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Your search keyword '"Xiang, Shiqiang"' showing total 8 results
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8 results on '"Xiang, Shiqiang"'

3. Stair-ascent strategies and performance evaluation for a lower limb exoskeleton

Author

Xu, Fashu, Huang, Rui, Cheng, Hong, Qiu, Jing, Xiang, Shiqiang, Shi, Congbin, and Ma, Wenhao

Abstract

Power lower limb exoskeleton has gained considerable interests since it is widely applied in both walking assistance and rehabilitation related applications. The most challenge problem of these kinds lower exoskeletons is how to deal with the complex environment, such as stairs in daily life. Based on a developed lower limb exoskeleton named AssItive DEvice for paRalyzed patients (AIDER), this paper proposed a novel stair parameters perception approach named Stick From the Origin (SFO) and a bio-spired stair gait trajectory generator based on Dynamic Movement Primitives (DMPs) and summarized the joint torque and power requirements. With two distance sensors, the low-cost and real-time stair parameters perception approach could be tested and verified in practice with acceptable accuracy. During the process, the Center of Pressure (CoP) of the whole system would be concerned to keep the pilot’s safety. With the reference stair gait and stair parameters brought in, a natural and flexible stair-ascent gait can be generated by the bio-spired stair gait trajectory generator based on DMPs, which was validated in practical application on the AIDERsystem with and without pilot. Based on the averaged torques and power across these trials, the peak body-mass-normalized knee and hip joint power, knee and hip torque during the stair-ascent movement are 1.82 W/kg and 1.52 W/kg, 1.36 Nm/kg and 1.22 Nm/kg, which are required during the process of lifting the leg onto the stair tread.

Published
2024
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8. [Phenotypic and genetic analysis of a Chinese pedigree affected with type 1 Otopalatodigital syndrome].

Author

Zhang B, Xiang G, Xiang S, and Zhang J

Subjects
Adolescent, Female, Humans, Male, China, East Asian People genetics, Exome Sequencing, Mutation, Missense, Filamins genetics, Pedigree, Phenotype
Abstract

Objective: To analyze the clinical phenotype and genetic basis of a Chinese pedigree affected with Otopalatodigital syndrome type 1 (OPD1)., Methods: A pedigree which was evaluated at the Department of Endocrinology, General Hospital of the Central Theater Command on December 3, 2020 was selected as the study subject. Clinical phenotype and genetic features of the proband were analyzed. Whole exome sequencing was employed to screen for genetic variants in the proband, and Sanger sequencing was used to verify the candidate variants in the proband's mother, uncle, maternal aunt, and paternal aunt. Pathogenicity analysis was also conducted for the candidate variants., Results: The proband, a 16-year-old male, had shown distinctive facial features including mildly prominent eyebrows, down-slanting palpebral fissures, hypertelorism, and depressed nasal bridge. Additionally, he had clubbing of bilateral thumbs and big toes, and central type diabetes insipidus. Genetic sequencing revealed that he has harbored a heterozygous c.586C>T (p.R196W) missense variant of the FLNA gene (NM_001110556.2), which was also carried by his mother and uncle. Based on the guidelines from the American College of Medical Genetics and Genomics (ACMG), this variant was classified as likely pathogenic (PM1+PM2_Supporting+PP2+PP3+PS4 Supporting)., Conclusion: The heterozygous c.586C>T (p.R196W) variant of the FLNA gene probably underlay the pathogenesis in this OPD1 family. The central type diabetes insipidus in the proband may represent a newly discovered phenotype of OPD1. Above finding has contributed crucial information for the comprehensive understanding of the clinical manifestations and pathogenic mechanisms of OPD1.

Published
2024
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