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338 results on '"Xia, Leilei"'

2. Multiscale magneto-mechanical coupling of magnetorheological elastomer isolators

Author

Hu, Zhijian, Xia, Leilei, and Sun, Lizhi

Subjects
Mathematical Sciences, Engineering, Design Practice & Management
Abstract

Due to their variable stiffness characteristics, magnetorheological elastomers (MREs) can be applied for seismic isolators in civil infrastructure systems. The lateral stiffness variation of MRE isolators is affected by the change of MRE shear stiffness. The natural frequency of the MRE-based isolation systems is related to the lateral stiffness of the MRE isolators with the range of lateral stiffness variation of MRE isolators serving as a critical objective to determine the shift ability of natural frequencies of the isolation systems. Here we develop a multiscale computational method to determine the magneto-mechanical coupling of MRE isolators. The field-dependent stiffness variation of the isolators is achieved with the consideration of combined magnetic field and deformation. Effects of MRE microstructural feature (e.g., particle concentrations in chains and between chains) and macroscopic geometry (e.g., thicknesses of MRE laminate and steel) on the magneto-mechanical responses of the isolators are specifically investigated, so as to guide the design of MRE-based isolating structures. The magnetic field and lateral stiffness of several MRE-based isolator prototypes from experiments are obtained by finite element-based shear simulation. Simulation results are quantitatively compared with experimental data, verifying and validating the accuracy and applicability of the proposed method.

Published
2023

5. PD38-12 NATIONAL PERFORMANCE OF LYMPHADENECTOMY FOR MUSCLE-INVASIVE UROTHELIAL CANCER AND AN EXPLORATORY ANALYSIS TO DEFINE OPTIMAL LYMPH NODE YIELD BASED ON SOUTHWEST ONCOLOGY GROUP S1011 TRIAL

Author

Xia, Leilei, primary, Roberson, Daniel S., additional, Wood, Erika L., additional, Dadabhoy, Anosh, additional, Knudsen, Everett, additional, Romano, Sofia, additional, Guzzo, Thomas J., additional, Bivalacqua, Trinity J., additional, and Daneshmand, Siamak, additional

Published
2024
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8. MP34-19 ROLE OF SELF-ASSESSED SOCIAL SUPPORT AND SOCIAL DEPRIVATION INDEX IN PREDICTING COMPLICATIONS FOLLOWING RADICAL CYSTECTOMY

Author

Dadabhoy, Anosh S., primary, Sheybaeemoghaddam, Farshad, additional, Mehta, Sejal, additional, Wood, Erika, additional, Liu, Natalie, additional, Sobhani, Sina, additional, Wong, Kasen, additional, Xia, Leilei, additional, Ledi-Seyedian, Sanam, additional, Bajakian, Thalia, additional, Miranda, Gus, additional, Alsyouf, Muhannad, additional, and Daneshmand, Siamak, additional

Published
2024
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30. The characterization, cytotoxicity, macrophage response and tissue regeneration of decellularized cartilage in costal cartilage defects

Author

Zhao Bo, Jiang Haiyue, Xia Leilei, Wang Hongquan, Pan Bo, and Wang Changchen

Subjects
Pathology, medicine.medical_specialty, Biocompatibility, Swine, Biomedical Engineering, Biochemistry, Biomaterials, Extracellular matrix, Glycosaminoglycan, medicine, Animals, Molecular Biology, Process (anatomy), Decellularization, Chemistry, Macrophages, Cartilage, General Medicine, Costal cartilage, Chondrogenesis, Extracellular Matrix, Costal Cartilage, medicine.anatomical_structure, Biotechnology
Abstract

After harvesting multiple costal cartilages, the local defect disrupts the integrity of the chest wall and may lead to obvious thoracic complications, such as local depression and asymmetry of the bilateral thoracic height. Decellularized materials have been used for tissue reconstruction in clinical surgeries. To apply xenogenic decellularized cartilage in costal cartilage defects, porcine-derived auricular and costal cartilage was tested for characterization, cytotoxicity, macrophage response, and tissue regeneration. Most of the DNA and α-Gal were effectively removed, and the collagen was well preserved after the decellularization process. The glycosaminoglycan (GAG) content decreased significantly compared to that in untreated cartilage. The decellularized auricular cartilage had a larger pore size, more pores, and a higher degradation rate than the decellularized costal cartilage. No apparent nuclei or structural damage was observed in the extracellular matrix. The decellularized auricular cartilage had a higher cell proliferation rate and more prominent immunomodulatory effect than the other groups. Two types of decellularized cartilage, particularly decellularized auricular cartilage, promoted the tissue regeneration in the cartilage defect area, combined with noticeable cartilage morphology and increased chondrogenic gene expression. In our research, the functional components and structure of the extracellular matrix were well preserved after the decellularization process. The decellularized cartilage had better biocompatibility and suitable microenvironment for tissue regeneration in the defect area, suggesting its potential application in cartilage repair during the surgery. Statement of significance Autologous costal cartilage has been widely used in various surgeries, while the cartilage defects after the harvesting of multiple costal cartilages may cause localized chest wall deformities. Decellularized cartilage is an ideal material that could be produced in the factory and applied in surgeries. In this study, both decellularized costal cartilage and auricular cartilage preserved original structure, functional biocompatibility, immunosuppressive effects, and promoted tissue regeneration in the cartilage defect area.

Published
2021

37. Intraoperative Molecular Imaging Combined With Positron Emission Tomography Improves Surgical Management of Peripheral Malignant Pulmonary Nodules

Author

Predina, Jarrod D., Newton, Andrew D., Keating, Jane, Barbosa, Eduardo M., Jr., Okusanya, Olugbenga, Xia, Leilei, Dunbar, Ashley, Connolly, Courtney, Baldassari, Michael P., Mizelle, Jack, Delikatny, Edward J., Kucharczuk, John C., Deshpande, Charuhas, Kularatne, Sumith A., Low, Phillip, Drebin, Jeffrey, and Singhal, Sunil

Published
2017
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38. Additional file 1 of Distant metastasis without regional progression in non-muscle invasive bladder cancer: case report and pooled analysis of literature

Author

Xu, Tianyuan, Gu, Wenyu, Wang, Xianjin, Xia, Leilei, He, Yanyan, Dong, Fan, Yang, Bin, and Yao, Xudong

Abstract

Additional file 1: Table S1. Gene list of next-generation sequencing for the case of our center. Table S2. Comparison of baseline clinicopathologic features and metastatic patterns between subgroups with favorable and unfavorable outcomes.

Published
2022
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43. Outcomes of mohs microgrpahic resection for cutaneous malignancy involving the scrotum

Author

Roberson, Daniel, primary, Chelluri, Raju, additional, Skokan, Alexander J., additional, Xia, Leilei, additional, Heavner, Matthew G., additional, Lukowiak, Tess, additional, Schwartz, Lauren, additional, Lee, Daniel J., additional, Guzzo, Thomas J., additional, Kovach, Stephen J., additional, Miller, Christopher, additional, and Kovell, R. Caleb, additional

Published
2021
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49. Corrigendum: Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury

Author

Wu, Fangfang, primary, Xu, Ke, additional, Liu, Lei, additional, Zhang, Kairui, additional, Xia, Leilei, additional, Zhang, Man, additional, Teng, Chenhuai, additional, Tong, Heyan, additional, He, Yifang, additional, Xue, Yujie, additional, Zhang, Hongyu, additional, Chen, Daqing, additional, and Hu, Aiping, additional

Published
2021
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