1. Research progress in steroidal saponins from the genus Polygonatum: Chemical components, biosynthetic pathways and pharmacological effects.
- Author
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Xu, Chunfang, Xia, Bohou, Zhang, Zhimin, Lin, Yan, Li, Chun, and Lin, Limei
- Subjects
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SAPONINS , *STEROID saponins , *STRUCTURE-activity relationships , *LILIACEAE - Abstract
The genus Polygonatum Mill. belongs to the Liliaceae family, which is widely distributed all over the world. Modern studies have found that Polygonatum plants are very rich in chemical compounds such as saponins, polysaccharides and flavonoids. Steroidal saponins are the most commonly studied saponins in the genus Polygonatum and a total of 156 compounds have been isolated from 10 species of the genus. These molecules possess antitumor, immunoregulatory, anti-inflammatory, antibacterial, antiviral, hypoglycemic, lipid-lowering and anti-osteoporotic activities. In this review, we summarize recent advances in studies of the chemical constituents of steroidal saponins from Polygonatum , including their structural characteristics, possible biosynthetic pathways and pharmacological effects. Then , the relationship between the structure and some physiological activities is considered. This review aims to provide reference for further exploitation and utilization of the genus Polygonatum. The structures, biosynthesis, and pharmacological effects of 156 steroidal saponins isolated from the genus Polygonatum are covered. [Display omitted] • Steroid saponins from Polygonatum have several potential pharmaceutical applications. • The structures and structural characteristics of these compounds are summarized. • The biosynthetic pathway of steroid saponins in Polygonatum is summarized. • The structure-activity relationship among Polygonatum steroid saponins is described. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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