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438 results on '"Xia, Xiaojun"'

9. Small Private Online Judge: A New Tool for Empirical Education Research

Author

Zhu, Yunchi, Zhao, Zuohan, Tong, Chengda, and Xia, Xiaojun

Subjects
Computer Science - Computers and Society
Abstract

This paper puts forward the concept of Small Private Online Judge (SPOJ). Compared with Massive Open Online Judge (MOOJ), SPOJ has advantages in structured data acquisition of students' virtual behavior for its specific function and tight coupling with the classroom. SPOJ-based empirical education research can be conducted within "Acquisition-Analysis-Application" (3A) Framework. The case study of a SPOJ program clarifies the standard pattern of SPOJ-based 3A research and highlights the emergence of education-intelligence concept. The challenges of SPOJ-based empirical education research and implications of SPOJ are also discussed.

Published
2020

12. 4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer

Author

Yin, Jiaxin, primary, Chen, Jianfeng, additional, Hong, Jing Han, additional, Huang, Yulin, additional, Xiao, Rong, additional, Liu, Shini, additional, Deng, Peng, additional, Sun, Yichen, additional, Chai, Kelila Xin Ye, additional, Zeng, Xian, additional, Chan, Jason Yongsheng, additional, Guan, Peiyong, additional, Wang, Yali, additional, Wang, Peili, additional, Tong, Chongjie, additional, Yu, Qiang, additional, Xia, Xiaojun, additional, Ong, Choon Kiat, additional, Teh, Bin Tean, additional, Xiong, Ying, additional, and Tan, Jing, additional

Published
2024
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16. Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response

Author

He, Jingjing, Xiong, Xinxin, Yang, Han, Li, Dandan, Liu, Xuefei, Li, Shuo, Liao, Shuangye, Chen, Siyu, Wen, Xizhi, Yu, Kuai, Fu, Lingyi, Dong, Xingjun, Zhu, Kaiyu, Xia, Xiaojun, Kang, Tiebang, Bian, Chaochao, Li, Xiang, Liu, Haiping, Ding, Peirong, Zhang, Xiaoshi, Liu, Zhenjiang, Li, Wende, Zuo, Zhixiang, and Zhou, Penghui

Published
2022
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19. RECQL4 Inhibits Radiation‐Induced Tumor Immune Awakening via Suppressing the cGAS‐STING Pathway in Hepatocellular Carcinoma

Author

Hong, Weifeng, primary, Zhang, Yang, additional, Wang, Siwei, additional, Li, Zongjuan, additional, Zheng, Danxue, additional, Hsu, Shujung, additional, Zhou, Jian, additional, Fan, Jia, additional, Chen, Zhesheng, additional, Xia, Xiaojun, additional, Zeng, Zhaochong, additional, Gao, Qiang, additional, Yu, Min, additional, and Du, Shisuo, additional

Published
2024
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20. SQLE-mediated squalene metabolism is critical for mitochondrial biogenesis and tumor development in K-ras-driven cancer

Author

Liu, Jinyun, primary, Pan, Junchen, additional, Liu, Rui, additional, Zhang, Huiqin, additional, Lu, Wenhua, additional, Peng, Hongyu, additional, Yang, Jing, additional, Zhang, Qianrui, additional, Yu, Tiantian, additional, Huo, Bitao, additional, Wei, Xiaoying, additional, Zhou, Lin, additional, Liang, Haixi, additional, Hu, Yumin, additional, Wen, Shijun, additional, Xia, Xiaojun, additional, and Huang, Peng, additional

Published
2024
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28. IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways

Author

Song, Na-Young, Zhu, Feng, Wang, Zining, Willette-Brown, Jami, Xi, Sichuan, Sun, Zhonghe, Su, Ling, Wu, Xiaolin, Ma, Buyong, Nussinov, Ruth, Xia, Xiaojun, Schrump, David S, Johnson, Peter F, Karin, Michael, and Hu, Yinling

Subjects
Rare Diseases, Lung Cancer, Lung, Digestive Diseases, Cancer, Acetophenones, Acetylcysteine, Adenocarcinoma, Animals, Cell Proliferation, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p21, Epigenesis, Genetic, Humans, I-kappa B Kinase, Lung Neoplasms, Mice, NADPH Oxidase 2, NF-E2-Related Factor 2, Proto-Oncogene Proteins p21(ras), Reactive Oxygen Species, Tumor Suppressor Protein p53, lung adenocarcinoma, IKK alpha, ROS, cell senescence, tumor progression, IKKα
Abstract

Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct and predominant types of human lung cancer. IκB kinase α (IKKα) has been shown to suppress lung SCC development, but its role in ADC is unknown. We found inactivating mutations and homologous or hemizygous deletions in the CHUK locus, which encodes IKKα, in human lung ADCs. The CHUK deletions significantly reduced the survival time of patients with lung ADCs harboring KRAS mutations. In mice, lung-specific Ikkα ablation (IkkαΔLu ) induces spontaneous ADCs and promotes KrasG12D-initiated ADC development, accompanied by increased cell proliferation, decreased cell senescence, and reactive oxygen species (ROS) accumulation. IKKα deletion up-regulates NOX2 and down-regulates NRF2, leading to ROS accumulation and blockade of cell senescence induction, which together accelerate ADC development. Pharmacologic inhibition of NADPH oxidase or ROS impairs KrasG12D-mediated ADC development in IkkαΔLu mice. Therefore, IKKα modulates lung ADC development by controlling redox regulatory pathways. This study demonstrates that IKKα functions as a suppressor of lung ADC in human and mice through a unique mechanism that regulates tumor cell-associated ROS metabolism.

Published
2018

35. Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations

Author

Au, Wing-Yan, Chiu, Brian, Fan, Lei, Li, Zheng, LAM, Tai Hing, Liang, Raymond, Yeh, Su-Peng, Xu, Jun, Ip, Dennis Kai Ming, Li, Gandi, Xu, Gang, Wang, Xiaodong, Bai, Ou, Cai, Qing-Qing, Xia, Yi, Chen, Jie-Rong, Luo, Chun-Ling, Xiong, Xiang-Yu, Zeng, Yanni, Wei, Pan-Pan, Liu, Chu-Jun, Liu, Yu-Xiang, Cao, Yu-Lu, He, Shuai, Liu, Yang, Ha, Jeslin Chian Hung, Khoo, Lay Poh, Kee, Rebecca Xiangpin, Tan, Jing, Liu, Yanhui, Zhang, Fen, Feng, Yanfen, Rao, Huilan, Chng, Wee Joo, Chan, Jason Yong Sheng, Somasundaram, Nagavalli D/O, Tao, Miriam, Ras, Mohamad Farid Bin Harunal, Yeoh, Kheng-Wei, Goh, Yeow Tee, Ong, Shin Yeu, Grigoropoulos, Nicholas Francis, Wong, Esther Kam Yin, Pang, Jane Wan Lu, Lim, Jing Quan, Chia, Burton Kuan Hui, Kim, Seok Jin, Yoon, Sang Eun, Choi, Seungkyu, Kuo, Ching-Yuan, Chen, Tsai-Yun, Su, Yu-Chieh, Huang, Wen-Tsung, Lee, Ming-Yang, Yao, Wenxiu, Ngan, Kai-Cheong, Liu, Herman, Lee, Harold, Yip, Sze-Fai, Liu, Jie, Li, Jianyong, Rabkin, Charles S., Berndt, Sonja, Bassig, Bryan, Hu, Wei, Zhao, Mingfeng, Li, Yuming, Zhai, Qiongli, Shao, Zonghong, Qiu, Lugui, Wang, Jianxiang, Xu, Fu-Ping, Chen, Ling, Hou, Yu, Xu, Shuangnian, Huang, Zhen, Xie, Mingling, Li, Ming, Zhong, Shilong, Zhang, Yan, Gu, Dongqing, Wang, Xin, Foo, Jia Nee, Li, Zhiqiang, Dai, Juncheng, Sun, Liangdan, Wang, Zhenzhen, Liu, Hong, Zhou, Hui, Sun, Yonghu, Koh, Woon-Puay, Heng, Chew-Kiat, Hong, Chew Soo, Ahn, Jeeyun, Park, Kyu Hyung, Tin, Aung, Gu, Jieruo, Xia, Xiaojun, Li, Bo, Yu, Xueqing, Lin, Guo-Wang, Xu, Caigang, Chen, Kexin, Huang, Hui-Qiang, Chen, Jieping, Song, Bao, Chan, John K C, Li, Wenyu, Liu, Weiping, Shih, Lee-Yung, Chuang, Wen-Yu, Kim, Won Seog, Tan, Wen, Peng, Rou-Jun, Laurensia, Yurike, Cheah, Daryl Ming Zhe, Huang, DaChuan, Cheng, Chee Leong, Su, Yi-Jiun, Tan, Soo-Yong, Ng, Siok-Bian, Tang, Tiffany Pooi Ling, Han, Kyudong, Wang, Vivien Ya-Fan, Jia, Wei-Hua, Pei, Zhong, Li, Ya-Jun, Gao, Song, Shi, Yongyong, Hu, Zhibin, Zhang, Furen, Zhang, Ben, Zeng, Yi-Xin, Shen, Hongbing, He, Lin, Ong, Choon Kiat, Lim, Soon Thye, Chanock, Stephen, Kwong, Yok-Lam, Lin, Dongxin, Rothman, Nathaniel, Khor, Chiea Chuen, Lan, Qing, and Bei, Jin-Xin

Published
2020
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39. cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity

Author

Wang, Zining, Chen, Jiemin, Hu, Jie, Zhang, Hongxia, Xu, Feifei, He, Wenzhuo, Wang, Xiaojuan, Li, Mengyun, Lu, Wenhua, Zeng, Gucheng, Zhou, Penghui, Huang, Peng, Chen, Siyu, Li, Wende, Xia, Liang-ping, and Xia, Xiaojun

Subjects
Cancer treatment, Cancer -- Drug therapy, Cell death, Immunotherapy, Dendritic cells, Chromosomal proteins, Antibodies, Immune response, T cells, Biochemistry, Antineoplastic agents, Tumors, DNA, Genetic research, Cancer cells, Genes, DNA damage, Health care industry
Abstract

Checkpoint blockade antibodies have been approved as immunotherapy for multiple types of cancer, but the response rate and efficacy are still limited. There are few immunogenic cell death-inducing (ICD-inducing) drugs available that can kill cancer cells, enhance tumor immunogenicity, increase in vivo immune infiltration, and thereby boost a tumor response to immunotherapy. So far, the ICD markers have been identified as the few immunostimulating characteristics of dead cells, but whether the presence of such ICD markers on tumor cells translates into enhanced antitumor immunity in vivo is still being investigated. To identify anticancer drugs that could induce tumor cell death and boost T cell response, we performed drug screenings based on both an ICD reporter assay and a T cell activation assay. We showed that teniposide, a DNA topoisomerase II inhibitor, could induce high-mobility group box 1 (HMGB1) release and type I IFN signaling in tumor cells and that teniposide-treated tumor cells could activate antitumor T cell response both in vitro and in vivo. Mechanistically, teniposide induced tumor cell DNA damage and innate immune signaling, including NF-[kappa]B activation and stimulator of IFN genes-dependent (STING-dependent) type I IFN signaling, both of which contribute to the activation of dendritic cells and subsequent T cells. Furthermore, teniposide potentiated the antitumor efficacy of anti-PD1 in multiple types of mouse tumor models. Our findings showed that teniposide could trigger tumor immunogenicity and enabled a potential chemoimmunotherapeutic approach to potentiating the therapeutic efficacy of anti-PD1 immunotherapy., Introduction Cancer immunotherapy has become the major theme of cancer treatment regimens in the last few years, testifying to the genuine capability of the immune control of cancer (1, 2). [...]

Published
2019
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41. A Thermal Error Prediction Method of High-Speed Motorized Spindle Based on Pelican Optimization Algorithm and CNN-LSTM.

Author

Gao, Ying, Xia, Xiaojun, and Guo, Yinrui

Subjects
OPTIMIZATION algorithms, CONVOLUTIONAL neural networks, AUTOMATION, MACHINE tools
Abstract

Given motorized spindles' extensive periods of prolonged high-velocity operation, they are prone to temperature changes, which leads to the problem of thermal error, leading to diminished precision in machining operations. To address the thermal error issue in motorized spindles of computer numerical control (CNC) machine tools, this study proposes a pelican optimization algorithm (POA)-optimized convolutional neural network (CNN)–long short-term memory (LSTM) hybrid neural network model (POA-CNN-LSTMNN). Initially, the identification of temperature-sensitive locations in the spindle system is performed using a combination of hierarchical clustering, the K-medoids algorithm, and Pearson's coefficient calculation. Subsequently, the temperature data from these identified points, along with real-time collected spindle thermal error data, are employed to construct the model. The Pelican optimization algorithm is used to enhance the model parameters to achieve the best performance. Finally, the proposed model is subjected to a comparative analysis with other thermal error prediction models. Drawing from the experimental findings, it is evident that the POA-CNN-LSTMNN model exhibits superior prediction performance. [ABSTRACT FROM AUTHOR]

Published
2024
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44. A Nanovaccine Based on Adjuvant Peptide FK‐13 and l ‐Phenylalanine Poly(ester amide) Enhances CD8 + T Cell‐Mediated Antitumor Immunity

Author

Xie, Chunyuan, primary, You, Xinru, additional, Zhang, Hongxia, additional, Li, Jiahui, additional, Wang, Liying, additional, Liu, Yongxiang, additional, Wang, Zining, additional, Yao, Ruhui, additional, Tong, Tong, additional, Li, Mengyun, additional, Wang, Xiaojuan, additional, Cui, Lei, additional, Zhang, Huanling, additional, Guo, Hui, additional, Li, Chunwei, additional, Wu, Jun, additional, and Xia, Xiaojun, additional

Published
2023
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47. Supplementary Tables 1-4 from DGKA Mediates Resistance to PD-1 Blockade

Author

Fu, Lingyi, primary, Li, Sen, primary, Xiao, WeiWei, primary, Yu, Kuai, primary, Li, Shuo, primary, Yuan, Sujing, primary, Shen, Jianfei, primary, Dong, Xingjun, primary, Fang, Ziqian, primary, Zhang, Jianeng, primary, Chen, Siyu, primary, Li, Wende, primary, You, Hua, primary, Xia, Xiaojun, primary, Kang, Tiebang, primary, Tan, Jing, primary, Chen, Gong, primary, Yang, An-Kui, primary, Gao, YuanHong, primary, and Zhou, Penghui, primary

Published
2023
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48. Supplementary Figure 2 from DGKA Mediates Resistance to PD-1 Blockade

Author

Fu, Lingyi, primary, Li, Sen, primary, Xiao, WeiWei, primary, Yu, Kuai, primary, Li, Shuo, primary, Yuan, Sujing, primary, Shen, Jianfei, primary, Dong, Xingjun, primary, Fang, Ziqian, primary, Zhang, Jianeng, primary, Chen, Siyu, primary, Li, Wende, primary, You, Hua, primary, Xia, Xiaojun, primary, Kang, Tiebang, primary, Tan, Jing, primary, Chen, Gong, primary, Yang, An-Kui, primary, Gao, YuanHong, primary, and Zhou, Penghui, primary

Published
2023
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49. Supplementary Figure 5 from DGKA Mediates Resistance to PD-1 Blockade

Author

Fu, Lingyi, primary, Li, Sen, primary, Xiao, WeiWei, primary, Yu, Kuai, primary, Li, Shuo, primary, Yuan, Sujing, primary, Shen, Jianfei, primary, Dong, Xingjun, primary, Fang, Ziqian, primary, Zhang, Jianeng, primary, Chen, Siyu, primary, Li, Wende, primary, You, Hua, primary, Xia, Xiaojun, primary, Kang, Tiebang, primary, Tan, Jing, primary, Chen, Gong, primary, Yang, An-Kui, primary, Gao, YuanHong, primary, and Zhou, Penghui, primary

Published
2023
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50. Supplementary Figure 3 from DGKA Mediates Resistance to PD-1 Blockade

Author

Fu, Lingyi, primary, Li, Sen, primary, Xiao, WeiWei, primary, Yu, Kuai, primary, Li, Shuo, primary, Yuan, Sujing, primary, Shen, Jianfei, primary, Dong, Xingjun, primary, Fang, Ziqian, primary, Zhang, Jianeng, primary, Chen, Siyu, primary, Li, Wende, primary, You, Hua, primary, Xia, Xiaojun, primary, Kang, Tiebang, primary, Tan, Jing, primary, Chen, Gong, primary, Yang, An-Kui, primary, Gao, YuanHong, primary, and Zhou, Penghui, primary

Published
2023
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