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The current study examined the influence of guilt on young children's honesty about their transgression. Children (N = 192; 4-6 years of age; 49.5% male, 50.5% female; middle-income Chinese families) participated in a modified temptation resistance paradigm where they were asked not to peek at a toy in the absence of an experimenter. Next, the children were randomly assigned to 1 of 3 conditions: (a) guilt condition, where children were induced with guilt using a revised mishap paradigm; (b) sadness condition, where children were induced with sadness by watching a video; and (c) baseline condition, where children did not participate in any additional emotion-inducing task. When later questioned about whether they peeked at the toy, children in the guilt condition were significantly less likely to lie compared with those in the sadness or baseline conditions. There was no significant difference between the sadness and baseline conditions. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), 514 patients with treatment-naïve advanced ESCC were randomized (1:1) to receive toripalimab or placebo in combination with paclitaxel plus cisplatin (TP) every 3 weeks for up to 6 cycles, followed by toripalimab or placebo maintenance. At the prespecified final analysis of progression-free survival (PFS), a significant improvement in PFS is observed for the toripalimab arm over the placebo arm (hazard ratio [HR] = 0.58; 95% CI, 0.46-0.74; p 0.0001). The prespecified interim analysis of overall survival (OS) also reveals a significant OS improvement for patients treated with toripalimab plus TP over placebo plus TP (HR = 0.58; 95% CI, 0.43-0.78; p = 0.0004). The incidences of grade ≥3 treatment-emergent adverse events are similar between the two arms. Toripalimab plus TP significantly improves PFS and OS in patients with treatment-naïve, advanced ESCC, with a manageable safety profile.

The current study examined whether emotions mediate the relationship between apologies and repaired trust following a transgression. Children (9- and 11-year-olds; N = 180) completed a two-round trust game where if they invested tokens in their counterpart, the tokens tripled in value and the counterpart would decide how many tokens to return. Based on participants’ condition, either half of the tokens were returned, none of the tokens were returned, or none were returned followed by an apology. Children’s investment in their counterpart in the second round of the trust game was a measure of trusting behavior. In addition, children completed an emotion evaluation measure of their feelings toward their counterpart. Results demonstrate that children who received an apology following a transgression were significantly more likely to demonstrate trusting behaviors and positive emotions compared with children who received no apology. In addition, both positive and negative emotions were found to mediate the effect of an apology on trust.

Group B Streptococcus (GBS) causes life-threatening bacterial sepsis, especially in newborns and pregnant women. Patients suffering from sepsis often display low platelet counts, characterized by thrombocytopenia, because of platelet activation. In the present study, the roles of six GBS strains from septic patients in platelet aggregation, as well as the underlying mechanisms, were investigated. Incubation of platelets with three of the strains induced platelet aggregation, increased the secretion of cellular adhesin molecule CD62P and activation of GPIIb/IIIa. Furthermore, the GBS strains that induced platelet activation also caused an increase in the expression of Toll-like receptor (TLR) 2 in platelets. Pre-incubation of platelets with anti-TLR2 monoclonal antibody, but not anti-TLR4 monoclonal antibody, inhibited these functional responses induced by GBS. TLR2 stimulation also activated the phosphoinositide 3-kinase (PI3-K)/Akt signalling pathway in platelets, and inhibition of PI3-K significantly reduced GBS-induced platelet responses. Our results indicate that three of the GBS strains from the septic patients can trigger platelet activation by interacting with platelets, which involves the elevation of platelet TLR2 expression.

The present study examined whether perceptions of a transgressor’s trustworthiness mediates the relationship between apologies and repaired trust, and the moderating role of negative emotions within this process. Chinese undergraduate students (N = 221) completed a trust game where they invested tokens in their counterpart, and either experienced no trust violation (i.e., half of the tokens returned), a trust violation (i.e., no tokens returned), or a trust violation followed by an apology. Participant’s trust behavior was measured by the number of tokens they re-invested in their counterpart in a second round of the game. Participants also completed measures to assess perceptions of the transgressor’s trustworthiness and emotional state. Results revealed that participants who received an apology were more likely to trust in their counterpart, compared to those who did not receive an apology, and this relationship was mediated by perceptions of the transgressor’s trustworthiness. Further, the relationship between apologies and perceptions of the transgressors trustworthiness was moderated by negative emotions; apologies only improved perceptions of trustworthiness for participants who experienced less negative emotions.

Inadequacy of posterior osteophyte resection in anterior cervical decompression and fusion (ACDF) surgery has long been a clinical concern as it may influence surgical outcome. There has been no agreement on the prognosis in the presence of remnant posterior osteophytes. This study retrospectively investigated 26 cervical spondylotic myelopathy patients after ACDF in whom a remnant posterior osteophyte was identified by long-term follow-up CT scans (minimum of 2 years). Remnant posterior osteophytes and osseous spinal canal were measured and compared between pre-operation CT and long-term post-operation CT. The post-operative clinical outcomes were also studied. The remnant osteophytes did not obviously decrease in size in any patient and significantly enlarged in 10 patients, with a new posterior osteophyte developing in one patient. In patients whose remnant osteophyte is enlarged, the incidence of pseudoarthrosis, as well as clinical deterioration during follow-up was significantly higher than patients with stable osteophytes. Contrary to previous reports, none of the remnant posterior osteophytes decreased obviously in size during follow up. Despite the persistence of posterior osteophytes, ACDF is still effective in CSM treatment. Posterior osteophyte enlargement at fused segment appears to be associated with symptomatic pseudoarthrosis and clinical deterioration after surgery.

Prior studies have demonstrated that social-cognitive factors such as children’s false-belief understanding and parenting style are related to children’s lie-telling behaviors. The present study aimed to investigate how earlier forms of theory-of-mind understanding contribute to children’s lie-telling as well as how parenting practices are related to children’s antisocial lie-telling behaviors (rather than prosocial lie-telling as examined in previous studies). Seventy-three three-year-olds from Hangzhou, P. R. China were asked not to peek at a toy in the experimenter’s absence. The majority of children who peeked, lied about it. Children’s lies were positively related to performance on the knowledge-ignorance theory-of-mind task. Additionally, Control parenting, characterized by high levels of monitoring and demanding, unquestioning obedience, was negatively related to three-year-olds’ lying. The relation between Control parenting and lie-telling was partially mediated by children’s theory-of-mind unders...

Fibroblast growth factor 23 (FGF23) is a bone-derived protein produced mainly by osteocytes and osteoblasts and at low levels in specific parts of the brain. It has been shown to associate with mood regulation. Lithium treatment gives rise to significant elevations of serum FGF23 levels in depressive patients. High peripheral blood FGF23 levels correlated with poor cognitive performance in hemodialysis patients. However, no direct evidence demonstrates a relationship between FGF23 and mood regulation. In this study, we aimed to measure the concentration of cerebrospinal fluid (CSF) FGF23 and to explore its relationship with a cluster of emotional characteristics. We measured CSF FGF23 levels in 96 male Chinese subjects. All subjects completed the Chinese version of the Barratt Impulsiveness Scale (BIS 11), the Beck Depression Inventory (BDI) and the Self-Rating Anxiety Scale (SAS). CSF FGF23 levels ranged from 12.8 to 99.3 pg/mL. Negative correlations were found between CSF FGF23 concentrations and BIS non-planning, BIS cognition and BIS total score (all p 0.05). Nevertheless, except for the BIS cognition scores, these correlations became insignificant after Bonferroni correction. No correlations were found between CSF FGF23 concentrations and BDI or SAS scores. These findings suggest that CSF FGF23 levels correlate with a measure of impulsivity.

Fibroblast growth factor 19 (FGF19) is a type of gut-derived postprandial hormone. FGF19 plays a key role in coordinating liver bile acid biosynthesis and gallbladder motility and acts as a regulator of metabolic homeostasis, including strengthening insulin sensitivity, decreasing triglyceride concentrations, and reducing body weight. In the present study, we investigated the presence of FGF19 in human cerebrospinal fluid (CSF) and investigated relationships with a cluster of characteristic emotions and behaviors. Eighty-three male subjects were recruited and participated in the study. The levels of CSF FGF19 were assayed by enzyme-linked immunosorbent assay, and FGF19 levels showed considerable interindividual variations, ranging from 80.54 to 1479.78 pg/ml. Pearson correlation analysis revealed no correlation between CSF FGF19 levels and age or Body Mass Index. Significant correlations were found between CSF FGF19 levels and Pittsburgh Sleep Quality Index scores, Suicide Attitude Questionnaire factors, Barratt Impulsiveness Scale scores, and Beck Depression Inventory scores, and CSF FGF19 levels independently affected Beck Depression Inventory scores. Our findings provide evidence of the presence of FGF19 in human CSF and the role of FGF19 in mood regulation in humans.

Background Intimate partner violence (IPV) is a significant public health issue among married rural-to-urban migrant workers, the largest group of internal migrants in China. This study aims to explore the prevalence, patterns and associated factors of intimate partner violence against married rural-to-urban migrant workers in eastern China. Methods A cross-sectional study was conducted in Zhejiang province in China between July 2015 and April 2016, and a total of 1,744 married rural-to-urban migrant workers ultimately took part in the study. Conflict Tactics Scales and several short demographic questions were applied. Data were principally analyzed with logistic regression. Results The majority of married rural-to-urban migrant workers were middle-aged couples with a low education level and a relatively long-term duration of migration in fixed migrant cities. Nearly 45% of married rural-to-urban migrant workers were experienced at least one incident of intimate partner violence during the past 12 months. The joint occurrence of multiple forms of violence is the most commonly reported features of intimate partner violence, especially three overlapping patterns of intimate partner violence. Some individual (education and age), relationship (marital satisfaction, premarital sex and extramarital affairs) and social (duration of migration and number of migratory cities) factors of the respondents, were negatively or positively associated with intimate partner violence against married rural-to-urban migrant workers. Conclusion The results indicated that one out of two married rural-to-urban migrant workers experienced at least one incident of intimate partner violence during the past 12 months in China. Accordingly, there is an obvious demand of intervention and treatment activities to prevent and reduce the occurrence of intimate partner violence among the millions of migrant workers in China. Electronic supplementary material The online version of this article (doi:10.1186/s12889-016-3896-x) contains supplementary material, which is available to authorized users.

This study examined developmental changes in children’s abilities to make trustworthiness judgements based on faces and the relationship between a child’s perception of trustworthiness and facial attractiveness. One hundred and one 8-, 10- and 12-year-olds, along with 37 undergraduates, were asked to judge the trustworthiness of 200 faces. Next, they issued facial attractiveness judgements. The results indicated that children made consistent trustworthiness and attractiveness judgements based on facial appearance, but with-adult and within-age agreement levels of facial judgements increased with age. Additionally, the agreement levels of judgements made by girls were higher than those by boys. Furthermore, the relationship between trustworthiness and attractiveness judgements increased with age, and the relationship between two judgements made by girls was closer than those by boys. These findings suggest that face-based trait judgement ability develops throughout childhood and that, like adults, children may use facial attractiveness as a heuristic cue that signals a stranger’s trustworthiness.

A transcript of the questionnaire. Description of data: A socio-demographic questionnaire and a Chinese version of short form of the revised Conflict Tactics Scales (CTS2) (DOC 76 kb)

Existing research suggests that adults make effective trustworthiness judgments based on facial attractiveness during initial interactions. However, little is known about how children judge trustworthiness from faces. The present study examined the facial features that contributed to judgments of trustworthiness and attractiveness by three groups of Chinese children aged 8 years old ( n = 34; 17 boys), 10 years old ( n = 34; 17 boys), and 12 years old ( n = 34; 17 boys) and a comparison group of 37 undergraduates (M age = 20.2 yr.; 16 men). Using FaceGen Modeler 3.1, a total of 400 East Asian adult faces (200 male, 200 female) portraying neutral emotions with direct gazes were generated. The faces were represented by 61 shape features and were presented for a maximum of 3,000 msec. in the center of the computer screen in randomized order. The participants were asked to judge whether each person was trustworthy and to rate the level of trustworthiness; 1 month later, the attractiveness of the same faces was judged using a similar procedure. The children and the adults used similar facial features to judge trustworthiness (e.g., the brow ridge, nose, and chin). Some of the facial features used by the different age groups as the basis for the trustworthiness and attractiveness judgments were similar. Facial attractiveness accounted for roughly 30 to 60% of the variance in the groups' trustworthiness judgments. Thus, facial attractiveness may serve as a heuristic property that signals trustworthiness and guides adaptive social decisions. More importantly, even children as young as 8 years old use a strategy similar to that of adults to make trustworthiness judgments, although some differences in the use of specific facial features were observed among the age groups.

Abstract 5264 Objective Toll-like receptor 4 (TLR-4) has the ability to activate platelet and involve in intravascular coagulation, inflammatory cytokine and oxidative stressors release in sepsis. Nitric oxide (NO) synthesis in platelets is adjusted by iNOS and/or eNOS and contributes to platelet aggregation and adhesion. Our previous study has found that increased platelet aggregation in patients with sepsis was associated with the expression of TLR4 on platelets and NO synthesis in platelets. This study was to investigate whether inhibition of TLR-4 activation on platelets decreases eNOS(endothelial NO synthase)/NO disturbance-related platelet aggregation. Methods Blood samples were collected from 10 patients with severe sepsis and 10 healthy volunteers as controls. PRP(platelet-rich plasma) and PPP (platelet-poor plasma) were prepared for platelet aggregation, and platelet suspension (at a concentration of 2×108/mL platelets) for next experimemts. After the platelet suspension from healthy volunteers was incubated with L-Arginine (LA, 10 mM) alone, and LA and L-NAME (NΩ-Nitro-L-arginine methyl ester hydrochloride, 25mg/mL, a nonselective NOS inhibitor) for 1 hour, LPS(10.0μg/ml) was respectively added them. In separate experiments, the platelet suspension was preincubated with anti-TLR-4 Abs (10μg/mL) and then repeat above experiments. The levels of serine phosphorylation in eNOS (p-eNOS) and NO production, and platelet aggregation were determined with Western blotting, nitrate concentration analysis and platelet aggregometer, respectively. Results The protein levels of p-eNOS and NO production had 2.2-fold and 1.8-fold of increases in platelets from septic patients, and in vitro had 1.8-fold and 1.7-fold of increases in LA-incubated platelets stimulated with LPS as compared to controls. The p-eNOS expression and NO production were inhibited in the presence of L-NAME. Furthermore, thrombin-induced platelet aggregation was markedly promoted by LPS and L-NAME [(61 □ ‘98) %, (80□ ‘100)% versus (40□ ‘72)% of control) ], and the effect of LPS was abolished by LA pretreatment [(54□ ‘76)% ]. Blockade of TLR-4 didn't alter the elevated levels of p-eNOS and NO under LPS challenge, but the inhibition of L-NAME on p-eNOS and NO was significantly decreased. Importantly, blockade of TLR-4 significantly decreased platelet aggregation induced by LPS, and both LPS and L-NAME, but had no effects on LA pretreatment. Conclusion These data suggest that inhibition of TLR-4 may play a role in prevention from sepsis-induced platelet aggregation and maintaining platelet eNOS activity in sepsis. Disclosures: No relevant conflicts of interest to declare.