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7 results on '"Xia, Ling-Li"'

5. [Effect of Pinggan Xifeng decoction on hippocampal mitochondrial membrane potential after intracerebral hemorrhage in rat brain]

Author

Yong, Tan, Qing-Hua, Liang, and Xia-Ling, Li

Subjects
Male, Rats, Sprague-Dawley, Random Allocation, Animals, Female, Hippocampus, Cerebral Hemorrhage, Drugs, Chinese Herbal, Membrane Potentials, Mitochondria, Rats
Abstract

To observe the effects of Pinggan Xifeng decoction (PGXFD) on the change of mitochondrial membrane potential (MMP) after intracerebral hemorrhage (ICH) injury in rat brain and to explore the mechanism of PGXF decoction in the treatment of ICH.VII type collagenase was stereotaxically injected into the globas pallidus of rats and spectrofluorometer was used to detect the fluorescence value of mitochondrial suspension. The neurobehavioral scores were used to evaluate the neurological defect.Neurological function defects were seen after ICH in rats and PGXFD decreased the neurological grades. The MMP of rats with ICH was reduced significantly 4 hours after the operation, peaking at 1 d and was higher at 3 d and 7 d than that of the sham group . MMP in the PGXFD group was obviously higher than that in the control group at 1 d, 3 d, and 7 d.MMP decreased in rats suffering from ICH. PGXFD can markedly depress the decreation of MMP.

Published
2005

6. [Effect of bizhongxiao decoction on the expression of VEGF in the synovial membrane of C II-induced rheumatoid arthritis in rats]

Author

Qing-hua, Liang, Jin-hua, He, and Xia-ling, Li

Subjects
Male, Vascular Endothelial Growth Factor A, Lymphokines, Vascular Endothelial Growth Factors, Synovial Membrane, Endothelial Growth Factors, Rats, Arthritis, Rheumatoid, Rats, Sprague-Dawley, Random Allocation, Methotrexate, Animals, Intercellular Signaling Peptides and Proteins, Female, Collagen Type II, Immunosuppressive Agents, Drugs, Chinese Herbal, Phytotherapy
Abstract

To observe the effect of bizhongxiao (BZX) decoction on the expression of VEGF in the synovial membrane of C II-induced arthritis(CIA) in rats and to explore the mechanism of BZX decoction in the treatment of rheumatoid arthritis RA.Seventy-five SD rats were randomly divided into four groups. The rat experimental arthritis model was established by subcutaneous injection of II collogen. The expression of VEGF was detected with immunohistochemistry in different times.The incidence of arthritis in the rats immunized with C II was approximately 88.57%. The arthritis index of the model group was rising, but that of the BZX decoction group and the methotrexate (MTX) group were decreasing on the 30th day. No expression of VEGF was found in the synovial membrane of the normal group. The expression of VEGF of the model group was notably higher than that of the BZX decoction group and the MTX group in different times (P0.01). The expression of VEGF of the model group rose step by step, but that of the BZX decoction group and the MTX group decreased and was significantly lower than that of the model group (P0.01). The expression of VEGF of the BZX decoction group was significantly lower than that of the MTX group(P0.05).The expression of VEGF is relative to the synovial pannus formation in RA. BZX decoction and MTX could decrease the expression of VEGF, but the curative effect of BZX decoction is significantly better than that of MTX. BZX decoction could inhibit the formation of the synovial pannus or bone in RA by decreasing the expression of VEGF.

Published
2003

7. New Mechanistic Insight into the Protective Effects of Ganoderma lucidumPolysaccharides Against Palmitic Acid-Induced Cell Damage in Porcine Intestinal Epithelial Cell Line IPEC-J2

Author

Liang, Zengenni, Yuan, Zhi-Hang, Wang, Yan, Du, Zhong-Hua, Guo, Jia-Jing, Xia, Ling-Li, and Shan, Yang

Abstract

Ganoderma lucidum(G. lucidum) is one of the well-known mushrooms in China, which has G. lucidum polysaccharides (GLP) that have been widely studied for various biological activities, such as antioxidant, antitumor, antiinflammatory, antiviral, antidiabetes, and immunomodulatory activities. A signal transducer and activator of transcription (STAT) signaling pathway is related to cell proliferation and apoptosis. The relationship between STAT and intestinal protection of GLP is still unknown. We studied the inhibitors AG490 in the STAT pathway and its downstream molecules to analyze the unique effects in the protection of GLP against palmitic acid (PA)-induced porcine intestinal epithelial cells (IPEC-J2) injury. Compared to PA treatment, GLP?+?PA obviously decreased Ca2+concentration, H2O2production, NF-E2-related factor 2 (Nrf2) nuclear translocation, STAT1 and STAT2 protein levels, and increased nuclear factor kappa-B (NF-?B) nuclear translocation and p-STAT3/STAT3 ratio in IPEC-J2 cells. After inhibition of STAT3 signaling, p-STAT3/STAT3 ratio, NF-?B nuclear translocation obviously decreased and Nrf2 nuclear translocation significantly increased in the GLP?+?PA group. The protection of GLP on proliferation and apoptosis of PA-induced IPEC-J2 cells was suppressed by inhibiting STAT3. The STAT3 pathway regulated the enterocyte-protective effects of GLP by modulating the nuclear translocation of Nrf2 and NF-?B. We provide new insights into the mechanism of STAT signaling for the protection of GLP on PA-induced intestinal epithelial cell injury.

Published
2022
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