The PeARL multinational cohort included 1,054 children with asthma and 505 non-asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID-19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control. Results: During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty-six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre-bronchodilatation FEV₁ and peak expiratory flow rate were improved during the pandemic. When compared to non-asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged. Conclusions: Childhood asthma outcomes, including control, were improved during the first wave of the COVID-19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID-19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent.

Published
2021

4. Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

Author

Li, N. (Nina), Mirzakhani, H. (Hoomann), Kiefer, A. (Alexander), Koelle, J. (Julia), Vuorinen, T. (Tytti), Rauh, M. (Manfred), Yang, Z. (Zuqin), Krammer, S. (Susanne), Xepapadaki, P. (Paraskevi), Lewandowska-Polak, A. (Anna), Lukkarinen, H. (Heikki), Zhang, N. (Nan), Stanic, B. (Barbara), Zimmermann, T. (Theodor), Kowalski, M. L. (Marek L.), Jartti, T. (Tuomas), Bachert, C. (Claus), Akdis, M. (Mübeccel), Papadopoulos, N. G. (Nikolaos G.), Raby, B. A. (Benjamin A.), Weiss, S. T. (Scott T.), Finotto, S. (Susetta), Li, N. (Nina), Mirzakhani, H. (Hoomann), Kiefer, A. (Alexander), Koelle, J. (Julia), Vuorinen, T. (Tytti), Rauh, M. (Manfred), Yang, Z. (Zuqin), Krammer, S. (Susanne), Xepapadaki, P. (Paraskevi), Lewandowska-Polak, A. (Anna), Lukkarinen, H. (Heikki), Zhang, N. (Nan), Stanic, B. (Barbara), Zimmermann, T. (Theodor), Kowalski, M. L. (Marek L.), Jartti, T. (Tuomas), Bachert, C. (Claus), Akdis, M. (Mübeccel), Papadopoulos, N. G. (Nikolaos G.), Raby, B. A. (Benjamin A.), Weiss, S. T. (Scott T.), and Finotto, S. (Susetta)

Abstract

RANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.

Published
2021

5. The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

Author

Kocatürk, E., Salman, A. (Andaç), Cherrez-Ojeda, I. (Ivan), Ricardo Criado, P. (Paulo), Peter, J. (Jonny), Comert-Ozer, E. (Elif), Abuzakouk, M. (M.), Câmara Agondi, R. (Rosana), Al-Ahmad, M. (Mona), Altrichter, S. (Sabine), Arnaout, R. (Rand), Arruda, L.K. (Luisa Karla), Asero, R. (Riccardo), Bauer, A. (Andrea), Ben-Shoshan, M. (Moshe), Bernstein, J.A. (Jonathan A.), Bizjak, M. (Mojca), Boccon-Gibod, I. (Isabelle), Bonnekoh, H. (Hanna), Bouillet, L. (Laurence), Brzoza, Z. (Zenon), Busse, P. (Paula), Campos, R.A. (Regis A), Carne, E. (Emily), Conlon, N. (Niall), Criado, R.F. (Roberta F.), de Souza Lima, E.M. (Eduardo M.), Demir, S. (Semra), Dissemond, J. (Joachim), Doğan Günaydın, S. (Sibel), Dorofeeva, I. (Irina), Felipe Ensina, L. (Luis), Ertaş, R. (Ragıp), Mariel Ferrucci, S. (Silvia), Figueras-Nart, I. (Ignasi), Fomina, D. (Daria), Franken, S.M. (Sylvie M), Fukunaga, A. (Atsushi), Giménez-Arnau, A., Godse, K., Gonçalo, M. (Margarida), Gotua, M. (M.), Grattan, C., Guillet, C. (Carole), Inomata, N. (Naoko), Jakob, T. (Thilo), Karakaya, G. (Gul), Kasperska-Zając, A. (Alicja), Katelaris, C.H. (Constance H), Košnik, M. (Mitja), Krasowska, D. (Dorota), Kulthanan, K. (Kanokvalai), Sendhil Kumaran, M. (M.), Lang, C. (Claudia), Ignacio Larco-Sousa, J. (José), Lazaridou, E. (Elisavet), Anika Leslie, T. (Tabi), Lippert, U. (Undine), Calderón llosa, O. (Oscar), Makris, M. (Michael), Marsland, A. (Alexander), Medina, I.V. (Iris V.), Meshkova, R. (Raisa), Bastos Palitot, E. (Esther), Parisi, C.A.S. (Claudio A.S.), Pickert, J. (Julia), Ramon, G.D. (German D.), Rodríguez-Gonzalez, M. (Mónica), Rosario, N. (Nelson), Rudenko, M. (Michael), Rutkowski, K. (Krzysztof), Sánchez, J. (Jorge), Schliemann, S. (Sibylle), Sekerel, B.E. (Bulent Enis), Serpa, F.S. (Faradiba S.), Serra-Baldrich, E. (Esther), Song, Z. (Zhiqiang), Soria, A. (Angèle), Staevska, M. (Maria), Staubach, P. (Petra), Tagka, A. (Anna), Takahagi, S. (Shunsuke), Thomsen, S.F. (Simon Francis), Treudler, R. (Regina), Vadasz, Z. (Zahava), Oliveira Rodrigues Valle, S. (Solange), Doorn, M.B.A. (Martijn) van, Vestergaard, C. (C.), Wagner, N. (Nicola), Wang, D. (Dahu), Wang, L. (Liangchun), Wedi, B. (Bettina), Xepapadaki, P. (Paraskevi), Yücel, E. (Esra), Zalewska-Janowska, A. (Anna), Zhao, Z. (Zuotao), Zuberbier, T. (Torsten), Maurer, M. (Marcus), Kocatürk, E., Salman, A. (Andaç), Cherrez-Ojeda, I. (Ivan), Ricardo Criado, P. (Paulo), Peter, J. (Jonny), Comert-Ozer, E. (Elif), Abuzakouk, M. (M.), Câmara Agondi, R. (Rosana), Al-Ahmad, M. (Mona), Altrichter, S. (Sabine), Arnaout, R. (Rand), Arruda, L.K. (Luisa Karla), Asero, R. (Riccardo), Bauer, A. (Andrea), Ben-Shoshan, M. (Moshe), Bernstein, J.A. (Jonathan A.), Bizjak, M. (Mojca), Boccon-Gibod, I. (Isabelle), Bonnekoh, H. (Hanna), Bouillet, L. (Laurence), Brzoza, Z. (Zenon), Busse, P. (Paula), Campos, R.A. (Regis A), Carne, E. (Emily), Conlon, N. (Niall), Criado, R.F. (Roberta F.), de Souza Lima, E.M. (Eduardo M.), Demir, S. (Semra), Dissemond, J. (Joachim), Doğan Günaydın, S. (Sibel), Dorofeeva, I. (Irina), Felipe Ensina, L. (Luis), Ertaş, R. (Ragıp), Mariel Ferrucci, S. (Silvia), Figueras-Nart, I. (Ignasi), Fomina, D. (Daria), Franken, S.M. (Sylvie M), Fukunaga, A. (Atsushi), Giménez-Arnau, A., Godse, K., Gonçalo, M. (Margarida), Gotua, M. (M.), Grattan, C., Guillet, C. (Carole), Inomata, N. (Naoko), Jakob, T. (Thilo), Karakaya, G. (Gul), Kasperska-Zając, A. (Alicja), Katelaris, C.H. (Constance H), Košnik, M. (Mitja), Krasowska, D. (Dorota), Kulthanan, K. (Kanokvalai), Sendhil Kumaran, M. (M.), Lang, C. (Claudia), Ignacio Larco-Sousa, J. (José), Lazaridou, E. (Elisavet), Anika Leslie, T. (Tabi), Lippert, U. (Undine), Calderón llosa, O. (Oscar), Makris, M. (Michael), Marsland, A. (Alexander), Medina, I.V. (Iris V.), Meshkova, R. (Raisa), Bastos Palitot, E. (Esther), Parisi, C.A.S. (Claudio A.S.), Pickert, J. (Julia), Ramon, G.D. (German D.), Rodríguez-Gonzalez, M. (Mónica), Rosario, N. (Nelson), Rudenko, M. (Michael), Rutkowski, K. (Krzysztof), Sánchez, J. (Jorge), Schliemann, S. (Sibylle), Sekerel, B.E. (Bulent Enis), Serpa, F.S. (Faradiba S.), Serra-Baldrich, E. (Esther), Song, Z. (Zhiqiang), Soria, A. (Angèle), Staevska, M. (Maria), Staubach, P. (Petra), Tagka, A. (Anna), Takahagi, S. (Shunsuke), Thomsen, S.F. (Simon Francis), Treudler, R. (Regina), Vadasz, Z. (Zahava), Oliveira Rodrigues Valle, S. (Solange), Doorn, M.B.A. (Martijn) van, Vestergaard, C. (C.), Wagner, N. (Nicola), Wang, D. (Dahu), Wang, L. (Liangchun), Wedi, B. (Bettina), Xepapadaki, P. (Paraskevi), Yücel, E. (Esra), Zalewska-Janowska, A. (Anna), Zhao, Z. (Zuotao), Zuberbier, T. (Torsten), and Maurer, M. (Marcus)

Abstract

Introduction: The COVID-19 pandemic dramatically disrupts health care around the globe. The impact of the pandemic on chronic urticaria (CU) and its management are largely unknown. Aim: To understand how CU patients are affected by the COVID-19 pandemic; how specialists alter CU patient management; and the course of CU in patients with COVID-19. Materials and Methods: Our cross-sectional, international, questionnaire-based, multicenter UCARE COVID-CU study assessed the impact of the pandemic on patient consultations, remote treatment, changes in medications, and clinical consequences. Results: The COVID-19 pandemic severely impairs CU patient care, with less than 50% of the weekly numbers of patients treated as compared to before the pandemic. Reduced patient referrals and clinic hours were the major reasons. Almost half of responding UCARE physicians were involved in COVID-19 patient care, which negatively impacted on the care of urticaria patients. The rate of face-to-face consultations decreased by 62%, from 90% to less than half, whereas the rate of remote consultations increased by more than 600%, from one in 10 to more than two thirds. Cyclosporine and systemic corticosteroids, but not antihistamines or omalizumab, are used less during the pandemic. CU does not affect the course of COVID-19, but COVID-19 results in CU exacerbation in one of three pat

Published
2020
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6. Research needs in allergy: An EAACI position paper, in collaboration with EFA

Author

Papadopoulos, N., Agache, I., Bavbek, S. (Sevim), Bilo, B.M. (Beatrice M.), Braido, F. (Fulvio), Cardona, D. (Doris), Custovic, A. (Adnan), DeMonchy, J. (Jan), Demoly, P., Eigenmann, P.A. (Philippe), Gayraud, J. (J.), Grattan, C., Heffler, E. (E.), Hellings, P.W. (Peter), Jutel, M. (M.), Knol, E.F. (Edward Frank), Lötvall, J. (Jan), Murarol, A. (Antonella), Poulsen, L.K., Roberts, G., Schmid-Grendelmeier, P. (Peter), Skevaki, C. (Chrysanthi), Triggiani, M. (M.), VanRee, R. (Ronald), Werfel, T., Flood, B. (Breda), Palkonen, S., Savli, R. (Roberta), Allegri, P. (Pia), Annesi-Maesano, I. (Isabella), Annunziato, F. (Francesco), Antolin-Amerigo, D. (Dario), Apfelbacher, M. (Manuela), Blanca, M. (Miguel), Bogacka, E. (Ewa), Bonadonna, P. (Patrizia), Bonini, M. (Matteo), Boyman, O. (Onur), Brockow, K. (Knut), Burney, P. (Peter), Buters, J. (Jeroen), Butiene, I. (Indre), Calderon, M. (Moises), Cardell, L.O., Caubet, J.-C. (Jean-Christoph), Celenk, S. (Sevcan), Cichocka-Jarosz, E., Cingi, C. (Cemal), Couto, M. (Mariana), DeJong, N. (Nicolette), Del Giacco, S. (Stefano), Douladiris, N. (Nikolaos), Fassio, F. (Filippo), Fauquert, J.-L. (Jean-Luc), Fernandez, J. (Javier), Rivas, M.F. (Montserrat Fernandez), Ferrer, M. (Marta), Flohr, C. (Carsten), Gardner, J. (James), Genuneit, J. (Jon), Gevaert, P. (P.), Groblewska, A. (Anna), Hamelmann, E. (Eckard), Hoffmann, H.J. (Hans Jürgen), Hoffmann-Sommergruber, K. (K.), Hovhannisyan, L. (Lilit), Hox, V. (Valérie), Jahnsen, F.L. (Frode L.), Kalayci, O. (Omer), Kalpaklioglu, A.F. (Ayse Füsun), Kleine-Tebbe, J. (Jörg), Konstantinou, G. (George), Kurowski, M. (Marcin), Lau, S. (Susanne), Lauener, R. (Roger), Lauerma, A. (Antti), Logan, K. (K.), Magnan, A. (Antoine), Makowska, J. (Joanna), Makrinioti, H. (Heidi), Mangina, P. (Paraskevi), Manole, F. (Felicia), Mari, A. (A.), Mazón, A., Mills, C. (Clare), Mingomataj, E.Ç. (Ervin Ç), Niggemann, B., Nilsson, G. (Gunnar), Ollert, M. (Markus), O'Mahony, L. (Liam), O'Neil, S. (Serena), Pala, G. (Gianni), Papi, A. (Alberto), Passalacqua, G. (Giovanni), Perkin, M. (Michael), Pfaar, O. (Oliver), Pitsios, C., Quirce, S. (S.), Raap, U., Raulf-Heimsoth, M., Rhyner, C. (Claudio), Robson-Ansley, P. (Paula), Alves, R.R. (Rodrigo Rodrigues), Roje, Z. (Zeljka), Rondon, C. (Carmen), Rudzeviciene, O. (Odilija), Rueff, F. (Franziska), Rukhadze, M. (Maia), Rumi, G. (Gabriele), Sackesen, C. (Cansin), Santos, A.F. (Alexandra F.), Santucci, A. (Annalisa), Scharf, C. (Christian), Schmidt-Weber, C.B., Schnyder, B. (Benno), Schwarze, J. (Jürgen), Senna, G.E. (Gianenrico), Sergejeva, S. (Svetlana), Seys, S. (Sven), Siracusa, A. (Andrea), Skypala, I. (I.), Sokolowska, M. (Milena), Spertini, F. (Francois), Spiewak, R. (Radoslaw), Sprikkelman, A.B. (Aline), Sturm, G.J., Swoboda, I., Terreehorst, I., Toskala, E., Traidl-Hoffmann, C. (Claudia), Venter, C. (C.), Vlieg-Boerstra, B.J., Whitacker, P. (Paul), Worm, M. (M.), Xepapadaki, P. (Paraskevi), Akdis, C.A., Papadopoulos, N., Agache, I., Bavbek, S. (Sevim), Bilo, B.M. (Beatrice M.), Braido, F. (Fulvio), Cardona, D. (Doris), Custovic, A. (Adnan), DeMonchy, J. (Jan), Demoly, P., Eigenmann, P.A. (Philippe), Gayraud, J. (J.), Grattan, C., Heffler, E. (E.), Hellings, P.W. (Peter), Jutel, M. (M.), Knol, E.F. (Edward Frank), Lötvall, J. (Jan), Murarol, A. (Antonella), Poulsen, L.K., Roberts, G., Schmid-Grendelmeier, P. (Peter), Skevaki, C. (Chrysanthi), Triggiani, M. (M.), VanRee, R. (Ronald), Werfel, T., Flood, B. (Breda), Palkonen, S., Savli, R. (Roberta), Allegri, P. (Pia), Annesi-Maesano, I. (Isabella), Annunziato, F. (Francesco), Antolin-Amerigo, D. (Dario), Apfelbacher, M. (Manuela), Blanca, M. (Miguel), Bogacka, E. (Ewa), Bonadonna, P. (Patrizia), Bonini, M. (Matteo), Boyman, O. (Onur), Brockow, K. (Knut), Burney, P. (Peter), Buters, J. (Jeroen), Butiene, I. (Indre), Calderon, M. (Moises), Cardell, L.O., Caubet, J.-C. (Jean-Christoph), Celenk, S. (Sevcan), Cichocka-Jarosz, E., Cingi, C. (Cemal), Couto, M. (Mariana), DeJong, N. (Nicolette), Del Giacco, S. (Stefano), Douladiris, N. (Nikolaos), Fassio, F. (Filippo), Fauquert, J.-L. (Jean-Luc), Fernandez, J. (Javier), Rivas, M.F. (Montserrat Fernandez), Ferrer, M. (Marta), Flohr, C. (Carsten), Gardner, J. (James), Genuneit, J. (Jon), Gevaert, P. (P.), Groblewska, A. (Anna), Hamelmann, E. (Eckard), Hoffmann, H.J. (Hans Jürgen), Hoffmann-Sommergruber, K. (K.), Hovhannisyan, L. (Lilit), Hox, V. (Valérie), Jahnsen, F.L. (Frode L.), Kalayci, O. (Omer), Kalpaklioglu, A.F. (Ayse Füsun), Kleine-Tebbe, J. (Jörg), Konstantinou, G. (George), Kurowski, M. (Marcin), Lau, S. (Susanne), Lauener, R. (Roger), Lauerma, A. (Antti), Logan, K. (K.), Magnan, A. (Antoine), Makowska, J. (Joanna), Makrinioti, H. (Heidi), Mangina, P. (Paraskevi), Manole, F. (Felicia), Mari, A. (A.), Mazón, A., Mills, C. (Clare), Mingomataj, E.Ç. (Ervin Ç), Niggemann, B., Nilsson, G. (Gunnar), Ollert, M. (Markus), O'Mahony, L. (Liam), O'Neil, S. (Serena), Pala, G. (Gianni), Papi, A. (Alberto), Passalacqua, G. (Giovanni), Perkin, M. (Michael), Pfaar, O. (Oliver), Pitsios, C., Quirce, S. (S.), Raap, U., Raulf-Heimsoth, M., Rhyner, C. (Claudio), Robson-Ansley, P. (Paula), Alves, R.R. (Rodrigo Rodrigues), Roje, Z. (Zeljka), Rondon, C. (Carmen), Rudzeviciene, O. (Odilija), Rueff, F. (Franziska), Rukhadze, M. (Maia), Rumi, G. (Gabriele), Sackesen, C. (Cansin), Santos, A.F. (Alexandra F.), Santucci, A. (Annalisa), Scharf, C. (Christian), Schmidt-Weber, C.B., Schnyder, B. (Benno), Schwarze, J. (Jürgen), Senna, G.E. (Gianenrico), Sergejeva, S. (Svetlana), Seys, S. (Sven), Siracusa, A. (Andrea), Skypala, I. (I.), Sokolowska, M. (Milena), Spertini, F. (Francois), Spiewak, R. (Radoslaw), Sprikkelman, A.B. (Aline), Sturm, G.J., Swoboda, I., Terreehorst, I., Toskala, E., Traidl-Hoffmann, C. (Claudia), Venter, C. (C.), Vlieg-Boerstra, B.J., Whitacker, P. (Paul), Worm, M. (M.), Xepapadaki, P. (Paraskevi), and Akdis, C.A.

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and tre

Published
2012
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