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Purpose. To compare corneal higher-order aberrations (HOAs), refractive error, and ocular biological parameters before and after phacoemulsification combined with goniosynechialysis (Phaco-GSL) in primary angle closure/glaucoma (PAC/PACG) patients with different axial lengths (ALs). Methods. In this prospective study, cataract patients diagnosed with PAC/PACG were categorized into two groups based on their ALs: the short AL group (AL ≤ 22.5 mm) and the normal AL group (22.5 < AL ≤ 24.5 mm). The pre- and postsurgery measurements of intraocular pressure (IOP) and best-corrected visual acuity (BCVA) were conducted at 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months. Additionally, the assessments included corneal HOAs, the number of antiglaucoma medications, visual field parameters, manifest refraction, and other ocular biological parameters before surgery and at the final follow-up. Results. Prior to surgery, the two groups exhibited no significant differences, except for AL, curvature value, and Z (4, 0) of the posterior corneal surface (all P < 0.01). Following surgery, BCVA improved, and IOP decreased significantly in both groups (P < 0.01). Both anterior and total corneal HOAs, along with Z (3, −3), increased in the two groups (all P < 0.05), with the normal AL group exhibiting a significantly greater increase in total cornea Z (3, −3) than the short AL group (P = 0.047). The normal AL group also exhibited a slight tendency towards hyperopia (P < 0.01). Significant changes were observed in the visual field index and mean deviation in both groups (P < 0.05). Conclusions. Phaco-GSL resulted in an increased corneal HOAs, particularly trefoil, with variations based on the patient's AL. Patients with normal ALs tended to shift towards hyperopia after surgery. [ABSTRACT FROM AUTHOR]

The article presents the discussion on Glycosaminoglycans (GAGs) being major component of extracellular matrix. Topics include necessary for the regulation of cell growth and proliferation and the maintenance of tissue hydration; and slit lamp examination revealed corneal edema with diffuse granular opacity, while funduscopic examination showed a hazy but flat retina.

Although biologics improve the quality of life of psoriasis patients, they also impose a substantial economic burden. There is a lack of research addressing the economic and humanistic impact of biologics in China. This cross-sectional investigation aims to assess the economic cost, quality of life, and patient satisfaction among individuals with psoriasis treated with biologics and non-biologics. From July 2021 to December 2022, eligible patients with psoriasis were recruited through both on-site and online questionnaire completion. The questionnaires collected sociodemographic data, clinical characteristics of psoriasis, economic costs associated with treatment, and the Dermatological Life Quality Index (DLQI). 481 patients with a mean age of 40.8 ± 13.4 years old were included and classified into a non-biologic (n = 195) and biologic (n = 286) treatment group. The direct medical cost for non-biologics patients was 7,249 CNY, accounting for 70.0% of the total cost, while biologics patients incurred 15,176 CNY, making up 94.3% of the total cost. The non-biologic group had higher costs related to hospitalization, self-purchase of drugs, and indirect costs than the biologic treatment group. Additionally, DLQI scores were higher in the non-biologic group. Patients in the biologic group experienced a higher economic burden and better quality of life than those in the non-biologic group. [ABSTRACT FROM AUTHOR]

Background: Verruciform xanthoma is a rare benign proliferative lesion of the skin and mucosa which mainly affects oral mucosa. Cases of verruciform xanthomas occurring outside the oral mucosa are rare. Verrucous nevus, also called epidermal nevus, is a cutaneous hamartoma caused by abnormal proliferation of epidermal keratinocytes. Aim: Here, we reported a 39‐year‐old woman diagnosed verruciform xanthoma of the vulva with generalized verrucous nevus on extremities. Patient: A 39‐year‐old woman presented to the dermatology department. The vulva cauliflower tumor was accompanied by verrucous tumor of limbs for 33 years. The skin lesions showed cauliflower like growth in the size of fist in the perineum, and the Yellow verrucous vegetations of limbs were arranged in strips. Results The pathological diagnosis confirmed that the vulva verrucous xanthoma was combined with generalized verrucous nevus of limbs. No clinically relevant genes with pathogenic variants were detected by high‐throughput sequencing technology and whole exome sequencing of genetic diseases. Results: The pathological diagnosis confirmed that the vulva verrucous xanthoma was combined with generalized verrucous nevus of limbs. No clinically relevant genes with pathogenic variants were detected by high‐throughput sequencing technology and whole exome sequencing of genetic diseases. Conclusion: The case was confirmed to be verruciform xanthoma, a benign proliferative xanthoma‐like lesion with high incidence on the oral cavity. Combinded with generalized verrucous nevus,which is caused by excessive development of the epidermis, resulting in localized epidermal developmental abnormalities. Vulvar and peripheral lesions were treated through surgical approach. Lesions on the extremities were treated through oral administration of Acitretin capsules after obtaining informed consent from the patient. After a 3‐month follow‐up, the skin lesions on the hands and feet had partially disappeared. However, the outcome needs further follow‐up and examination. [ABSTRACT FROM AUTHOR]

Background Odontogenic cutaneous fistulas (OCST) are pathological connections between the facial skin and oral cavity caused by chronic dental infection. They are often misdiagnosed or underdiagnosed by dermatologists. Aims This study explores the clinical and radiographic features of patients with odontogenic cutaneous fistulas. Methods This study retrospectively analysed the clinical data of 60 patients diagnosed with odontogenic cutaneous fistulas between January 2016 and February 2022. Results The study identified a predominance of OCST in males (53.3%) with a mean age of 49 years. There was a significant difference in the distribution between the maxillary and mandibular zones [(14/60, 23.3%) vs (46/60, 76.7%), p < 0.001]. Nodules are the most frequent morphology (48.3%). Imaging findings included periapical radiolucency, bone erosion and the presence of a sinus tract. All patients responded well to dental treatments with no recurrences noted. Limitations This is a retrospective study design and has a limited number of patients. Conclusion Collaborative efforts between dentists and dermatologists are crucial for accurate diagnosis and treatment, enhancing patient outcomes.