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30 results on '"Xia, Jinquan"'

5. LASSO-Based Identification of Risk Factors and Development of a Prediction Model for Sepsis Patients

Author

Hong,Chengying, Xiong,Yihan, Xia,Jinquan, Huang,Wei, Xia,Andi, Xu,Shunyao, Chen,Yuting, Xu,Zhikun, Chen,Huaisheng, Zhang,Zhongwei, Hong,Chengying, Xiong,Yihan, Xia,Jinquan, Huang,Wei, Xia,Andi, Xu,Shunyao, Chen,Yuting, Xu,Zhikun, Chen,Huaisheng, and Zhang,Zhongwei

Abstract

Chengying Hong,1 Yihan Xiong,2 Jinquan Xia,3 Wei Huang,4 Andi Xia,1 Shunyao Xu,1 Yuting Chen,1 Zhikun Xu,1 Huaisheng Chen,1 Zhongwei Zhang5 1Department of Critical Care Medicine, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, 518020, People’s Republic of China; 2Neurology Department, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, 518020, People’s Republic of China; 3Department of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, 518020, People’s Republic of China; 4Department of Clinical Microbiology, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, 518020, People’s Republic of China; 5Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of ChinaCorrespondence: Huaisheng Chen, Department of Critical Care Medicine, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, 518020, People’s Republic of China, Email sunshinic@hotmail.com Zhongwei Zhang, Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China, Email 716461751@qq.comObjective: The objective of this study was to utilize LASSO regression (Least Absolute Shrinkage and Selection Operator Regression) to identify key variables in septic patients and develop a predictive model f

Published
2024

6. LASSO-Based Machine Learning Algorithm for Prediction of PICS Associated with Sepsis.

Author

Hui, Kangping, Hong, Chengying, Xiong, Yihan, Xia, Jinquan, Huang, Wei, Xia, Andi, Xu, Shunyao, Chen, Yuting, Zhang, Zhongwei, and Chen, Huaisheng

Subjects
MACHINE learning, TROPICAL medicine, LACTIC acidosis, PREDICTION models, ARTIFICIAL respiration
Abstract

Objective is to amalgamate a diverse array of indicators and pathogenic microbial data to pinpoint pivotal predictive variables, enabling effective intervention specifically tailored to the context of tropical diseases. Methods: A focused analysis was conducted on 1733 patients admitted to the ICU between December 2016 and July 2019. Utilizing the Least Absolute Shrinkage and Selection Operator (LASSO) regression, disease severity and laboratory indices were scrutinized. The identified variables served as the foundation for constructing a predictive model designed to forecast the occurrence of PICS. Results: Among the subjects, 13.79% met the diagnostic criteria for PICS, correlating with a mortality rate of 38.08%. Key variables, including red-cell distribution width coefficient of variation (RDW-CV), hemofiltration (HF), mechanical ventilation (MV), Norepinephrine (NE), lactic acidosis, and multiple-drug resistant bacteria (MDR) infection, were identified through LASSO regression. The resulting predictive model exhibited a robust performance with an Area Under the Curve (AUC) of 0.828, an accuracy of 0.862, and a specificity of 0.977. Subsequent validation in an independent cohort yielded an AUC of 0.848. Discussion: The acquisition of RDW-CV, HF requirement, MV requirement, NE requirement, lactic acidosis, and MDR upon ICU admission emerges as a pivotal factor for prognosticating PICS onset in the context of tropical diseases. This study highlights the potential for significant improvements in clinical outcomes through the implementation of timely and targeted interventions tailored specifically to the challenges posed by tropical diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Yin Yang 1 promotes aggressive cell growth in high‐grade breast cancer by directly transactivating kinectin 1

Author

Gao, Lin, primary, Zhou, Wenbin, additional, Xie, Ni, additional, Qiu, Junying, additional, Huang, Jingyi, additional, Zhang, Zhe, additional, Hong, Malin, additional, Xia, Jinquan, additional, Xu, Jing, additional, Zhao, Pan, additional, Fu, Li, additional, Luo, Yuwei, additional, Jiang, Jing, additional, Gong, Hui, additional, Wang, Jigang, additional, Dai, Yong, additional, Luo, Dixian, additional, and Zou, Chang, additional

Published
2022
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15. Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity

Author

Gao, Lin, primary, Chen, Shanze, additional, Hong, Malin, additional, Zhou, Wenbin, additional, Wang, Bilan, additional, Qiu, Junying, additional, Xia, Jinquan, additional, Zhao, Pan, additional, Fu, Li, additional, Wang, Jigang, additional, Dai, Yong, additional, Xie, Ni, additional, Yang, Qinhe, additional, Huang, Hsien-Da, additional, Gao, Xiang, additional, and Zou, Chang, additional

Published
2021
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16. Mutational Pattern in Multiple Pulmonary Nodules Are Associated With Early Stage Lung Adenocarcinoma

Author

Dong, Shao-wei, primary, Li, Rong, additional, Cheng, Zhiqiang, additional, Liu, Dong-cheng, additional, Xia, Jinquan, additional, Xu, Jing, additional, Li, Shixuan, additional, Wang, Jian, additional, Yue, Yongjian, additional, Fan, Yingrui, additional, Cao, Yundi, additional, Dai, Lingyun, additional, Wang, Jigang, additional, Zhao, Pan, additional, Wang, Xin, additional, Xiao, Zhangang, additional, Qiu, Chen, additional, Wang, Guang-suo, additional, and Zou, Chang, additional

Published
2021
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18. Genome sequencing of the sweetpotato whitefly Bemisia tabaci MED/Q

Author

Xie, Wen, primary, Chen, Chunhai, additional, Yang, Zezhong, additional, Guo, Litao, additional, Yang, Xin, additional, Wang, Dan, additional, Chen, Ming, additional, Huang, Jinqun, additional, Wen, Yanan, additional, Zeng, Yang, additional, Liu, Yating, additional, Xia, Jixing, additional, Tian, Lixia, additional, Cui, Hongying, additional, Wu, Qingjun, additional, Wang, Shaoli, additional, Xu, Baoyun, additional, Li, Xianchun, additional, Tan, Xinqiu, additional, Ghanim, Murad, additional, Qiu, Baoli, additional, Pan, Huipeng, additional, Chu, Dong, additional, Delatte, Helene, additional, Maruthi, M. N., additional, Ge, Feng, additional, Zhou, Xueping, additional, Wang, Xiaowei, additional, Wan, Fanghao, additional, Du, Yuzhou, additional, Luo, Chen, additional, Yan, Fengming, additional, Preisser, Evan L., additional, Jiao, Xiaoguo, additional, Coates, Brad S., additional, Zhao, Jinyang, additional, Gao, Qiang, additional, Xia, Jinquan, additional, Yin, Ye, additional, Liu, Yong, additional, Brown, Judith K., additional, Zhou, Xuguo “Joe”, additional, and Zhang, Youjun, additional

Published
2017
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19. Genome sequencing of the sweetpotato whitefly Bemisia tabaci MED/Q

Author

Xie, Wen, Chen, Chunhai, Yang, Zezhong, Guo, Litao, Yang, Xin, Wang, Dan, Chen, Ming, Huang, Jinqun, Wen, Yanan, Zeng, Yang, Liu, Yating, Xia, Jixing, Tian, Lixia, Cui, Hongying, Wu, Qingjun, Wang, Shaoli, Wu, Baoyun, Li, Xianchiun, Tan, Xinqiu, Ghanim, Murad, Qiu, Baoli, Pan, Huipeng, Chu, Dong, Delatte, Hélène, Maruthi, M.N., Ge, Feng, Zhou, Xueping, Wang, Xiaowei, Wan, Fang-Hao, Du, Yuzhou, Luo, Chen, Yan, Fengming, Preisser, Evan L., Jiao, Xiaoguo, Coates, Brad S., Zhao, Jinyang, Gao, Qiang, Xia, Jinquan, Yin, Ye, Liu, Yong, Brown, Judith, Zhou, Xuguo-Joe, Zhang, Youjun, Xie, Wen, Chen, Chunhai, Yang, Zezhong, Guo, Litao, Yang, Xin, Wang, Dan, Chen, Ming, Huang, Jinqun, Wen, Yanan, Zeng, Yang, Liu, Yating, Xia, Jixing, Tian, Lixia, Cui, Hongying, Wu, Qingjun, Wang, Shaoli, Wu, Baoyun, Li, Xianchiun, Tan, Xinqiu, Ghanim, Murad, Qiu, Baoli, Pan, Huipeng, Chu, Dong, Delatte, Hélène, Maruthi, M.N., Ge, Feng, Zhou, Xueping, Wang, Xiaowei, Wan, Fang-Hao, Du, Yuzhou, Luo, Chen, Yan, Fengming, Preisser, Evan L., Jiao, Xiaoguo, Coates, Brad S., Zhao, Jinyang, Gao, Qiang, Xia, Jinquan, Yin, Ye, Liu, Yong, Brown, Judith, Zhou, Xuguo-Joe, and Zhang, Youjun

Abstract

The sweetpotato whitefly Bemisia tabaci is a highly destructive agricultural and ornamental crop pest. It damages host plants through both phloem feeding and vectoring plant pathogens. Introductions of B. tabaci are difficult to quarantine and eradicate because of its high reproductive rates, broad host plant range, and insecticide resistance. A total of 791 Gb of raw DNA sequence from whole genome shotgun sequencing, and 13 BAC pooling libraries were generated by Illumina sequencing using different combinations of mate-pair and pair-end libraries. Assembly gave a final genome with a scaffold N50 of 437 kb, and a total length of 658 Mb. Annotation of repetitive elements and coding regions resulted in 265.0 Mb TEs (40.3%) and 20 786 protein-coding genes with putative gene family expansions, respectively. Phylogenetic analysis based on orthologs across 14 arthropod taxa suggested that MED/Q is clustered into a hemipteran clade containing A. pisum and is a sister lineage to a clade containing both R. prolixus and N. lugens. Genome completeness, as estimated using the CEGMA and Benchmarking Universal Single-Copy Orthologs pipelines, reached 96% and 79%. These MED/Q genomic resources lay a foundation for future 'pan-genomic' comparisons of invasive vs. noninvasive, invasive vs. invasive, and native vs. exotic Bemisia, which, in return, will open up new avenues of investigation into whitefly biology, evolution, and management.

Published
2017

20. The yak genome and adaptation to life at high altitude

Author

Qiu, Qiang, Zhang, Guojie, Ma, Tao, Qian, Wubin, Ye, Zhiqiang, Cao, Changchang, Hu, Quanjun, Kim, Jaebum, Larkin, Denis M., Auvil, Loretta, Capitanu, Boris, Ma, Jian, Lewin, Harris A., Qian, Xiaoju, Lang, Yongshan, Zhou, Ran, Wang, Lizhong, Wang, Kun, Xia, Jinquan, Liao, Shengguang, Pan, Shengkai, Lu, Xu, Hou, Haolong, Wang, Yan, Zang, Xuetao, Yin, Ye, Ma, Hui, Zhang, Jian, Wang, Zhaofeng, Zhang, Yingmei, Zhang, Dawei, Yonezawa, Takahiro, Hasegawa, Masami, Zhong, Yang, Liu, Wenbin, Zhang, Yan, Huang, Zhiyong, Zhang, Shengxiang, Long, Ruijun, Yang, Huanming, Lenstra, Johannes A., Cooper, David N., Wu, Yi, Wang, Jun, Shi, Peng, Wang, Jian, Liu, Jianquan, Wang, Junyis, LS IRAS Tox Algemeen, Faculty of Veterinary Medicine Research Groups, and Algemeen Onderzoek DGK

Subjects
Genetics
Abstract

Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans. © 2012 Nature America, Inc. All rights reserved.

Published
2012

22. Two Antarctic penguin genomes reveal insights into their evolutionary history and molecular changes related to the Antarctic environment

Author

Li, Cai, Zhang, Yong, Li, Jianwen, Kong, Lesheng, Hu, Haofu, Pan, Hailin, Xu, Luohao, Deng, Yuan, Li, Qiye, Jin, Lijun, Yu, Hao, Chen, Yan, Liu, Binghang, Yang, Linfeng, Liu, Shiping, Zhang, Yan, Lang, Yongshan, Xia, Jinquan, He, Weiming, Shi, Qiong, Subramanian, Sankar, Millar, Craig D., Meader, Stephen, Rands, Chris M., Fujita, Matthew K., Greenwold, Matthew J., Castoe, Todd A., Pollock, David D., Gu, Wanjun, Nam, Kiwoong, Ellegren, H, Ho, Simon Y. W., Burt, David W., Ponting, Chris P., Jarvis, Erich D., Gilbert, M. Thomas P., Yang, Huanming, Wang, Jian, Lambert, David M., Wang, Jun, Zhang, Guojie, Li, Cai, Zhang, Yong, Li, Jianwen, Kong, Lesheng, Hu, Haofu, Pan, Hailin, Xu, Luohao, Deng, Yuan, Li, Qiye, Jin, Lijun, Yu, Hao, Chen, Yan, Liu, Binghang, Yang, Linfeng, Liu, Shiping, Zhang, Yan, Lang, Yongshan, Xia, Jinquan, He, Weiming, Shi, Qiong, Subramanian, Sankar, Millar, Craig D., Meader, Stephen, Rands, Chris M., Fujita, Matthew K., Greenwold, Matthew J., Castoe, Todd A., Pollock, David D., Gu, Wanjun, Nam, Kiwoong, Ellegren, H, Ho, Simon Y. W., Burt, David W., Ponting, Chris P., Jarvis, Erich D., Gilbert, M. Thomas P., Yang, Huanming, Wang, Jian, Lambert, David M., Wang, Jun, and Zhang, Guojie

Abstract

Background: Penguins are flightless aquatic birds widely distributed in the Southern Hemisphere. The distinctive morphological and physiological features of penguins allow them to live an aquatic life, and some of them have successfully adapted to the hostile environments in Antarctica. To study the phylogenetic and population history of penguins and the molecular basis of their adaptations to Antarctica, we sequenced the genomes of the two Antarctic dwelling penguin species, the Adelie penguin [Pygoscelis adeliae] and emperor penguin [Aptenodytes forsteri]. Results: Phylogenetic dating suggests that early penguins arose similar to 60 million years ago, coinciding with a period of global warming. Analysis of effective population sizes reveals that the two penguin species experienced population expansions from similar to 1 million years ago to similar to 100 thousand years ago, but responded differently to the climatic cooling of the last glacial period. Comparative genomic analyses with other available avian genomes identified molecular changes in genes related to epidermal structure, phototransduction, lipid metabolism, and forelimb morphology. Conclusions: Our sequencing and initial analyses of the first two penguin genomes provide insights into the timing of penguin origin, fluctuations in effective population sizes of the two penguin species over the past 10 million years, and the potential associations between these biological patterns and global climate change. The molecular changes compared with other avian genomes reflect both shared and diverse adaptations of the two penguin species to the Antarctic environment.

Published
2014
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23. Genome and transcriptome of the porcine whipworm Trichuris suis

Author

Jex, Aaron R., Nejsum, Peter, Schwarz, Erich M., Hu, Li, Young, Neil D., Hall, Ross S., Korhonen, Pasi K., Liao, Shengguang, Thamsborg, Stig Milan, Xia, Jinquan, Xu, Pengwei, Wang, Shaowei, Scheerlinck, Jean-Pierre Y., Hofmann, Andreas, Sternberg, Paul W., Wang, Jun, Gasser, Robin B., Jex, Aaron R., Nejsum, Peter, Schwarz, Erich M., Hu, Li, Young, Neil D., Hall, Ross S., Korhonen, Pasi K., Liao, Shengguang, Thamsborg, Stig Milan, Xia, Jinquan, Xu, Pengwei, Wang, Shaowei, Scheerlinck, Jean-Pierre Y., Hofmann, Andreas, Sternberg, Paul W., Wang, Jun, and Gasser, Robin B.

Published
2014

24. Two Antarctic penguin genomes reveal insights into their evolutionary history and molecular changes related to the Antarctic environment

Author

Li, Cai, primary, Zhang, Yong, additional, Li, Jianwen, additional, Kong, Lesheng, additional, Hu, Haofu, additional, Pan, Hailin, additional, Xu, Luohao, additional, Deng, Yuan, additional, Li, Qiye, additional, Jin, Lijun, additional, Yu, Hao, additional, Chen, Yan, additional, Liu, Binghang, additional, Yang, Linfeng, additional, Liu, Shiping, additional, Zhang, Yan, additional, Lang, Yongshan, additional, Xia, Jinquan, additional, He, Weiming, additional, Shi, Qiong, additional, Subramanian, Sankar, additional, Millar, Craig D, additional, Meader, Stephen, additional, Rands, Chris M, additional, Fujita, Matthew K, additional, Greenwold, Matthew J, additional, Castoe, Todd A, additional, Pollock, David D, additional, Gu, Wanjun, additional, Nam, Kiwoong, additional, Ellegren, Hans, additional, Ho, Simon YW, additional, Burt, David W, additional, Ponting, Chris P, additional, Jarvis, Erich D, additional, Gilbert, M Thomas P, additional, Yang, Huanming, additional, Wang, Jian, additional, Lambert, David M, additional, Wang, Jun, additional, and Zhang, Guojie, additional

Published
2014
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25. Peregrine and saker falcon genome sequences provide insights into evolution of a predatory lifestyle

Author

Zhan, Xiangjiang, Pan, Shengkai, Wang, Junyi, Dixon, Andrew, He, Jing, Muller, Margit G., Ni, Peixiang, Hu, Li, Liu, Yuan, Hou, Haolong, Chen, Yuanping, Xia, Jinquan, Luo, Qiong, Xu, Pengwei, Chen, Ying, Liao, Shengguang, Cao, Changchang, Gao, Shukun, Wang, Zhaobao, Yue, Zhen, Li, Guoqing, Yin, Ye, Fox, Nick C., Wang, Jun, Bruford, Michael W., Zhan, Xiangjiang, Pan, Shengkai, Wang, Junyi, Dixon, Andrew, He, Jing, Muller, Margit G., Ni, Peixiang, Hu, Li, Liu, Yuan, Hou, Haolong, Chen, Yuanping, Xia, Jinquan, Luo, Qiong, Xu, Pengwei, Chen, Ying, Liao, Shengguang, Cao, Changchang, Gao, Shukun, Wang, Zhaobao, Yue, Zhen, Li, Guoqing, Yin, Ye, Fox, Nick C., Wang, Jun, and Bruford, Michael W.

Published
2013

26. The yak genome and adaptation to life at high altitude

Author

LS IRAS Tox Algemeen, Faculty of Veterinary Medicine Research Groups, Algemeen Onderzoek DGK, Qiu, Qiang, Zhang, Guojie, Ma, Tao, Qian, Wubin, Ye, Zhiqiang, Cao, Changchang, Hu, Quanjun, Kim, Jaebum, Larkin, Denis M., Auvil, Loretta, Capitanu, Boris, Ma, Jian, Lewin, Harris A., Qian, Xiaoju, Lang, Yongshan, Zhou, Ran, Wang, Lizhong, Wang, Kun, Xia, Jinquan, Liao, Shengguang, Pan, Shengkai, Lu, Xu, Hou, Haolong, Wang, Yan, Zang, Xuetao, Yin, Ye, Ma, Hui, Zhang, Jian, Wang, Zhaofeng, Zhang, Yingmei, Zhang, Dawei, Yonezawa, Takahiro, Hasegawa, Masami, Zhong, Yang, Liu, Wenbin, Zhang, Yan, Huang, Zhiyong, Zhang, Shengxiang, Long, Ruijun, Yang, Huanming, Lenstra, Johannes A., Cooper, David N., Wu, Yi, Wang, Jun, Shi, Peng, Wang, Jian, Liu, Jianquan, Wang, Junyis, LS IRAS Tox Algemeen, Faculty of Veterinary Medicine Research Groups, Algemeen Onderzoek DGK, Qiu, Qiang, Zhang, Guojie, Ma, Tao, Qian, Wubin, Ye, Zhiqiang, Cao, Changchang, Hu, Quanjun, Kim, Jaebum, Larkin, Denis M., Auvil, Loretta, Capitanu, Boris, Ma, Jian, Lewin, Harris A., Qian, Xiaoju, Lang, Yongshan, Zhou, Ran, Wang, Lizhong, Wang, Kun, Xia, Jinquan, Liao, Shengguang, Pan, Shengkai, Lu, Xu, Hou, Haolong, Wang, Yan, Zang, Xuetao, Yin, Ye, Ma, Hui, Zhang, Jian, Wang, Zhaofeng, Zhang, Yingmei, Zhang, Dawei, Yonezawa, Takahiro, Hasegawa, Masami, Zhong, Yang, Liu, Wenbin, Zhang, Yan, Huang, Zhiyong, Zhang, Shengxiang, Long, Ruijun, Yang, Huanming, Lenstra, Johannes A., Cooper, David N., Wu, Yi, Wang, Jun, Shi, Peng, Wang, Jian, Liu, Jianquan, and Wang, Junyis

Published
2012

27. Peregrine and saker falcon genome sequences provide insights into evolution of a predatory lifestyle

Author

Zhan, Xiangjiang, primary, Pan, Shengkai, additional, Wang, Junyi, additional, Dixon, Andrew, additional, He, Jing, additional, Muller, Margit G, additional, Ni, Peixiang, additional, Hu, Li, additional, Liu, Yuan, additional, Hou, Haolong, additional, Chen, Yuanping, additional, Xia, Jinquan, additional, Luo, Qiong, additional, Xu, Pengwei, additional, Chen, Ying, additional, Liao, Shengguang, additional, Cao, Changchang, additional, Gao, Shukun, additional, Wang, Zhaobao, additional, Yue, Zhen, additional, Li, Guoqing, additional, Yin, Ye, additional, Fox, Nick C, additional, Wang, Jun, additional, and Bruford, Michael W, additional

Published
2013
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28. The yak genome and adaptation to life at high altitude

Author

Qiu, Qiang, primary, Zhang, Guojie, additional, Ma, Tao, additional, Qian, Wubin, additional, Wang, Junyi, additional, Ye, Zhiqiang, additional, Cao, Changchang, additional, Hu, Quanjun, additional, Kim, Jaebum, additional, Larkin, Denis M, additional, Auvil, Loretta, additional, Capitanu, Boris, additional, Ma, Jian, additional, Lewin, Harris A, additional, Qian, Xiaoju, additional, Lang, Yongshan, additional, Zhou, Ran, additional, Wang, Lizhong, additional, Wang, Kun, additional, Xia, Jinquan, additional, Liao, Shengguang, additional, Pan, Shengkai, additional, Lu, Xu, additional, Hou, Haolong, additional, Wang, Yan, additional, Zang, Xuetao, additional, Yin, Ye, additional, Ma, Hui, additional, Zhang, Jian, additional, Wang, Zhaofeng, additional, Zhang, Yingmei, additional, Zhang, Dawei, additional, Yonezawa, Takahiro, additional, Hasegawa, Masami, additional, Zhong, Yang, additional, Liu, Wenbin, additional, Zhang, Yan, additional, Huang, Zhiyong, additional, Zhang, Shengxiang, additional, Long, Ruijun, additional, Yang, Huanming, additional, Wang, Jian, additional, Lenstra, Johannes A, additional, Cooper, David N, additional, Wu, Yi, additional, Wang, Jun, additional, Shi, Peng, additional, and Liu, Jianquan, additional

Published
2012
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29. ACKR1 hi ECs Promote Aortic Dissection Through Adjusting Macrophage Behavior.

Author

Wang Y, Jia X, Zhang Y, Zhang B, Zhou Y, Li X, Zhu X, Xia J, Ren J, Zou C, and Zheng Q

Abstract

Background: Type A aortic dissection (TAAD) is a life-threatening condition characterized by complex pathophysiology, in which macrophages play a critical but not yet fully understood role. This study focused on the role of endothelial cells with elevated expression of ACKR1 (atypical chemokine receptor 1) and their interaction with proinflammatory macrophages in TAAD development., Methods and Results: Single-cell transcriptomic analysis of human aortic tissues revealed increased populations of endothelial cells exhibiting high ACKR1 expression and proinflammatory macrophages in TAAD samples. Both clinical and animal studies revealed that ACKR1 expression levels were strongly linked to TAAD severity. Gain- and loss-of-function studies demonstrated that ACKR1 promotes TAAD progression. Specific knockdown of ACKR1 in endothelial cells suppressed the NF-κB (nuclear factor-κB) signaling pathway and SPP1 (secreted phosphoprotein 1) expression, leading to reduced macrophage migration and proinflammatory polarization, which subsequently inhibited TAAD development. Conversely, ACKR1 overexpression accelerated TAAD progression. Notably, molecular docking and comprehensive evaluation identified amikacin as a potential novel modulator of ACKR1. Extensive in vitro and in vivo studies demonstrated that amikacin can regulate macrophage behavior through the ACKR1/NF-κB/SPP1 signaling pathway, thereby attenuating TAAD progression and improving survival rates in TAAD mice., Conclusions: This study reveals how endothelial cells exhibiting high ACKR1 expression modulate macrophage migration and proinflammatory polarization through the ACKR1/NF-κB/SPP1 signaling pathway, a crucial mechanism in TAAD progression. Targeting ACKR1 through both functional and pharmacological approaches effectively suppressed TAAD progression and extended survival in TAAD mice, offering promising new intervention strategies for clinical evaluation.

Published
2024
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30. Phytochemical profiling and evaluation of antimicrobial activities of common culinary spices: Syzygium aromaticum (clove) and Piper nigrum (black pepper).

Author

Zhao K, Wonta KB, Xia J, Zhong F, and Sharma V

Abstract

Background: The increasing resistance of microbial pathogens to conventional antibiotics necessitates the exploration of alternative antimicrobial agents. This study aims to evaluate the antimicrobial potential and phytochemical properties of Syzygium aromaticum (clove) and Piper nigrum (black pepper) extracts, both of which are known for their historical use in traditional medicine and culinary applications., Methods: Hydroalcoholic and aqueous extracts of clove and black pepper were prepared. The antimicrobial activity of these extracts was assessed using the disk diffusion method against Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , Candida albicans , and Aspergillus niger . Minimum inhibitory concentration (MIC) was determined using the broth dilution method. Qualitative phytochemical screening identified the presence of key bioactive compounds, while quantitative analysis measured total phenolic and flavonoid contents. LC-HRMS/MS analysis of ethanolic extracts was performed., Results: Both spices extracts exhibited significant antimicrobial activity, with inhibition zones ranging from 14 to 18 mm. clove showed superior antimicrobial efficacy compared to black paper, particularly against fungi. MIC values ranged between 3 mg/mL and 6 mg/mL for both spices. Phytochemical analysis revealed higher total phenolic and flavonoid contents in clove, with hydroalcoholic extracts showing greater concentrations than aqueous extracts. HPLC quantified higher eugenol content in clove extracts and higher piperine content in black pepper extracts. The differences in bioactive compound content were statistically significant ( p  < 0.05)., Conclusion: The study confirms that both spices possess significant antimicrobial properties, attributable to their rich phytochemical composition, particularly phenolics and flavonoids. Clove exhibited slightly superior antimicrobial activity compared to black paper. These findings support the potential use of these spices as complementary antimicrobial agents. Further research should investigate their synergistic effects with conventional antibiotics and explore their applications in food preservation and alternative medicine., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhao, Wonta, Xia, Zhong and Sharma.)

Published
2024
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