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30 results on '"Xiang, Jingying"'

23. Preparation and biodistribution of 188Re-labeled folate conjugated human serum albumin magnetic cisplatin nanoparticles (188Re-folate-CDDP/HSA MNPs) in vivo

Author

Tang,Qiu-Sha, Chen,Dao-Zhen, Xue ,Wen-qun, Xiang,Jingying, Gong,Yong-chi, Zhang,Li, Guo,Cai-qin, Tang,Qiu-Sha, Chen,Dao-Zhen, Xue ,Wen-qun, Xiang,Jingying, Gong,Yong-chi, Zhang,Li, and Guo,Cai-qin

Abstract

Qiu-Sha Tang1,*, Dao-Zhen Chen2,*, Wen-Qun Xue2, Jing-Ying Xiang2, Yong-Chi Gong1, Li Zhang2, Cai-Qin Guo21Department of Pathology and Pathophysiology, Medical College, Southeast University, Nanjing, Jiangsu; 2Central Laboratory, Wuxi Hospital for Maternal and Child Health Care, Affiliated Medical School of Nanjin, Wuxi, Jiangsu, China *Authors contributed equally to this workBackground: The purpose of this study was to develop intraperitoneal hyperthermic therapy based on magnetic fluid hyperthermia, nanoparticle-wrapped cisplatin chemotherapy, and magnetic particles of albumin. In addition, to combine the multiple-killing effects of hyperthermal targeting therapy, chemotherapy, and radiotherapy, the albumin-nanoparticle surfaces were linked with radionuclide 188Re-labeled folic acid ligand (188Re-folate-CDDP/HSA).Methods: Human serum albumin was labeled with 188Re using the pre-tin method. Reaction time and optimal conditions of labeling were investigated. The particles were intravenously injected into mice, which were sacrificed at different time points. Radioactivity per gram of tissue of percent injected dose (% ID/g) was measured in vital organs. The biodistribution of 188Re-folate-CDDP/HAS magnetic nanoparticles was assessed.Results: Optimal conditions for 188Re-labeled folate-conjugated albumin combined with cisplatin magnetic nanoparticles were: 0.1 mL of sodium gluconate solution (0.3 mol/L), 0.1 mL of concentrated hydrochloric acid with dissolved stannous chloride (10 mg/mL), 0.04 mL of acetic acid buffer solution (pH 5, 0.2 mol/L), 30 mg of folate-conjugated albumin combined with cisplatin magnetic nanoparticles, and 188ReO4 eluent (0.1 mL). The rate of 188Re-folate-CDDP-HSA magnetic nanoparticle formation exceeded 90%, and radiochemical purity exceeded 95%. The overall labeling rate was 83% in calf serum at 37°C. The major uptake tissues were the liver, kidney, intestine, and tumor after the 188Re-folate-CDDP/HSA magnetic nanoparticles were inje

Published
2011

27. The expression and significance of FOXO3a and Jab1 in human ovarian cancer

Author

Lu, Mudan, Xu, Fei, Wang, Yong, Yin, Yongxiang, Xiang, Jingying, and Chen, Daozhen

Abstract

Background: Ovarian carcinoma represents one of the most insidious and aggressive cancers. Ovarian carcinoma is the most lethal gynecological malignancy. To discover new relevant biomarkers to increase specificity and sensitivity for early diagnosis and prognosis of ovarian cancer is important and urgently needed. FOXO3a possesses a large series function including cellular proliferation, transformation, differentiation, and longevity. Jab1 is also known as subunit 5 (CSN5) of the COP9 signalosome (CSN), a multifunctional protein complex involved in modulating signal transduction, gene transcription, and protein stability.

Published
2013
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28. Oncogenic MicroRNA-27a is a Target for Genistein in Ovarian Cancer Cells

Author

Xu, Linlin, Xiang, Jingying, Shen, Jian, Zou, Xi, Zhai, Sulan, Yin, Yongxiang, Li, Ping, Wang, Xuerong, and Sun, Qingmin

Abstract

MicroRNAs (miRNAs) are emerging as important regulators in various pathobiological processes in cancer. Genistein, as a major isoflavonoid isolated from dietary soybean, possesses a wide variety of biological activities particularly in cancer prevention. However, the molecular mechanisms by which genistein elicits its effects on ovarian cancer cells have not been fully elucidated. In this study, we reported that expression of miR-27a was higher in human ovarian cancer relative to benign ovarian tissues. Meanwhile, transfection of SKOV3 cells with the inhibitor of miR-27a suppressed growth and migration of tumor cells. Our study also found that treatment of ovarian cancer cells with genistein caused an inhibition of ovarian cancer cell growth and migration. Further cellular mechanistic studies revealed that genistein down-regulated miR-27a expression, which was accompanied by significantly increased expression of Sprouty2, a putative miR-27a target gene. Taken together, our findings reveal that oncogenic miR-27a plays an important role in ovarian cancer cell growth and metastasis, and genistein, as nontoxic inactivators of miRNA, can block ovarian cancer cell growth and migration, offering novel insights into the mechanisms of genistein therapeutic actions.

Published
2013

29. Knockdown of CRM1 inhibits the nuclear export of p27Kip1 phosphorylated at serine 10 and plays a role in the pathogenesis of epithelial ovarian cancer.

Author

Wang, You, Wang, Yingying, Xiang, Jingying, Ji, Fang, Deng, Yan, Tang, Chunhui, Yang, Shuyun, Xi, Qinghua, Liu, Rong, and Di, Wen

Subjects
*CANCER genetics, *OVARIAN cancer, *CANCER cell proliferation, *CHROMOSOMES, *NUCLEAR nonproliferation, *PHOSPHORYLATION, *SERINE, *CARCINOGENESIS
Abstract

Highlights: [•] CRM1 and pSer10p27 expression levels are high in primary EOC tissues. [•] Reduced CRM1 level affects p27Kip1 stabilization and nuclear export in SKOV3 cells. [•] CRM1 regulates SKOV3 cells proliferation via serine10 phosphorylation in p27Kip1. [Copyright &y& Elsevier]

Published
2014
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30. The clinical and prognostic significance of CCN3 expression in patients with cervical cancer.

Author

Zhang T, Zhao C, Luo L, Xiang J, Sun Q, Cheng J, and Chen D

Subjects
Adult, Aged, Cervix Uteri chemistry, Female, Humans, Middle Aged, Neoplasm Staging, Nephroblastoma Overexpressed Protein analysis, Nephroblastoma Overexpressed Protein genetics, Prognosis, Uterine Cervical Neoplasms chemistry, Uterine Cervical Neoplasms mortality, Uterine Cervical Neoplasms pathology, Nephroblastoma Overexpressed Protein physiology, Uterine Cervical Neoplasms etiology
Abstract

Background: CCN3 plays important roles in growth, differentiation, angiogenesis and adhesion. Recently, the role of CCN3 in human carcinogenesis has become an area of great interest. However, little is known about the function of CCN3 in human cervical cancer., Objectives: The aim of this study was to investigate the expression profile of CCN3 in cervical cancer and to assess its clinical significance., Material and Methods: In this study, qRT-PCR, immunohistochemistry and Western blotting analysis were used in the detection of CCN3 mRNA and protein expression, both in cervical cancer and in corresponding normal tissue, respectively. The data was correlated with clinicopathological features. A survival analysis was performed to assess the prognostic significance., Results: CCN3 mRNA was overexpressed in cervical cancer tissue when compared with corresponding normal tissue, as was CCN3 protein. Upregulation of CCN3 was significantly associated with the stage of the disease (P = 0.017) and with lymph node involvement (P = 0.006). Using the Kaplan-Meier analysis, a comparison of survival curves of low vs. high expressers of CCN3 revealed a highly significant difference in human cervical cancer tissue (P = 0.021), which suggests that overexpression of CCN3 is associated with a poorer prognosis., Conclusions: The results of the current study suggest that CCN3 may play an important role in cervical carcinogenesis and therefore may have potential as a biomarker for prognosis and as a therapeutic target in cervical cancer.

Published
2013

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