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341 results on '"Xia, Hongmei"'

5. Impact of Living Environment on the Development of Cognitive Navigation Strategy in Chinese Urban and Rural Children

Author

Xia, Hongmei, Li, Xinyu, and Chen, Raine

Subjects
cognitive science
Abstract

Previous studies suggest that environment affect human spatial navigation ability. It remains in question when and how the environment assert influence on the developmental changes of spatial cognition. To answer this question, current study compared the general navigation ability and the specific ability in using allocentric vs. egocentric cues between urban and rural children in China. Our results showed urban and rural children did not differ in their general navigation ability when they can use various cognitive strategies in a free navigation task. However, the 9 to12-yrs old rural children performed significantly better than the age-matched urban children when they were instructed to use allocentric cues in a similar maze navigation task. No such difference was found between the 5 to 8-yrs old rural and urban children, suggesting that living environment plays an important role in the development of the allocentric processing ability for navigation during the middle childhood.

Published
2021

10. PD-1 inhibitor combined with Docetaxel exerts synergistic anti-prostate cancer effect in mice by down-regulating the expression of PI3K/AKT/NFKB-P65/PD-L1 signaling pathway.

Author

Zhou, Sixu, Wang, Baogui, Wei, Yingying, Dai, Peiru, Chen, Yan, Xiao, Yingyi, Xia, Hongmei, Chen, Chunlin, and Yin, Weihua

Subjects
PROSTATE cancer, DOCETAXEL, PROGRAMMED cell death 1 receptors, CELLULAR signal transduction, ANDROGEN receptors, IMMUNE checkpoint inhibitors, IMMUNE checkpoint proteins
Abstract

BACKGROUND: Docetaxel is a yew compound antitumor agent with accurate antitumor efficacy, but its application is limited due to the high and serious adverse effects, and finding effective combination therapy options is a viable strategy. Immune checkpoint inhibitors have become hotspots in enhancing anti-tumor immunity by blocking immune checkpoint signaling pathways, but their response rate to monotherapy use is not high and the efficacy is minimal. OBJECTIVE: To explore the anti-tumor effects and mechanisms of the combination of PD-1 inhibitors and Docetaxel through in vivo experiments and develop a feasible combination treatment for the therapy of prostate cancer. METHODS: Tumor-bearing mice were subcutaneously injected with 0.1 ml RM-1 cells. Treatment were taken when the tumor growed up to 3 mm, after which the tumor and spleen were removed to test the antitumor effect with Flow cytometric (FACS) analysis, Immunohistochemistry, Western Blot. RESULTS: In this experiment, we found that PD-1 inhibitors combined with Docetaxel had a synergistic effect on mouse prostate cancer, inhibited the growth of prostate cancer, improved survival and reduced adverse reactions, increased spleen and tumor infiltrative CD4+ and CD8+ T cells, especially in group combination with low-dose Docetaxel, and were related to the PI3K/AKT/NFKB-P65/PD-L1 signaling pathway. CONCLUSION: Our study confirms that PD-1 inhibitors in combination with Docetaxel are a viable combination strategy and provide a safe and effective combination option for the clinical treatment of prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Decreasing amplitude of left ventricular outflow tract gradient and its influencing factors after alcohol septal ablation

Author

ZHANG Yong, LIU Xiaoyan, CHENG Xiaofeng, LI Ping, HE Yongming, CHEN Jia, XIA Hongmei, XU Yali, and WANG Jiang

Subjects
hypertrophic cardiomyopathy, hypertrophic obstructive cardiomyopathy, alcohol septal ablation, left ventricular outflow tract gradient, Medicine (General), R5-920
Abstract

Objective To analyze the decreasing amplitude of left ventricular outflow tract gradient(LVOTG) and its influencing factors after alcohol septal ablation(ASA) in treatment of hypertrophic obstructive cardiomyopathy(HOCM). Methods A total of 58 HOCM patients treated by ASA in our hospital from August 2011 to August 2019 were recruited in this study. The changes of echocardiography before and after ASA(a median follow-up period of 34 d) were compared to evaluate the decreasing amplitude of LVOTG after surgery. According to whether the LVOTG was decreased by 50%, the patients were divided into the significant LVOTG decline group(LVOTG decline ≥50%) and the non-significant decline group(LVOTG decline < 50%). The clinical data were compared between the 2 groups. The independent influential factors of significant LVOTG decline were analyzed, and receiver operation characteristic(ROC) curve analysis was also performed for the influencing factors. Results The LVOTG of the 58 patients was decreased from 90.77±33.38 mmHg preoperatively to 46.13±39.31 mmHg(P < 0.05). The interventricular septum thickness, left atrial diameter, mitral regurgitation area and systolic anterior motion were all significantly reduced after surgery (P < 0.05). Multivariate logistic regression analysis indicated that alcohol dose(OR=3.222, 95%CI: 1.345~7.717, P=0.009) was an independent influencing factor of significant LVOTG decline in short term, with the area under curve(AUC) of 0.707(95%CI: 0.573~0.841, P=0.009). Conclusion ASA can effectively reduce LVOTG in HOCM patients. And the higher the alcohol dose is, the more significant the decreasing amplitude is.

Published
2020
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25. 4Doodle: 4D Printing Artifacts Without 3D Printers

Author

Tao, Ye, primary, Wang, Shuhong, additional, Ji, Junzhe, additional, Cai, Linlin, additional, Xia, Hongmei, additional, Wang, Zhiqi, additional, He, Jinghai, additional, Fan, Yitao, additional, Pan, Shengzhang, additional, Xu, Jinghua, additional, Yang, Cheng, additional, Sun, Lingyun, additional, and Wang, Guanyun, additional

Published
2023
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39. Anatomic predictor of severe prosthesis malposition following transcatheter aortic valve replacement with self- expandable Venus-A Valve among pure aortic regurgitation: A multicenter retrospective study

Author

Wang, Yong, primary, Yu, Shiyong, additional, Qian, Dehui, additional, Li, Jie, additional, Fang, Zhenfei, additional, Cheng, Wei, additional, Li, Xiaoqing, additional, Liu, Ting, additional, Zeng, Ying, additional, Xia, Hongmei, additional, and Jin, Jun, additional

Published
2022
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